Experts and Doctors on beta catenin in Iowa City, Iowa, United States


Locale: Iowa City, Iowa, United States
Topic: beta catenin

Top Publications

  1. Monick M, Carter A, Robeff P, Flaherty D, Peterson M, Hunninghake G. Lipopolysaccharide activates Akt in human alveolar macrophages resulting in nuclear accumulation and transcriptional activity of beta-catenin. J Immunol. 2001;166:4713-20 pubmed
    ..This is the first demonstration that LPS exposure activates AKT, inactivates GSK-3, and causes accumulation and transcriptional activity of beta-catenin in the nucleus of any cell, including alveolar macrophages. ..
  2. Trotter T, Li M, Pan Q, Peker D, Rowan P, Li J, et al. Myeloma cell-derived Runx2 promotes myeloma progression in bone. Blood. 2015;125:3598-608 pubmed publisher
    ..Thus, Runx2 expression supports the aggressive phenotype of MM and is correlated with poor prognosis. These data implicate Runx2 expression as a major regulator of MM progression in bone and myeloma bone disease. ..
  3. Winter M, Shasby S, Shasby D. Compromised E-cadherin adhesion and epithelial barrier function with activation of G protein-coupled receptors is rescued by Y-to-F mutations in beta-catenin. Am J Physiol Lung Cell Mol Physiol. 2008;294:L442-8 pubmed
    ..We also conclude that activation of PAR-2 has no effect on the TER without first interrupting E-cadherin adhesion. ..
  4. Sinn H, Balsamo J, Lilien J, Lin J. Localization of the novel Xin protein to the adherens junction complex in cardiac and skeletal muscle during development. Dev Dyn. 2002;225:1-13 pubmed
    ..Furthermore, temporal and spatial expressions of Xin in relation to intercalated disc proteins and thin filament proteins suggest roles for Xin in the formation of cell-cell contacts and possibly in myofibrillogenesis. ..
  5. Li X, Florez S, Wang J, Cao H, Amendt B. Dact2 represses PITX2 transcriptional activation and cell proliferation through Wnt/beta-catenin signaling during odontogenesis. PLoS ONE. 2013;8:e54868 pubmed publisher
    ..In summary, we have identified a novel role for Dact2 as an inhibitor of the canonical Wnt pathway in embryonic tooth development through its regulation of cell proliferation and differentiation. ..
  6. Xu G, Craig A, Greer P, Miller M, Anastasiadis P, Lilien J, et al. Continuous association of cadherin with beta-catenin requires the non-receptor tyrosine-kinase Fer. J Cell Sci. 2004;117:3207-19 pubmed
    ..Expression of wild-type Fer or culture in epidermal growth factor restores the cadherin complex and localization at cell-cell contacts. ..
  7. Xu Z, Xing S, Shan Q, Gullicksrud J, Bair T, Du Y, et al. Cutting Edge: β-Catenin-Interacting Tcf1 Isoforms Are Essential for Thymocyte Survival but Dispensable for Thymic Maturation Transitions. J Immunol. 2017;198:3404-3409 pubmed publisher
    ..Rather than being dominant-negative regulators, Tcf1 short isoforms are adequate in supporting developing thymocytes to traverse through maturation steps and in regulating the expression of most Tcf1 target genes. ..
  8. Xie W, Lynch T, Liu X, Tyler S, Yu S, Zhou X, et al. Sox2 modulates Lef-1 expression during airway submucosal gland development. Am J Physiol Lung Cell Mol Physiol. 2014;306:L645-60 pubmed publisher
    ..These studies support a model whereby Wnt signals and Sox2 dynamically regulate the expression of Lef-1 in airway epithelia and potentially also during SMG development. ..
  9. Schneider P, Slusarski D, Houston D. Differential role of Axin RGS domain function in Wnt signaling during anteroposterior patterning and maternal axis formation. PLoS ONE. 2012;7:e44096 pubmed publisher
    ..We further report that expression of a membrane-localized Axin construct is sufficient to inhibit Wnt/?-catenin signaling and to promote Axin protein turnover. ..

