Genomes and Genes
Experts and Doctors on mice in Iowa City, Iowa, United States
Locale: Iowa City, Iowa, United States
Publications754 found, 100 shown here
- Peng W, Dunton C, Holtz D, Parva M, Stampler K, Forwood M, et al. DNA nanotherapy for pre-neoplastic cervical lesions. Gynecol Oncol. 2013;128:101-106 pubmed publisher..Topical application of a Lutrol F127 thermal gel/nanoparticle mix is illustrative of how to restrict exposure of cells to therapeutic nanoparticles, thereby allowing for targeted DNA delivery to cervical pre-cancerous lesions. ..
- Sobhakumari A, Love Homan L, Fletcher E, Martin S, Parsons A, Spitz D, et al. Susceptibility of human head and neck cancer cells to combined inhibition of glutathione and thioredoxin metabolism. PLoS ONE. 2012;7:e48175 pubmed publisher..These results support the conclusion that simultaneous inhibition of GSH and Trx metabolism pathways induces oxidative stress and clonogenic killing in HNSCCs and this strategy may be useful in sensitizing HNSCCs to EGFR inhibitors. ..
- Mohan K, Kecova H, Hernandez Merino E, Kardon R, Harper M. Retinal ganglion cell damage in an experimental rodent model of blast-mediated traumatic brain injury. Invest Ophthalmol Vis Sci. 2013;54:3440-50 pubmed publisher..These objective responses may serve as surrogate tests for higher CNS functions following traumatic brain injury that are difficult to quantify. ..
- Tao G, Kahr P, Morikawa Y, Zhang M, Rahmani M, Heallen T, et al. Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury. Nature. 2016;534:119-23 pubmed publisher..These findings reveal a genetic pathway activated by tissue damage that is essential for cardiac repair. ..
- Tvinnereim A, Hamilton S, Harty J. CD8(+)-T-cell response to secreted and nonsecreted antigens delivered by recombinant Listeria monocytogenes during secondary infection. Infect Immun. 2002;70:153-62 pubmed..monocytogenes replication. Thus, the level of antivector immunity impacts the control of infection and efficiency of priming responses against new antigens introduced with the same vector. ..
- Didion S, Ryan M, Didion L, Fegan P, Sigmund C, Faraci F. Increased superoxide and vascular dysfunction in CuZnSOD-deficient mice. Circ Res. 2002;91:938-44 pubmed..CuZnSOD-deficiency results in altered responsiveness in both large arteries and microvessels. ..
- Pewe L, Netland J, Heard S, Perlman S. Very diverse CD8 T cell clonotypic responses after virus infections. J Immunol. 2004;172:3151-6 pubmed..These results suggest that T cell response diversity is greater by 1-2 orders of magnitude than predicted previously...
- Lim R, Zaheer A, Khosravi H, Freeman J, Halverson H, Wemmie J, et al. Impaired motor performance and learning in glia maturation factor-knockout mice. Brain Res. 2004;1024:225-32 pubmed..The structural abnormality in GMF-null mice explained their impaired ability for both motor performance and motor learning. ..
- Yarovinsky T, Mohning M, Bradford M, Monick M, Hunninghake G. Increased sensitivity to staphylococcal enterotoxin B following adenoviral infection. Infect Immun. 2005;73:3375-84 pubmed..These data suggest that a preexisting viral infection primes mice for subsequent staphylococcal enterotoxin B exposure, possibly via a gamma-interferon-mediated mechanism. ..
- Dayal S, Wilson K, Leo L, Arning E, Bottiglieri T, Lentz S. Enhanced susceptibility to arterial thrombosis in a murine model of hyperhomocysteinemia. Blood. 2006;108:2237-43 pubmed
- Schnizler K, Shutov L, Van Kanegan M, Merrill M, Nichols B, McKnight G, et al. Protein kinase A anchoring via AKAP150 is essential for TRPV1 modulation by forskolin and prostaglandin E2 in mouse sensory neurons. J Neurosci. 2008;28:4904-17 pubmed publisher..Together, these data suggest that PKA anchoring by AKAP150 is essential for the enhancement of TRPV1 function by activation of the PGE(2)/PKA signaling pathway. ..
