Experts and Doctors on molecular sequence data in Indianapolis, Indiana, United States

Summary

Locale: Indianapolis, Indiana, United States
Topic: molecular sequence data

Top Publications

  1. Harris R, Popov K, Shimomura Y, Zhao Y, Jaskiewicz J, Nanaumi N, et al. Purification, characterization, regulation and molecular cloning of mitochondrial protein kinases. Adv Enzyme Regul. 1992;32:267-84 pubmed
    ..Rather, clofibric acid is a potent inhibitor of the activity of the branched-chain alpha-ketoacid dehydrogenase kinase and this may be the molecular mechanism responsible for the myotonic effects of clofibric acid in man. ..
  2. Hromas R, Collins S, Raskind W, Deaven L, Kaushansky K. Hem-1, a potential membrane protein, with expression restricted to blood cells. Biochim Biophys Acta. 1991;1090:241-4 pubmed
    ..The gene is located at 12q13.1, a region of occasional translocations in hematopoietic neoplasia and a rare folic acid fragile site, Fra 12A. ..
  3. Kwon B, Halaban R, Chintamaneni C. Molecular basis of mouse Himalayan mutation. Biochem Biophys Res Commun. 1989;161:252-60 pubmed
    ..These results indicate the possibility that the altered residue at amino acid 420 of mouse tyrosinase may be important in stabilization of the tyrosinase molecule, or in interaction with other molecules, such as tyrosinase inhibitors. ..
  4. Xiao Q, Weiner H, Johnston T, Crabb D. The aldehyde dehydrogenase ALDH2*2 allele exhibits dominance over ALDH2*1 in transduced HeLa cells. J Clin Invest. 1995;96:2180-6 pubmed
    ..ALDH2 activity in these cells was reduced below that of the parental ALDH2*1-expressing cells. Thus, the ALDH2*2 allele is sufficient to cause ALDH2 deficiency in vitro. ..
  5. Hintz N, Ennis D, Liu W, Larsen S. The recA gene of Chlamydia trachomatis: cloning, sequence, and characterization in Escherichia coli. FEMS Microbiol Lett. 1995;127:175-80 pubmed
    ..coli homologue. As detected by an SOS gene fusion, a small but measurable amount of LexA co-cleavage was indicated. ..
  6. Benson M, Liepnieks J, Uemichi T, Wheeler G, Correa R. Hereditary renal amyloidosis associated with a mutant fibrinogen alpha-chain. Nat Genet. 1993;3:252-5 pubmed
    ..This is the first demonstration of hereditary amyloidosis associated with a variant fibrinogen alpha-chain. Variants of circulating fibrinogen may be the cause of a number of systemic amyloidoses with primarily renal involvement. ..
  7. Feng G, Ouyang Y, Hu D, Shi Z, Gentz R, Ni J. Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway. J Biol Chem. 1996;271:12129-32 pubmed
    ..These results show that a family of Grb2-like proteins exist and couple signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. ..
  8. Smith D, Zhang X, Frolik C, Harvey A, Chandrasekhar S, Black E, et al. Structure and functional expression of a complementary DNA for porcine parathyroid hormone/parathyroid hormone-related peptide receptor. Biochim Biophys Acta. 1996;1307:339-47 pubmed
    ..These response characteristics differentiate the porcine receptor from the previously cloned rat and opossum PTH/PTHrP receptors. ..
  9. Alborn W, Hoskins J, Unal S, Flokowitsch J, Hayes C, Dotzlaf J, et al. Cloning and characterization of femA and femB from Staphylococcus epidermidis. Gene. 1996;180:177-81 pubmed
    ..Recombinant FEMA, produced in Escherichia coli (Ec), was purified to near homogeneity. Identity of the purified protein was verified by N-terminal amino acid (aa) sequence analysis. ..

More Information

Publications169 found, 100 shown here

  1. Autry J, Jones L. Functional Co-expression of the canine cardiac Ca2+ pump and phospholamban in Spodoptera frugiperda (Sf21) cells reveals new insights on ATPase regulation. J Biol Chem. 1997;272:15872-80 pubmed
  2. Miles R, Turner C, Santerre R, Tu Y, McClelland P, Argot J, et al. Analysis of differential gene expression in rat tibia after an osteogenic stimulus in vivo: mechanical loading regulates osteopontin and myeloperoxidase. J Cell Biochem. 1998;68:355-65 pubmed
    ..These results suggest a role for both OPN and MPO expression in bone cell function. ..
  3. Rebhun J, Chen H, Quilliam L. Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral. J Biol Chem. 2000;275:13406-10 pubmed
    ..In contrast to the Ral guanine nucleotide dissociation stimulator family of Ral GEFs, the RalGPS proteins do not possess a Ras-GTP-binding domain, suggesting that they are activated in a Ras-independent manner. ..
