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..The silencer region interacts with similar proteins from retina- and nonretina-derived cell lines. ..
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..Antiserum against ADH-F recognized corresponding protein in the chicken liver homogenate. We suggest that ADH-F represents a new class of alcohol dehydrogenase, class VII, based on its primary structure and catalytic properties. ..
Popov K, Kedishvili N, Zhao Y, Shimomura Y, Crabb D, Harris R. Primary structure of pyruvate dehydrogenase kinase establishes a new family of eukaryotic protein kinases. J Biol Chem. 1993;268:26602-6 pubmed
..Thus, molecular cloning of these proteins establishes a new eukaryotic family of protein kinases that is related to a prokaryotic family of protein kinases. ..
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Lee J, Skalnik D. Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes. Mol Cell Biol. 2008;28:609-18 pubmed
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Hromas R, Collins S, Raskind W, Deaven L, Kaushansky K. Hem-1, a potential membrane protein, with expression restricted to blood cells. Biochim Biophys Acta. 1991;1090:241-4 pubmed
..The gene is located at 12q13.1, a region of occasional translocations in hematopoietic neoplasia and a rare folic acid fragile site, Fra 12A. ..
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..In human cerebellum, hybridization was detected in the granule cell layer. In the mouse, GCAP-8 is expressed at least as early as embryonic day 14 (E14) in the central nervous system (CNS). ..
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..These novel antibodies as well as an antibody recognizing FTH1 immunolabeled the bodies. This study of this disorder has provided additional knowledge and insights in the growing area of ferritin-related neurodegeneration. ..
Yang J, Hurley T, DePaoli Roach A. Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif. J Biol Chem. 2000;275:22635-44 pubmed
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..These data support our hypothesis that Nmp4/CIZ is a transcriptional attenuator that suppresses osteoid synthesis and PTH-mediated acquisition of cancellous bone. J. Cell. Physiol. 219: 734-743, 2009. (c) 2009 Wiley-Liss, Inc. ..
Liang Y, Mestek A, Yu L, Carr L. Cloning and characterization of the promoter region of the mouse mu opioid receptor gene. Brain Res. 1995;679:82-8 pubmed
..2-kb region upstream from the transcription initiation site possesses a functional promoter, which directs the expression of the reporter gene in vitro and may possess promoter activity for the mouse MOR gene in vivo. ..
Chen F, Ogawa K, Liu X, Stringfield T, Chen Y. Repression of Smad2 and Smad3 transactivating activity by association with a novel splice variant of CCAAT-binding factor C subunit. Biochem J. 2002;364:571-7 pubmed
Csortos C, Zolnierowicz S, Bako E, Durbin S, DePaoli Roach A. High complexity in the expression of the B' subunit of protein phosphatase 2A0. Evidence for the existence of at least seven novel isoforms. J Biol Chem. 1996;271:2578-88 pubmed
..Our data indicate that at least seven B' subunit isoforms may participate in the generation of a large number of PP2A0 holoenzymes that may be spatially and/or functionally targeted to different cellular processes. ..
Voo K, Carlone D, Jacobsen B, Flodin A, Skalnik D. Cloning of a mammalian transcriptional activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1. Mol Cell Biol. 2000;20:2108-21 pubmed
..These data indicate that hCGBP is a transcriptional activator that recognizes unmethylated CpG dinucleotides, suggesting a role in modulating the expression of genes located within CpG islands. ..
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..Characterization of the genomic organization and chromosomal localization of LHX3 will enable molecular evaluation and genetic diagnoses of pituitary diseases and central nervous system developmental disorders in humans. ..
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..This is the first demonstration of a role for host cell iPLA(2)β in cancer, and these findings suggest that iPLA(2)β is a potential target for developing novel antineoplastic therapeutic strategies. ..
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. The mouse 5-HT1C receptor contains eight hydrophobic domains and is X-linked. Brain Res Mol Brain Res. 1991;11:143-9 pubmed
..By hybridization analysis of Chinese hamster x mouse somatic cell hybrid lines, the gene for the receptor, designated Htr1c, has been assigned to the mouse X chromosome. ..
Huang D, Farkas I, Roach P. Pho85p, a cyclin-dependent protein kinase, and the Snf1p protein kinase act antagonistically to control glycogen accumulation in Saccharomyces cerevisiae. Mol Cell Biol. 1996;16:4357-65 pubmed
..We propose that Pho85p is a physiological glycogen synthase kinase, possibly acting downstream of Snf1p. ..
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..We conclude that the LHX3 LIM homeodomain transcription factor is involved in activation of the FSH beta-subunit gene in the pituitary gonadotrope cell. ..
Rinker S, Trombley M, Gu X, Fortney K, Bauer M. Deletion of mtrC in Haemophilus ducreyi increases sensitivity to human antimicrobial peptides and activates the CpxRA regulon. Infect Immun. 2011;79:2324-34 pubmed publisher
..This is the first report of a β-defensin resistance mechanism in H. ducreyi and shows that LL-37 resistance in H. ducreyi is multifactorial...
