Stone E, Lotery A, Munier F, Heon E, Piguet B, Guymer R, et al
. A single EFEMP1 mutation associated with both Malattia Leventinese and Doyne honeycomb retinal dystrophy. Nat Genet. 1999;22:199-202 pubmed
..Identification of this mutation may aid in the development of an animal model for drusen, as well as in the identification of other genes involved in human macular degeneration. ..
Dexter F. Why calculating PACU staffing is so hard and why/how operations research specialists can help. J Perianesth Nurs. 2007;22:357-9 pubmed
Fritzsch B, Jahan I, Pan N, Kersigo J, Duncan J, Kopecky B. Dissecting the molecular basis of organ of Corti development: Where are we now?. Hear Res. 2011;276:16-26 pubmed publisher
..In summary, the emerging molecular complexity of organ of Corti development demands further study before a rational approach towards regeneration of unique types of hair cells in specific positions is possible...
Kukoyi O, Carney C. Curses, madness, and mefloquine. Psychosomatics. 2003;44:339-41 pubmed
Thunell D, Tymkiw K, Johnson G, Joly S, Burnell K, Cavanaugh J, et al
. A multiplex immunoassay demonstrates reductions in gingival crevicular fluid cytokines following initial periodontal therapy. J Periodontal Res. 2010;45:148-52 pubmed publisher
Thiel D, Francis P, Heckman M, Winfield H. Prospective evaluation of factors affecting operating time in a residency/fellowship training program incorporating robot-assisted laparoscopic prostatectomy. J Endourol. 2008;22:1331-8 pubmed publisher
..RALP can be incorporated successfully into a residency/fellowship training program with acceptable operative times and outcomes even while the supervising physician is on his "learning curve." ..
Wayne S, Robinson R. Upper aerodigestive tract squamous dysplasia: correlation with p16, p53, pRb, and Ki-67 expression. Arch Pathol Lab Med. 2006;130:1309-14 pubmed
..Differential expression of cell cycle-associated proteins may correlate with human papillomavirus status and may help delineate degree of dysplasia in upper aerodigestive tract squamous lesions...
Prohinar P, Re F, Widstrom R, Zhang D, Teghanemt A, Weiss J, et al
. Specific high affinity interactions of monomeric endotoxin.protein complexes with Toll-like receptor 4 ectodomain. J Biol Chem. 2007;282:1010-7 pubmed
..MD-2/TLR4 complex. The ability to assay specific high affinity interactions of monomeric endotoxin.protein complexes with TLR4ECD should allow better definition of the structural requirements for endotoxin-induced TLR4 activation. ..
Schultz H, Weiss J. The bactericidal/permeability-increasing protein (BPI) in infection and inflammatory disease. Clin Chim Acta. 2007;384:12-23 pubmed
Edwards J, Apicella M. I-domain-containing integrins serve as pilus receptors for Neisseria gonorrhoeae adherence to human epithelial cells. Cell Microbiol. 2005;7:1197-211 pubmed
..Collectively, these data suggest that while CD46 might be able to bind gonococcal pilus, IDC integrins are preferentially used as the initial docking site for gonococci on UECs, on urethral tissue and on some immortal cell lines. ..
Leontiev V, Maury W, Hadany L. Drug induced superinfection in HIV and the evolution of drug resistance. Infect Genet Evol. 2008;8:40-50 pubmed
Dayoub H, Rodionov R, Lynch C, Cooke J, Arning E, Bottiglieri T, et al
. Overexpression of dimethylarginine dimethylaminohydrolase inhibits asymmetric dimethylarginine-induced endothelial dysfunction in the cerebral circulation. Stroke. 2008;39:180-4 pubmed
..These findings provide the first evidence that overexpression of DDAH-1 increases basal levels of vascular NO and protects against ADMA-induced endothelial dysfunction in the cerebral circulation. ..
Korgaonkar C, Hagen J, Tompkins V, Frazier A, Allamargot C, Quelle F, et al
. Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function. Mol Cell Biol. 2005;25:1258-71 pubmed
..Conversely, NPM overexpression antagonized ARF function while increasing its nucleolar localization. These data suggest that NPM inhibits ARF's p53-dependent activity by targeting it to nucleoli and impairing ARF-Mdm2 association. ..
