Experts and Doctors on amino acid sequence in Baton Rouge, Louisiana, United States


Locale: Baton Rouge, Louisiana, United States
Topic: amino acid sequence

Top Publications

  1. Foster T, Alvarez X, Kousoulas K. Plasma membrane topology of syncytial domains of herpes simplex virus type 1 glycoprotein K (gK): the UL20 protein enables cell surface localization of gK but not gK-mediated cell-to-cell fusion. J Virol. 2003;77:499-510 pubmed
  2. Xiao L, Williams A, Grove A. The C-terminal domain of yeast high mobility group protein HMO1 mediates lateral protein accretion and in-phase DNA bending. Biochemistry. 2010;49:4051-9 pubmed publisher
    ..This mode of binding is reminiscent of that proposed for the mammalian RNA polymerase I transcription factor UBF. ..
  3. Cavalier M, Yim Y, Asamizu S, Neau D, Almabruk K, Mahmud T, et al. Mechanistic insights into validoxylamine A 7'-phosphate synthesis by VldE using the structure of the entire product complex. PLoS ONE. 2012;7:e44934 pubmed publisher
  4. Melvin A, Dumberger L, Woss G, Waters M, Allbritton N. Identification of a p53-based portable degron based on the MDM2-p53 binding region. Analyst. 2016;141:570-8 pubmed publisher
    ..This analysis identified the five amino acid sequence, KGSYG, corresponding to residues 105-108 with an added N-terminal lysine, as a portable degron since this sequence demonstrated the most rapid ubiquitination kinetics. ..
  5. Karan R, Subudhi P. Overexpression of a nascent polypeptide associated complex gene (Sa?NAC) of Spartina alterniflora improves tolerance to salinity and drought in transgenic Arabidopsis. Biochem Biophys Res Commun. 2012;424:747-52 pubmed publisher
  6. Pakhomova S, Rife C, Armstrong R, Newcomer M. Structure of fosfomycin resistance protein FosA from transposon Tn2921. Protein Sci. 2004;13:1260-5 pubmed
    ..However, the absence of K+, which has been shown to enhance enzymatic activity, appears to contribute to conformational heterogeneity in the K(+)-binding loops. ..
  7. Sunyakumthorn P, Petchampai N, Kearney M, Sonenshine D, Macaluso K. Molecular characterization and tissue-specific gene expression of Dermacentor variabilis ?-catenin in response to rickettsial infection. Insect Mol Biol. 2012;21:197-204 pubmed publisher
    ..Studying tick-derived molecules associated with rickettsial infection will provide a better understanding of the transmission dynamics of tick-borne rickettsial diseases. ..
  8. Oldham M, Brash A, Newcomer M. Insights from the X-ray crystal structure of coral 8R-lipoxygenase: calcium activation via a C2-like domain and a structural basis of product chirality. J Biol Chem. 2005;280:39545-52 pubmed
    ..Moreover, a structural basis for R chiral specificity is also revealed; creation of a small oxygen pocket next to Gly(428) (Ala in all S-LOX isozymes) promoted C-8 oxygenation with R chirality on the activated fatty acid substrate. ..
  9. Meades G, McLachlan A, Sallans L, Limbach P, Frankel L, Bricker T. Association of the 17-kDa extrinsic protein with photosystem II in higher plants. Biochemistry. 2005;44:15216-21 pubmed
    ..These residues appear to identify a protein domain involved in the interaction of the 17-kDa protein with the other components of the photosystem. ..

More Information


  1. Wei H, Wang Y, Chowdhury S. Bovine herpesvirus type 1 (BHV-1) UL49.5 luminal domain residues 30 to 32 are critical for MHC-I down-regulation in virus-infected cells. PLoS ONE. 2011;6:e25742 pubmed publisher
    ..In vitro, BHV-1 U(L)49.5 ?30-32 CT-null virus growth property was similar to that of BHV-1 wt and like the wt U(L)49.5, the mutant U(L)49.5 was incorporated in the virion envelope and it formed a complex with gM in the infected cells. ..