More Information


  1. Shasby D, Winter M. H1 and PAR2 receptors enhance delivery of immune-competent cells and molecules by interrupting E-cadherin adhesion in epithelia. Trans Am Clin Climatol Assoc. 2011;122:217-28 pubmed
    ..Hence, G-protein-coupled receptors responding to immune-defense molecules temporarily and focally interrupt the lung epithelial barrier by compromising cadherin-based adhesion. ..
  2. Peng X, Cuff L, Lawton C, DeMali K. Vinculin regulates cell-surface E-cadherin expression by binding to beta-catenin. J Cell Sci. 2010;123:567-77 pubmed publisher
    ..Thus, our study identifies vinculin as a novel regulator of E-cadherin function and provides important new insight into the dynamic regulation of adherens junctions. ..
  3. Cuykendall T, Houston D. Vegetally localized Xenopus trim36 regulates cortical rotation and dorsal axis formation. Development. 2009;136:3057-65 pubmed publisher
    ..Taken together, our results suggest a role for Trim36 in controlling the stability of proteins regulating microtubule polymerization during cortical rotation, and subsequently axis formation. ..
  4. Rhee J, Buchan T, Zukerberg L, Lilien J, Balsamo J. Cables links Robo-bound Abl kinase to N-cadherin-bound beta-catenin to mediate Slit-induced modulation of adhesion and transcription. Nat Cell Biol. 2007;9:883-92 pubmed
    ..Thus, Slit-induced formation of the Robo-N-cadherin complex results in a rapid loss of cadherin-mediated adhesion and has more lasting effects on gene transcription. ..
  5. Rhee J, Mahfooz N, Arregui C, Lilien J, Balsamo J, VanBerkum M. Activation of the repulsive receptor Roundabout inhibits N-cadherin-mediated cell adhesion. Nat Cell Biol. 2002;4:798-805 pubmed
    ..Local formation of such a receptor complex is an ideal mechanism to steer the growth cone while still allowing adhesion and growth in other directions. ..
  6. Westfall T, Hjertos B, Slusarski D. Requirement for intracellular calcium modulation in zebrafish dorsal-ventral patterning. Dev Biol. 2003;259:380-91 pubmed
    ..These results provide evidence that modulation of calcium release is critical for early embryonic patterning and acts by influencing the stabilization of beta-catenin protein. ..
  7. Zhao D, Yu S, Zhou X, Haring J, Held W, Badovinac V, et al. Constitutive activation of Wnt signaling favors generation of memory CD8 T cells. J Immunol. 2010;184:1191-9 pubmed publisher
    ..Thus, constitutive activation of the canonical Wnt pathway favors memory CD8 T cell formation during initial immunization, resulting in enhanced immunity upon second encounter with the same pathogen. ..
  8. Zhou X, Yu S, Zhao D, Harty J, Badovinac V, Xue H. Differentiation and persistence of memory CD8(+) T cells depend on T cell factor 1. Immunity. 2010;33:229-40 pubmed publisher
    ..Our studies thus identify TCF-1 as a critical player in a transcriptional program that regulates memory CD8 differentiation and longevity. ..
  9. Lobas M, Helsper L, Vernon C, Schreiner D, Zhang Y, Holtzman M, et al. Molecular heterogeneity in the choroid plexus epithelium: the 22-member ?-protocadherin family is differentially expressed, apically localized, and implicated in CSF regulation. J Neurochem. 2012;120:913-27 pubmed publisher
    ..Together, these results suggest an unsuspected role for the ?-Pcdhs in CSF production and demonstrate a surprising molecular heterogeneity in the CP epithelium. ..
  10. Schneider P, Olthoff J, Matthews A, Houston D. Use of fully modified 2'-O-methyl antisense oligos for loss-of-function studies in vertebrate embryos. Genesis. 2011;49:117-23 pubmed publisher
    ..These results show that fully modified 2'-OMe oligos can function as RNase-H independent antisense reagents in vertebrate embryos and can thus serve as an alternative modification to morpholinos in some cases. ..
  11. Miller J, Weiss R, Serrano K, Castaneda L, Brooks R, Zimmerman K, et al. Evidence for active regulation of pro-osteogenic signaling in advanced aortic valve disease. Arterioscler Thromb Vasc Biol. 2010;30:2482-6 pubmed publisher
  12. Chao S, Nagoshi R. Induction of apoptosis in the germline and follicle layer of Drosophila egg chambers. Mech Dev. 1999;88:159-72 pubmed