- Osborn Heaford H, Ryan A, Murthy S, Racila A, He C, Sieren J, et al. Mitochondrial Rac1 GTPase import and electron transfer from cytochrome c are required for pulmonary fibrosis. J Biol Chem. 2012;287:3301-12 pubmed publisher..These observations demonstrate that mitochondrial import and direct electron transfer from cytochrome c to Rac1 modulates mitochondrial H(2)O(2) production in alveolar macrophages pulmonary fibrosis. ..
- Shelton D, Fornalik H, Neff T, Park S, Bender D, Degeest K, et al. The role of LEF1 in endometrial gland formation and carcinogenesis. PLoS ONE. 2012;7:e40312 pubmed publisher..Finally, Lef1 is overexpressed in human and mouse endometrial tumors, consistent with it playing a role in gland proliferation. ..
- Li X, Venugopalan S, Cao H, Pinho F, Paine M, Snead M, et al. A model for the molecular underpinnings of tooth defects in Axenfeld-Rieger syndrome. Hum Mol Genet. 2014;23:194-208 pubmed publisher..Moreover, our findings validate the etiology of the enamel defect in a novel mouse model of ARS. ..
- CASSEL S, Janczy J, Bing X, Wilson S, Olivier A, Otero J, et al. Inflammasome-independent IL-1? mediates autoinflammatory disease in Pstpip2-deficient mice. Proc Natl Acad Sci U S A. 2014;111:1072-7 pubmed publisher..These data provide a rationale for directly targeting IL-1RI or IL-1? as a therapeutic strategy in CRMO. ..
- Moreland J, Davis A, Bailey G, Nauseef W, Lamb F. Anion channels, including ClC-3, are required for normal neutrophil oxidative function, phagocytosis, and transendothelial migration. J Biol Chem. 2006;281:12277-88 pubmed..In summary, PMNs lacking normal anion channel function exhibited reduced NADPH oxidase activity, diminished phagocytosis, and impaired migration. ClC-3 was specifically involved in the respiratory burst and phagocytosis. ..
- McLoughlin H, Fineberg S, Ghosh L, Tecedor L, Davidson B. Dicer is required for proliferation, viability, migration and differentiation in corticoneurogenesis. Neuroscience. 2012;223:285-95 pubmed publisher..These results significantly extend earlier works, and emphasize the impact of miRNAs on neural progenitor cell proliferation, apoptosis, migration, and differentiation in the developing mammalian brain. ..
- Allen B, Bhatia S, Buatti J, Brandt K, Lindholm K, Button A, et al. Ketogenic diets enhance oxidative stress and radio-chemo-therapy responses in lung cancer xenografts. Clin Cancer Res. 2013;19:3905-13 pubmed publisher..These results show that a ketogenic diet enhances radio-chemo-therapy responses in lung cancer xenografts by a mechanism that may involve increased oxidative stress. ..
- Robillard J, Page W, Mathews M, Schutte B, Nuyt A, Segar J. Differential gene expression and regulation of renal angiotensin II receptor subtypes (AT1 and AT2) during fetal life in sheep. Pediatr Res. 1995;38:896-904 pubmed..In summary, this study demonstrates that AII, but not glucocorticoids, contributes to the regulation of renal AT2 gene expression during development and that there is differential regulation of AT1 and AT2 receptors. ..
- Erickson L, Foy T, Waldschmidt T. Murine B1 B cells require IL-5 for optimal T cell-dependent activation. J Immunol. 2001;166:1531-9 pubmed
- Knudson C, Johnson G, Lin Y, Korsmeyer S. Bax accelerates tumorigenesis in p53-deficient mice. Cancer Res. 2001;61:659-65 pubmed..We conclude that BAX-induced proliferation is synergistic with a defect in apoptosis contributed by p53-deficiency. Thus, the dual roles of BAX can either accelerate or inhibit tumorigenesis depending on the genetic context. ..