  2. Li S, Ding B, Chen R, Ruggiero C, Chen X. Evidence that the transcription elongation function of Rpb9 is involved in transcription-coupled DNA repair in Saccharomyces cerevisiae. Mol Cell Biol. 2006;26:9430-41 pubmed
    ..Our data suggest that the transcription elongation function of Rpb9 is involved in TCR. ..
  3. Zhang X, Kousoulas K, Storz J. The hemagglutinin/esterase gene of human coronavirus strain OC43: phylogenetic relationships to bovine and murine coronaviruses and influenza C virus. Virology. 1992;186:318-23 pubmed
    ..Phylogenetic analysis suggests that the HE genes of coronaviruses and influenza C virus have a common ancestral origin, and that bovine coronaviruses and HCV-OC43 are closely related. ..
  4. Chowdhury S. Identification of an epitope within the Bovine herpesvirus 1 glycoprotein E cytoplasmic tail and use of a monoclonal antibody directed against the epitope for the differentiation between vaccinated and infected animals. J Virol Methods. 2016;233:97-104 pubmed publisher
    ..Therefore, the gE CT-ELISA, based on the mAb2H8F3 and E. coli expressed gE CT protein, is suitable for differentiating the wt virus-infected and BoHV-1 tmv-vaccinated cattle. ..
  5. Sabanadzovic S, Wintermantel W, Valverde R, McCreight J, Aboughanem Sabanadzovic N. Cucumis melo endornavirus: Genome organization, host range and co-divergence with the host. Virus Res. 2016;214:49-58 pubmed publisher
    ..Such diverse host range is unreported for known endornaviruses and suggests a long history of CmEV association with cucurbits predating their speciation. ..
  6. Schully S, Hellberg M. Positive selection on nucleotide substitutions and indels in accessory gland proteins of the Drosophila pseudoobscura subgroup. J Mol Evol. 2006;62:793-802 pubmed publisher
    ..pseudoobscura subgroup were up to several times those in noncoding regions of the Drosophila genome. This suggests that indel substitutions may be under positive selection and may play a key role in the divergence of some Acps...
  7. Wei H, He J, Paulsen D, Chowdhury S. Bovine herpesvirus type 1 (BHV-1) mutant lacking U(L)49.5 luminal domain residues 30-32 and cytoplasmic tail residues 80-96 induces more rapid onset of virus neutralizing antibody and cellular immune responses in calves than the wild-type strain Coop. Vet Immunol Immunopathol. 2012;147:223-9 pubmed publisher
    ..05) and 14 days (VN Ab; P<0.05) earlier, respectively. Therefore, relative to wt in the BHV-1U(L)49.5 mutant virus-infected calves, primary neutralizing antibody and cellular immune responses were induced significantly more rapidly. ..
  8. Ali M, Torian B, Vedeckis W. Identification of human, mouse, and rat retinoic acid receptor alpha using monoclonal antibodies. Biochem Biophys Res Commun. 1992;182:1032-9 pubmed
    ..These monoclonal antibodies also detected differing levels of RAR alpha in various rat tissues. These monoclonal antibodies will serve as powerful reagents to study the structure and regulation of the retinoic acid receptor protein. ..
  9. Yang W, Moroney J, Moore T. Membrane lipid biosynthesis in Chlamydomonas reinhardtii: ethanolaminephosphotransferase is capable of synthesizing both phosphatidylcholine and phosphatidylethanolamine. Arch Biochem Biophys. 2004;430:198-209 pubmed
    ..reinhardtii EPT, similar to plant aminoalcoholphosphotransferase, is capable of catalyzing the final step of phosphatidylcholine biosynthesis, as well as that of phosphatidylethanolamine in the Kennedy pathway. ..
  10. Thompkins K, Chattopadhyay B, Xiao Y, Henk M, Doerrler W. Temperature sensitivity and cell division defects in an Escherichia coli strain with mutations in yghB and yqjA, encoding related and conserved inner membrane proteins. J Bacteriol. 2008;190:4489-500 pubmed publisher
    ..It is likely that YghB and YqjA play redundant but critical roles in membrane biology that are essential for completion of cell division in E. coli. ..
  11. Craig R, Cutrera J, Zhu S, Xia X, Lee Y, Li S. Administering plasmid DNA encoding tumor vessel-anchored IFN-alpha for localizing gene product within or into tumors. Mol Ther. 2008;16:901-6 pubmed publisher
    ..This gene product-based tumor-targeted gene therapy approach could complement any other tumor-targeted gene delivery method for improving tumor-targeting efficiency. ..
