Experts and Doctors on phosphorylation in Ames, Iowa, United States


Locale: Ames, Iowa, United States
Topic: phosphorylation

Top Publications

  1. Jin Y, Wang Y, Johansen J, Johansen K. JIL-1, a chromosomal kinase implicated in regulation of chromatin structure, associates with the male specific lethal (MSL) dosage compensation complex. J Cell Biol. 2000;149:1005-10 pubmed
    ..Thus, these results strongly indicate JIL-1 associates with the MSL complex and further suggests JIL-1 functions in signal transduction pathways regulating chromatin structure. ..
  2. Kaul S, Anantharam V, Yang Y, Choi C, Kanthasamy A, Kanthasamy A. Tyrosine phosphorylation regulates the proteolytic activation of protein kinase Cdelta in dopaminergic neuronal cells. J Biol Chem. 2005;280:28721-30 pubmed
    ..To our knowledge, these data demonstrate for the first time that phosphorylation of Tyr-311 on PKCdelta can regulate the proteolytic activation and proapoptotic function of the kinase in dopaminergic neuronal cells. ..
  3. Zhang D, Kanthasamy A, Yang Y, Anantharam V, Kanthasamy A. Protein kinase C delta negatively regulates tyrosine hydroxylase activity and dopamine synthesis by enhancing protein phosphatase-2A activity in dopaminergic neurons. J Neurosci. 2007;27:5349-62 pubmed
    ..Collectively, these results suggest that PKCdelta phosphorylates PP2Ac to enhance its activity and thereby reduces TH-ser40 phosphorylation and TH activity and ultimately dopamine synthesis. ..
  4. Boggiatto P, Jie F, Ghosh M, Gibson Corley K, Ramer Tait A, Jones D, et al. Altered dendritic cell phenotype in response to Leishmania amazonensis amastigote infection is mediated by MAP kinase, ERK. Am J Pathol. 2009;174:1818-26 pubmed publisher
    ..L. amazonensis amastigotes, through activation of extracellular signal-regulated kinase 1/2, inhibit the ability of DC to undergo proper maturation both in vitro and in vivo. ..
  5. Meyer M, Lichti C, Townsend R, Rao A. Identification of in vitro autophosphorylation sites and effects of phosphorylation on the Arabidopsis CRINKLY4 (ACR4) receptor-like kinase intracellular domain: insights into conformation, oligomerization, and activity. Biochemistry. 2011;50:2170-86 pubmed publisher
    ..Sedimentation velocity and gel filtration experiments indicate that the ICD has a propensity to oligomerize and that this property is lost upon autophosphorylation. ..
  6. Liu J, Horstman H, Braun E, Graham M, Zhang C, Navarre D, et al. Soybean homologs of MPK4 negatively regulate defense responses and positively regulate growth and development. Plant Physiol. 2011;157:1363-78 pubmed publisher
    ..Taken together, our results indicate that GmMPK4s negatively regulate SA accumulation and defense response but positively regulate plant growth and development, and their functions are conserved across plant species. ..
  7. Wang C, Yao C, Li Y, Cai W, Bao X, Girton J, et al. Evidence against a role for the JIL-1 kinase in H3S28 phosphorylation and 14-3-3 recruitment to active genes in Drosophila. PLoS ONE. 2013;8:e62484 pubmed publisher
    ..Thus, our results argue strongly against a model where JIL-1 is required for H3S28 phosphorylation and 14-3-3 recruitment at active genes. ..
  8. Li Y, Cai W, Wang C, Yao C, Bao X, Deng H, et al. Domain requirements of the JIL-1 tandem kinase for histone H3 serine 10 phosphorylation and chromatin remodeling in vivo. J Biol Chem. 2013;288:19441-9 pubmed publisher
  9. Laederach A, Cradic K, Brazin K, Zamoon J, Fulton D, Huang X, et al. Competing modes of self-association in the regulatory domains of Bruton's tyrosine kinase: intramolecular contact versus asymmetric homodimerization. Protein Sci. 2002;11:36-45 pubmed

More Information


  1. Johansen K, Johansen J. Regulation of chromatin structure by histone H3S10 phosphorylation. Chromosome Res. 2006;14:393-404 pubmed
  2. Hines J, Fromm H, Honzatko R. Structures of activated fructose-1,6-bisphosphatase from Escherichia coli. Coordinate regulation of bacterial metabolism and the conservation of the R-state. J Biol Chem. 2007;282:11696-704 pubmed
    ..Findings here unify disparate observations regarding bacterial FBPases, implicating a mechanism of feed-forward activation in bacterial central metabolism. ..
  3. Cai W, Bao X, Deng H, Jin Y, Girton J, Johansen J, et al. RNA polymerase II-mediated transcription at active loci does not require histone H3S10 phosphorylation in Drosophila. Development. 2008;135:2917-25 pubmed publisher
  4. Devkota S, Joseph R, Boyken S, Fulton D, Andreotti A. An Autoinhibitory Role for the Pleckstrin Homology Domain of Interleukin-2-Inducible Tyrosine Kinase and Its Interplay with Canonical Phospholipid Recognition. Biochemistry. 2017;56:2938-2949 pubmed publisher
  5. Li Y, Wang C, Cai W, Sengupta S, Zavortink M, Deng H, et al. H2Av facilitates H3S10 phosphorylation but is not required for heat shock-induced chromatin decondensation or transcriptional elongation. Development. 2017;144:3232-3240 pubmed publisher
    ..These data strongly suggest that H2Av or H3S10 phosphorylation by JIL-1 is not required for chromatin decondensation or transcriptional elongation in Drosophila. ..