Experts and Doctors on mice in Baton Rouge, Louisiana, United States


Locale: Baton Rouge, Louisiana, United States
Topic: mice

Top Publications

  1. Vandergrifft E, Horohov D. Molecular cloning and expression of equine interleukin 2. Vet Immunol Immunopathol. 1993;39:395-406 pubmed
    ..Specific substitutions in those regions associated with p55 and p75 binding appear to account for this species-specifity. ..
  2. Zuppardo A, Siebeling R. An epimerase gene essential for capsule synthesis in Vibrio vulnificus. Infect Immun. 1998;66:2601-6 pubmed
    ..vulnificus that each express a serologically distinct CPS. Our results indicate that the epimerase gene is essential for capsule expression in V. vulnificus. ..
  3. Truett G, Tempelman R, Walker J, Wilson J. Misty (m) affects growth traits. Am J Physiol. 1998;275:R29-32 pubmed
    ..More accurate estimates of Leprdb genotype effects can be made by removing m from populations segregating Leprdb and using a direct assay to measure Leprdb genotype. ..
  4. Stephens J, Lumpkin S, Fishman J. Activation of signal transducers and activators of transcription 1 and 3 by leukemia inhibitory factor, oncostatin-M, and interferon-gamma in adipocytes. J Biol Chem. 1998;273:31408-16 pubmed
    ..These studies demonstrate the highly specific and quantitative activation of STATs 1 and 3 by LIF, OSM, and IFNgamma in adipocytes and indicate that STAT 3 is a substrate for MAPK in adipocytes. ..
  5. Floyd Z, Stephens J. Interferon-gamma-mediated activation and ubiquitin-proteasome-dependent degradation of PPARgamma in adipocytes. J Biol Chem. 2002;277:4062-8 pubmed
  6. Floyd Z, Stephens J. STAT5A promotes adipogenesis in nonprecursor cells and associates with the glucocorticoid receptor during adipocyte differentiation. Diabetes. 2003;52:308-14 pubmed
    ..Moreover, we have shown that STAT5A is associated with the glucocorticoid receptor during adipogenesis in a highly regulated manner. ..
  7. Lin L, York D. 5-HT1B receptors modulate the feeding inhibitory effects of enterostatin. Brain Res. 2005;1062:26-31 pubmed
    ..The data imply that the enterostatin anorectic response may be modulated by 5-HT1B receptors and that a neuronal pathway from the amygdala to the PVN regulates the enterostatin response through activation of 5-HTlB receptors in PVN. ..
  8. Zheng H, Patterson L, Berthoud H. Orexin signaling in the ventral tegmental area is required for high-fat appetite induced by opioid stimulation of the nucleus accumbens. J Neurosci. 2007;27:11075-82 pubmed
  9. Marigo V, Courville K, Hsu W, Feng J, Cheng H. TRPM4 impacts on Ca2+ signals during agonist-induced insulin secretion in pancreatic beta-cells. Mol Cell Endocrinol. 2009;299:194-203 pubmed publisher
    ..Our data suggest that depolarizing currents generated by TRPM4 are an important component in the control of intracellular Ca(2+) signals necessary for insulin secretion and perhaps glucagon from alpha-cells. ..

More Information

Publications250 found, 100 shown here

  1. Zhang L, Ebenezer P, Dasuri K, Bruce Keller A, Liu Y, Keller J. Proteasome inhibition modulates kinase activation in neural cells: relevance to ubiquitination, ribosomes, and survival. J Neurosci Res. 2009;87:3231-8 pubmed publisher
    ..Together these data indicate that ERK1/2 and JNK activation may play differential roles in modulating neurochemical disturbances and neurotoxicity induced by proteasome inhibition. ..
  2. Kim J, Kang K, Kim J. YY1's role in DNA methylation of Peg3 and Xist. Nucleic Acids Res. 2009;37:5656-64 pubmed publisher
    ..Overall, the current study suggests that YY1 likely plays a role in the de novo DNA methylation of the DMRs of Peg3 and Xist during oogenesis and also in the maintenance of unmethylation status of these DMRs during spermatogenesis. ..
