Experts and Doctors on protein kinases in Iowa City, Iowa, United States


Locale: Iowa City, Iowa, United States
Topic: protein kinases

Top Publications

  1. Lim R, Zaheer A. Phorbol ester stimulates rapid intracellular phosphorylation of glia maturation factor. Biochem Biophys Res Commun. 1995;211:928-34 pubmed
    ..The rapid and transient phosphorylation of GMF upon cellular activation suggests an intracellular role, possibly with involvement in signal transduction. ..
  2. Yoshida Moriguchi T, Willer T, Anderson M, Venzke D, Whyte T, Muntoni F, et al. SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function. Science. 2013;341:896-9 pubmed publisher
    ..These findings suggest how mutations in GTDC2, B3GALNT2, and SGK196 disrupt dystroglycan receptor function and lead to congenital muscular dystrophy. ..
  3. Zhu Y, PE ERY T, Peng J, Ramanathan Y, Marshall N, Marshall T, et al. Transcription elongation factor P-TEFb is required for HIV-1 tat transactivation in vitro. Genes Dev. 1997;11:2622-32 pubmed
  4. Lu J, Deschenes R, Fassler J. Saccharomyces cerevisiae histidine phosphotransferase Ypd1p shuttles between the nucleus and cytoplasm for SLN1-dependent phosphorylation of Ssk1p and Skn7p. Eukaryot Cell. 2003;2:1304-14 pubmed
    ..The need to translocate the signal into different intracellular compartments contributes a spatial dimension to eukaryotic two-component pathways compared to the prototypical two-component pathways of prokaryotes. ..
  5. Deschenes R, Lin H, Ault A, Fassler J. Antifungal properties and target evaluation of three putative bacterial histidine kinase inhibitors. Antimicrob Agents Chemother. 1999;43:1700-3 pubmed
    ..Based on these results, we conclude that these compounds have antifungal properties; however, their mode of action appears to be independent of histidine kinase inhibition. ..
  6. Yin Y, Donlevy S, Smolikove S. Coordination of Recombination with Meiotic Progression in the Caenorhabditis elegans Germline by KIN-18, a TAO Kinase That Regulates the Timing of MPK-1 Signaling. Genetics. 2016;202:45-59 pubmed publisher
    ..Meiosis is a conserved process; thus, revealing that KIN-18 is a novel regulator of meiotic progression in C. elegans would help to elucidate TAO kinase's role in germline development in higher eukaryotes. ..
  7. Olson M, Nygaard T, Ackermann L, Watkins R, Zurek O, Pallister K, et al. Staphylococcus aureus nuclease is an SaeRS-dependent virulence factor. Infect Immun. 2013;81:1316-24 pubmed publisher
    ..Altogether, our findings demonstrate that Nuc is an important S. aureus virulence factor and part of the SaeRS regulon...
  8. Sarsour E, Kumar M, Kalen A, Goswami M, Buettner G, Goswami P. MnSOD activity regulates hydroxytyrosol-induced extension of chronological lifespan. Age (Dordr). 2012;34:95-109 pubmed publisher
    ..g., MnSOD expression. These results demonstrate that HT extends CLS by increasing MnSOD activity and decreasing age-associated mitochondrial reactive oxygen species accumulation. ..
  9. Samuel I. Bile and pancreatic juice exclusion activates acinar stress kinases and exacerbates gallstone pancreatitis. Surgery. 2008;143:434-40 pubmed publisher
    ..The proposed hypothesis draws on fresh evidence to present a new paradigm that reexamines the role of exocrine pancreatic hyperstimulation in gallstone pancreatitis pathogenesis...

