Experts and Doctors on transcription factors in Iowa City, Iowa, United States


Locale: Iowa City, Iowa, United States
Topic: transcription factors

Top Publications

  1. Fassler J, West A. Fungal Skn7 stress responses and their relationship to virulence. Eukaryot Cell. 2011;10:156-67 pubmed publisher
    ..Here we review the molecular and phenotypic characteristics of different fungal Skn7 proteins and consider how each of these properties may contribute to fungal virulence. ..
  2. Leslie E, Liu H, Carlson J, Shaffer J, Feingold E, WEHBY G, et al. A Genome-wide Association Study of Nonsyndromic Cleft Palate Identifies an Etiologic Missense Variant in GRHL3. Am J Hum Genet. 2016;98:744-54 pubmed publisher
    ..This finding advances our understanding of the genetic basis of craniofacial development and might ultimately lead to improvements in recurrence risk prediction, treatment, and prognosis. ..
  3. Paul S, Schmidt J, Moye Rowley W. Regulation of the CgPdr1 transcription factor from the pathogen Candida glabrata. Eukaryot Cell. 2011;10:187-97 pubmed publisher
    ..These data demonstrate that CgPdr1 appears to combine features of ScPdr1 and ScPdr3 to produce a transcription factor with chimeric regulatory properties. ..
  4. Gulshan K, Thommandru B, Moye Rowley W. Proteolytic degradation of the Yap1 transcription factor is regulated by subcellular localization and the E3 ubiquitin ligase Not4. J Biol Chem. 2012;287:26796-805 pubmed publisher
    ..These data uncover a new, conserved pathway for regulation of the oxidative stress response that serves to temporally limit the duration of Yap1-dependent transcriptional activation. ..
  5. Zhu C, Domann F. Dominant negative interference of transcription factor AP-2 causes inhibition of ErbB-3 expression and suppresses malignant cell growth. Breast Cancer Res Treat. 2002;71:47-57 pubmed
    ..Interference with the function of transcription factor AP-2 might provide a potential strategy for modulation of the malignant phenotype. ..
  6. Gulshan K, Rovinsky S, Moye Rowley W. YBP1 and its homologue YBP2/YBH1 influence oxidative-stress tolerance by nonidentical mechanisms in Saccharomyces cerevisiae. Eukaryot Cell. 2004;3:318-30 pubmed
    ..Together, these data argue that these two homologous proteins act as parallel positive regulators of H2O2 tolerance. ..
  7. Shen S, Lin L, Cai J, Jiang P, Kenkel E, Stroik M, et al. Widespread establishment and regulatory impact of Alu exons in human genes. Proc Natl Acad Sci U S A. 2011;108:2837-42 pubmed publisher
  8. Monick M, Samavati L, Butler N, Mohning M, Powers L, Yarovinsky T, et al. Intracellular thiols contribute to Th2 function via a positive role in IL-4 production. J Immunol. 2003;171:5107-15 pubmed
    ..The sum of these effects may contribute to alterations in the balance between Th1 and Th2 responses in lung diseases associated alterations in intracellular thiol pools. ..
  9. Fassler J, Gray W, Malone C, Tao W, Lin H, Deschenes R. Activated alleles of yeast SLN1 increase Mcm1-dependent reporter gene expression and diminish signaling through the Hog1 osmosensing pathway. J Biol Chem. 1997;272:13365-71 pubmed
    ..Thus, it appears that increased Sln1p phosphorylation both stimulates Mcm1p activity and diminishes signaling through the Hog1 osmosensing pathway. ..

More Information

Publications196 found, 100 shown here

  1. Ackermann L, Wollenweber L, Denning G. IL-4 and IFN-gamma increase steady state levels of polymeric Ig receptor mRNA in human airway and intestinal epithelial cells. J Immunol. 1999;162:5112-8 pubmed
    ..These studies provide additional insights into the mechanisms by which cytokines regulate expression of the pIgR, a central player in mucosal immunity. ..
  2. Renner D, Yamaguchi Y, Wada T, Handa H, Price D. A highly purified RNA polymerase II elongation control system. J Biol Chem. 2001;276:42601-9 pubmed
    ..We show that TFIIF functionally competes with DSIF and NELF, and this competition is dependent on the relative concentrations of TFIIF and NELF. ..
  3. Sharma Y, Cheung U, Larsen E, Eberl D. PPTGAL, a convenient Gal4 P-element vector for testing expression of enhancer fragments in drosophila. Genesis. 2002;34:115-8 pubmed
  4. Gode Potratz C, McCarter L. Quorum sensing and silencing in Vibrio parahaemolyticus. J Bacteriol. 2011;193:4224-37 pubmed publisher
  5. Li X, Venugopalan S, Cao H, Pinho F, Paine M, Snead M, et al. A model for the molecular underpinnings of tooth defects in Axenfeld-Rieger syndrome. Hum Mol Genet. 2014;23:194-208 pubmed publisher
    ..Moreover, our findings validate the etiology of the enamel defect in a novel mouse model of ARS. ..