  4. Liu X, Nagarajan R, Vale W, Chen Y. Phosphorylation regulation of the interaction between Smad7 and activin type I receptor. FEBS Lett. 2002;519:93-8 pubmed
    ..These studies not only illustrated the counter regulatory function of Smad7 on activin signaling, but also indicated the involvement of phosphorylation at activin type I receptor in the inhibitory action of Smad7. ..
  5. Cocklin R, Wang M. Identification of methylation and acetylation sites on mouse histone H3 using matrix-assisted laser desorption/ionization time-of-flight and nanoelectrospray ionization tandem mass spectrometry. J Protein Chem. 2003;22:327-34 pubmed
    ..The reported mass spectrometric method provides an efficient and sensitive way for analyzing post-translational modifications of histone proteins. ..
  6. Ge Y, Ghosh C, Song W, Maloney B, Lahiri D. Mechanism of promoter activity of the beta-amyloid precursor protein gene in different cell lines: identification of a specific 30 bp fragment in the proximal promoter region. J Neurochem. 2004;90:1432-44 pubmed
    ..Characterization of the APP regulatory region's interaction with cell type-specific nuclear factor(s) is important to understand tissue-specific expression of APP seen in AD subjects. ..
  7. Yamauchi A, Marchal C, Molitoris J, Pech N, Knaus U, Towe J, et al. Rac GTPase isoform-specific regulation of NADPH oxidase and chemotaxis in murine neutrophils in vivo. Role of the C-terminal polybasic domain. J Biol Chem. 2005;280:953-64 pubmed
    ..Thus, the composition of the polybasic domain is sufficient for determining Rac isoform specificity in the production of superoxide and chemotaxis in murine neutrophils in vivo. ..
  8. You J, Gelfanova V, Knierman M, Witzmann F, Wang M, Hale J. The impact of blood contamination on the proteome of cerebrospinal fluid. Proteomics. 2005;5:290-6 pubmed
    ..This analysis was aimed at identification of proteins found primarily in CSF, those found primarily in blood and assessment of the impact of blood contamination on those proteins found in both fluids. ..
  9. Laukaitis C, Dlouhy S, Emes R, Ponting C, Karn R. Diverse spatial, temporal, and sexual expression of recently duplicated androgen-binding protein genes in Mus musculus. BMC Evol Biol. 2005;5:40 pubmed
    ..The glands expressing Abp paralogues produce secretions (lacrimal and salivary) or detect odors (MOE and VNO) and thus it appears highly likely that ABP proteins play a role in olfactory communication. ..
  10. Schmidt C, Zhao J, Chain J, Hepburn D, Gitter B, Sandusky G, et al. Resistance to myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis by death receptor 6-deficient mice. J Immunol. 2005;175:2286-92 pubmed
    ..Taken together, our data demonstrate that DR6 plays an important role in regulating leukocyte infiltration and function in the induction and progression of experimental autoimmune encephalomyelitis. ..
  11. Clendenon S, Shah B, Miller C, Schmeisser G, Walter A, Gattone V, et al. Cadherin-11 controls otolith assembly: evidence for extracellular cadherin activity. Dev Dyn. 2009;238:1909-22 pubmed publisher
  12. Liu S, Yu Z, Yu X, Huang S, Luo Y, Wu L, et al. SHP2 is a target of the immunosuppressant tautomycetin. Chem Biol. 2011;18:101-10 pubmed publisher
    ..Moreover, the structure furnishes molecular insights upon which therapeutics targeting SHP2 can be developed on the basis of the TTN scaffold. ..
  13. Mayer M, Caplin B, Marshall M. CDC43 and RAM2 encode the polypeptide subunits of a yeast type I protein geranylgeranyltransferase. J Biol Chem. 1992;267:20589-93 pubmed
    ..Interestingly, the recombinant enzyme functioned with calcium as the only divalent cation, although addition of zinc increased calcium-dependent activity 2-fold. ..
  14. Hromas R, Collins S, Hickstein D, Raskind W, Deaven L, O HARA P, et al. A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells. J Biol Chem. 1991;266:14183-7 pubmed
    ..Thus, this new zinc finger gene (designated MZF-1) may be one regulator of transcriptional events during hemopoietic development. ..
  15. Chen J, Sahota A, Stambrook P, Tischfield J. Polymerase chain reaction amplification and sequence analysis of human mutant adenine phosphoribosyltransferase genes: the nature and frequency of errors caused by Taq DNA polymerase. Mutat Res. 1991;249:169-76 pubmed
    ..All the errors were due to the PCR process and not to subcloning, as shown by sequence analysis of 5 APRT-positive clones isolated from a phage genomic library. ..