- Brown K, Hostager B, Bishop G. Regulation of TRAF2 signaling by self-induced degradation. J Biol Chem. 2002;277:19433-8 pubmed..Several approaches show that ubiquitination and proteasomal activity are integral to TRAF2 degradation, and inhibition of this process potentiates CD40 signaling. ..
- Porter B, Harty J. The onset of CD8+-T-cell contraction is influenced by the peak of Listeria monocytogenes infection and antigen display. Infect Immun. 2006;74:1528-36 pubmed..These results demonstrate a direct relationship between the course of infection and Ag display and that the timing of these events is important in shaping the T-cell response to infection. ..
- Thompson S, Foster R, Stone E, Sheffield V, Mrosovsky N. Classical and melanopsin photoreception in irradiance detection: negative masking of locomotor activity by light. Eur J Neurosci. 2008;27:1973-9 pubmed publisher..Together the evidence demonstrates a pronounced and sustained classical photoreceptor input to irradiance detection for negative masking, and suggests one role of classical photoreceptor input is to constrain dynamic range. ..
- Kashiwada M, Levy D, McKeag L, Murray K, Schroder A, CANFIELD S, et al. IL-4-induced transcription factor NFIL3/E4BP4 controls IgE class switching. Proc Natl Acad Sci U S A. 2010;107:821-6 pubmed publisher..Moreover, NFIL3 binds to Iepsilon promoter in vivo. Together, these results identify NFIL3 as a key regulator of IL-4-induced GLepsilon transcription in response to IL-4 and subsequent IgE class switching. ..
- Langlois R, Legge K. Plasmacytoid dendritic cells enhance mortality during lethal influenza infections by eliminating virus-specific CD8 T cells. J Immunol. 2010;184:4440-6 pubmed publisher..Together, these results suggest that pDCs play a heretofore unknown deleterious role during lethal dose IAV infections by limiting the CD8 T cell response. ..
- Yu S, Zhou X, Hsiao J, Yu D, Saunders T, Xue H. Fidelity of a BAC-EGFP transgene in reporting dynamic expression of IL-7R? in T cells. Transgenic Res. 2012;21:201-15 pubmed publisher..Our approach thus represents a critical initial step towards systematic dissection of the cis regulatory elements controlling dynamic IL-7R? regulation during T cell development and cellular immune responses. ..
- Tucker B, Park I, Qi S, Klassen H, Jiang C, Yao J, et al. Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in degenerative mice. PLoS ONE. 2011;6:e18992 pubmed publisher..As such, adult fibroblast-derived iPSCs provide a viable source for the production of retinal precursors to be used for transplantation and treatment of retinal degenerative disease. ..
- Riordan J, Keng V, Tschida B, Scheetz T, Bell J, Podetz Pedersen K, et al. Identification of rtl1, a retrotransposon-derived imprinted gene, as a novel driver of hepatocarcinogenesis. PLoS Genet. 2013;9:e1003441 pubmed publisher..In addition to identifying Rtl1 as a novel driver of HCC, our study represents one of the first direct in vivo demonstrations of a role for such a co-opted genetic element in promoting carcinogenesis. ..
- Pan H, Guan D, Liu X, Li J, Wang L, Wu J, et al. SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2. Cell Res. 2016;26:190-205 pubmed publisher..Our study uncovers a novel function of SIRT6 in maintaining hMSC homeostasis by serving as a NRF2 coactivator, which represents a new layer of regulation of oxidative stress-associated stem cell decay. ..
- Coral Vazquez R, Cohn R, Moore S, Hill J, Weiss R, Davisson R, et al. Disruption of the sarcoglycan-sarcospan complex in vascular smooth muscle: a novel mechanism for cardiomyopathy and muscular dystrophy. Cell. 1999;98:465-74 pubmed..Our data indicate that disruption of the SG-SSPN complex in vascular smooth muscle perturbs vascular function, which initiates cardiomyopathy and exacerbates muscular dystrophy. ..