  6. Katzmann D, Hallstrom T, Mahe Y, Moye Rowley W. Multiple Pdr1p/Pdr3p binding sites are essential for normal expression of the ATP binding cassette transporter protein-encoding gene PDR5. J Biol Chem. 1996;271:23049-54 pubmed
    ..A single PDRE placed upstream of a yeast gene lacking its normal upstream activation sequence is sufficient to confer Pdr1p responsiveness to this heterologous promoter...
  7. Driskell R, Liu X, Luo M, Filali M, Zhou W, Abbott D, et al. Wnt-responsive element controls Lef-1 promoter expression during submucosal gland morphogenesis. Am J Physiol Lung Cell Mol Physiol. 2004;287:L752-63 pubmed
    ..These findings suggest that Wnt regulation of the Lef-1 promoter at the WRE may play an important role during airway submucosal glandular bud formation. ..
  8. Lal G, Padmanabha L, Smith B, Nicholson R, Howe J, O DORISIO M, et al. RIZ1 is epigenetically inactivated by promoter hypermethylation in thyroid carcinoma. Cancer. 2006;107:2752-9 pubmed
    ..The current study suggested an important role for RIZ1 expression in thyroid tumorigenesis and identified a potential novel therapeutic target for tumors unresponsive to other therapies. ..
  9. Calva D, Dahdaleh F, Woodfield G, Weigel R, Carr J, Chinnathambi S, et al. Discovery of SMAD4 promoters, transcription factor binding sites and deletions in juvenile polyposis patients. Nucleic Acids Res. 2011;39:5369-78 pubmed publisher
    ..The elucidation of these promoters and identification of TFBS has important implications for future studies in sporadic tumors from multiple sites, and in JP patients. ..
  10. Seo S, Zhang Q, Bugge K, Breslow D, Searby C, Nachury M, et al. A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened. PLoS Genet. 2011;7:e1002358 pubmed publisher
    ..Finally, we found that BBS proteins and LZTFL1 regulate ciliary trafficking of hedgehog signal transducer, Smoothened. Our findings suggest that LZTFL1 is an important regulator of BBSome ciliary trafficking and hedgehog signaling. ..
  11. Musci M, Hendricks Taylor L, Motto D, Paskind M, Kamens J, Turck C, et al. Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases. J Biol Chem. 1997;272:11674-7 pubmed
    ..These data suggest that SLP-76 recruits a negative regulator, SLAP-130, as well as positive regulators of signal transduction in T cells. ..
  12. Lidral A, Reising B. The role of MSX1 in human tooth agenesis. J Dent Res. 2002;81:274-8 pubmed
    ..Supporting this theory, no mutations were found in more common cases of incisor or premolar agenesis, indicating that these have a different etiology. ..
  13. Katz L, Schultz R, Semina E, Torfs C, Krahn K, Murray J. Mutations in PITX2 may contribute to cases of omphalocele and VATER-like syndromes. Am J Med Genet A. 2004;130A:277-83 pubmed
    ..We did not find any mutations in exon 5 of FLNA in 179 omphalocele cases studied. ..
  14. Fahlen T, Mathur N, Jones B. Identification and characterization of mutants with increased expression of hilA, the invasion gene transcriptional activator of Salmonella typhimurium. FEMS Immunol Med Microbiol. 2000;28:25-35 pubmed
    ..These data implicate new regions of SPI-1 as being involved in the regulation of invasion by S. typhimurium and identify new invasion gene regulators located outside of SPI-1...
  15. Tao G, Kahr P, Morikawa Y, Zhang M, Rahmani M, Heallen T, et al. Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury. Nature. 2016;534:119-23 pubmed publisher
    ..These findings reveal a genetic pathway activated by tissue damage that is essential for cardiac repair. ..
  16. Jiang Y, Price D. Rescue of the TTF2 knockdown phenotype with an siRNA-resistant replacement vector. Cell Cycle. 2004;3:1151-3 pubmed
    ..Importantly, the mitotic phenotype seen with TTF2-siRNA is rescued by expression of the siRNA-resistant GFP-tagged TTF2 proving that reduced TTF2 is responsible for the retention of RNA polymerase II on mitotic chromosomes. ..
  17. Hinson S, Nagoshi R. Regulatory and functional interactions between the somatic sex regulatory gene transformer and the germline genes ovo and ovarian tumor. Development. 1999;126:861-71 pubmed
  18. He X, Mulford K, Fassler J. Oxidative stress function of the Saccharomyces cerevisiae Skn7 receiver domain. Eukaryot Cell. 2009;8:768-78 pubmed publisher
    ..A working model is proposed in which the association of Yap1 with Skn7 in the nucleus is a prerequisite for Skn7 phosphorylation and the activation of oxidative stress response genes. ..