  12. Godeny E, Zeng L, Smith S, Brinton M. Molecular characterization of the 3' terminus of the simian hemorrhagic fever virus genome. J Virol. 1995;69:2679-83 pubmed
    ..In its virion morphology and size, genome structure and length, and replication strategy, SHFV is most similar to lactate dehydrogenase-elevating virus, equine arteritis virus, and porcine reproductive and respiratory syndrome virus. ..
  13. Grove A, Saavedra T. The role of surface-exposed lysines in wrapping DNA about the bacterial histone-like protein HU. Biochemistry. 2002;41:7597-603 pubmed
    ..We propose that Lys3 forms an internal saltbridge to Asp26 in HU homologues characterized by shorter binding sites and that its surface exposure, and hence a longer binding site, may correlate with absence of this aspartate. ..
  14. Karan R, Subudhi P. A stress inducible SUMO conjugating enzyme gene (SaSce9) from a grass halophyte Spartina alterniflora enhances salinity and drought stress tolerance in Arabidopsis. BMC Plant Biol. 2012;12:187 pubmed publisher
    ..In addition, this study demonstrates the potential of the halophyte grass S. alterniflora as a reservoir of abiotic stress related genes for crop improvement. ..
  15. Neau D, Gilbert N, Bartlett S, Boeglin W, Brash A, Newcomer M. The 1.85 A structure of an 8R-lipoxygenase suggests a general model for lipoxygenase product specificity. Biochemistry. 2009;48:7906-15 pubmed publisher
    ..We demonstrate that mutations within the channel significantly impact enzyme activity and propose a novel model for substrate binding potentially applicable to other members of this enzyme family. ..
  16. Huang H, Mackel B, Grove A. Streptomyces coelicolor encodes a urate-responsive transcriptional regulator with homology to PecS from plant pathogens. J Bacteriol. 2013;195:4954-65 pubmed publisher
    ..Since production of urate is associated with generation of reactive oxygen species by xanthine dehydrogenase, we propose that PecS functions under conditions of oxidative stress. ..
  17. Cavalier M, Kim S, Neau D, Lee Y. Molecular basis of the fructose-2,6-bisphosphatase reaction of PFKFB3: transition state and the C-terminal function. Proteins. 2012;80:1143-53 pubmed publisher
    ..These findings provide a new insight into the understanding of the phosphoryl transfer reaction. ..
  18. Pakhomova S, Gao B, Boeglin W, Brash A, Newcomer M. The structure and peroxidase activity of a 33-kDa catalase-related protein from Mycobacterium avium ssp. paratuberculosis. Protein Sci. 2009;18:2559-68 pubmed publisher
    ..Its structural features and the result of the enzyme assays support a role for MAP-2744c and its close homologues in mitigating challenge by a variety of reactive oxygen species. ..
  19. Xue Q, Hellberg M, Schey K, Itoh N, Eytan R, Cooper R, et al. A new lysozyme from the eastern oyster, Crassostrea virginica, and a possible evolutionary pathway for i-type lysozymes in bivalves from host defense to digestion. BMC Evol Biol. 2010;10:213 pubmed publisher
  20. Seo M, Lee Y. PFKFB3 regulates oxidative stress homeostasis via its S-glutathionylation in cancer. J Mol Biol. 2014;426:830-42 pubmed publisher
    ..This study provides a new insight into the roles of PFKFB3 as switch that senses and controls redox homeostasis in cancer in addition to its role in cancer glycolysis. ..
  21. Chenevert S, Fossett N, Chang S, Tsigelny I, Baker M, Lee W. Amino acids important in enzyme activity and dimer stability for Drosophila alcohol dehydrogenase. Biochem J. 1995;308 ( Pt 2):419-23 pubmed
  22. Kamau E, Bauerle K, Grove A. The Saccharomyces cerevisiae high mobility group box protein HMO1 contains two functional DNA binding domains. J Biol Chem. 2004;279:55234-40 pubmed
    ..The unique DNA binding properties of HMO1 are consistent with global roles in the maintenance of chromatin structure. ..