  3. Tu H, Hsuchou H, Kastin A, Wu X, Pan W. Unique leptin trafficking by a tailless receptor. FASEB J. 2010;24:2281-91 pubmed publisher
    ..Thus, leptin-induced internalization of the ligand-receptor complex can occur without specific sorting signals in the cytoplasmic region of ObR. This novel finding may have significant implications for leptin transport. ..
  4. Purpera M, Shen L, Taghavi M, Munzberg H, Martin R, Hutson S, et al. Impaired branched chain amino acid metabolism alters feeding behavior and increases orexigenic neuropeptide expression in the hypothalamus. J Endocrinol. 2012;212:85-94 pubmed publisher
    ..These data thus suggest that either BCAAs do not act as physiological signals of protein status or the loss of BCAA metabolism within brain glia impairs the detection of protein balance. ..
  5. Pan W, Hsuchou H, Jayaram B, Khan R, Huang E, Wu X, et al. Leptin action on nonneuronal cells in the CNS: potential clinical applications. Ann N Y Acad Sci. 2012;1264:64-71 pubmed publisher
    ..Overall, the glial leptin system shows robust regulation and plays an essential role in obesity. Strategies to manipulate this nonneuronal leptin signaling may have major clinical impact. ..
  6. Davis G, Ray N, Lahiri R, Gillis T, Krahenbuhl J, Williams D, et al. Molecular assays for determining Mycobacterium leprae viability in tissues of experimentally infected mice. PLoS Negl Trop Dis. 2013;7:e2404 pubmed publisher
    ..The purpose of this study was to develop a simple and sensitive molecular assay for determining M. leprae viability directly from infected tissues...
  7. Wise G, Marks S, Zhao L. Effect of CSF-1 on in vivo expression of c-fos in the dental follicle during tooth eruption. Eur J Oral Sci. 1998;106 Suppl 1:397-400 pubmed
    ..In turn, c-fos might act to promote fusion of monocytes into the osteoclasts needed for alveolar bone resorption and tooth eruption. ..
  8. Baghian A, Chouljenko V, Dauvergne O, Newmant M, Baghian S, Kousoulas K. Protective immunity against lethal HSV-1 challenge in mice by nucleic acid-based immunisation with herpes simplex virus type-1 genes specifying glycoproteins gB and gD. J Med Microbiol. 2002;51:350-7 pubmed
    ..p. route induced humoral responses in some mice and protected the animals against lethal HSV-1 challenge only when the formulations contained copolymers. The BALB/c mouse model was shown to be as good a model as the hairless mouse model. ..
  9. Job C, McCormick G, Scollard D, Truman R. Electron microscope appearance of lepromatous footpads of nude mice [corrected]. Int J Lepr Other Mycobact Dis. 2003;71:231-9 pubmed
    ..leprae were identified in Schwann cells and endothelial cells, singly and in clumps. M. leprae filled macrophages, and free M. leprae were found in large numbers in the endoneurium without producing any significant demyelination. ..
  10. Kim J, Hinz A, Choo J, Stubbs L, Kim J. YY1 as a controlling factor for the Peg3 and Gnas imprinted domains. Genomics. 2007;89:262-9 pubmed
    ..YY1 knockdown also resulted in changes in the expression levels of Xist and Snrpn. These results support the idea that YY1 plays a major role, as a trans factor, in the control of these imprinted domains. ..
  11. Ye J, Gao Z, Yin J, He Q. Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab. 2007;293:E1118-28 pubmed
    ..These data suggest a potential role of hypoxia in the induction of chronic inflammation and inhibition of adiponectin in the adipose tissue in obesity. ..
  12. Truman R, Andrews P, Robbins N, Adams L, Krahenbuhl J, Gillis T. Enumeration of Mycobacterium leprae using real-time PCR. PLoS Negl Trop Dis. 2008;2:e328 pubmed publisher
    ..Molecular enumeration is a rapid, objective and highly reproducible means to estimate the numbers of M. leprae in tissues, and application of the technique can facilitate work with this agent in many laboratories...