- Fahlen T, Wilson R, Boddicker J, Jones B. Hha is a negative modulator of transcription of hilA, the Salmonella enterica serovar Typhimurium invasion gene transcriptional activator. J Bacteriol. 2001;183:6620-9 pubmed..These data add detail to the developing model of the regulation of Salmonella invasion genes. ..
- Jones K, Myers L, Judge D, Kirby P, Dietz H, Sponseller P. Toward an understanding of dural ectasia: a light microscopy study in a murine model of Marfan syndrome. Spine (Phila Pa 1976). 2005;30:291-3 pubmed..These changes may be due in part to transforming growth factor beta overactivation and gelatinase-A-mediated elastolysis and collagen breakdown. ..
- Li J, Marionneau C, Zhang R, Shah V, Hell J, Nerbonne J, et al. Calmodulin kinase II inhibition shortens action potential duration by upregulation of K+ currents. Circ Res. 2006;99:1092-9 pubmed..These findings provide novel in vivo and cellular evidence that CaMKII links Ca(2+)(i) to cardiac repolarization and suggest that PLN may be a critical CaMKII target for feedback regulation of APD in ventricular myocytes. ..
- Hund T, Mohler P. Ankyrin-based targeting pathway regulates human sinoatrial node automaticity. Channels (Austin). 2008;2:404-6 pubmed..In summary, our new findings define a novel genetic basis for human SND and expand our understanding of the critical role that ankyrin-based targeting pathways play in excitable cell physiology. ..
- Matsuda J, Filali M, Moreland J, Miller F, Lamb F. Activation of swelling-activated chloride current by tumor necrosis factor-alpha requires ClC-3-dependent endosomal reactive oxygen production. J Biol Chem. 2010;285:22864-73 pubmed publisher..Thus, activation of ICl(swell) by TNF-alpha requires ClC-3-dependent endosomal H(2)O(2) production. This demonstrates a functional link between two distinct anion currents, ClC-3 and ICl(swell). ..
- Tai P, Ascoli M. Reactive oxygen species (ROS) play a critical role in the cAMP-induced activation of Ras and the phosphorylation of ERK1/2 in Leydig cells. Mol Endocrinol. 2011;25:885-93 pubmed publisher..We conclude that, in Leydig cells, cAMP enhances the phosphorylation of ERK1/2 via a mitochondria-derived, ROS-dependent activation of Ras...
- Kashiwada M, Pham N, Pewe L, Harty J, Rothman P. NFIL3/E4BP4 is a key transcription factor for CD8α⁺ dendritic cell development. Blood. 2011;117:6193-7 pubmed publisher..Thus, NFIL3 plays an essential role in the development of CD8α(+) cDCs. ..
- Santillan D, Rai K, Santillan M, Krishnamachari Y, Salem A, Hunter S. Efficacy of polymeric encapsulated C5a peptidase-based group B streptococcus vaccines in a murine model. Am J Obstet Gynecol. 2011;205:249.e1-8 pubmed publisher..Encapsulated C5a peptidase elicited significant immune responses and protection against a GBS challenge. C5a peptidase microsphere encapsulation has potential as a GBS vaccine. ..
- McDermott D, Varga S. Quantifying antigen-specific CD4 T cells during a viral infection: CD4 T cell responses are larger than we think. J Immunol. 2011;187:5568-76 pubmed publisher..Our results indicate that the magnitude of the virus-specific CD4 T cell response is much greater than previously recognized. ..
- Ebert S, Dyle M, Kunkel S, Bullard S, Bongers K, Fox D, et al. Stress-induced skeletal muscle Gadd45a expression reprograms myonuclei and causes muscle atrophy. J Biol Chem. 2012;287:27290-301 pubmed publisher..These results elucidate a critical stress-induced pathway that reprograms muscle gene expression to cause atrophy. ..
- Miller J, Chu Y, Castaneda L, Serrano K, Brooks R, Heistad D. Vascular function during prolonged progression and regression of atherosclerosis in mice. Arterioscler Thromb Vasc Biol. 2013;33:459-65 pubmed publisher..Both of these changes can be prevented by normalizing blood lipids during moderately severe or advanced atherosclerosis. ..