  23. Chen X, Ruggiero C, Li S. Yeast Rpb9 plays an important role in ubiquitylation and degradation of Rpb1 in response to UV-induced DNA damage. Mol Cell Biol. 2007;27:4617-25 pubmed
    ..Furthermore, we show that Rpb1, rather than the whole Pol II complex, is degraded in response to UV radiation and that the degradation is primarily mediated by the 26S proteasome. ..
  24. Plant K, Thune R. Cloning and characterisation of a channel catfish (Ictalurus punctatus) Mx gene. Fish Shellfish Immunol. 2004;16:391-405 pubmed
    ..Mx mRNA was constitutively expressed in channel catfish ovary (CCO) cells, but in higher quantities in response to poly I:C treatment. Mx was induced in channel catfish following injection with channel catfish virus (CCV) and poly I:C. ..
  25. Swiderski C, Sobol G, Lunn D, Horohov D. Molecular cloning, sequencing, and expression of equine interleukin-6. Vet Immunol Immunopathol. 2000;77:213-20 pubmed
    ..Treatment of B9 cells with an anti-IL-6 receptor antibody ablated the response to the recombinant equine IL-6. ..
  26. Harper J, Sussman M, Schaller G, Putnam Evans C, Charbonneau H, Harmon A. A calcium-dependent protein kinase with a regulatory domain similar to calmodulin. Science. 1991;252:951-4 pubmed
    ..The predicted structure of this kinase explains its direct regulation via calcium binding and establishes it as a prototype for a new family of calcium-regulated protein kinases...
  27. Kim J, Bergmann A, Choo J, Stubbs L. Genomic organization and imprinting of the Peg3 domain in bovine. Genomics. 2007;90:85-92 pubmed
    ..The imprinting of Mim1 and Usp29 along with Peg3 is the most evolutionarily selected feature in this imprinted domain, suggesting significant function of these three genes, either as protein-coding or as untranslated transcript genes. ..
  28. Itoh N, Xue Q, Schey K, Li Y, Cooper R, La Peyre J. Characterization of the major plasma protein of the eastern oyster, Crassostrea virginica, and a proposed role in host defense. Comp Biochem Physiol B Biochem Mol Biol. 2011;158:9-22 pubmed publisher
    ..Other possible functions of dominin in antioxidation, wound repair, metal transport and shell mineralization are discussed leading us to conclude that dominin is likely a multifunctional protein...
  29. Waggener J, DiMario P. Two splice variants of Nopp140 in Drosophila melanogaster. Mol Biol Cell. 2002;13:362-81 pubmed
    ..Conversely, we see no unusual accumulation of coilin in cells expressing DmNopp140-RGG. ..
  30. Zhang Y, Shih D. Isolation of an osmotin-like protein gene from strawberry and analysis of the response of this gene to abiotic stresses. J Plant Physiol. 2007;164:68-77 pubmed
  31. Yang Y, Zhu Y, Ottea J, Husseneder C, Leonard B, Abel C, et al. Down regulation of a gene for cadherin, but not alkaline phosphatase, associated with Cry1Ab resistance in the sugarcane borer Diatraea saccharalis. PLoS ONE. 2011;6:e25783 pubmed publisher
    ..Down-regulation of DsCAD1 expression by RNAi was functionally correlated with a decrease in Cry1Ab susceptibility. These results suggest that down-regulation of DsCAD1 is associated with resistance to Cry1Ab in D. saccharalis. ..
  32. Petit C, Melancon J, Chouljenko V, Colgrove R, Farzan M, Knipe D, et al. Genetic analysis of the SARS-coronavirus spike glycoprotein functional domains involved in cell-surface expression and cell-to-cell fusion. Virology. 2005;341:215-30 pubmed
    ..This genetic analysis reveals that the SARS-CoV S glycoprotein contains extracellular domains that regulate cell fusion as well as distinct endodomains that function in intracellular transport, cell-surface expression, and cell fusion. ..
  33. Wu M, Laine R. Sequence of the V. parahaemolyticus gene for cytoplasmic N, N'-diacetylchitobiase and homology with related enzymes. J Biochem. 1999;125:1086-93 pubmed
    ..This is consistent with its limited substrate specificity to small GlcNAc terminated oligosaccharides and its cytoplasmic rather than periplasmic localization. ..