  13. Yang H, Youm Y, Sun Y, Rim J, Galban C, Vandanmagsar B, et al. Axin expression in thymic stromal cells contributes to an age-related increase in thymic adiposity and is associated with reduced thymopoiesis independently of ghrelin signaling. J Leukoc Biol. 2009;85:928-38 pubmed publisher
    ..Our data are consistent with the hypothesis that blocking the specific proadipogenic signals in the thymus may complement the present approaches to rejuvenate thymic function during aging. ..
  14. Israyelyan A, Shannon E, Baghian A, Kearney M, Kousoulas K. Thalidomide suppressed the growth of 4T1 cells into solid tumors in Balb/c mice in a combination therapy with the oncolytic fusogenic HSV-1 OncdSyn. Cancer Chemother Pharmacol. 2009;64:1201-10 pubmed publisher
    ..Compared to PBS controls, there was a significant difference in the number of metastatic nodes in the lungs. Thalidomide alone delayed tumor growth, but the combination of thalidomide with OncdSyn appeared to produce the best results. ..
  15. Salbaum J, Kappen C. Neural tube defect genes and maternal diabetes during pregnancy. Birth Defects Res A Clin Mol Teratol. 2010;88:601-11 pubmed publisher
    ..Unraveling the mechanisms underlying such epigenetic modifications in diabetic pregnancies will help to understand how teratogenic insults compromise embryonic development and possibly provide avenues for therapeutic intervention. ..
  16. Chang J, Fernand V, Zhang Y, Shin J, Jun H, Joshi Y, et al. NT-PGC-1α protein is sufficient to link β3-adrenergic receptor activation to transcriptional and physiological components of adaptive thermogenesis. J Biol Chem. 2012;287:9100-11 pubmed publisher
    ..Furthermore, the transcriptional shift from exon 1a to 1b supports isoform-specific roles for NT-PGC-1α in basal and adaptive thermogenesis. ..
  17. Baños Lara M, Ghosh A, Guerrero Plata A. Critical role of MDA5 in the interferon response induced by human metapneumovirus infection in dendritic cells and in vivo. J Virol. 2013;87:1242-51 pubmed publisher
    ..These findings are relevant for a better understanding of the pathogenesis of hMPV infection. ..
  18. Bae J, Ricciardi C, Esposito D, Komarnytsky S, Hu P, Curry B, et al. Activation of pattern recognition receptors in brown adipocytes induces inflammation and suppresses uncoupling protein 1 expression and mitochondrial respiration. Am J Physiol Cell Physiol. 2014;306:C918-30 pubmed publisher
    ..Our results uncover novel targets in BAT for obesity treatment and prevention. ..
  19. Ali M, Torian B, Vedeckis W. Identification of human, mouse, and rat retinoic acid receptor alpha using monoclonal antibodies. Biochem Biophys Res Commun. 1992;182:1032-9 pubmed
    ..These monoclonal antibodies also detected differing levels of RAR alpha in various rat tissues. These monoclonal antibodies will serve as powerful reagents to study the structure and regulation of the retinoic acid receptor protein. ..
  20. DeLany J, West D. Changes in body composition with conjugated linoleic acid. J Am Coll Nutr. 2000;19:487S-493S pubmed
    ..Most of the studies conducted so far must be repeated using the purified isomers in order to determine which isomers are responsible for each of the identified actions of CLA. ..
  21. Liu X, Rossmeisl M, McClaine J, Riachi M, Harper M, Kozak L. Paradoxical resistance to diet-induced obesity in UCP1-deficient mice. J Clin Invest. 2003;111:399-407 pubmed
    ..We propose that in the absence of nonshivering thermogenesis, alternative, calorically more costly pathways of metabolism must be used to maintain body temperature. ..
  22. Pakhomova S, Luka Z, Grohmann S, Wagner C, Newcomer M. Glycine N-methyltransferases: a comparison of the crystal structures and kinetic properties of recombinant human, mouse and rat enzymes. Proteins. 2004;57:331-7 pubmed
    ..There is an increase in kcat when going from rat to mouse to human, suggesting a correlation with the increased flexibility of some structural elements of the respective enzymes. ..