    ..Germ cells degenerating as a normal consequence of oogenesis displayed a similar set of phenotypes, suggesting that a common apoptotic mechanism may underlie these different germline death phenomena. ..
  13. Baldwin A, Clemons A, Phillips B. Unique and redundant β-catenin regulatory roles of two Dishevelled paralogs during C. elegans asymmetric cell division. J Cell Sci. 2016;129:983-93 pubmed publisher
    ..Overall, we have further defined the role of Dishevelled in the WβA signaling pathway, and demonstrated that DSH-2 and MIG-5 regulate cell fate, β-catenin nuclear levels and the polarity of β-catenin regulation. ..
  14. Shasby D, Ries D, Shasby S, Winter M. Histamine stimulates phosphorylation of adherens junction proteins and alters their link to vimentin. Am J Physiol Lung Cell Mol Physiol. 2002;282:L1330-8 pubmed
    ..Within 60 s, histamine simulated a doubling in the phosphorylation of VE-cadherin and beta- and gamma-catenin. The VE-cadherin immunoprecipitate contained kinase activity that phosphorylated VE-cadherin and gamma-catenin in vitro. ..
  15. Xu G, Arregui C, Lilien J, Balsamo J. PTP1B modulates the association of beta-catenin with N-cadherin through binding to an adjacent and partially overlapping target site. J Biol Chem. 2002;277:49989-97 pubmed
    ..Thus, interaction of PTP1B with N-cadherin is essential for its association with beta-catenin, stable expression at the cell surface, and consequently, cadherin function. ..
  16. Choi S, Gustafson Wagner E, Wang Q, Harlan S, Sinn H, Lin J, et al. The intercalated disk protein, mXinalpha, is capable of interacting with beta-catenin and bundling actin filaments [corrected]. J Biol Chem. 2007;282:36024-36 pubmed
    ..In support of this model, we found that the actin binding and bundling activity of mXinalpha was enhanced in the presence of beta-catenin. ..
  17. Schneider I, Schneider P, Derry S, Lin S, Barton L, Westfall T, et al. Zebrafish Nkd1 promotes Dvl degradation and is required for left-right patterning. Dev Biol. 2010;348:22-33 pubmed publisher
    ..Our findings show that Nkd1 acts as a β-catenin antagonist in the DFCs necessary for LR patterning. ..
  18. Westfall T, Brimeyer R, Twedt J, Gladon J, Olberding A, Furutani Seiki M, et al. Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/beta-catenin activity. J Cell Biol. 2003;162:889-98 pubmed
    ..The Wnt-5 loss-of-function defect is consistent with Ca2+ modulation having an antagonistic interaction with Wnt/beta-catenin signaling. ..
  19. Schneider I, Houston D, Rebagliati M, Slusarski D. Calcium fluxes in dorsal forerunner cells antagonize beta-catenin and alter left-right patterning. Development. 2008;135:75-84 pubmed
    ..As in zebrafish, manipulation of Ca(2+) release results in ectopic nuclear beta-catenin and altered laterality. Overall, our data support a conserved early Ca(2+) requirement in DFC-like cell function in zebrafish and Xenopus. ..
  20. Grosskurth S, Bhattacharya D, Wang Q, Lin J. Emergence of Xin demarcates a key innovation in heart evolution. PLoS ONE. 2008;3:e2857 pubmed publisher
    ..We postulate that the emergence of the Xin paralogs and their functional differentiation may have played a key role in the evolutionary development of the heart. ..
  21. Hulstrand A, Schneider P, Houston D. The use of antisense oligonucleotides in Xenopus oocytes. Methods. 2010;51:75-81 pubmed publisher
    ..Although these methods can be technically demanding, the use of antisense in oocytes can be used to address biological questions that are intractable in other experimental settings. ..
  22. Filali M, Cheng N, Abbott D, Leontiev V, Engelhardt J. Wnt-3A/beta-catenin signaling induces transcription from the LEF-1 promoter. J Biol Chem. 2002;277:33398-410 pubmed
    ..In summary, these results provide evidence for transcriptional regulation of the LEF-1 promoter by Wnt and enhance the mechanistic understanding of Wnt/beta-catenin signaling in the regulation of LEF-1-dependent developmental processes. ..
  23. Chunthapong J, Seftor E, Khalkhali Ellis Z, Seftor R, Amir S, Lubaroff D, et al. Dual roles of E-cadherin in prostate cancer invasion. J Cell Biochem. 2004;91:649-61 pubmed
    ..These results suggest that E-cadherin plays an important role in regulating the invasive potential of prostate cancer cells through an unique paracrine mechanism. ..