  16. Wegener A, Simmerman H, Lindemann J, Jones L. Phospholamban phosphorylation in intact ventricles. Phosphorylation of serine 16 and threonine 17 in response to beta-adrenergic stimulation. J Biol Chem. 1989;264:11468-74 pubmed
  17. Zolnierowicz S, Csortos C, Bondor J, Verin A, Mumby M, DePaoli Roach A. Diversity in the regulatory B-subunits of protein phosphatase 2A: identification of a novel isoform highly expressed in brain. Biochemistry. 1994;33:11858-67 pubmed
    ..In conclusion, our data reveal even greater complexity of PP2A trimeric holoenzymes due to the identification of a novel B regulatory subunit isoform of PP2A1 and a distinct B' subunit associated with PP2A0. ..
  18. Chen J, Engle S, Seilhamer J, Tischfield J. Cloning, expression and partial characterization of a novel rat phospholipase A2. Biochim Biophys Acta. 1994;1215:115-20 pubmed
  19. Pavalko F, Laroche S. Activation of human neutrophils induces an interaction between the integrin beta 2-subunit (CD18) and the actin binding protein alpha-actinin. J Immunol. 1993;151:3795-807 pubmed
    ..In addition to its actin bundling activity, alpha-actinin has a major function as an actin membrane linker molecule, and integrin avidity may be affected by an association with the actin cytoskeleton involving alpha-actinin. ..
  20. Chen J, Engle S, Seilhamer J, Tischfield J. Cloning and recombinant expression of a novel human low molecular weight Ca(2+)-dependent phospholipase A2. J Biol Chem. 1994;269:2365-8 pubmed
  21. Ni B, Du Y, Wu X, DeHoff B, Rosteck P, Paul S. Molecular cloning, expression, and chromosomal localization of a human brain-specific Na(+)-dependent inorganic phosphate cotransporter. J Neurochem. 1996;66:2227-38 pubmed
    ..Using fluorescent in situ hybridization, we localized hBNPI to the long arm of chromosome 19 (19q13) in close proximity to the late-onset familial Alzheimer's disease locus. ..
  22. Youn B, Kim K, Kwon B. A critical role of Sp1- and Ets-related transcription factors in maintaining CTL-specific expression of the mouse perforin gene. J Immunol. 1996;157:3499-509 pubmed
    ..5- to 3-fold reduction of CAT activity. The results suggest that a combination of the three proximal cis-acting elements may constitute a minimal region responsible for CTL-specific expression of perforin. ..
  23. Krathwohl M, Hromas R, Brown D, Broxmeyer H, Fife K. Functional characterization of the C---C chemokine-like molecules encoded by molluscum contagiosum virus types 1 and 2. Proc Natl Acad Sci U S A. 1997;94:9875-80 pubmed
    ..The significance of hematopoietic progenitor cell inhibition in viral pathogenesis is uncertain...
  24. Zhao C, Yu D, Shen R, Feng G. Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1. J Biol Chem. 1999;274:19649-54 pubmed
    ..This is the first evidence that an intracellular molecule with a PH domain operates as a negative effector in signal relay to the regulation of gene expression. ..
  25. Ozes O, Mayo L, Gustin J, Pfeffer S, Pfeffer L, Donner D. NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature. 1999;401:82-5 pubmed
    ..Mutation of this amino acid blocks phosphorylation by Akt or TNF and activation of NF-kappaB. These findings indicate that Akt is part of a signalling pathway that is necessary for inducing key immune and inflammatory responses. ..
  26. White K, Lorenz B, Evans W, Meitinger T, Strom T, Econs M. Molecular cloning of a novel human UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, GalNAc-T8, and analysis as a candidate autosomal dominant hypophosphatemic rickets (ADHR) gene. Gene. 2000;246:347-56 pubmed
    ..In summary, these studies identified the human GalNAc-T8 gene, as well as multiple genomic polymorphisms that will be useful for further understanding the structure-function relations of the ppGaNTases. ..
  27. Hartsfield J, Everett E. The Ephx1(d) allele encoding an Arg338Cys substitution is associated with heat lability. Mamm Genome. 2000;11:915-8 pubmed
    ..5cm (lod = 10.0). ..
  28. Herring B, Lyons G, Hoggatt A, Gallagher P. Telokin expression is restricted to smooth muscle tissues during mouse development. Am J Physiol Cell Physiol. 2001;280:C12-21 pubmed
    ..The increase in telokin expression correlated with an increase in the expression of several other smooth muscle-restricted proteins, including smooth muscle myosin and alpha-actin...
  29. Pincheira R, Chen Q, Zhang J. Identification of a 170-kDa protein over-expressed in lung cancers. Br J Cancer. 2001;84:1520-7 pubmed
    ..g. bone marrow) and tissues during development (e.g. fetal tissues). This study suggests that p170 and eIF3 may be important factors for cell growth, development, and tumorigenesis. ..