  23. Roy M, Reiland J, Murry B, Chouljenko V, Kousoulas K, Marchetti D. Antisense-mediated suppression of Heparanase gene inhibits melanoma cell invasion. Neoplasia. 2005;7:253-62 pubmed
  24. Gao Z, Chiao P, Zhang X, Zhang X, Lazar M, Seto E, et al. Coactivators and corepressors of NF-kappaB in IkappaB alpha gene promoter. J Biol Chem. 2005;280:21091-8 pubmed
    ..This model may represent a mechanism for integration of extracellular signals into a precise control of gene transcription. ..
  25. Luo C, Lu X, Stubbs L, Kim J. Rapid evolution of a recently retroposed transcription factor YY2 in mammalian genomes. Genomics. 2006;87:348-55 pubmed
  26. Coulter A, Stephens J. STAT5 activators modulate acyl CoA oxidase (AOX) expression in adipocytes and STAT5A binds to the AOX promoter in vitro. Biochem Biophys Res Commun. 2006;344:1342-5 pubmed
    ..Our observations are consistent with other studies that demonstrate that STAT5 activators modulate fatty acid oxidation. ..
  27. Goh B, Wu X, Evans A, Johnson M, Hill M, Gimble J. Food entrainment of circadian gene expression altered in PPARalpha-/- brown fat and heart. Biochem Biophys Res Commun. 2007;360:828-33 pubmed
    ..Likewise, PPARalpha responsive genes in the livers of PPARalpha null mice exhibited a significantly prolonged phase shift relative to control mice. These findings confirm and extend recent observations in the literature. ..
  28. Sriramula S, Haque M, Majid D, Francis J. Involvement of tumor necrosis factor-alpha in angiotensin II-mediated effects on salt appetite, hypertension, and cardiac hypertrophy. Hypertension. 2008;51:1345-51 pubmed publisher
    ..These results suggest that TNF-alpha plays a mechanistic role in mediating chronic Ang II-induced effects on salt appetite and blood pressure, as well as on cardiac hypertrophy. ..
  29. Iyer A, Pahar B, Boudreaux M, Wakamatsu N, Roy A, Chouljenko V, et al. Recombinant vesicular stomatitis virus-based west Nile vaccine elicits strong humoral and cellular immune responses and protects mice against lethal challenge with the virulent west Nile virus strain LSU-AR01. Vaccine. 2009;27:893-903 pubmed publisher
    ..These results suggest that VSV-vectored vaccines administered intranasally can efficiently induce protective humoral and cellular immune responses against WNV infections. ..
  30. Mynatt R. Carnitine and type 2 diabetes. Diabetes Metab Res Rev. 2009;25 Suppl 1:S45-9 pubmed publisher
    ..Carefully controlled clinical trials are warranted to determine the efficacy dietary carnitine supplementation as an adjunctive treatment for type 2 diabetes...
  31. Gao X, Raghavamenon A, D Auvergne O, Uppu R. Cholesterol secoaldehyde induces apoptosis in J774 macrophages via mitochondrial pathway but not involving reactive oxygen species as mediators. Biochem Biophys Res Commun. 2009;389:382-7 pubmed publisher
  32. Sathishkumar K, Raghavamenon A, Ganeshkumar K, Telaprolu R, Parinandi N, Uppu R. Simultaneous analysis of expression of multiple redox-sensitive and apoptotic genes in hypothalamic neurons exposed to cholesterol secoaldehyde. Methods Mol Biol. 2010;610:263-84 pubmed publisher
  33. Dhurandhar E, Dubuisson O, Mashtalir N, Krishnapuram R, Hegde V, Dhurandhar N. E4orf1: a novel ligand that improves glucose disposal in cell culture. PLoS ONE. 2011;6:e23394 pubmed publisher
    ..Thus, the highly attractive anti-hyperglycemic effect of Ad36 is mirrored by E4orf1 protein, which may offer a novel ligand to develop anti-hyperglycemic drugs. ..
  34. Dhurandhar E, Krishnapuram R, Hegde V, Dubuisson O, Tao R, Dong X, et al. E4orf1 improves lipid and glucose metabolism in hepatocytes: a template to improve steatosis & hyperglycemia. PLoS ONE. 2012;7:e47813 pubmed publisher
    ..Elucidating the underlying molecular mechanism may help develop therapeutic approaches for treating diabetes or non-alcoholic fatty liver disease(NAFLD). ..