  34. Bilder P, Ding H, Newcomer M. Crystal structure of the ancient, Fe-S scaffold IscA reveals a novel protein fold. Biochemistry. 2004;43:133-9 pubmed
    ..In addition, the crystal packing reveals a helical assembly that is constructed from two possible tetrameric oligomers of IscA. ..
  35. Perera I, Grove A. Molecular mechanisms of ligand-mediated attenuation of DNA binding by MarR family transcriptional regulators. J Mol Cell Biol. 2010;2:243-54 pubmed publisher
    ..Specifying the position of ligand-binding pockets further has the potential to aid in identifying the ligands for MarR homologs for which the ligand remains unknown. ..
  36. Vandergrifft E, Horohov D. Molecular cloning and expression of equine interleukin 2. Vet Immunol Immunopathol. 1993;39:395-406 pubmed
    ..Specific substitutions in those regions associated with p55 and p75 binding appear to account for this species-specifity. ..
  37. Ramsay T, Yan X, Morrison C. The obesity gene in swine: sequence and expression of porcine leptin. J Anim Sci. 1998;76:484-90 pubmed
    ..These data indicate that leptin is expressed in pigs, the expressed protein is secreted into the bloodstream, and obese swine express higher levels of leptin mRNA and protein than nonobese swine at similar body weight. ..
  38. Foster T, Melancon J, Olivier T, Kousoulas K. Herpes simplex virus type 1 glycoprotein K and the UL20 protein are interdependent for intracellular trafficking and trans-Golgi network localization. J Virol. 2004;78:13262-77 pubmed
    ..These results are consistent with the hypothesis that gK and UL20p directly interact and that this interaction facilitates their TGN localization, an important prerequisite for cytoplasmic virion envelopment and egress. ..
  39. Taylor S, Jenkins D, Arcese P. Loss of MHC and neutral variation in Peary caribou: genetic drift is not mitigated by balancing selection or exacerbated by MHC allele distributions. PLoS ONE. 2012;7:e36748 pubmed publisher
    ..However, gene conversion and recombination at Mhc loci may act to increase variation following bottlenecks. ..
  40. Ding H, Clark R. Characterization of iron binding in IscA, an ancient iron-sulphur cluster assembly protein. Biochem J. 2004;379:433-40 pubmed
    ..The results suggest that IscA is capable of recruiting intracellular iron and delivering iron for iron-sulphur clusters in proteins. ..
  41. Kumar K, Trevaskis J, Lam D, Sutton G, Koza R, Chouljenko V, et al. Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism. Cell Metab. 2008;8:468-81 pubmed publisher
    ..Adropin may therefore be a factor governing glucose and lipid homeostasis, which protects against hepatosteatosis and hyperinsulinemia associated with obesity. ..
  42. Xie Y, Chen Z, Brown R, Bhatnagar D. Expression and functional characterization of two pathogenesis-related protein 10 genes from Zea mays. J Plant Physiol. 2010;167:121-30 pubmed publisher
    ..Also, ZmPR10.1 showed a stronger inhibition against bacterium Pseudomonas syringae pv. tomato DC3000 in vivo and fungus A. flavus in vitro than ZmPR10, indicating that ZmPR10.1 may also play an important role in host plant defense...
  43. Zheng L, Wang X, Braymer H. Purification and N-terminal amino acid sequences of two polypeptides encoded by the mcrB gene from Escherichia coli K-12. Gene. 1992;112:97-100 pubmed
    ..J. Bacteriol. 171 (1989b) 1974-1981]. The 33-kDa protein totally overlaps the C-terminal part of the 51-kDa protein. ..
  44. Xue Q, Itoh N, Schey K, Cooper R, La Peyre J. Evidence indicating the existence of a novel family of serine protease inhibitors that may be involved in marine invertebrate immunity. Fish Shellfish Immunol. 2009;27:250-9 pubmed publisher
  45. Kim H, Kang K, Kim J. AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2. Nucleic Acids Res. 2009;37:2940-50 pubmed publisher
    ..In fact, many of these loci are co-occupied by the two proteins, AEBP2 and SUZ12. This suggests that AEBP2 is most likely a targeting protein for the mammalian PRC2 complex. ..