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Karn R, Orth A, Bonhomme F, Boursot P. The complex history of a gene proposed to participate in a sexual isolation mechanism in house mice. Mol Biol Evol. 2002;19:462-71 pubmed
..Thus the selective mechanism behind the evolution of Abpa remains to be resolved, and we suggest that it may have changed during the recent colonization history of the house mouse. ..
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..However, it markedly inhibited the angiogenesis of human endothelial cells and induced endothelial cells to produce IL-2, TGF-beta, and monocyte chemoattractant protein-1. ..
Yaden B, Garcia M, Smith T, Rhodes S. Two promoters mediate transcription from the human LHX3 gene: involvement of nuclear factor I and specificity protein 1. Endocrinology. 2006;147:324-37 pubmed
..In addition, a distal element within intron 1a that is recognized by nuclear factor I is critical for hLHX3b promoter function. We conclude that dual promoters allow regulated production of two hLHX3 mRNAs. ..
Chen W, Vanopdorp N, Fitzl D, Tewari J, Friedemann P, Greene T, et al
. Transposon insertion in a cinnamyl alcohol dehydrogenase gene is responsible for a brown midrib1 mutation in maize. Plant Mol Biol. 2012;80:289-97 pubmed publisher
..Based on specific changes in bm1-das1 and bm1-ref, high throughput TaqMan and KBioscience's allele specific PCR assays capable of differentiating mutant and WT alleles have been developed to accelerate bm1 molecular breeding. ..
Xiong X, Tao R, Depinho R, Dong X. The autophagy-related gene 14 (Atg14) is regulated by forkhead box O transcription factors and circadian rhythms and plays a critical role in hepatic autophagy and lipid metabolism. J Biol Chem. 2012;287:39107-14 pubmed publisher
..In summary, our data suggest that Atg14 is a new target gene of FoxOs and the core clock machinery, and this gene plays an important role in hepatic lipid metabolism. ..
Wang Z, Kusam S, Munugalavadla V, Kapur R, Brutkiewicz R, Dent A. Regulation of Th2 cytokine expression in NKT cells: unconventional use of Stat6, GATA-3, and NFAT2. J Immunol. 2006;176:880-8 pubmed
..Thus, NFAT2, GATA-3, and Stat6 have surprisingly different roles in NKT cells than in conventional T cells. We propose that one mechanism by which CD4+ NKT cells express IL-4 independent of Stat6 is via increased NFAT2 activity. ..
Han B, Xie H, Chen Q, Zhang J. Sensitizing hormone-refractory prostate cancer cells to drug treatment by targeting 14-3-3sigma. Mol Cancer Ther. 2006;5:903-12 pubmed
..Based on these studies, we propose that therapeutic intervention targeting 14-3-3sigma may be useful for sensitizing hormone-refractory prostate cancers to chemotherapy by both G2-M checkpoint abrogation and apoptosis enhancement. ..
Bridwell J, Price J, Parker G, McCutchan Schiller A, Sloop K, Rhodes S. Role of the LIM domains in DNA recognition by the Lhx3 neuroendocrine transcription factor. Gene. 2001;277:239-50 pubmed
..We also propose that there are distinct classes of LIM homeodomain transcription factors in which the LIM domains play different roles in modulating interactions with DNA sites in target genes. ..
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..Furthermore, we demonstrate the ability to improve the catalytic efficiency of this enzyme through carbohydrate modifications. ..
Uemichi T, Gertz M, Benson M. Amyloid polyneuropathy in two German-American families: a new transthyretin variant (Val 107). J Med Genet. 1994;31:416-7 pubmed
..DNA analysis of the transthyretin gene showed a new point mutation which is responsible for substitution of valine for isoleucine at position 107 of the transthyretin molecule...
Fong S. Characterization of the human rod transducin alpha-subunit gene. Nucleic Acids Res. 1992;20:2865-70 pubmed
..The putative promoter regions of the human and mouse Tr alpha genes have an identity of 78.1%. As found in the mouse gene (2), no TATA consensus sequence is present in the human gene. ..
Farkas I, Hardy T, Goebl M, Roach P. Two glycogen synthase isoforms in Saccharomyces cerevisiae are coded by distinct genes that are differentially controlled. J Biol Chem. 1991;266:15602-7 pubmed
..The GSY2 gene product appears to be the predominant glycogen synthase with activity linked to nutrient depletion. ..
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..Analysis of skeletal muscle from rats made diabetic by streptozotocin treatment reveals that the level of R(GL) protein is the same as in control animals, indicating that expression is not regulated by insulin. ..
Thirunavukkarasu K, Halladay D, Miles R, Geringer C, Onyia J. Analysis of regulator of G-protein signaling-2 (RGS-2) expression and function in osteoblastic cells. J Cell Biochem. 2002;85:837-50 pubmed
..In summary, our data suggest that PTH treatment results in a direct transcriptional stimulation of RGS-2 that in turn may play a role in modulating the duration/intensity of PTH receptor signaling. ..
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. Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates. Biochem Biophys Res Commun. 2005;332:735-42 pubmed
..These data suggested that hSCD5 plays a role distinct from that of hSCD1 during development and in normal physiological conditions. ..