  35. Lupachyk S, Watcho P, Stavniichuk R, Shevalye H, Obrosova I. Endoplasmic reticulum stress plays a key role in the pathogenesis of diabetic peripheral neuropathy. Diabetes. 2013;62:944-52 pubmed publisher
    ..Our findings reveal an important role of endoplasmic reticulum stress in the development of diabetic peripheral neuropathy and identify a potential new therapeutic target. ..
  36. Primeaux S, Barnes M, Braymer H. Hypothalamic QRFP: regulation of food intake and fat selection. Horm Metab Res. 2013;45:967-74 pubmed publisher
    ..The present review discusses the role of QRFP in the regulation of feeding behavior, with emphasis on the intake of dietary fat. ..
  37. Jin L, Batra S, Jeyaseelan S. Diminished neutrophil extracellular trap (NET) formation is a novel innate immune deficiency induced by acute ethanol exposure in polymicrobial sepsis, which can be rescued by CXCL1. PLoS Pathog. 2017;13:e1006637 pubmed publisher
  38. West D, Waguespack J, York B, Goudey Lefevre J, Price R. Genetics of dietary obesity in AKR/J x SWR/J mice: segregation of the trait and identification of a linked locus on chromosome 4. Mamm Genome. 1994;5:546-52 pubmed
    ..However, a quantitative trait locus was found that maps distal to the db gene on Chromosome (Chr) 4. This locus has been designated dietary obese 1 or Do1. ..
  39. Bilder P, Ding H, Newcomer M. Crystal structure of the ancient, Fe-S scaffold IscA reveals a novel protein fold. Biochemistry. 2004;43:133-9 pubmed
    ..In addition, the crystal packing reveals a helical assembly that is constructed from two possible tetrameric oligomers of IscA. ..
  40. Pan W, Tu H, Hsuchou H, Daniel J, Kastin A. Unexpected amplification of leptin-induced Stat3 signaling by urocortin: implications for obesity. J Mol Neurosci. 2007;33:232-8 pubmed
    ..By unexpectedly potentiating leptin signaling through Stat, urocortin amplifies the cellular response of leptin. This novel phenomenon suggests that urocortin can play an important compensatory role during leptin resistance in obesity. ..
  41. Murphy G, Rouse R, Polk W, Henk W, Barker S, Boudreaux M, et al. Combustion-derived hydrocarbons localize to lipid droplets in respiratory cells. Am J Respir Cell Mol Biol. 2008;38:532-40 pubmed
    ..These PAHs, including several found in BDS and in cigarette smoke, activate xenobiotic metabolism pathways and thereby potentiate their toxicity. ..
  42. Nel Themaat L, Gómez M, Pope C, Lopez M, Wirtu G, Cole A, et al. Cloned embryos from semen. Part 1: in vitro proliferation of epithelial cells on embryonic fibroblasts after isolation from semen by gradient centrifugation. Cloning Stem Cells. 2008;10:143-60 pubmed publisher
    ..Specifically, cells isolated and cultured from cryopreserved semen of nonliving males could be used for producing embryos by somatic cell nuclear transfer. ..
  43. Lahiri R, Randhawa B, Krahenbuhl J. Infection of mouse macrophages with viable Mycobacterium leprae does not induce apoptosis. J Infect Dis. 2010;201:1736-42 pubmed publisher
    ..leprae. The results strongly suggest that the viability and purity of the leprosy bacilli used for in vitro studies determines the extent of apoptosis observed in infected host cells. ..
  44. Yang H, Youm Y, Vandanmagsar B, Ravussin A, Gimble J, Greenway F, et al. Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance. J Immunol. 2010;185:1836-45 pubmed publisher
    ..Development of future long-term T cell depletion protocols specific to visceral fat may represent an additional strategy to manage obesity-associated comorbidities. ..
  45. Seemanapalli S, Xu Q, McShan K, Liang F. Outer surface protein C is a dissemination-facilitating factor of Borrelia burgdorferi during mammalian infection. PLoS ONE. 2010;5:e15830 pubmed publisher
    ..burgdorferi to disseminate to remote tissues after inoculation into mice. The study indicates that OspC plays an important role in dissemination of B. burgdorferi during mammalian infection. ..