Tao Y, Segaloff D. Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation. J Clin Endocrinol Metab. 2004;89:3936-42 pubmed
..The corresponding residue is also important for agonist-induced human melanocortin-4 receptor and lutropin receptor activation. In summary, we identify a residue that is critical for activation of G protein-coupled receptors. ..
Nyunoya T, Gross T, Rooney C, Mendoza S, Kline J. Massive pleural transudate following a vertebral fusion in a 49-year-old woman. Chest. 2003;123:1280-3 pubmed
Zhao L, Samuels T, Winckler S, Korgaonkar C, Tompkins V, Horne M, et al
. Cyclin G1 has growth inhibitory activity linked to the ARF-Mdm2-p53 and pRb tumor suppressor pathways. Mol Cancer Res. 2003;1:195-206 pubmed
..These findings reveal that cyclin G1 has growth inhibitory activity that is mechanistically linked to ARF-p53 and pRb tumor suppressor pathways. ..
Arensdorf A, Rutkowski D. Endoplasmic reticulum stress impairs IL-4/IL-13 signaling through C/EBPβ-mediated transcriptional suppression. J Cell Sci. 2013;126:4026-36 pubmed publisher
..This work identifies a novel role for C/EBPβ in regulating transcriptional suppression and inflammatory signaling during ER stress. ..
Wolinsky F, Bentler S, Cook E, Chrischilles E, Liu L, Wright K, et al
. A 12-year prospective study of stroke risk in older Medicare beneficiaries. BMC Geriatr. 2009;9:17 pubmed publisher
..This suggests an especially vulnerable post-hospital transition period from adverse effects associated with both their underlying health shock (the reasons for the recent hospital admission) and the consequences of their treatments. ..
Streit J, Yang M, Cavanaugh J, Polgreen P. Upward trend in dengue incidence among hospitalized patients, United States. Emerg Infect Dis. 2011;17:914-6 pubmed publisher
..We conducted a retrospective cohort analysis of trends in dengue among hospitalized patients by using the National Inpatient Sample (2000-2007); the number of cases more than tripled (p<0.0001). ..
Cyr A, Nimmakayalu M, Longmuir S, Patil S, Keppler Noreuil K, Shchelochkov O. A novel 4p16.3 microduplication distal to WHSC1 and WHSC2 characterized by oligonucleotide array with new phenotypic features. Am J Med Genet A. 2011;155A:2224-8 pubmed publisher
..This patient's presentation and genomic findings help further delineate clinical significance of re-arrangements in the 4p16 region without the involvement of WHS critical region. ..
Martin L, Sill M, Shahin M, Powell M, Disilvestro P, Landrum L, et al
. A phase II evaluation of AMG 102 (rilotumumab) in the treatment of persistent or recurrent epithelial ovarian, fallopian tube or primary peritoneal carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol. 2014;132:526-30 pubmed publisher
Zhu Y, Hollis J. Tooth loss and its association with dietary intake and diet quality in American adults. J Dent. 2014;42:1428-35 pubmed publisher
..People with missing teeth are recommended to monitor their dietary intake to avoid nutrient deficiency and to improve their diet quality for better health. ..
Matsumura K, Tome F, Collin H, Azibi K, Chaouch M, Kaplan J, et al
. Deficiency of the 50K dystrophin-associated glycoprotein in severe childhood autosomal recessive muscular dystrophy. Nature. 1992;359:320-2 pubmed
..Therefore, the loss of this glycoprotein is a common denominator of the pathological process leading to muscle cell necrosis in two forms of muscular dystrophy, DMD and SCARMD. ..
Brown M, Miller F, Li W, Ellingson A, Mozena J, Chatterjee P, et al
. Overexpression of human catalase inhibits proliferation and promotes apoptosis in vascular smooth muscle cells. Circ Res. 1999;85:524-33 pubmed
..Our results suggest that endogenously produced H(2)O(2) importantly modulates survival and proliferation of vascular smooth muscle cells. ..
Eppinga R, Li Y, Lin J, Mak A, Lin J. Requirement of reversible caldesmon phosphorylation at P21-activated kinase-responsive sites for lamellipodia extensions during cell migration. Cell Motil Cytoskeleton. 2006;63:543-62 pubmed
..We conclude that phosphorylation of caldesmon by PAK is a dynamic process required to regulate actin dynamics and membrane protrusions in wound-induced cell migration. ..