  30. Ko L, Cardona G, Henrion Caude A, Chin W. Identification and characterization of a tissue-specific coactivator, GT198, that interacts with the DNA-binding domains of nuclear receptors. Mol Cell Biol. 2002;22:357-69 pubmed
    ..These data suggest that GT198 is a tissue-specific, kinase-regulated nuclear receptor coactivator that interacts with the DNA-binding domains of nuclear receptors. ..
  31. Skurat A, Dietrich A, Zhai L, Roach P. GNIP, a novel protein that binds and activates glycogenin, the self-glucosylating initiator of glycogen biosynthesis. J Biol Chem. 2002;277:19331-8 pubmed
    ..GNIPs may represent a novel participant in the initiation of glycogen synthesis. ..
  32. Savkur R, Wu Y, Bramlett K, Wang M, Yao S, Perkins D, et al. Alternative splicing within the ligand binding domain of the human constitutive androstane receptor. Mol Genet Metab. 2003;80:216-26 pubmed
    ..Although the role of hCAR2 and hCAR3 is currently unclear, these additional splice variants may provide for increased diversity in terms of responsiveness to xenobiotics. ..
  33. Cao J, Liu Y, Lockwood J, Burn P, Shi Y. A novel cardiolipin-remodeling pathway revealed by a gene encoding an endoplasmic reticulum-associated acyl-CoA:lysocardiolipin acyltransferase (ALCAT1) in mouse. J Biol Chem. 2004;279:31727-34 pubmed
    ..ALCAT1 represents the first identified cardiolipin-remodeling enzyme from any living organism; its identification implies a novel role for the endoplasmic reticulum in cardiolipin metabolism. ..
  34. Parker G, West B, Witzmann F, Rhodes S. Serine/threonine/tyrosine phosphorylation of the LHX3 LIM-homeodomain transcription factor. J Cell Biochem. 2005;94:67-80 pubmed
    ..In conclusion, we have identified unique amino acids within LHX3 that are important for its transcriptional activity and are phosphorylated. ..
  35. Zhang E, Emerick R, Pak Y, Wrighton S, Hillgren K. Comparison of human and monkey peptide transporters: PEPT1 and PEPT2. Mol Pharm. 2004;1:201-10 pubmed
    ..Finally, Northern and RT-PCR analyses revealed some differences in tissue mRNA levels of peptide transporters between human and monkey. ..
  36. Nevins A, Thurmond D. Caveolin-1 functions as a novel Cdc42 guanine nucleotide dissociation inhibitor in pancreatic beta-cells. J Biol Chem. 2006;281:18961-72 pubmed
    ..Through its interaction with the Cdc42-VAMP2-bound insulin granule complex, Cav-1 may contribute to the specific targeting of granules to "active sites" of exocytosis organized by caveolae. ..
  37. Deem A, Bultema R, Crowell D. Prenylcysteine methylesterase in Arabidopsis thaliana. Gene. 2006;380:159-66 pubmed
    ..Our findings are discussed in the context of prenylcysteine methylation/demethylation as a potential regulatory mechanism for membrane association and function of prenylated proteins in Arabidopsis. ..
  38. Staschke K, Dong S, Saha J, Zhao J, Brooks N, Hepburn D, et al. IRAK4 kinase activity is required for Th17 differentiation and Th17-mediated disease. J Immunol. 2009;183:568-77 pubmed publisher
    ..The results of these studies demonstrate that IL-1-mediated IRAK4 kinase activity in T cells is essential for induction of IL-23R expression, Th17 differentiation, and autoimmune disease. ..
  39. Lu J, Ye Q. Expression and characterization of Mycobacterium tuberculosis methionine aminopeptidase type 1a. Bioorg Med Chem Lett. 2010;20:2776-9 pubmed publisher
    ..The differences in catalysis and inhibition predicted the significant differences in active site structure. ..
  40. Wagner G, Payne R. Widespread and enzyme-independent N?-acetylation and N?-succinylation of proteins in the chemical conditions of the mitochondrial matrix. J Biol Chem. 2013;288:29036-45 pubmed publisher
    ..These findings may have implications for the evolutionary roles that the mitochondria-localized SIRT3 deacetylase and SIRT5 desuccinylase have in the maintenance of metabolic health. ..
  41. Lira J, Beringer J, Burton S, Griffin S, Sheets J, Tan S, et al. Insecticidal activity of Bacillus thuringiensis Cry1Bh1 against Ostrinia nubilalis (Hubner) (Lepidoptera: Crambidae) and other lepidopteran pests. Appl Environ Microbiol. 2013;79:7590-7 pubmed publisher
    ..The lack of cross-resistance with Cry1Ab and Cry1Fa along with independent membrane binding sites in O. nubilalis makes Cry1Bh1 a candidate to further optimize for in-plant resistance to this pest. ..