  46. He Q, Gao Z, Yin J, Zhang J, Yun Z, Ye J. Regulation of HIF-1{alpha} activity in adipose tissue by obesity-associated factors: adipogenesis, insulin, and hypoxia. Am J Physiol Endocrinol Metab. 2011;300:E877-85 pubmed publisher
    ..Adipose tissue HIF-1? activity is influenced by multiple signals, including adipogenesis, insulin, and hypoxia in obesity. The transcriptional activity of HIF-1? is inhibited by HDAC3-SMRT corepressor in the VEGF gene promoter. ..
  47. Stavniichuk R, Drel V, Shevalye H, Maksimchyk Y, Kuchmerovska T, Nadler J, et al. Baicalein alleviates diabetic peripheral neuropathy through inhibition of oxidative-nitrosative stress and p38 MAPK activation. Exp Neurol. 2011;230:106-13 pubmed publisher
    ..The findings provide rationale for studying hydroxyflavones with an improved pharmacological profile as potential treatments for diabetic neuropathy and other diabetic complications...
  48. Drost J, Lee W. Biological basis of germline mutation: comparisons of spontaneous germline mutation rates among drosophila, mouse, and human. Environ Mol Mutagen. 1995;25 Suppl 26:48-64 pubmed
  49. Wise G, Huang H, Que B. Gene expression of potential tooth eruption molecules in the dental follicle of the mouse. Eur J Oral Sci. 1999;107:482-6 pubmed
    ..These results provide a standard for future studies on eruption in the mouse molar and extends the number of species in which putative eruption molecules are expressed at a critical time of eruption. ..
  50. Rossmeisl M, Rim J, Koza R, Kozak L. Variation in type 2 diabetes--related traits in mouse strains susceptible to diet-induced obesity. Diabetes. 2003;52:1958-66 pubmed
    ..In conclusion, phenotypic variation in insulin resistance and glucose production in the B6 and AKR strains could provide a genetic system for the identification of genes controlling glucose homeostasis. ..
  51. Zhu S, Waguespack M, Barker S, Li S. Doxorubicin directs the accumulation of interleukin-12 induced IFN gamma into tumors for enhancing STAT1 dependent antitumor effect. Clin Cancer Res. 2007;13:4252-60 pubmed
    ..The enhanced antitumor efficacy by coadministration of doxorubicin and IL-12 is dependent on the accumulation of IFN gamma in tumors. This discovery provides a possible strategy to reduce side effects caused by IL-12. ..
  52. Ptitsyn A, Gimble J. Analysis of circadian pattern reveals tissue-specific alternative transcription in leptin signaling pathway. BMC Bioinformatics. 2007;8 Suppl 7:S15 pubmed
    ..We hypothesize that differential oscillation of alternative transcripts may provide a mechanism to maintain steady levels of expression in spite of circadian baseline variation. ..
  53. Xu Q, McShan K, Liang F. Essential protective role attributed to the surface lipoproteins of Borrelia burgdorferi against innate defences. Mol Microbiol. 2008;69:15-29 pubmed publisher
    ..Taken together, the study demonstrated that the surface lipoproteins provide B. burgdorferi with an essential protective function against host innate elimination. ..
  54. Zhang J, Gao Z, Yin J, Quon M, Ye J. S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2. J Biol Chem. 2008;283:35375-82 pubmed publisher
    ..We present a new mechanism for TNF-alpha to induce insulin resistance that involves activation of S6K by an IKK2-dependent pathway. S6K directly phosphorylates IRS-1 on multiple serine residues to inhibit insulin signaling. ..
  55. Cai S, Zemans R, Young S, Worthen G, Jeyaseelan S. Myeloid differentiation protein-2-dependent and -independent neutrophil accumulation during Escherichia coli pneumonia. Am J Respir Cell Mol Biol. 2009;40:701-9 pubmed publisher
    ..coli-induced neutrophil accumulation and pulmonary host defense. ..
  56. Greenway F, Whitehouse M, Guttadauria M, Anderson J, Atkinson R, Fujioka K, et al. Rational design of a combination medication for the treatment of obesity. Obesity (Silver Spring). 2009;17:30-9 pubmed publisher
    ..This novel treatment approach (BUP+NAL) holds promise for the treatment of obesity.\ ..