- Iwabuchi S, Kakazu Y, Koh J, Harata N. Abnormal cytoplasmic calcium dynamics in central neurons of a dystonia mouse model. Neurosci Lett. 2013;548:61-6 pubmed publisher..As the [Ca(2+)]c is readout and regulator of neuronal excitability, its abnormality represents an important cellular phenotype of dystonia. ..
- Dayal S, Brown K, Weydert C, Oberley L, Arning E, Bottiglieri T, et al. Deficiency of glutathione peroxidase-1 sensitizes hyperhomocysteinemic mice to endothelial dysfunction. Arterioscler Thromb Vasc Biol. 2002;22:1996-2002 pubmed
- Ding S, Tecedor L, Stein C, Davidson B. A knock-in reporter mouse model for Batten disease reveals predominant expression of Cln3 in visual, limbic and subcortical motor structures. Neurobiol Dis. 2011;41:237-48 pubmed publisher..These findings have also revealed potential target brain regions and time periods for future investigations of the disease mechanisms and therapeutic intervention. ..
- Geary S, Lemke C, Lubaroff D, Salem A. Tumor immunotherapy using adenovirus vaccines in combination with intratumoral doses of CpG ODN. Cancer Immunol Immunother. 2011;60:1309-17 pubmed publisher..These findings highlight the therapeutic potential of combining intratumoral CpG and vaccination with virus encoding tumor antigen. ..
- Brincks E, Gurung P, Langlois R, Hemann E, Legge K, Griffith T. The magnitude of the T cell response to a clinically significant dose of influenza virus is regulated by TRAIL. J Immunol. 2011;187:4581-8 pubmed publisher..Together, these data suggest that TRAIL regulates the magnitude of the IAV-specific CD8 T cell response during a clinically significant IAV infection to decrease the chance for infection-induced immunopathology. ..
- Harty J, Bevan M. Specific immunity to Listeria monocytogenes in the absence of IFN gamma. Immunity. 1995;3:109-17 pubmed..monocytogenes and this resistance appears to be CD8 T cell mediated. These studies demonstrate that vaccination-induced immunity can overcome the absence of a cytokine that is critical for resistance to acute infection. ..
- Takahashi K, Kozono Y, Waldschmidt T, Berthiaume D, Quigg R, Baron A, et al. Mouse complement receptors type 1 (CR1;CD35) and type 2 (CR2;CD21): expression on normal B cell subpopulations and decreased levels during the development of autoimmunity in MRL/lpr mice. J Immunol. 1997;159:1557-69 pubmed..We hypothesize that the early decrease in complement receptor expression such as that demonstrated by MRL/lpr mice plays an important role in the pathogenesis of murine and perhaps human SLE. ..
- Badovinac V, Hamilton S, Harty J. Viral infection results in massive CD8+ T cell expansion and mortality in vaccinated perforin-deficient mice. Immunity. 2003;18:463-74 pubmed..Thus, perforin was essential for resistance to secondary LCMV infection, and, in the absence of perforin, vaccination resulted in lethal disease mediated by dysregulated CD8(+) T cell expansion and cytokine production. ..
- Siemens D, Crist S, Austin J, Tartaglia J, Ratliff T. Comparison of viral vectors: gene transfer efficiency and tissue specificity in a bladder cancer model. J Urol. 2003;170:979-84 pubmed..The viral vectors examined in these experiments resulted in significantly different gene transfer in the orthotopic bladder cancer model, underscoring the importance of vector selection in gene therapy protocols. ..
- Faraci F, Lamping K, Modrick M, Ryan M, Sigmund C, Didion S. Cerebral vascular effects of angiotensin II: new insights from genetic models. J Cereb Blood Flow Metab. 2006;26:449-55 pubmed..There are marked gender differences in cerebral vascular responses to Ang II. Endothelial function is greatly impaired in a genetic model of Ang II-dependent hypertension via a mechanism that involves superoxide. ..