  42. Zhang X, Liu S, Li X, Wang J, Ding Q, Wang H, et al. Changes of soil prokaryotic communities after clear-cutting in a karst forest: evidences for cutting-based disturbance promoting deterministic processes. FEMS Microbiol Ecol. 2016;92: pubmed publisher
    ..But assembly processes in the secondary forest returned a similar level compared to the intact primary forest. These findings suggest that bacterial community dynamics may be predictable during the natural recovery process. ..
  43. Gehlert D, Beavers L, Johnson D, Gackenheimer S, Schober D, Gadski R. Expression cloning of a human brain neuropeptide Y Y2 receptor. Mol Pharmacol. 1996;49:224-8 pubmed
    ..Thus, the receptor protein has the pharmacological properties and distribution of the human Y2 receptor. ..
  44. Miles R, Sluka J, Santerre R, Hale L, Bloem L, Boguslawski G, et al. Dynamic regulation of RGS2 in bone: potential new insights into parathyroid hormone signaling mechanisms. Endocrinology. 2000;141:28-36 pubmed
    ..Additionally, these results suggest the exciting possibility that increased RGS2 expression in osteoblasts may be one of the early events influencing PTH signaling. ..
  45. Steinhelper M, Field L. Assignment of the angiogenin gene to mouse chromosome 14 using a rapid PCR-RFLP mapping technique. Genomics. 1992;12:177-9 pubmed
  46. Robertson G, Zhao J, Desai B, Coleman W, Nicas T, Gilmour R, et al. Vancomycin tolerance induced by erythromycin but not by loss of vncRS, vex3, or pep27 function in Streptococcus pneumoniae. J Bacteriol. 2002;184:6987-7000 pubmed
    ..Based on these findings, we propose that vancomycin tolerance in S. pneumoniae does not result from loss of vncS function alone...
  47. Stephenson A, Huang G, Huang G, Nguyen N, Reuter S, McBride J, et al. snf1lk encodes a protein kinase that may function in cell cycle regulation. Genomics. 2004;83:1105-15 pubmed
    ..We show data that indicate that SNF1LK does not share functional homology with other SNF1-related kinases, but represents a new subclass with novel molecular activities. ..
  48. Firulli B, Krawchuk D, Centonze V, Vargesson N, Virshup D, Conway S, et al. Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities. Nat Genet. 2005;37:373-81 pubmed publisher
  49. Kursar J, Nelson D, Wainscott D, Cohen M, Baez M. Molecular cloning, functional expression, and pharmacological characterization of a novel serotonin receptor (5-hydroxytryptamine2F) from rat stomach fundus. Mol Pharmacol. 1992;42:549-57 pubmed
    ..These data suggest a probable relationship between this novel 5-HT2F receptor and the serotonin contractile receptor of the rat stomach fundus. ..
  50. Flotow H, Graves P, Wang A, Fiol C, Roeske R, Roach P. Phosphate groups as substrate determinants for casein kinase I action. J Biol Chem. 1990;265:14264-9 pubmed
    ..Thus, casein kinase I may be involved in hierarchal substrate phosphorylation schemes in which its activity is controlled by the phosphorylation state of its substrates. ..
  51. Ou X, Pollock J, Dinauer M, Gharehbaghi Schnell E, Skalnik D. Identification and functional characterization of the murine Rac2 gene promoter. DNA Cell Biol. 1999;18:253-63 pubmed
    ..7 and NIH-3T3 cells. Additional cis elements may be required to restrict Rac2 promoter activity to hematopoietic cells expressing the endogenous gene. ..
  52. Majumdar M, Feng L, Medlock E, Toksoz D, Williams D. Identification and mutation of primary and secondary proteolytic cleavage sites in murine stem cell factor cDNA yields biologically active, cell-associated protein. J Biol Chem. 1994;269:1237-42 pubmed
    ..These results suggest that the regulation of processing of the secondary proteolytic cleavage site could play a critical role in the function of membrane-associated SCF protein. ..
  53. Rebhun J, Castro A, Quilliam L. Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction. J Biol Chem. 2000;275:34901-8 pubmed
    ..In addition, a constitutively active M-Ras(71L) mutant inhibited the ability of MR-GEF to promote Rap1A activation in a dose-dependent manner. These data suggest that M-Ras may inhibit Rap1 in order to elicit its biological effects. ..
  54. Kedishvili N, Popov K, Rougraff P, Zhao Y, Crabb D, Harris R. CoA-dependent methylmalonate-semialdehyde dehydrogenase, a unique member of the aldehyde dehydrogenase superfamily. cDNA cloning, evolutionary relationships, and tissue distribution. J Biol Chem. 1992;267:19724-9 pubmed
    ..MMSDH clearly belongs to a superfamily of aldehyde dehydrogenases and is closely related to betaine aldehyde dehydrogenase, 2-hydroxymuconic semialdehyde dehydrogenase, and class 1 and 2 aldehyde dehydrogenases. ..