  57. Youm Y, Yang H, Sun Y, Smith R, Manley N, Vandanmagsar B, et al. Deficient ghrelin receptor-mediated signaling compromises thymic stromal cell microenvironment by accelerating thymic adiposity. J Biol Chem. 2009;284:7068-77 pubmed publisher
    ..These data suggest that Ghrl may be a novel regulator of EMT and preserves thymic stromal cell microenvironment by controlling age-related adipocyte development within the thymus. ..
  58. Sutton G, Centanni A, Butler A. Protein malnutrition during pregnancy in C57BL/6J mice results in offspring with altered circadian physiology before obesity. Endocrinology. 2010;151:1570-80 pubmed publisher
    ..Altered circadian physiology may be symptomatic of the metabolic dysregulation associated with IUGR, and altered feeding behavior and substrate metabolism may contribute to the obese phenotype. ..
  59. Xu Q, McShan K, Liang F. Two regulatory elements required for enhancing ospA expression in Borrelia burgdorferi grown in vitro but repressing its expression during mammalian infection. Microbiology. 2010;156:2194-204 pubmed publisher
    ..burgdorferi with a molecular mechanism to quickly adapt to the distinct environments during its enzootic life cycle. ..
  60. Barnes M, Rogers R, Van Meter M, Hermann G. Co-localization of TRHR1 and LepRb receptors on neurons in the hindbrain of the rat. Brain Res. 2010;1355:70-85 pubmed publisher
    ..These anatomical arrangements may provide a basis for the synergy between leptin and TRH to increase thermogenesis. ..
  61. White U, Stewart W, Stephens J. Gp130 cytokines exert differential patterns of crosstalk in adipocytes both in vitro and in vivo. Obesity (Silver Spring). 2011;19:903-10 pubmed publisher
  62. McMains E, Krishnan V, Prasad S, Gleason E. Expression and localization of CLC chloride transport proteins in the avian retina. PLoS ONE. 2011;6:e17647 pubmed publisher
    ..These findings, which represent the first systematic investigation of CLC transporter expression in the retina, support diverse functions for the different CLCs in this tissue. ..
  63. Floyd Z, Stephens J. Controlling a master switch of adipocyte development and insulin sensitivity: covalent modifications of PPAR?. Biochim Biophys Acta. 2012;1822:1090-5 pubmed publisher
    ..In the following review, we have highlighted the regulation of PPAR? by covalent modifications, the interplay between these interactions and how these post-translational modifications impact metabolic disease states. ..
  64. Salbaum J, Kappen C. Responses of the embryonic epigenome to maternal diabetes. Birth Defects Res A Clin Mol Teratol. 2012;94:770-81 pubmed publisher
  65. Richardson A, Fischer K, Speakman J, De Cabo R, Mitchell S, Peterson C, et al. Measures of Healthspan as Indices of Aging in Mice-A Recommendation. J Gerontol A Biol Sci Med Sci. 2016;71:427-30 pubmed publisher
    ..Finally, we strongly recommend that functional measurements be performed in both males and females so that sex differences in the rate of functional decline in different domains are taken into consideration. ..
  66. Chowdhury S. Identification of an epitope within the Bovine herpesvirus 1 glycoprotein E cytoplasmic tail and use of a monoclonal antibody directed against the epitope for the differentiation between vaccinated and infected animals. J Virol Methods. 2016;233:97-104 pubmed publisher
    ..Therefore, the gE CT-ELISA, based on the mAb2H8F3 and E. coli expressed gE CT protein, is suitable for differentiating the wt virus-infected and BoHV-1 tmv-vaccinated cattle. ..
  67. Kim J, He H, Kim H. Inversion of the imprinting control region of the Peg3 domain. PLoS ONE. 2017;12:e0181591 pubmed publisher
    ..Overall, the current study suggests that the orientation of the Peg3-ICR may play no role in its allele-specific DNA methylation, but very critical for the transcriptional regulation of the entire imprinted domain. ..