  46. Jambunathan N, Martinez A, Robert E, Agochukwu N, Ibos M, Dugas S, et al. Multiple bromodomain genes are involved in restricting the spread of heterochromatic silencing at the Saccharomyces cerevisiae HMR-tRNA boundary. Genetics. 2005;171:913-22 pubmed
    ..Our results suggest that multiple bromodomain proteins are involved in restricting the propagation of heterochromatin at HMR. ..
  47. Losso J. The biochemical and functional food properties of the bowman-birk inhibitor. Crit Rev Food Sci Nutr. 2008;48:94-118 pubmed publisher
  48. Kim J, Faulk C, Kim J. Retroposition and evolution of the DNA-binding motifs of YY1, YY2 and REX1. Nucleic Acids Res. 2007;35:3442-52 pubmed
    ..Overall, the conservation of YY2 and REX1 in all placental mammals predicts that each duplicate has co-evolved with some unique features of eutherian mammals. ..
  49. Chau M, Nelson J. Cooperative disulfide bond formation in apamin. Biochemistry. 1992;31:4445-50 pubmed
    ..The second disulfide bond forms with an equilibrium constant of approximately 17 M. Thus, apamin folding is very cooperative, but the native structure is only modestly stabilized by urea- or temperature-denaturable secondary structure. ..
  50. Vandergrifft E, Swiderski C, Horohov D. Molecular cloning and sequencing of equine interleukin 4. Vet Immunol Immunopathol. 1994;40:379-84 pubmed
    ..The cDNA was amplified from mitogen-stimulated equine peripheral blood mononuclear cells (PBMC). The cloned PCR product shares extensive homology ith IL-4 sequences from other species...
  51. Kaltenboeck B, Kousoulas K, Storz J. Structures of and allelic diversity and relationships among the major outer membrane protein (ompA) genes of the four chlamydial species. J Bacteriol. 1993;175:487-502 pubmed
    ..trachomatis through biochemical characteristics. These data demonstrate that chlamydial ompA allelic relationships, except for human serovars of C. trachomatis, are cognate with chromosomal phylogenies...
  52. Pakhomova S, Luka Z, Grohmann S, Wagner C, Newcomer M. Glycine N-methyltransferases: a comparison of the crystal structures and kinetic properties of recombinant human, mouse and rat enzymes. Proteins. 2004;57:331-7 pubmed
    ..There is an increase in kcat when going from rat to mouse to human, suggesting a correlation with the increased flexibility of some structural elements of the respective enzymes. ..
  53. Reon B, Nguyen K, Bhattacharyya G, Grove A. Functional comparison of Deinococcus radiodurans Dps proteins suggests distinct in vivo roles. Biochem J. 2012;447:381-91 pubmed publisher
  54. Grove A, Wilkinson S. Differential DNA binding and protection by dimeric and dodecameric forms of the ferritin homolog Dps from Deinococcus radiodurans. J Mol Biol. 2005;347:495-508 pubmed publisher
    ..While dodecameric Dps-1 does bind DNA, resulting in formation of large aggregates, cooperative DNA binding by dimeric Dps-1 leads to formation of protein-DNA complexes of finite stoichiometry...
  55. Hsuchou H, Kastin A, Tu H, Markadakis E, Stone K, Wang Y, et al. Effects of cell-type specific leptin receptor mutation on leptin transport across the BBB. Peptides. 2011;32:1392-9 pubmed publisher
    ..The ELKO and ALKO mice provide new models to determine the dynamic regulation of leptin transport in metabolic and inflammatory disorders where cellular distribution of LRs is shifted. ..
  56. Perera I, Grove A. MarR homologs with urate-binding signature. Protein Sci. 2011;20:621-9 pubmed publisher
    ..We propose the designation UrtR (urate responsive transcriptional regulator) for this distinct subfamily of MarR homologs based on their common mechanism of urate-mediated attenuation of DNA binding. ..
  57. Gilbert N, Bartlett S, Waight M, Neau D, Boeglin W, Brash A, et al. The structure of human 5-lipoxygenase. Science. 2011;331:217-9 pubmed publisher
    ..Here, we report the crystal structure at 2.4 angstrom resolution of human 5-LOX stabilized by replacement of this sequence. ..