  55. Jones L, Field L. Residues 2-25 of phospholamban are insufficient to inhibit Ca2+ transport ATPase of cardiac sarcoplasmic reticulum. J Biol Chem. 1993;268:11486-8 pubmed
  56. Crowell D, Huizinga D, Deem A, Trobaugh C, Denton R, Sen S. Arabidopsis thaliana plants possess a specific farnesylcysteine lyase that is involved in detoxification and recycling of farnesylcysteine. Plant J. 2007;50:839-47 pubmed
    ..The effects of FCLY mutations on ABA sensitivity are even greater in the presence of exogenous FC. These data suggest that plants possess a specific FC detoxification and recycling pathway. ..
  57. Chen J, Sahota A, Laxdal T, Scrine M, Bowman S, Cui C, et al. Identification of a single missense mutation in the adenine phosphoribosyltransferase (APRT) gene from five Icelandic patients and a British patient. Am J Hum Genet. 1991;49:1306-11 pubmed
    ..The finding of the same mutation in a patient from Britain suggests that this mutation may have originated in mainland Europe. ..
  58. Jin Y, Blue E, Dixon S, Shao Z, Gallagher P. A death-associated protein kinase (DAPK)-interacting protein, DIP-1, is an E3 ubiquitin ligase that promotes tumor necrosis factor-induced apoptosis and regulates the cellular levels of DAPK. J Biol Chem. 2002;277:46980-6 pubmed
    ..These studies also demonstrate that DAPK is an in vitro and in vivo target for ubiquitination by DIP-1, thereby providing a mechanism by which DAPK activities can be regulated through proteasomal degradation. ..
  59. Spence J, Liang T, Eriksson C, Taylor R, Wall T, Ehlers C, et al. Evaluation of aldehyde dehydrogenase 1 promoter polymorphisms identified in human populations. Alcohol Clin Exp Res. 2003;27:1389-94 pubmed
    ..The underlying mechanisms contributing to these trends are still unknown. ..
  60. Spinola S, Hiltke T, Fortney K, Shanks K. The conserved 18,000-molecular-weight outer membrane protein of Haemophilus ducreyi has homology to PAL. Infect Immun. 1996;64:1950-5 pubmed
    ..Antibodies that bound to PAL were removed by absorption with a lysate of Haemophilus sp. antigens, suggesting that patients with chancroid do not develop an H. ducreyi-specific antibody response to PAL...
  61. Desai M, Burnett J, Mayne N, Schoepp D. Cloning and expression of a human metabotropic glutamate receptor 1 alpha: enhanced coupling on co-transfection with a glutamate transporter. Mol Pharmacol. 1995;48:648-57 pubmed
    ..These studies suggest that co-expression of mGluR1 alpha with a glutamate transporter prevents desensitization of the receptor, thus achieving optimal coupling of the receptor with its effector system. ..
  62. Sood R, Porter A, Ma K, Quilliam L, Wek R. Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress. Biochem J. 2000;346 Pt 2:281-93 pubmed
    ..These results suggest that decreased translation initiation by PEK during ER stress may provide the cell with an opportunity to remedy the folding problem prior to introducing newly synthesized proteins into the secretory pathway. ..
  63. Blue E, Goeckeler Z, Jin Y, Hou L, Dixon S, Herring B, et al. 220- and 130-kDa MLCKs have distinct tissue distributions and intracellular localization patterns. Am J Physiol Cell Physiol. 2002;282:C451-60 pubmed
    ..These results suggest that in vivo, the physiological functions of the 220- and 130-kDa MLCKs are likely to be regulated by their intracellular trafficking and distribution. ..
  64. Sharp J, White D, Chiou X, Goodson T, Gamboa G, McClure D, et al. Molecular cloning and expression of human Ca(2+)-sensitive cytosolic phospholipase A2. J Biol Chem. 1991;266:14850-3 pubmed
    ..The molecular cloning of cPLA2 will allow further studies defining the structure, function, and regulation of this novel PLA2. ..
  65. Pickard R, Chiou X, Strifler B, DeFelippis M, Hyslop P, Tebbe A, et al. Identification of essential residues for the catalytic function of 85-kDa cytosolic phospholipase A2. Probing the role of histidine, aspartic acid, cysteine, and arginine. J Biol Chem. 1996;271:19225-31 pubmed
    ..Our results, supported by circular dichroism, provide evidence that Asp-549 and Arg-200 are critical to the enzyme's function and suggest that the cPLA2 catalytic center is novel. ..
  66. Khanna M, Chelladurai B, Gavini A, Li L, Shao M, Courtney D, et al. Targeting ovarian tumor cell adhesion mediated by tissue transglutaminase. Mol Cancer Ther. 2011;10:626-36 pubmed publisher
    ..This suggests a potential allosteric mechanism for the compound in light of its distal target site. ..