Sarikonda G, Wang H, Puan K, Liu X, Lee H, Song Y, et al
. Photoaffinity antigens for human gammadelta T cells. J Immunol. 2008;181:7738-50 pubmed
..Taken together, these results suggest that nonpeptide Ags are presented by a novel-Ag-presenting molecule that is widely distributed and nonpolymorphic, but not classical MHC class I, MHC class II, or CD1...
Teoh M, Fitzgerald M, Oberley L, Domann F. Overexpression of extracellular superoxide dismutase attenuates heparanase expression and inhibits breast carcinoma cell growth and invasion. Cancer Res. 2009;69:6355-63 pubmed publisher
..Our study implies that overexpression of EcSOD is a promising strategy to enhance the efficacy of heparin/LMWH by inhibiting heparanase as a novel treatment for breast cancer. ..
Doerschug K, Schmidt G. Intensive care ultrasound: III. Lung and pleural ultrasound for the intensivist. Ann Am Thorac Soc. 2013;10:708-12 pubmed publisher
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. Membrane targeting and stabilization of sarcospan is mediated by the sarcoglycan subcomplex. J Cell Biol. 1999;145:153-65 pubmed
..In addition, the SG- SPN subcomplex functions to stabilize alpha-dystroglycan to the muscle plasma membrane. Taken together, our data provide important information about assembly and function of the SG-SPN subcomplex. ..
Rogers L, Riordan J, Swick B, Meyerholz D, Dupuy A. Ectopic expression of Zmiz1 induces cutaneous squamous cell malignancies in a mouse model of cancer. J Invest Dermatol. 2013;133:1863-9 pubmed publisher
..Finally, we provide evidence that ZMIZ1 is overexpressed in a significant percentage of human breast, ovarian, and colon cancers in addition to human SCCs, suggesting that ZMIZ1 may play a broader role in epithelial cancers. ..
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. Safety of a new micronized formulation of isotretinoin in patients with severe recalcitrant nodular acne: A randomized trial comparing micronized isotretinoin with standard isotretinoin. J Am Acad Dermatol. 2001;45:196-207 pubmed
..The safety profile of the micronized formulation has not been described previously...
Khera R, Jain S, Pandey A, Agusala V, Kumbhani D, Das S, et al
. Comparison of Readmission Rates After Acute Myocardial Infarction in 3 Patient Age Groups (18 to 44, 45 to 64, and ≥65 Years) in the United States. Am J Cardiol. 2017;120:1761-1767 pubmed publisher
..Future investigations would need to be targeted toward a better understanding and improvement of the rehospitalization burden for vulnerable patient groups. ..
Mullins R, Skeie J, Malone E, Kuehn M. Macular and peripheral distribution of ICAM-1 in the human choriocapillaris and retina. Mol Vis. 2006;12:224-35 pubmed
Prentice R, Aragaki A, Van Horn L, Thomson C, Beresford S, Robinson J, et al
. Low-fat dietary pattern and cardiovascular disease: results from the Women's Health Initiative randomized controlled trial. Am J Clin Nutr. 2017;106:35-43 pubmed publisher
..This trial was registered at clinicaltrials.gov as NCT00000611. ..
Klionsky D, Abdelmohsen K, Abe A, Abedin M, Abeliovich H, Acevedo Arozena A, et al
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Quezada Joaquin N, Diekema D, Perencevich E, Bailey G, Winokur P, Schweizer M. Long-term risk for readmission, methicillin-resistant Staphylococcus aureus (MRSA) infection, and death among MRSA-colonized veterans. Antimicrob Agents Chemother. 2013;57:1169-72 pubmed publisher
..Noncarriers are at very low risk of subsequent MRSA infection. Future studies should address whether interventions such as nasal or skin decolonization could result in improved outcomes for MRSA carriers. ..
Kondratowicz A, Hunt C, Davey R, Cherry S, Maury W. AMP-activated protein kinase is required for the macropinocytic internalization of ebolavirus. J Virol. 2013;87:746-55 pubmed publisher
..In total, these findings implicate AMPK in macropinocytic events needed for EBOV GP-dependent entry and identify a novel cellular target for new filoviral antivirals. ..