- Ozer E, Pezzulo A, Shih D, Chun C, Furlong C, Lusis A, et al. Human and murine paraoxonase 1 are host modulators of Pseudomonas aeruginosa quorum-sensing. FEMS Microbiol Lett. 2005;253:29-37 pubmed..Thus, paraoxonase interruption of bacterial communication represents a novel mechanism to modulate quorum-sensing by bacteria. The consequences for host immunity are yet to be determined. ..
- Beedle A, Nienaber P, Campbell K. Fukutin-related protein associates with the sarcolemmal dystrophin-glycoprotein complex. J Biol Chem. 2007;282:16713-7 pubmed..These data offer the first evidence of an FKRP complex in muscle and suggest that FKRP may influence the glycosylation status of dystroglycan from within the sarcolemmal dystrophin-glycoprotein complex. ..
- Kusner D, Thompson C, Melrose N, Pitson S, Obeid L, Iyer S. The localization and activity of sphingosine kinase 1 are coordinately regulated with actin cytoskeletal dynamics in macrophages. J Biol Chem. 2007;282:23147-62 pubmed..Thus, the localization and activity of SK1 are coordinately regulated with actin dynamics during macrophage activation. ..
- Peters A, Stunz L, Bishop G. CD40 and autoimmunity: the dark side of a great activator. Semin Immunol. 2009;21:293-300 pubmed publisher..This review discusses the role of CD40:CD154 interaction in human and mouse autoimmunity, human polymorphisms associated with disease incidence, and disrupting CD40:CD154 interactions as an autoimmune therapy. ..
- Ostedgaard L, Meyerholz D, Vermeer D, Karp P, Schneider L, Sigmund C, et al. Cystic fibrosis transmembrane conductance regulator with a shortened R domain rescues the intestinal phenotype of CFTR-/- mice. Proc Natl Acad Sci U S A. 2011;108:2921-6 pubmed publisher..These results indicate that the N-terminal part of the CFTR R domain is dispensable for in vivo intestinal physiology. Thus, CFTR?R may have utility for AAV-mediated gene transfer in CF. ..
- Muniz V, Barnes J, Paliwal S, Zhang X, Tang X, Chen S, et al. The ARF tumor suppressor inhibits tumor cell colonization independent of p53 in a novel mouse model of pancreatic ductal adenocarcinoma metastasis. Mol Cancer Res. 2011;9:867-77 pubmed publisher..These findings establish a new bioluminescent mouse tumor model for rapidly assessing the biological significance of suspected PDAC metastasis genes. This system may also provide a valuable platform for testing innovative therapies. ..
- Fraczek L, Martin C, Martin B. c-Jun and c-Fos regulate the complement factor H promoter in murine astrocytes. Mol Immunol. 2011;49:201-10 pubmed publisher..These results suggest a relationship between cell cycle and complement regulation, and how these transcription factors and CFH affect disease will be a valuable area of investigation. ..
- Martin M, Condotta S, Harty J, Badovinac V. Population dynamics of naive and memory CD8 T cell responses after antigen stimulations in vivo. J Immunol. 2012;188:1255-65 pubmed publisher..Taken together, the data in this study revealed previously unappreciated differences between naive and memory CD8 T cells and will help further define the functional potential for both cell types. ..
- Kempuraj D, Khan M, Thangavel R, Xiong Z, Yang E, Zaheer A. Glia maturation factor induces interleukin-33 release from astrocytes: implications for neurodegenerative diseases. J Neuroimmune Pharmacol. 2013;8:643-50 pubmed publisher..In conclusion, IL-33 augments GMF-mediated neuroinflammation and may provide a new drug target for neurodegenerative and autoimmune diseases. ..
- Sharma M, Ferguson P. Autoinflammatory bone disorders: update on immunologic abnormalities and clues about possible triggers. Curr Opin Rheumatol. 2013;25:658-64 pubmed publisher..To provide an update on the genetics and immunologic basis of autoinflammatory bone disorders including chronic recurrent multifocal osteomyelitis including the monogenic forms of the disease...