  19. Guo J, Turek M, Price D. Regulation of RNA polymerase II termination by phosphorylation of Gdown1. J Biol Chem. 2014;289:12657-65 pubmed publisher
    ..Gdown1 Ser-270 phosphorylation occurs predominately during mitosis, and we suggest that this would enable TTF2 to terminate all Pol II even if it is associated with Gdown1. ..
  20. Cao H, Jheon A, Li X, Sun Z, Wang J, Florez S, et al. The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation. Development. 2013;140:3348-59 pubmed publisher
    ..Our in vivo and in vitro studies reveal a multistep transcriptional program involving the Pitx2:miR-200c/141:noggin regulatory pathway that is important in epithelial cell differentiation and tooth development. ..
  21. Stauffer L, Stauffer G. Roles for GcvA-binding sites 3 and 2 and the Lrp-binding region in gcvT::lacZ expression in Escherichia coli. Microbiology. 1998;144 ( Pt 10):2865-72 pubmed
    ..Based on these results, a model for gcv regulation is presented in which Lrp plays a primarily structural role, by bending the DNA and GcvA functions as the activator protein. ..
  22. Chen H, Jackson S, Doro M, McGowan S. Perinatal expression of genes that may participate in lipid metabolism by lipid-laden lung fibroblasts. J Lipid Res. 1998;39:2483-92 pubmed
    ..These findings indicate that characteristic adipocyte genes are also expressed in lipid-laden pulmonary fibroblasts and may participate in triglyceride accumulation and metabolism by these cells. ..
  23. Allen B, Allen Brady K, Weeks D. Reduction of XNkx2-10 expression leads to anterior defects and malformation of the embryonic heart. Mech Dev. 2006;123:719-29 pubmed
    ..We find that a decrease in XNkx2-10 leads to a broad spectrum of developmental abnormalities including a reduction in heart size. We conclude that XNkx2-10, like XNkx2-3 and XNkx2-5, is necessary for normal Xenopus heart development. ..
  24. Liu M, Olson A, Edgington N, Moye Rowley W, Pessin J. Myocyte enhancer factor 2 (MEF2) binding site is essential for C2C12 myotube-specific expression of the rat GLUT4/muscle-adipose facilitative glucose transporter gene. J Biol Chem. 1994;269:28514-21 pubmed
    ..This region encompasses a MEF2 binding site which was necessary, but not sufficient, for transcriptional activation. ..
  25. Marshall N, Peng J, Xie Z, Price D. Control of RNA polymerase II elongation potential by a novel carboxyl-terminal domain kinase. J Biol Chem. 1996;271:27176-83 pubmed
    ..We propose that phosphorylation of the CTD by P-TEFb controls the transition from abortive into productive elongation mode. ..
  26. Saadi I, Semina E, Amendt B, Harris D, Murphy K, Murray J, et al. Identification of a dominant negative homeodomain mutation in Rieger syndrome. J Biol Chem. 2001;276:23034-41 pubmed
    ..These results describe the first dominant negative missense mutation in a homeodomain and support a model that may partially explain the phenotypic variation within Rieger syndrome. ..
  27. Kolaczkowski M, Kolaczkowska A, Gaigg B, Schneiter R, Moye Rowley W. Differential regulation of ceramide synthase components LAC1 and LAG1 in Saccharomyces cerevisiae. Eukaryot Cell. 2004;3:880-92 pubmed
    ..These data demonstrate extensive coordinate control of sphingolipid biosynthesis and multidrug resistance in yeast. ..
  28. Chiang A, Beck J, Yen H, Tayeh M, Scheetz T, Swiderski R, et al. Homozygosity mapping with SNP arrays identifies TRIM32, an E3 ubiquitin ligase, as a Bardet-Biedl syndrome gene (BBS11). Proc Natl Acad Sci U S A. 2006;103:6287-92 pubmed
  29. Bartlett C, Gharani N, Millonig J, Brzustowicz L. Three autism candidate genes: a synthesis of human genetic analysis with other disciplines. Int J Dev Neurosci. 2005;23:221-34 pubmed
    ..Integrating results from several scientific frameworks provides new hypotheses and alternative data collection strategies for future work. ..
  30. Krasowski M, Ni A, Hagey L, Ekins S. Evolution of promiscuous nuclear hormone receptors: LXR, FXR, VDR, PXR, and CAR. Mol Cell Endocrinol. 2011;334:39-48 pubmed publisher
  31. Yu S, Zhou X, Steinke F, Liu C, Chen S, Zagorodna O, et al. The TCF-1 and LEF-1 transcription factors have cooperative and opposing roles in T cell development and malignancy. Immunity. 2012;37:813-26 pubmed publisher
    ..TCF-1 thus has dual roles, i.e., acting cooperatively with LEF-1 to promote thymocyte maturation while restraining LEF-1 expression to prevent malignant transformation of developing thymocytes. ..