  67. Baraibar M, Muhoberac B, Garringer H, Hurley T, Vidal R. Unraveling of the E-helices and disruption of 4-fold pores are associated with iron mishandling in a mutant ferritin causing neurodegeneration. J Biol Chem. 2010;285:1950-6 pubmed publisher
  68. Bloem L, Pickard T, Acton S, Donoghue M, Beavis R, Knierman M, et al. Tissue distribution and functional expression of a cDNA encoding a novel mixed lineage kinase. J Mol Cell Cardiol. 2001;33:1739-50 pubmed
    ..These data suggest that MLK7 is a new member of the mixed lineage kinase family that modulates cardiac SAPK/JNK pathway and may play a role in cardiac hypertrophy and progression to heart failure. ..
  69. Ko L, Cardona G, Iwasaki T, Bramlett K, Burris T, Chin W. Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs. Mol Endocrinol. 2002;16:128-40 pubmed
    ..As the differential recruitment of TRBP to ERalpha and ERbeta may rely on S884, our finding provides insight into estrogen signaling and may lead to the development of therapeutic receptor-selective peptide antagonists. ..
  70. Tobin M, Fleming M, Skatrud P, Miller J. Molecular characterization of the acyl-coenzyme A:isopenicillin N acyltransferase gene (penDE) from Penicillium chrysogenum and Aspergillus nidulans and activity of recombinant enzyme in Escherichia coli. J Bacteriol. 1990;172:5908-14 pubmed
    ..Therefore, a single gene is responsible for converting IPN to penicillin G. The active form of the enzyme may result from processing of the 40-kDa monomeric precursor to a heterodimer containing subunits of 11 and 29 kDa. ..
  71. Zhou Z, Kim S, Hurtado J, Lee Z, Kim K, Pollok K, et al. Characterization of human homologue of 4-1BB and its ligand. Immunol Lett. 1995;45:67-73 pubmed
    ..Daudi, a B-cell lymphoma, was one of the B-cell lines that carried a higher number of ligands. Scatchard analysis showed that the Kd = 1.4 x 10(9) M and the number of ligands in Daudi cell was 4.2 x 10(3). ..
  72. Hsiung H, Smith D, Zhang X, Bennett T, Rosteck P, Lai M. Structure and functional expression of a complementary DNA for porcine growth hormone-releasing hormone receptor. Neuropeptides. 1993;25:1-10 pubmed
    ..Furthermore, challenge of the 293 cells expressing the receptor by GHRH leads to efficient stimulation of cytoplasmic cAMP production. ..
  73. Kumasaka T, Quinlan W, Doyle N, Condon T, Sligh J, Takei F, et al. Role of the intercellular adhesion molecule-1(ICAM-1) in endotoxin-induced pneumonia evaluated using ICAM-1 antisense oligonucleotides, anti-ICAM-1 monoclonal antibodies, and ICAM-1 mutant mice. J Clin Invest. 1996;97:2362-9 pubmed
  74. Klemsz M, Hromas R, Raskind W, Bruno E, Hoffman R. PE-1, a novel ETS oncogene family member, localizes to chromosome 1q21-q23. Genomics. 1994;20:291-4 pubmed
    ..8-kb transcript observed. PE-1 was the most common ETS domain gene found in CD34+HLA-DR- hematopoietic progenitors. PE-1 was localized to human chromosome 1q21-q23 using both in situ chromosomal hybridization and human-hamster hybrids. ..
  75. Lee J, Skalnik D. Rbm15-Mkl1 interacts with the Setd1b histone H3-Lys4 methyltransferase via a SPOC domain that is required for cytokine-independent proliferation. PLoS ONE. 2012;7:e42965 pubmed publisher
    ..These results reveal altered Setd1b complex function and consequent altered epigenetic regulation as a possible molecular mechanism that mediates the leukemogenic activity of the Rbm15-Mkl1 fusion protein in AMKL. ..
  76. Klug M, Soonpaa M, Koh G, Field L. Genetically selected cardiomyocytes from differentiating embronic stem cells form stable intracardiac grafts. J Clin Invest. 1996;98:216-24 pubmed
    ..Moreover, the resulting cardiomyocytes are suitable for the formation of intracardiac grafts. This selection approach should be applicable to all ES-derived cell lineages. ..
  77. Hoskins J, Matsushima P, Mullen D, Tang J, Zhao G, Meier T, et al. Gene disruption studies of penicillin-binding proteins 1a, 1b, and 2a in Streptococcus pneumoniae. J Bacteriol. 1999;181:6552-5 pubmed
    ..These results also suggest that PBP2a is a functional transglycosylase in S. pneumoniae...
  78. Yang Y, Chen Q, Zhang J. Structural and functional consequences of mutating cysteine residues in the amino terminus of human multidrug resistance-associated protein 1. J Biol Chem. 2002;277:44268-77 pubmed
    ..Based on these studies, we conclude that the amino terminus of human MRP1 is important and that the Cys(7) residue plays a critical role in maintaining the proper structure and function of human MRP1. ..