- Kaiser E, Russo A. CGRP and migraine: could PACAP play a role too?. Neuropeptides. 2013;47:451-61 pubmed publisher..Thus, comparisons between the actions of these two migraine-inducing neuropeptides, CGRP and PACAP, may provide new insights into migraine pathophysiology. ..
- Chaly Y, Fu Y, Marinov A, Hostager B, Yan W, Campfield B, et al. Follistatin-like protein 1 enhances NLRP3 inflammasome-mediated IL-1? secretion from monocytes and macrophages. Eur J Immunol. 2014;44:1467-79 pubmed publisher..These results suggest that FSTL-1 may act on the NLRP3 inflammasome to promote IL-1? secretion from monocytes/macrophages. ..
- Lin S, Tzeng B, Lee K, Smith R, Campbell K, Chen C. Cav3.2 T-type calcium channel is required for the NFAT-dependent Sox9 expression in tracheal cartilage. Proc Natl Acad Sci U S A. 2014;111:E1990-8 pubmed publisher..Our findings define a previously unidentified mechanism that Ca(2+) influx via the Cav3.2 T-type Ca(2+) channel regulates Sox9 expression through the calcineurin/NFAT signaling pathway during tracheal chondrogenesis. ..
- Na E, De Jesus Cortes H, Martinez Rivera A, Kabir Z, Wang J, Ramesh V, et al. D-cycloserine improves synaptic transmission in an animal model of Rett syndrome. PLoS ONE. 2017;12:e0183026 pubmed publisher..DCS treatment did, however, partially restore lower BDNF levels in the brain stem and striatum. Thus, treatment with DCS may mitigate the severity of some of the neurobehavioral symptoms experienced by patients with Rett syndrome. ..
- Gurnett C, Kahl S, Anderson R, Campbell K. Absence of the skeletal muscle sarcolemma chloride channel ClC-1 in myotonic mice. J Biol Chem. 1995;270:9035-8 pubmed..Immunohistochemistry of skeletal muscle from ADR and other mouse models of human muscle disease demonstrate that the absence of ClC-1 chloride channel is a defect specific to ADR mice...
- Mark A, Shaffer R, Correia M, Morgan D, Sigmund C, Haynes W. Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice. J Hypertens. 1999;17:1949-53 pubmed
- Moreland J, Fuhrman R, Pruessner J, Schwartz D. CD11b and intercellular adhesion molecule-1 are involved in pulmonary neutrophil recruitment in lipopolysaccharide-induced airway disease. Am J Respir Cell Mol Biol. 2002;27:474-80 pubmed..These findings suggest that CD11b and ICAM-1 are important mediators of LPS-induced airway inflammation, but do not appear to be critical to the development of LPS-induced airway hyperreactivity. ..
- Trantow C, Mao M, Petersen G, Alward E, Alward W, Fingert J, et al. Lyst mutation in mice recapitulates iris defects of human exfoliation syndrome. Invest Ophthalmol Vis Sci. 2009;50:1205-14 pubmed publisher..The purpose of this study was to determine the anatomic basis for Lyst-mediated transillumination defects, test whether Lyst mutant mice develop other features of XFS, and describe the molecular basis of the beige mutation...
- Agassandian M, Chen B, Schuster C, Houtman J, Mallampalli R. 14-3-3zeta escorts CCTalpha for calcium-activated nuclear import in lung epithelia. FASEB J. 2010;24:1271-83 pubmed publisher..Agassandian, M., Chen, B. B., Schuster, C. C., Houtman, J. C. D., Mallampalli, R. K. 14-3-3zeta escorts CCTalpha for calcium-activated nuclear import in lung epithelia. ..
- Hunninghake G, Doerschug K, Nymon A, Schmidt G, Meyerholz D, Ashare A. Insulin-like growth factor-1 levels contribute to the development of bacterial translocation in sepsis. Am J Respir Crit Care Med. 2010;182:517-25 pubmed publisher..These data support the hypothesis that sepsis-induced reductions in IGF-1 levels contribute to the development of bacterial translocation in both a murine model and human subjects. ..