  32. Wu A, Wemmie J, Edgington N, Goebl M, Guevara J, Moye Rowley W. Yeast bZip proteins mediate pleiotropic drug and metal resistance. J Biol Chem. 1993;268:18850-8 pubmed
    ..The cadmium hypersensitivity of the delta yap1 mutant described here indicates that one major role of YAP1 in the yeast cell is to mediate resistance to this metal. ..
  33. Butler N, Monick M, Yarovinsky T, Powers L, Hunninghake G. Altered IL-4 mRNA stability correlates with Th1 and Th2 bias and susceptibility to hypersensitivity pneumonitis in two inbred strains of mice. J Immunol. 2002;169:3700-9 pubmed
    ..Moreover, our results indicate that regulation of mRNA stability may serve as an important mechanism underlying Th1/Th2 immune polarization. ..
  34. Saadi I, Kuburas A, Engle J, Russo A. Dominant negative dimerization of a mutant homeodomain protein in Axenfeld-Rieger syndrome. Mol Cell Biol. 2003;23:1968-82 pubmed
    ..These results suggest that the position 50 residue in the PITX2 homeodomain plays an important role in both DNA binding and dimerization activities. ..
  35. Munroe M, Bishop G. Role of tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) in distinct and overlapping CD40 and TNF receptor 2/CD120b-mediated B lymphocyte activation. J Biol Chem. 2004;279:53222-31 pubmed
    ..CD40 and CD120b used primarily divergent mechanisms to activate NF-kappaB, exemplifying how TNFR family members can use diverse mechanisms to mediate similar downstream events. ..
  36. Shahi P, Gulshan K, Moye Rowley W. Negative transcriptional regulation of multidrug resistance gene expression by an Hsp70 protein. J Biol Chem. 2007;282:26822-31 pubmed
    ..Finally, rho(0) cells had less Ssa1p bound to Pdr3p than rho(+) cells, consistent with Ssa1p-mediated repression of Pdr3p activity serving as a key regulatory step in control of multidrug resistance in yeast...
  37. Chan K, Bonde S, Klump H, Zavazava N. Hematopoiesis and immunity of HOXB4-transduced embryonic stem cell-derived hematopoietic progenitor cells. Blood. 2008;111:2953-61 pubmed
  38. Hallstrom T, Moye Rowley W. Divergent transcriptional control of multidrug resistance genes in Saccharomyces cerevisiae. J Biol Chem. 1998;273:2098-104 pubmed
    ..This suggests the possibility that UASYOR1 has promoter-specific sequence requirements that are satisfied by another Pdr1p/Pdr3p-regulated gene but not by a heterologous promoter. ..
  39. Ahmad N, Long S, Rebagliati M. A southpaw joins the roster: the role of the zebrafish nodal-related gene southpaw in cardiac LR asymmetry. Trends Cardiovasc Med. 2004;14:43-9 pubmed
  40. Lu P, Hankel I, Knisz J, Marquardt A, Chiang M, Grosse J, et al. The Justy mutation identifies Gon4-like as a gene that is essential for B lymphopoiesis. J Exp Med. 2010;207:1359-67 pubmed publisher
    ..1 were abnormally high in mutant B cell progenitors. Our findings indicate that the Gon4l protein is required for B lymphopoiesis and may function to regulate gene expression during this process. ..
  41. Wang G, Williams G, Xia H, Hickey M, Shao J, Davidson B, et al. Apical barriers to airway epithelial cell gene transfer with amphotropic retroviral vectors. Gene Ther. 2002;9:922-31 pubmed
    ..These results suggest that factors other than apical receptor abundance and the glycocalyx inhibit amphotropic retroviral gene transfer in human airway epithelia. ..
  42. Ghrist A, Stauffer G. Characterization of the Escherichia coli gcvR gene encoding a negative regulator of gcv expression. J Bacteriol. 1995;177:4980-4 pubmed
    ..Models explaining how GcvR and GcvA might interact to regulate gcv expression are proposed. ..
  43. Vieira A, Meira R, Modesto A, Murray J. MSX1, PAX9, and TGFA contribute to tooth agenesis in humans. J Dent Res. 2004;83:723-7 pubmed
    ..No mutations were found in MSX1 or PAX9 coding regions. There were statistically significant data suggesting that MSX1 interacts with PAX9. These findings suggest that MSX1, PAX9, and TGFA play a role in isolated dental agenesis. ..
  44. Li S, Ault A, Malone C, Raitt D, Dean S, Johnston L, et al. The yeast histidine protein kinase, Sln1p, mediates phosphotransfer to two response regulators, Ssk1p and Skn7p. EMBO J. 1998;17:6952-62 pubmed
    ..The identification of genes responsive to both classes of Skn7p function suggests a central role for Skn7p and the SLN1-SKN7 pathway in integrating and coordinating cellular response to various types of environmental stress. ..