  79. Berglund M, Schober D, Statnick M, McDonald P, Gehlert D. The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction. J Pharmacol Exp Ther. 2003;306:147-56 pubmed
  80. Joshi M, Jeoung N, Popov K, Harris R. Identification of a novel PP2C-type mitochondrial phosphatase. Biochem Biophys Res Commun. 2007;356:38-44 pubmed
    ..Whether there are other mitochondrial substrates for the enzyme is not known. ..
  81. Cheng C, Huang D, Roach P. Yeast PIG genes: PIG1 encodes a putative type 1 phosphatase subunit that interacts with the yeast glycogen synthase Gsy2p. Yeast. 1997;13:1-8 pubmed
  82. Sliva D, Gu M, Zhu Y, Chen J, Tsai S, Du X, et al. 14-3-3zeta interacts with the alpha-chain of human interleukin 9 receptor. Biochem J. 2000;345 Pt 3:741-7 pubmed
    ..The interaction between 14-3-3 and IL-9Ralpha but not IL-4Ralpha also suggests a potential role for 14-3-3 in determining cytokine specificity. ..
  83. Gehlert D, Yang P, George C, Wang Y, Schober D, Gackenheimer S, et al. Cloning and characterization of Rhesus monkey neuropeptide Y receptor subtypes. Peptides. 2001;22:343-50 pubmed
    ..These results indicate the Rhesus monkey and human NPY receptor subtypes have a close amino acid sequence conservation and that the peptide recognition domains are conserved as well. ..
  84. Chen F, Ogawa K, Nagarajan R, Zhang M, Kuang C, Chen Y. Regulation of TG-interacting factor by transforming growth factor-beta. Biochem J. 2003;371:257-63 pubmed
    ..Taken together, these experiments indicated that TGIF is a novel transcriptional target of TGF-beta and activin signalling and is likely involved in a negative feedback loop to desensitize TGF-beta/activin action. ..
  85. Fiol C, Williams J, Chou C, Wang Q, Roach P, Andrisani O. A secondary phosphorylation of CREB341 at Ser129 is required for the cAMP-mediated control of gene expression. A role for glycogen synthase kinase-3 in the control of gene expression. J Biol Chem. 1994;269:32187-93 pubmed
    ..We propose that the hierarchical phosphorylation at the PKA and GSK-3 sites of CREB are essential for cAMP control of CREB. ..
  86. Sanghani S, Sanghani P, Schiel M, Bosron W. Human carboxylesterases: an update on CES1, CES2 and CES3. Protein Pept Lett. 2009;16:1207-14 pubmed
    ..There is little information on the substrate specificity of CES3 but it seems to have a lower catalytic efficiency than the other two CESs for selected substrates. ..
  87. Liu J, He Y, Benmerzouga I, Sullivan W, Morrissette N, Murray J, et al. An ensemble of specifically targeted proteins stabilizes cortical microtubules in the human parasite Toxoplasma gondii. Mol Biol Cell. 2016;27:549-71 pubmed publisher
    ..Finally, proteins associated with cortical microtubules collectively protect the stability of the polymers with a remarkable degree of functional redundancy. ..
  88. Hosted T, Baltz R. Mutants of Streptomyces roseosporus that express enhanced recombination within partially homologous genes. Microbiology. 1996;142 ( Pt 10):2803-13 pubmed
    ..Southern hybridization analysis revealed single unique sites for the insertion of each of the plasmids, and the crossovers occurred in frame and in proper translational register, yielding functional chimeric glnA and whiG genes. ..
  89. Iwasaki T, Chin W, Ko L. Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM). J Biol Chem. 2001;276:33375-83 pubmed
    ..These data suggest that CoAA may serve as a mediator of coactivators such as TRBP in gene activation. ..
  90. Perez Miller S, Zou Q, Novotny M, Hurley T. High resolution X-ray structures of mouse major urinary protein nasal isoform in complex with pheromones. Protein Sci. 2010;19:1469-79 pubmed publisher
    ..These differences in cavity size and interactions between the protein and ligand are likely to contribute to the observed specificity of MUP-IV. ..
  91. Huang L, Lu X, Gough P, De Felippis M. Identification of racemization sites using deuterium labeling and tandem mass spectrometry. Anal Chem. 2010;82:6363-9 pubmed publisher
    ..Although the IgG subclasses have very similar primary protein sequences, our results interestingly indicated different racemization rates for specific amino acid residues. ..
  92. Nabinger S, Li X, Ramdas B, He Y, Zhang X, Zeng L, et al. The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo. Leukemia. 2013;27:398-408 pubmed publisher
    ..These findings demonstrate that Shp2 positively contributes to FLT3-ITD-induced leukemia and suggest that Shp2 inhibition may provide a novel therapeutic approach to AML. ..