- Murthy S, Ryan A, He C, Mallampalli R, Carter A. Rac1-mediated mitochondrial H2O2 generation regulates MMP-9 gene expression in macrophages via inhibition of SP-1 and AP-1. J Biol Chem. 2010;285:25062-73 pubmed publisher..Rac1 regulates MMP-9 transcription via mitochondrial H(2)O(2) generation, providing a potential mechanism by which Rac1 null mice fail to develop pulmonary fibrosis. ..
- Bhaskar K, Hobbs G, Yen S, Lee G. Tyrosine phosphorylation of tau accompanies disease progression in transgenic mouse models of tauopathy. Neuropathol Appl Neurobiol. 2010;36:462-77 pubmed publisher..Our results provide evidence for the association of tyrosine-phosphorylated tau with mechanisms of neuropathogenesis and indicate that SFK activation and cell cycle activation are also involved in JNPL3. ..
- Ness Schwickerath K, Morita C. Regulation and function of IL-17A- and IL-22-producing ?? T cells. Cell Mol Life Sci. 2011;68:2371-90 pubmed publisher..These observations highlight differences between humans and murine ?? T cells and underscore the importance of IL-17A- and IL-22-producing ?? T cells. ..
- Xie W, Fisher J, Lynch T, Luo M, Evans T, Neff T, et al. CGRP induction in cystic fibrosis airways alters the submucosal gland progenitor cell niche in mice. J Clin Invest. 2011;121:3144-58 pubmed publisher..This discovery may have important implications for injury/repair mechanisms in the CF airway. ..
- Sun Z, Tang X, Lin F, Chen S. The WD40 repeat protein WDR26 binds G?? and promotes G??-dependent signal transduction and leukocyte migration. J Biol Chem. 2011;286:43902-12 pubmed publisher..Collectively, these experiments identify WDR26 as a novel G??-binding protein that is required for the efficacy of G?? signaling and leukocyte migration. ..
- Tyra H, Spitz D, Rutkowski D. Inhibition of fatty acid oxidation enhances oxidative protein folding and protects hepatocytes from endoplasmic reticulum stress. Mol Biol Cell. 2012;23:811-9 pubmed publisher..Our results suggest that ER stress can be ameliorated through alteration of the oxidizing environment within the ER lumen, and they provide a potential logic for the transient regulation of metabolic pathways by the UPR during stress. ..
- Zhang Q, Yu D, Seo S, Stone E, Sheffield V. Intrinsic protein-protein interaction-mediated and chaperonin-assisted sequential assembly of stable bardet-biedl syndrome protein complex, the BBSome. J Biol Chem. 2012;287:20625-35 pubmed publisher..BBS1, BBS5, BBS8, and finally BBS4 are added to the BBSome core to form the complete BBSome. ..
- Sarsour E, Kalen A, Xiao Z, Veenstra T, Chaudhuri L, Venkataraman S, et al. Manganese superoxide dismutase regulates a metabolic switch during the mammalian cell cycle. Cancer Res. 2012;72:3807-16 pubmed publisher..These results support the hypothesis that MnSOD regulates a "metabolic switch" during progression from quiescent through the proliferative cycle. We propose MnSOD as a new molecular player contributing to the Warburg effect. ..
- Clay G, Valadares D, Graff J, Ulland T, Davis R, Scorza B, et al. An Anti-Inflammatory Role for NLRP10 in Murine Cutaneous Leishmaniasis. J Immunol. 2017;199:2823-2833 pubmed publisher..These data suggest a novel role for NLRP10 in the resolution of local inflammatory responses during L. major infection. ..
- Feddersen R, Van Ness B. Corrective recombination of mouse immunoglobulin kappa alleles in Abelson murine leukemia virus-transformed pre-B cells. Mol Cell Biol. 1990;10:569-76 pubmed..Both deletion and maintenance of the primary (nonfunctional) V-J join, as a reciprocal product, were observed...