  45. Swiderski R, Reiter R, Nishimura D, Alward W, Kalenak J, Searby C, et al. Expression of the Mf1 gene in developing mouse hearts: implication in the development of human congenital heart defects. Dev Dyn. 1999;216:16-27 pubmed
    ..This is further supported by our studies showing that mutations in the FKHL7 gene were associated with defects in the anterior segment of the eye as well as atrial septal defects or mitral valve defects. Dev Dyn 1999;216:16-27. ..
  46. Chao S, Nagoshi R. Induction of apoptosis in the germline and follicle layer of Drosophila egg chambers. Mech Dev. 1999;88:159-72 pubmed
    ..Germ cells degenerating as a normal consequence of oogenesis displayed a similar set of phenotypes, suggesting that a common apoptotic mechanism may underlie these different germline death phenomena. ..
  47. Soshnev A, Li X, Wehling M, Geyer P. Context differences reveal insulator and activator functions of a Su(Hw) binding region. PLoS Genet. 2008;4:e1000159 pubmed publisher
    ..These findings imply that the function of non-gypsy Su(Hw) BRs depends on the genomic environment, predicting that Su(Hw) BRs represent a diverse collection of genomic regulatory elements. ..
  48. Liu H, Leslie E, Jia Z, Smith T, Eshete M, Butali A, et al. Irf6 directly regulates Klf17 in zebrafish periderm and Klf4 in murine oral epithelium, and dominant-negative KLF4 variants are present in patients with cleft lip and palate. Hum Mol Genet. 2016;25:766-76 pubmed publisher
    ..These results indicate that rare NSCL/P risk variants can be found in members of the gene regulatory network governing periderm differentiation. ..
  49. Kephart D, Marshall N, Price D. Stability of Drosophila RNA polymerase II elongation complexes in vitro. Mol Cell Biol. 1992;12:2067-77 pubmed
  50. Miakotina O, Snyder J. TNF-alpha inhibits SP-A gene expression in lung epithelial cells via p38 MAPK. Am J Physiol Lung Cell Mol Physiol. 2002;283:L418-27 pubmed
    ..We conclude that TNF-alpha downregulates SP-A gene expression in lung epithelial cells via the p38 MAPK signal transduction pathway. ..
  51. Liu X, Luo M, Xie W, Wells J, Goodheart M, Engelhardt J. Sox17 modulates Wnt3A/beta-catenin-mediated transcriptional activation of the Lef-1 promoter. Am J Physiol Lung Cell Mol Physiol. 2010;299:L694-710 pubmed publisher
  52. Scott C, Marsden A, Rebagliati M, Zhang Q, Chamling X, Searby C, et al. Nuclear/cytoplasmic transport defects in BBS6 underlie congenital heart disease through perturbation of a chromatin remodeling protein. PLoS Genet. 2017;13:e1006936 pubmed publisher
    ..Our work identifies a new function for BBS6 in nuclear-cytoplasmic transport, and provides insight into the disease mechanism underlying the congenital heart defects in McKusick-Kaufman syndrome patients. ..
  53. Jourdan A, Stauffer G. Genetic analysis of the GcvA binding site in the gcvA control region. Microbiology. 1999;145 ( Pt 8):2153-62 pubmed
  54. Dillon J, Yaney G, Zhou Y, Voilley N, Bowen S, Chipkin S, et al. Dehydroepiandrosterone sulfate and beta-cell function: enhanced glucose-induced insulin secretion and altered gene expression in rodent pancreatic beta-cells. Diabetes. 2000;49:2012-20 pubmed
    ..This effect of DHEAS on insulin secretion may contribute to the amelioration of hyperglycemia seen in various rodent models of diabetes. ..
  55. Panwar S, Moye Rowley W. Long chain base tolerance in Saccharomyces cerevisiae is induced by retrograde signals from the mitochondria. J Biol Chem. 2006;281:6376-84 pubmed
    ..Together, these data indicate Pdr3p activation of RSB1 transcription is an important feature of the retrograde response allowing normal detoxification of an endogenous sphingolipid precursor. ..
  56. Gulshan K, Schmidt J, Shahi P, Moye Rowley W. Evidence for the bifunctional nature of mitochondrial phosphatidylserine decarboxylase: role in Pdr3-dependent retrograde regulation of PDR5 expression. Mol Cell Biol. 2008;28:5851-64 pubmed publisher
    ..Psd1 is a novel bifunctional protein required both for PE biosynthesis and regulation of multidrug resistance...