Stothard D, Van Der Pol B, Smith N, Jones R. Effect of serial passage in tissue culture on sequence of omp1 from Chlamydia trachomatis clinical isolates. J Clin Microbiol. 1998;36:3686-8 pubmed
..The possibility that C. trachomatis omp1 might undergo mutation during such expansion has not been examined systematically. We found no differences in the omp1 sequences from 10 clinical specimens before and after 20 in vitro passages...
Liang Y, Carr L. Identification of an octamer-1 transcription factor binding site in the promoter of the mouse mu-opioid receptor gene. J Neurochem. 1996;67:1352-9 pubmed
..Collectively, these data suggest that Oct-1 is binding to the octamer motif in the MOR gene and negatively modulating MOR gene expression. ..
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..The finding of the same mutation in a patient from Britain suggests that this mutation may have originated in mainland Europe. ..
Benson M, Liepnieks J, Uemichi T, Wheeler G, Correa R. Hereditary renal amyloidosis associated with a mutant fibrinogen alpha-chain. Nat Genet. 1993;3:252-5 pubmed
..This is the first demonstration of hereditary amyloidosis associated with a variant fibrinogen alpha-chain. Variants of circulating fibrinogen may be the cause of a number of systemic amyloidoses with primarily renal involvement. ..
Yin F, Hoggatt A, Zhou J, Herring B. 130-kDa smooth muscle myosin light chain kinase is transcribed from a CArG-dependent, internal promoter within the mouse mylk gene. Am J Physiol Cell Physiol. 2006;290:C1599-609 pubmed
..Altogether, these data suggest that SRF and SRF-associated factors play a key role in regulating the expression of smMLCK. ..
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..These findings suggest that TM2 in a polytopic membrane protein with an extracellular N-terminus may play a critical role in controlling correct membrane translocation and folding of the protein in general...
Han B, Liu N, Yang X, Sun H, Yang Y. MRG1 expression in fibroblasts is regulated by Sp1/Sp3 and an Ets transcription factor. J Biol Chem. 2001;276:7937-42 pubmed
..These results suggest that multiple transcription factors acting in synergy are responsible for MRG1 expression and the responsiveness of cells to different biological stimuli. ..
Mayer M, Caplin B, Marshall M. CDC43 and RAM2 encode the polypeptide subunits of a yeast type I protein geranylgeranyltransferase. J Biol Chem. 1992;267:20589-93 pubmed
..Interestingly, the recombinant enzyme functioned with calcium as the only divalent cation, although addition of zinc increased calcium-dependent activity 2-fold. ..
Rougraff P, Zhang B, Kuntz M, Harris R, Crabb D. Cloning and sequence analysis of a cDNA for 3-hydroxyisobutyrate dehydrogenase. Evidence for its evolutionary relationship to other pyridine nucleotide-dependent dehydrogenases. J Biol Chem. 1989;264:5899-903 pubmed
..The resemblance to malate and lactate dehydrogenases suggests that the nucleotide-binding domain is located in the N-terminal region of the protein. ..
Bloem L, Guo C, Pratt J. Identification of a splice variant of the rat and human mineralocorticoid receptor genes. J Steroid Biochem Mol Biol. 1995;55:159-62 pubmed
..The altered protein may influence the affinity of the MR for mineralocorticoid or glucocorticoid response elements. ..
Fong S, Fong W. Elements regulating the transcription of human interstitial retinoid-binding protein (IRBP) gene in cultured retinoblastoma cells. Curr Eye Res. 1999;18:283-91 pubmed
Cao J, Liu Y, Lockwood J, Burn P, Shi Y. A novel cardiolipin-remodeling pathway revealed by a gene encoding an endoplasmic reticulum-associated acyl-CoA:lysocardiolipin acyltransferase (ALCAT1) in mouse. J Biol Chem. 2004;279:31727-34 pubmed
..ALCAT1 represents the first identified cardiolipin-remodeling enzyme from any living organism; its identification implies a novel role for the endoplasmic reticulum in cardiolipin metabolism. ..
Kwon B, Weissman S. cDNA sequences of two inducible T-cell genes. Proc Natl Acad Sci U S A. 1989;86:1963-7 pubmed
..Both peptides contain putative leader sequences. The protein encoded by 4-1BB also has a potential membrane anchor segment and other features also seen in known receptor proteins. ..
Gough W, VanOoteghem S, Sint T, Kedishvili N. cDNA cloning and characterization of a new human microsomal NAD+-dependent dehydrogenase that oxidizes all-trans-retinol and 3alpha-hydroxysteroids. J Biol Chem. 1998;273:19778-85 pubmed
..RoDH-4 can potentially contribute to the biosynthesis of two powerful modulators of gene expression: retinoic acid from retinol and dihydrotestosterone from 3alpha-androstane-diol. ..
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. Combined adenine phosphoribosyltransferase and N-acetylgalactosamine-6-sulfate sulfatase deficiency. Mol Genet Metab. 1999;68:78-85 pubmed