Jones R, Tranel D. Severe developmental prosopagnosia in a child with superior intellect. J Clin Exp Neuropsychol. 2001;23:265-73 pubmed
..Our report extends the understanding of the neuropsychological features of developmental prosopagnosia, and may help narrow the search for neuroanatomical correlates of this condition, which have yet to be identified...
Maity B, Yang J, Huang J, Askeland R, Bera S, Fisher R. Regulator of G protein signaling 6 (RGS6) induces apoptosis via a mitochondrial-dependent pathway not involving its GTPase-activating protein activity. J Biol Chem. 2011;286:1409-19 pubmed publisher
..This work demonstrates a novel signaling action of RGS6 in cell death pathways and identifies it as a possible therapeutic target for treatment of breast cancer. ..
Wiemer A, Hohl R, Wiemer D. The intermediate enzymes of isoprenoid metabolism as anticancer targets. Anticancer Agents Med Chem. 2009;9:526-42 pubmed
Calva D, O Dorisio T, Sue O Dorisio M, Lal G, Sugg S, Weigel R, et al
. When is prophylactic thyroidectomy indicated for patients with the RET codon 609 mutation?. Ann Surg Oncol. 2009;16:2237-44 pubmed publisher
..We report a three-generation family with C609Y RET mutation where members having prophylactic or therapeutic thyroidectomy call the current recommendations for age at thyroidectomy into question...
Titze I, Broadhead K, Tresco P, Gray S. Strain distribution in an elastic substrate vibrated in a bioreactor for vocal fold tissue engineering. J Biomech. 2005;38:2406-14 pubmed
..A yet unsolved problem is a variable drag coefficient along the length of the material due to fluid turbulence in the culture medium. ..
Xiang J, Martinez Smith C, Gale M, Chang Q, LaBrecque D, Schmidt W, et al
. GB virus type C NS5A sequence polymorphisms: association with interferon susceptibility and inhibition of PKR-mediated eIF2alpha phosphorylation. J Interferon Cytokine Res. 2005;25:261-70 pubmed
Excoffon K, Traver G, Zabner J. The role of the extracellular domain in the biology of the coxsackievirus and adenovirus receptor. Am J Respir Cell Mol Biol. 2005;32:498-503 pubmed
..Surprisingly, the D2 domain was required for adenovirus fiber-knob binding and infection. In summary, the entire extracellular domain of CAR is of vital importance to the biology of this highly conserved and important protein...
Brainard A, Miller A, Martens J, England S. Maxi-K channels localize to caveolae in human myometrium: a role for an actin-channel-caveolin complex in the regulation of myometrial smooth muscle K+ current. Am J Physiol Cell Physiol. 2005;289:C49-57 pubmed
..These data indicate that the actin cytoskeleton is involved as part of a caveolar complex in the regulation of myometrial maxi-K channel function. ..
Li H, Goswami P, Domann F. AP-2gamma induces p21 expression, arrests cell cycle, and inhibits the tumor growth of human carcinoma cells. Neoplasia. 2006;8:568-77 pubmed
..In summary, expression of either AP-2gamma or AP-2alpha inhibited breast carcinoma cell growth; thus, these genes may be therapeutic targets for breast cancer. ..
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. Mitochondrial and Morphologic Alterations in Native Human Corneal Endothelial Cells Associated With Diabetes Mellitus. Invest Ophthalmol Vis Sci. 2017;58:2130-2138 pubmed publisher
..Additional studies are needed to determine the precise mechanism(s) by which mitochondria become impaired in diabetic corneal endothelial cells. ..
Abrera Abeleda M, Nishimura C, Smith J, Sethi S, McRae J, Murphy B, et al
. Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease). J Med Genet. 2006;43:582-9 pubmed
Styczynski P, Green M, Coffman B, Tephly T. Studies on tertiary amine UDP-glucuronosyltransferases from human and rabbit hepatic microsomes. Drug Metab Dispos. 1992;20:896-901 pubmed
..Furthermore, it would appear from immunoinhibition and [3H]chlorpromazine labeling experiments that tertiary ammonium glucuronidation is catalyzed by a unique and distinct UGT in rabbit and human liver microsomes...
Puan K, Jin C, Wang H, Sarikonda G, Raker A, Lee H, et al
. Preferential recognition of a microbial metabolite by human Vgamma2Vdelta2 T cells. Int Immunol. 2007;19:657-73 pubmed
..This preferential stimulation by a common microbial isoprenoid metabolite allows Vgamma2Vdelta2 T cells to respond to a broad array of pathogens using this pathway. ..