  57. Meyer K, Axelsen M, Sheffield V, Patil S, Wassink T. Germline mosaic transmission of a novel duplication of PXDN and MYT1L to two male half-siblings with autism. Psychiatr Genet. 2012;22:137-40 pubmed publisher
    ..Results from this study indicate that the 2p25.3 duplication disrupting PXDN and MYT1L is a potential autism-causing variant in the pedigree reported here and should receive further consideration as a candidate for autism. ..
  58. Srikantha T, Daniels K, Pujol C, Kim E, Soll D. Identification of genes upregulated by the transcription factor Bcr1 that are involved in impermeability, impenetrability, and drug resistance of Candida albicans a/? biofilms. Eukaryot Cell. 2013;12:875-88 pubmed publisher
  59. Stauffer L, Stauffer G. Spacing and orientation requirements of GcvA-binding sites 3 and 2 and the Lrp-binding region for gcvT::lacZ expression in Escherichia coli. Microbiology. 1998;144 ( Pt 5):1417-22 pubmed
    ..Because of the location of these target sites relative to the gcv promoter, it is also likely that DNA looping is required for this mechanism of regulation. ..
  60. Haider N, Jacobson S, Cideciyan A, Swiderski R, Streb L, Searby C, et al. Mutation of a nuclear receptor gene, NR2E3, causes enhanced S cone syndrome, a disorder of retinal cell fate. Nat Genet. 2000;24:127-31 pubmed
    ..Expression of NR2E3 was limited to the outer nuclear layer of the human retina. Our results suggest that NR2E3 has a role in determining photoreceptor phenotype during human retinogenesis. ..
  61. Dobbs M, Dietz F, Gurnett C, Morcuende J, Steyers C, Murray J. Localization of dominantly inherited isolated triphalangeal thumb to chromosomal region 7q36. J Orthop Res. 2000;18:340-4 pubmed
    ..Further analysis of the unique family with isolated triphalangeal thumb in the current study may demonstrate allelic variability of the gene involved in these disorders. ..
  62. Semina E, Brownell I, Mintz Hittner H, Murray J, Jamrich M. Mutations in the human forkhead transcription factor FOXE3 associated with anterior segment ocular dysgenesis and cataracts. Hum Mol Genet. 2001;10:231-6 pubmed
    ..The mutation was present in two affected individuals from this family and was not identified in 180 normal control chromosomes. ..
  63. Drake J, Barnes J, Madsen J, Domann F, Stipp C, Henry M. ZEB1 coordinately regulates laminin-332 and {beta}4 integrin expression altering the invasive phenotype of prostate cancer cells. J Biol Chem. 2010;285:33940-8 pubmed publisher
    ..These results provide a novel molecular basis for reduced laminin-332 observed in clinical prostate cancer specimens and demonstrate a context-dependent role for EMT in invasive cellular behavior. ..
  64. Hjalt T, Semina E, Amendt B, Murray J. The Pitx2 protein in mouse development. Dev Dyn. 2000;218:195-200 pubmed
    ..We demonstrate for the first time directly that Pitx2 is asymmetrically expressed in early heart, gut, and lung development. ..
  65. Lu P, Hankel I, Hostager B, Swartzendruber J, Friedman A, Brenton J, et al. The developmental regulator protein Gon4l associates with protein YY1, co-repressor Sin3a, and histone deacetylase 1 and mediates transcriptional repression. J Biol Chem. 2011;286:18311-9 pubmed publisher
    ..Our data suggest that Sin3a, HDAC1, and YY1 are co-factors for Gon4l and that Gon4l may function as a platform for the assembly of complexes that regulate gene expression. ..
  66. Roseman R, Pirrotta V, Geyer P. The su(Hw) protein insulates expression of the Drosophila melanogaster white gene from chromosomal position-effects. EMBO J. 1993;12:435-42 pubmed
    ..This separates enhancers and silencers distal to the su(Hw) binding region into an independent unit of gene activity, thereby causing their inactivation...
  67. Peng J, Marshall N, Price D. Identification of a cyclin subunit required for the function of Drosophila P-TEFb. J Biol Chem. 1998;273:13855-60 pubmed
    ..Deletion of the carboxyl-terminal domain of cyclin T in P-TEFb reduced both the kinase and transcription activity to about 10%. The CDK-activating kinase in TFIIH was unable to activate the CTD kinase activity of P-TEFb. ..
  68. Liu M, Xie Z, Price D. A human RNA polymerase II transcription termination factor is a SWI2/SNF2 family member. J Biol Chem. 1998;273:25541-4 pubmed
    ..Both factors were able to work on elongation complexes from either species. We discuss the mechanism of termination by factor 2 and the implications for the role of factor 2 in cellular activities. ..
  69. Egland P, Harwood C. HbaR, a 4-hydroxybenzoate sensor and FNR-CRP superfamily member, regulates anaerobic 4-hydroxybenzoate degradation by Rhodopseudomonas palustris. J Bacteriol. 2000;182:100-6 pubmed
    ..Our evidence indicates that AadR activates expression of hbaR in response to anaerobiosis and that HbaR, in turn, activates expression of 4-HBA degradation in response to 4-HBA as an effector molecule. ..