  58. Xue Q, Gauthier J, Schey K, Li Y, Cooper R, Anderson R, et al. Identification of a novel metal binding protein, segon, in plasma of the eastern oyster, Crassostrea virginica. Comp Biochem Physiol B Biochem Mol Biol. 2012;163:74-85 pubmed publisher
    ..Several possible functions of segon in metal transport and detoxification, host defense, antioxidation and shell mineralization are proposed as they relate to its capacity to bind metals. ..
  59. Bhattacharyya G, Grove A. The N-terminal extensions of Deinococcus radiodurans Dps-1 mediate DNA major groove interactions as well as assembly of the dodecamer. J Biol Chem. 2007;282:11921-30 pubmed
    ..Taken together, the mode of DNA interaction by dodecameric Dps-1 suggests interaction of two metal-anchored N-terminal tails in successive DNA major grooves, leading to DNA compaction by formation of stacked protein-DNA layers...
  60. Kim J, Kim J. YY1's longer DNA-binding motifs. Genomics. 2009;93:152-8 pubmed publisher
    ..Also, this shortening suggests that the DNA recognition by YY1 is mediated through the concerted, but not modular, contribution by its four zinc finger units. ..
  61. Ghosh S, Grove A. Histone-like protein HU from Deinococcus radiodurans binds preferentially to four-way DNA junctions. J Mol Biol. 2004;337:561-71 pubmed
  62. Jacobson P, Ukkola O, Rankinen T, Snyder E, Leon A, Rao D, et al. Melanocortin 4 receptor sequence variations are seldom a cause of human obesity: the Swedish Obese Subjects, the HERITAGE Family Study, and a Memphis cohort. J Clin Endocrinol Metab. 2002;87:4442-6 pubmed
    ..In conclusion, our results do not support the prevailing notion that sequence variation in the melanocortin 4 receptor gene is a frequent cause of human obesity. ..
  63. Pe a M, Adams J, Adams L, Gillis T, Williams D, Spencer J, et al. Expression and characterization of recombinant interferon gamma (IFN-gamma) from the nine-banded armadillo (Dasypus novemcinctus) and its effect on Mycobacterium leprae-infected macrophages. Cytokine. 2008;43:124-31 pubmed publisher
    ..leprae in vitro. These data indicate that the response of armadillo MPhi to rDnIFN-gamma is similar to that which occurs in humans, and demonstrates a potentially important value of the armadillo as a model in leprosy research...
  64. Hegde V, Kelley M, Xu Y, Mian I, Deutsch W. Conversion of the bifunctional 8-oxoguanine/beta-delta apurinic/apyrimidinic DNA repair activities of Drosophila ribosomal protein S3 into the human S3 monofunctional beta-elimination catalyst through a single amino acid change. J Biol Chem. 2001;276:27591-6 pubmed
  65. Larkin J, Walker J, Bolognesi Winfield A, Gray J, Walker A. Allele-specific interactions between ttg and gl1 during trichome development in Arabidopsis thaliana. Genetics. 1999;151:1591-604 pubmed
    ..These interactions are specific for the gl1-2 allele. The implication of these results for current models of trichome development is discussed. ..
  66. Chang J, Fernand V, Zhang Y, Shin J, Jun H, Joshi Y, et al. NT-PGC-1α protein is sufficient to link β3-adrenergic receptor activation to transcriptional and physiological components of adaptive thermogenesis. J Biol Chem. 2012;287:9100-11 pubmed publisher
    ..Furthermore, the transcriptional shift from exon 1a to 1b supports isoform-specific roles for NT-PGC-1α in basal and adaptive thermogenesis. ..
  67. Adams J, Pe a M, Gillis T, Williams D, Adams L, Truman R. Expression of nine-banded armadillo (Dasypus novemcinctus) interleukin-2 in E. coli. Cytokine. 2005;32:219-25 pubmed publisher
    ..The advent of the D. novemcinctus genome sequence and subsequent generation of immunological tools will assist in advancing the armadillo as a translational model for leprosy...