Kim J, Zhao K, Jiang P, Lu Z, Wang J, Murray J, et al
. Transcriptome landscape of the human placenta. BMC Genomics. 2012;13:115 pubmed publisher
..These data are publicly available providing the community with a rich resource for placental physiology and disease-related studies. ..
Haring S, Mason A, Binz S, Wold M. Cellular functions of human RPA1. Multiple roles of domains in replication, repair, and checkpoints. J Biol Chem. 2008;283:19095-111 pubmed publisher
..Our findings suggest that as long as a threshold of RPA-ssDNA binding activity is met, DNA replication can occur and that an RPA activity separate from ssDNA binding is essential for function in DNA repair. ..
Neil R, Shao J, Apicella M. Biofilm formation on human airway epithelia by encapsulated Neisseria meningitidis serogroup B. Microbes Infect. 2009;11:281-7 pubmed publisher
..These findings suggest that encapsulated meningococci can form biofilms on epithelial cells suggesting that biofilm formation may play a role in nasopharyngeal colonization. ..
Rodionov R, Dayoub H, Lynch C, Wilson K, Stevens J, Murry D, et al
. Overexpression of dimethylarginine dimethylaminohydrolase protects against cerebral vascular effects of hyperhomocysteinemia. Circ Res. 2010;106:551-8 pubmed publisher
..05) but not from accelerated carotid artery thrombosis induced by the HM/LF diet. Overexpression of DDAH1 protects from hyperhomocysteinemia-induced alterations in cerebral arteriolar structure and vascular muscle function. ..
Kline C, Kurata H, Hund T, Cunha S, Koval O, Wright P, et al
. Dual role of K ATP channel C-terminal motif in membrane targeting and metabolic regulation. Proc Natl Acad Sci U S A. 2009;106:16669-74 pubmed publisher
..Thus, the K(ATP) channel ABM serves as a previously unrecognized bifunctional touch-point for grading K(ATP) channel gating and membrane targeting and may play a fundamental role in controlling excitable cell metabolic regulation. ..
Wessels D, Kuhl S, Soll D. 2D and 3D quantitative analysis of cell motility and cytoskeletal dynamics. Methods Mol Biol. 2009;586:315-35 pubmed publisher
Jensen L, Hoehns J, Squires C. Oral antivirals for the acute treatment of recurrent herpes labialis. Ann Pharmacother. 2004;38:705-9 pubmed
..To evaluate the use and benefit of oral antivirals in the acute treatment of episodic, recurrent herpes labialis...
Krishnan S, Papworth D, Farivar R, Ueda K. Identification of coronary sinus injury by transesophageal echocardiography during placement of a retrograde cardioplegia catheter for minimally invasive cardiac surgery. Anesth Analg. 2013;116:560-2 pubmed publisher
Malinowski S, Pulido J, Goeken N, Brown C, Folk J. The association of HLA-B8, B51, DR2, and multiple sclerosis in pars planitis. Ophthalmology. 1993;100:1199-205 pubmed
..To establish a human leukocyte antigen (HLA) association in a homogeneous population of patients with pars planitis...
Wasserman L, Saltzman C, Amendola A. Minimally invasive ankle reconstruction: current scope and indications. Orthop Clin North Am. 2004;35:247-53 pubmed
..It provides an opportunity for treating those lesions that may go on to cause chronic pain, thereby possibly improving patient outcomes compared with carrying out a lateral ligament stabilization procedure alone...
Stone E, Braun T, Russell S, Kuehn M, Lotery A, Moore P, et al
. Missense variations in the fibulin 5 gene and age-related macular degeneration. N Engl J Med. 2004;351:346-53 pubmed
..7 percent of patients with AMD. Many variations in other fibulin genes were also found in these patients, and the evolutionary conservation of the affected residues suggests that several of these variations may also be involved in AMD. ..
Lavoie J, Liu X, Bianco R, Beltz T, Johnson A, Sigmund C. Evidence supporting a functional role for intracellular renin in the brain. Hypertension. 2006;47:461-6 pubmed
..These data support the concept of an intracellular form of renin in the brain, which may provoke functional changes in fluid homeostasis and BP regulation. ..