  70. Zhu C, Huang Y, Broman M, Domann F. Expression of AP-2 alpha in SV40 immortalized human lung fibroblasts is associated with a distinct pattern of cytosine methylation in the AP-2 alpha promoter. Biochim Biophys Acta. 2001;1519:85-91 pubmed
    ..Our results suggest that transcriptional activation of AP-2 alpha in the SV40-transformed cells is mediated, at least in part, by site-specific methylation of a negative regulatory cis-element in the AP-2 alpha promoter. ..
  71. Bergmann O, Mathahs M, Broadhurst K, Weydert J, Wilkinson N, Howe J, et al. Altered expression of iron regulatory genes in cirrhotic human livers: clues to the cause of hemosiderosis?. Lab Invest. 2008;88:1349-57 pubmed publisher
    ..However, there are complex alterations in DMT1 and ferroportin expression in cirrhotic liver, including decreases in ferroportin and DMT1 at the protein level that may play a role in aberrant regulation of iron metabolism in cirrhosis. ..
  72. Steinke F, Yu S, Zhou X, He B, Yang W, Zhou B, et al. TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4(+) T cell fate and interact with Runx3 to silence Cd4 in CD8(+) T cells. Nat Immunol. 2014;15:646-656 pubmed publisher
    ..Instead, TCF-1 physically interacted with Runx3 to cooperatively silence Cd4. Thus, TCF-1 and LEF-1 adopted distinct genetic 'wiring' to promote the CD4(+) T cell fate and establish CD8(+) T cell identity. ..
  73. Anderson M, Certel S, Certel K, Lee T, Montell D, Johnson W. Function of the Drosophila POU domain transcription factor drifter as an upstream regulator of breathless receptor tyrosine kinase expression in developing trachea. Development. 1996;122:4169-78 pubmed
    ..This example of a mechanism for maintenance of a committed cell fate offers a model for understanding how essential gene activities can be maintained throughout organogenesis. ..
  74. Alward W, Semina E, Kalenak J, Heon E, Sheth B, Stone E, et al. Autosomal dominant iris hypoplasia is caused by a mutation in the Rieger syndrome (RIEG/PITX2) gene. Am J Ophthalmol. 1998;125:98-100 pubmed
    ..Autosomal dominant iris hypoplasia is caused by a defect in the same gene that is defective in many cases of Rieger syndrome. ..
  75. Hallstrom T, Katzmann D, Torres R, Sharp W, Moye Rowley W. Regulation of transcription factor Pdr1p function by an Hsp70 protein in Saccharomyces cerevisiae. Mol Cell Biol. 1998;18:1147-55 pubmed
    ..These data support the view that Pdr13p influences pleiotropic drug resistance by enhancing the function of the transcriptional regulatory protein Pdr1p...
  76. Coleman S, Epping E, Steggerda S, Moye Rowley W. Yap1p activates gene transcription in an oxidant-specific fashion. Mol Cell Biol. 1999;19:8302-13 pubmed
    ..These data are consistent with the idea that the function of Yap1p is different at promoters of loci involved in H(2)O(2) tolerance from promoters of genes involved in diamide resistance. ..
  77. Hjalt T, Amendt B, Murray J. PITX2 regulates procollagen lysyl hydroxylase (PLOD) gene expression: implications for the pathology of Rieger syndrome. J Cell Biol. 2001;152:545-52 pubmed
    ..Mutations and rearrangements in PLOD-1 are known to be prevalent in patients with Ehlers-Danlos syndrome, kyphoscoliosis type (type VI [EDVI]). Several of the same organ systems are involved in Rieger syndrome and EDVI. ..
  78. Zhu C, Huang Y, Oberley L, Domann F. A family of AP-2 proteins down-regulate manganese superoxide dismutase expression. J Biol Chem. 2001;276:14407-13 pubmed
    ..These results indicate that AP-2-mediated transcriptional repression contributes to the constitutively low expression of Mn-SOD in SV40-transformed fibroblasts and suggest a mechanism for Mn-SOD down-regulation in cancer. ..
  79. Nwankwo J, Robbins M. Peroxisome proliferator-activated receptor- gamma expression in human malignant and normal brain, breast and prostate-derived cells. Prostaglandins Leukot Essent Fatty Acids. 2001;64:241-5 pubmed
  80. Patzkó A, Bai Y, Saporta M, Katona I, Wu X, Vizzuso D, et al. Curcumin derivatives promote Schwann cell differentiation and improve neuropathy in R98C CMT1B mice. Brain. 2012;135:3551-66 pubmed publisher
  81. Baldwin A, Clemons A, Phillips B. Unique and redundant β-catenin regulatory roles of two Dishevelled paralogs during C. elegans asymmetric cell division. J Cell Sci. 2016;129:983-93 pubmed publisher
    ..Overall, we have further defined the role of Dishevelled in the WβA signaling pathway, and demonstrated that DSH-2 and MIG-5 regulate cell fate, β-catenin nuclear levels and the polarity of β-catenin regulation. ..