  68. West D, Goudey Lefevre J, York B, Truett G. Dietary obesity linked to genetic loci on chromosomes 9 and 15 in a polygenic mouse model. J Clin Invest. 1994;94:1410-6 pubmed
    ..Both of these chromosomal regions contain candidate genes which may contribute to variation in the phenotype. These loci also exert a significant control over individual adipose depot weights. ..
  69. Zhou Y, Cheshire A, Howell L, Ryan D, Harris R. Neuroautoantibody immunoreactivity in relation to aging and stress in apolipoprotein E-deficient mice. Brain Res Bull. 1999;49:173-9 pubmed
    ..These results suggest that neuroautoimmunity associated with the aging process and exposure to chronic stress may be involved in early development of neurodegeneration in mice with ApoE-deficiency. ..
  70. Weidner E, Canning E, Rutledge C, Meek C. Mosquito (Diptera: Culicidae) host compatibility and vector competency for the human myositic parasite Trachipleistophora hominis (Phylum Microspora). J Med Entomol. 1999;36:522-5 pubmed
    ..Preliminary observations also showed that T. hominis spores can be passively transferred from infected mosquitoes to a sugar water substrate. ..
  71. Hogan J, Stephens J. The identification and characterization of a STAT 1 binding site in the PPARgamma2 promoter. Biochem Biophys Res Commun. 2001;287:484-92 pubmed
    ..These results and our previous work suggest that cytokine induced STAT 1 homodimers modulate the transcriptional repression of PPARgamma2 in adipocytes. ..
  72. Zvonic S, Cornelius P, Stewart W, Mynatt R, Stephens J. The regulation and activation of ciliary neurotrophic factor signaling proteins in adipocytes. J Biol Chem. 2003;278:2228-35 pubmed
    ..In summary, CNTF affects adipocyte gene expression, and the specific receptor for this cytokine is induced in rodent models of obesity/type II diabetes. ..
  73. Hansel W, Leuschner C, Gawronska B, Enright F. Targeted destruction of prostate cancer cells and xenografts by lytic peptide-betaLH conjugates. Reprod Biol. 2001;1:20-32 pubmed
    ..No changes in body weight or histological abnormalities were found in any of the organs examined, except the testes. ..
  74. Hogan J, Stephens J. The regulation of fatty acid synthase by STAT5A. Diabetes. 2005;54:1968-75 pubmed
    ..Furthermore, our results indicate that STAT5A has an antilipogenic function in adipocytes and may contribute to the regulation of energy balance. ..
  75. Pan W, Tu H, Kastin A. Differential BBB interactions of three ingestive peptides: obestatin, ghrelin, and adiponectin. Peptides. 2006;27:911-6 pubmed
    ..The differential interactions of obestatin, adiponectin, and ghrelin with the BBB illustrate their distinctive physiological interactions with the CNS. ..
  76. Gao Z, Wang Z, Zhang X, Butler A, Zuberi A, Gawronska Kozak B, et al. Inactivation of PKCtheta leads to increased susceptibility to obesity and dietary insulin resistance in mice. Am J Physiol Endocrinol Metab. 2007;292:E84-91 pubmed
    ..This study suggests that loss of PKCtheta reduces energy expenditure and increases the risk of dietary obesity and insulin resistance in mice. ..
  77. Vareniuk I, Pavlov I, Drel V, Lyzogubov V, Ilnytska O, Bell S, et al. Nitrosative stress and peripheral diabetic neuropathy in leptin-deficient (ob/ob) mice. Exp Neurol. 2007;205:425-36 pubmed
    ..Peroxynitrite decomposition catalysts alleviate Type 2 diabetes-associated sensory nerve dysfunction, likely by mechanism(s) not involving arrest of degenerative changes or enhanced regeneration of small sensory nerve fibers. ..
  78. Xu Q, Seemanaplli S, McShan K, Liang F. Increasing the interaction of Borrelia burgdorferi with decorin significantly reduces the 50 percent infectious dose and severely impairs dissemination. Infect Immun. 2007;75:4272-81 pubmed
    ..Taken together, the study highlights the importance of controlling surface antigen expression in the infectivity, dissemination, tissue colonization, pathogenicity, and persistence of B. burgdorferi during mammalian infection. ..
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