More Information


  1. Lu J, Deschenes R, Fassler J. Role for the Ran binding protein, Mog1p, in Saccharomyces cerevisiae SLN1-SKN7 signal transduction. Eukaryot Cell. 2004;3:1544-56 pubmed
  2. Fassler J, Gray W, Malone C, Tao W, Lin H, Deschenes R. Activated alleles of yeast SLN1 increase Mcm1-dependent reporter gene expression and diminish signaling through the Hog1 osmosensing pathway. J Biol Chem. 1997;272:13365-71 pubmed
    ..Thus, it appears that increased Sln1p phosphorylation both stimulates Mcm1p activity and diminishes signaling through the Hog1 osmosensing pathway. ..
  3. Lim R, Zaheer A. In vitro enhancement of p38 mitogen-activated protein kinase activity by phosphorylated glia maturation factor. J Biol Chem. 1996;271:22953-6 pubmed
    ..The results correlate well with a previous report that ERK and p38 carry out opposing functions and implicate GMF as a regulator of major cellular events. ..
  4. Li S, Ault A, Malone C, Raitt D, Dean S, Johnston L, et al. The yeast histidine protein kinase, Sln1p, mediates phosphotransfer to two response regulators, Ssk1p and Skn7p. EMBO J. 1998;17:6952-62 pubmed
    ..The identification of genes responsive to both classes of Skn7p function suggests a central role for Skn7p and the SLN1-SKN7 pathway in integrating and coordinating cellular response to various types of environmental stress. ..
  5. Li S, Dean S, Li Z, Horecka J, Deschenes R, Fassler J. The eukaryotic two-component histidine kinase Sln1p regulates OCH1 via the transcription factor, Skn7p. Mol Biol Cell. 2002;13:412-24 pubmed
    ..Our data support a model in which Skn7p receiver domain phosphorylation affects transcriptional activation rather than DNA binding to this class of DNA binding site. ..
  6. Ault A, Fassler J, Deschenes R. Altered phosphotransfer in an activated mutant of the Saccharomyces cerevisiae two-component osmosensor Sln1p. Eukaryot Cell. 2002;1:174-80 pubmed
  7. Elmendorf J, Chen D, Pessin J. Guanosine 5'-O-(3-thiotriphosphate) (GTPgammaS) stimulation of GLUT4 translocation is tyrosine kinase-dependent. J Biol Chem. 1998;273:13289-96 pubmed
    ..These data demonstrate that the GTPgammaS-stimulated GLUT4 translocation utilizes a novel tyrosine kinase pathway that is independent of both the phosphatidylinositol 3-kinase and the Akt kinase. ..
  8. Yeaman C, Ayala M, Wright J, Bard F, Bossard C, Ang A, et al. Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network. Nat Cell Biol. 2004;6:106-12 pubmed
    ..PKD activity is required only for the transport of proteins containing basolateral sorting information, and seems to be cargo specific...
  9. Okada S, Matsuda M, Anafi M, Pawson T, Pessin J. Insulin regulates the dynamic balance between Ras and Rap1 signaling by coordinating the assembly states of the Grb2-SOS and CrkII-C3G complexes. EMBO J. 1998;17:2554-65 pubmed
    ..Together, these data demonstrate that insulin treatment results in the de-repression of Rap1 inhibitory function on the Raf1 kinase concomitant with Ras activation and stimulation of the downstream Raf1/MEK/ERK cascade. ..
  10. Shankarnarayan S, Narang S, Malone C, Deschenes R, Fassler J. Modulation of yeast Sln1 kinase activity by the CCW12 cell wall protein. J Biol Chem. 2008;283:1962-73 pubmed
    ..Results of this analysis suggest that the activity of the plasma membrane localized Sln1p is affected by the presence or absence of specific outer cell wall proteins and that this effect is independent of turgor. ..
  11. Marshall N, Peng J, Xie Z, Price D. Control of RNA polymerase II elongation potential by a novel carboxyl-terminal domain kinase. J Biol Chem. 1996;271:27176-83 pubmed
    ..We propose that phosphorylation of the CTD by P-TEFb controls the transition from abortive into productive elongation mode. ..
  12. Willett J, Kirby J. Genetic and biochemical dissection of a HisKA domain identifies residues required exclusively for kinase and phosphatase activities. PLoS Genet. 2012;8:e1003084 pubmed publisher
    ..These data are consistent with conserved mechanisms for kinase and phosphatase activities in the broadly occurring HisKA family of sensor kinases in bacteria. ..
  13. Ritchie H, Wang L. Sequence determination of an extremely acidic rat dentin phosphoprotein. J Biol Chem. 1996;271:21695-8 pubmed
    ..Here we present the cDNA sequence, the deduced amino acid sequence, and the prospective Ser residue-specific casein kinase I and II phosphorylation sites for this putative phosphophoryn. ..
  14. Massa J, Fellows R, Maurer R. Rat RI beta isoform of type I regulatory subunit of cyclic adenosine monophosphate-dependent protein kinase: cDNA sequence analysis, mRNA tissue specificity, and rat/mouse difference in expression in testis. Mol Reprod Dev. 1990;26:129-33 pubmed
    ..First, there is a short open reading frame, which precedes the coding region in the rat but not the mouse. Second, unlike the mouse testis, the rat testis contains abundant levels of RI beta mRNA. ..