  82. Chan L, Chen Z, Braas D, Lee J, Xiao G, Geng H, et al. Metabolic gatekeeper function of B-lymphoid transcription factors. Nature. 2017;542:479-483 pubmed publisher
    ..Thus, B-lymphoid transcription factors function as metabolic gatekeepers by limiting the amount of cellular ATP to levels that are insufficient for malignant transformation. ..
  83. Amendt B, Sutherland L, Russo A. Transcriptional antagonism between Hmx1 and Nkx2.5 for a shared DNA-binding site. J Biol Chem. 1999;274:11635-42 pubmed
    ..5 attenuated each others activity, suggesting that genes containing the CAAGTG element can integrate signals from these proteins. Therefore, Hmx1 and Nkx2. 5 proteins bind a unique DNA sequence and act as transcriptional antagonists. ..
  84. Jourdan A, Stauffer G. GcvA-mediated activation of gcvT-lacZ expression involves the carboxy-terminal domain of the alpha subunit of RNA polymerase. FEMS Microbiol Lett. 1999;181:307-12 pubmed
    ..Amino acid residues in the alphaCTD important for GcvA-dependent activation, however, have no effect on GcvA-mediated repression of the operon. ..
  85. Girnun G, Domann F, Moore S, Robbins M. Identification of a functional peroxisome proliferator-activated receptor response element in the rat catalase promoter. Mol Endocrinol. 2002;16:2793-801 pubmed
    ..Thus, in addition to transrepression of proinflammatory transcription factors, PPARgamma may also be modulating catalase expression, and hence down-regulating the inflammatory response via scavenging of reactive oxygen species. ..
  86. Houston D, Wylie C. Maternal Xenopus Zic2 negatively regulates Nodal-related gene expression during anteroposterior patterning. Development. 2005;132:4845-55 pubmed
    ..ZIC2 is mutated in human holoprosencephaly (HPE), a severe defect in brain hemisphere separation, and these results strengthen the suggestion that increased Nodal-related activity is a cause of HPE. ..
  87. Ren J, Kee Y, Huibregtse J, Piper R. Hse1, a component of the yeast Hrs-STAM ubiquitin-sorting complex, associates with ubiquitin peptidases and a ligase to control sorting efficiency into multivesicular bodies. Mol Biol Cell. 2007;18:324-35 pubmed
    ..Additionally, we find that disruption of UBP2 and RUP1 inhibits MVB sorting of some cargos suggesting that Rsp5 requires association with Ubp2 to properly ubiquitinate cargo for efficient MVB sorting. ..
  88. Van Otterloo E, Li W, Bonde G, Day K, Hsu M, Cornell R. Differentiation of zebrafish melanophores depends on transcription factors AP2 alpha and AP2 epsilon. PLoS Genet. 2010;6:e1001122 pubmed publisher
    ..This work illustrates how analysis of single-gene mutants may fail to identify steps in a GRN that are affected by the redundant activity of related proteins. ..
  89. Hallstrom T, Moye Rowley W. Hyperactive forms of the Pdr1p transcription factor fail to respond to positive regulation by the hsp70 protein Pdr13p. Mol Microbiol. 2000;36:402-13 pubmed
    ..Biochemical fractionation experiments indicate that Pdr13p is associated with a high-molecular-weight complex and suggest the association of some fraction of Pdr13p with ribosomes. ..
  90. Butali A, Suzuki S, Cooper M, Mansilla A, Cuenco K, Leslie E, et al. Replication of genome wide association identified candidate genes confirm the role of common and rare variants in PAX7 and VAX1 in the etiology of nonsyndromic CL(P). Am J Med Genet A. 2013;161A:965-72 pubmed publisher
    ..Determining the role of rare variants clearly warrants further investigation. ..
  91. Semina E, Altherr M, Murray J. Cloning and chromosomal localization of two novel human genes encoding LIM-domain binding factors CLIM1 and CLIM2/LDB1/NLI. Mamm Genome. 1998;9:921-4 pubmed
  92. Wang D, Reiter R, Lin J, Wang Q, Williams H, Krob S, et al. Requirement of a novel gene, Xin, in cardiac morphogenesis. Development. 1999;126:1281-94 pubmed
    ..5 can transactivate a luciferase reporter driven by the mXin promoter in mouse fibroblasts. These results suggest that Xin may participate in a BMP-Nkx2.5-MEF2C pathway to control cardiac morphogenesis and looping. ..