  68. Luo C, Lu X, Stubbs L, Kim J. Rapid evolution of a recently retroposed transcription factor YY2 in mammalian genomes. Genomics. 2006;87:348-55 pubmed
  69. Bauerle K, Kamau E, Grove A. Interactions between N- and C-terminal domains of the Saccharomyces cerevisiae high-mobility group protein HMO1 are required for DNA bending. Biochemistry. 2006;45:3635-45 pubmed
    ..Taken together, our data suggest that interactions between box A and the C-terminal tail induce a conformation that is required for DNA bending. ..
  70. Cordaux R, Udit S, Batzer M, FESCHOTTE C. Birth of a chimeric primate gene by capture of the transposase gene from a mobile element. Proc Natl Acad Sci U S A. 2006;103:8101-6 pubmed
    ..Our results not only provide insight into the conditions required for a successful gene fusion, but they also suggest a mechanism by which the circuitry underlying complex regulatory networks may be rapidly established. ..
  71. Bordelon T, Wilkinson S, Grove A, Newcomer M. The crystal structure of the transcriptional regulator HucR from Deinococcus radiodurans reveals a repressor preconfigured for DNA binding. J Mol Biol. 2006;360:168-77 pubmed publisher
  72. Churchman M, Brown M, Kato N, Kirik V, Hulskamp M, Inze D, et al. SIAMESE, a plant-specific cell cycle regulator, controls endoreplication onset in Arabidopsis thaliana. Plant Cell. 2006;18:3145-57 pubmed
    ..We hypothesize that SIM encodes a plant-specific CDK inhibitor with a key function in the mitosis-to-endoreplication transition. ..
  73. Rosby R, Cui Z, Rogers E, deLivron M, Robinson V, DiMario P. Knockdown of the Drosophila GTPase nucleostemin 1 impairs large ribosomal subunit biogenesis, cell growth, and midgut precursor cell maintenance. Mol Biol Cell. 2009;20:4424-34 pubmed publisher
    ..We interpret the appearance of these structures as indicators of cell stress response. ..
  74. Chowdhury S, Brum M, Coats C, Doster A, Wei H, Jones C. The bovine herpesvirus type 1 envelope protein Us9 acidic domain is crucial for anterograde axonal transport. Vet Microbiol. 2011;152:270-9 pubmed publisher
    ..However, only the BHV-1 Us9 R83-90 virus was transported in an anterograde direction. These studies suggested that the Us9 acidic domain residues located between 83 and 90 were required for axonal anterograde transport...
  75. Liang F, Xu Q, Sikdar R, Xiao Y, Cox J, Doerrler W. BB0250 of Borrelia burgdorferi is a conserved and essential inner membrane protein required for cell division. J Bacteriol. 2010;192:6105-15 pubmed publisher
    ..These results demonstrate a strong conservation of function of the dedA gene family across diverse species of Gram-negative bacteria and a requirement for this protein family for normal membrane lipid composition and cell division. ..
  76. Yang Y, Zhu Y, Ottea J, Husseneder C, Leonard B, Abel C, et al. Molecular characterization and RNA interference of three midgut aminopeptidase N isozymes from Bacillus thuringiensis-susceptible and -resistant strains of sugarcane borer, Diatraea saccharalis. Insect Biochem Mol Biol. 2010;40:592-603 pubmed publisher
    ..saccharalis in vivo by RNAi resulted in a decrease in Cry1Ab susceptibility. Our results showed that reduction in expression of the three APNs is functionally associated with the Cry1Ab resistance in D. saccharalis. ..
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    ..Single amino acid changes within p195/p210 as well as within the S glycoprotein might contribute to the different phenotypes of the BCoV isolates...
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    ..Its tight binding to subtilisin and perkinsin suggests it plays a role in the oyster host defense against P. marinus...
  79. Smith S, Wang X, Godeny E. Sequence of the 3' end of the simian hemorrhagic fever virus genome. Gene. 1997;191:205-10 pubmed
    ..The coding capacity for each of the SHFV ORFs as well as the potential mass, pI and number of N-linked glycosylation sites for each of the encoded peptides was determined. ..
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    ..While showing that a bivalve mollusk employs different lysozymes for different functions, findings in this study suggest adaptive evolution of i type lysozymes for nutrition...