Experts and Doctors on animals in Indianapolis, Indiana, United States


Locale: Indianapolis, Indiana, United States
Topic: animals

Top Publications

  1. Pillwein K, Reardon M, Jayaram H, Natsumeda Y, Elliott W, Faderan M, et al. Insulin regulatory effects on purine- and pyrimidine metabolism in alloxan diabetic rat liver. Padiatr Padol. 1988;23:135-44 pubmed
  2. Jones L, Field L. Residues 2-25 of phospholamban are insufficient to inhibit Ca2+ transport ATPase of cardiac sarcoplasmic reticulum. J Biol Chem. 1993;268:11486-8 pubmed
  3. Fife K, Whitfeld M, Faust H, Goheen M, Bryan J, Brown D. Growth of molluscum contagiosum virus in a human foreskin xenograft model. Virology. 1996;226:95-101 pubmed
    ..A limited number of attempts to pass virus from one infected implant to another were not successful. This system is the most rapid and reproducible for growing MCV that has been reported to date...
  4. Slayback D, Dobkins J, Harper J, Allen R. Genetic factors influencing the development of chronic graft-versus-host disease in a murine model. Bone Marrow Transplant. 2000;26:931-8 pubmed
    ..The locus on chromosome 11 also appeared to influence the development of renal pathology associated with chronic GVHD. ..
  5. Klaunig J, Kamendulis L. Mode of action of butoxyethanol-induced mouse liver hemangiosarcomas and hepatocellular carcinomas. Toxicol Lett. 2005;156:107-15 pubmed
  6. Sajdyk T, Fitz S, Shekhar A. The role of neuropeptide Y in the amygdala on corticotropin-releasing factor receptor-mediated behavioral stress responses in the rat. Stress. 2006;9:21-8 pubmed
    ..These results provide further support that an interaction between NPY and CRF within the BLA may be critical for maintaining a normal homeostatic emotional state. ..
  7. Ito S, Mantel C, Han M, Basu S, Fukuda S, Cooper S, et al. Mad2 is required for optimal hematopoiesis: Mad2 associates with c-Kit in MO7e cells. Blood. 2007;109:1923-30 pubmed
    ..These results suggest that Mad2 is involved in synergistic growth of immature hematopoietic progenitor cells in response to SCF plus GM-CSF, effects that may be mediated via physical association of Mad2 with c-Kit. ..
  8. Wang M, Zhang W, Crisostomo P, Markel T, Meldrum K, Fu X, et al. STAT3 mediates bone marrow mesenchymal stem cell VEGF production. J Mol Cell Cardiol. 2007;42:1009-15 pubmed
    ..MSCs are a potent source of VEGF, the production of which is mediated by STAT3 under normoxia partly; however, following hypoxia or TNF exposure, MSC release of VEGF is mediated by both STAT3 and p38 MAPK. ..
  9. Yip Schneider M, Wu H, Ralstin M, Yiannoutsos C, Crooks P, Neelakantan S, et al. Suppression of pancreatic tumor growth by combination chemotherapy with sulindac and LC-1 is associated with cyclin D1 inhibition in vivo. Mol Cancer Ther. 2007;6:1736-44 pubmed
    ..These results suggest that LC-1 and sulindac may mediate their antitumor effects, in part, by altering cyclin D1 levels. Furthermore, this study provides preclinical evidence for the therapeutic efficacy of these agents. ..

More Information

Publications817 found, 100 shown here

  1. Blazek J, Gaddy A, Meyer R, Roper R, Li J. Disruption of bone development and homeostasis by trisomy in Ts65Dn Down syndrome mice. Bone. 2011;48:275-80 pubmed publisher
  2. Kubek D, Burr D, Allen M. Ovariectomy stimulates and bisphosphonates inhibit intracortical remodeling in the mouse mandible. Orthod Craniofac Res. 2010;13:214-22 pubmed publisher
    ..Based on this, if the suppression of intracortical remodeling is found to be part of the pathophysiology of ONJ, the ovariectomized C3H mouse could serve as a useful tool for studying this condition. ..
  3. Foroud T, Li T. Genetics of alcoholism: a review of recent studies in human and animal models. Am J Addict. 1999;8:261-78 pubmed
    ..Through the development of congenic lines and transgenic and knock-out animals, candidate genes can be identified and evaluated for their role in alcohol preference. ..
  4. Sood R, Porter A, Ma K, Quilliam L, Wek R. Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress. Biochem J. 2000;346 Pt 2:281-93 pubmed
    ..These results suggest that decreased translation initiation by PEK during ER stress may provide the cell with an opportunity to remedy the folding problem prior to introducing newly synthesized proteins into the secretory pathway. ..
  5. DeRosa D, Ryan P, Okragly A, Witcher D, Benschop R. Tumor-derived death receptor 6 modulates dendritic cell development. Cancer Immunol Immunother. 2008;57:777-87 pubmed
    ..These results implicate MMP-14 and DR6 as a mechanism tumor cells can employ to actively escape detection by the immune system by affecting the generation of antigen presenting cells. ..
  6. Johnson P, Lowry C, Truitt W, Shekhar A. Disruption of GABAergic tone in the dorsomedial hypothalamus attenuates responses in a subset of serotonergic neurons in the dorsal raphe nucleus following lactate-induced panic. J Psychopharmacol. 2008;22:642-52 pubmed publisher
  7. Gokmen Polar Y, Toroni R, Hocevar B, Badve S, Zhao Q, Shen C, et al. Dual targeting of EphA2 and ER restores tamoxifen sensitivity in ER/EphA2-positive breast cancer. Breast Cancer Res Treat. 2011;127:375-84 pubmed publisher
    ..Our data demonstrate that dual targeting of EphA2 and ER is a promising approach for delaying resistance to Tamoxifen. The data support our hypothesis that EphA2 impacts ER function via a FAK dependent pathway. ..
  8. Burlak C, Paris L, Chihara R, Sidner R, Reyes L, Downey S, et al. The fate of human platelets perfused through the pig liver: implications for xenotransplantation. Xenotransplantation. 2010;17:350-61 pubmed publisher
    ..The creation of a model system to study xenotransplantation-induced thrombocytopenia makes possible the investigation into mechanisms that mediate platelet loss. ..
  9. Tao R, Xiong X, Depinho R, Deng C, Dong X. Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6. J Lipid Res. 2013;54:2745-53 pubmed publisher
    ..Remarkably, Sirt6 or FoxO3 overexpression improves hypercholesterolemia in diet-induced or genetically obese mice. In summary, our data suggest an important role of hepatic Sirt6 and FoxO3 in the regulation of cholesterol homeostasis. ..
  10. Qin Y, Peng Y, Zhao W, Pan J, Ksiezak Reding H, Cardozo C, et al. Myostatin inhibits osteoblastic differentiation by suppressing osteocyte-derived exosomal microRNA-218: A novel mechanism in muscle-bone communication. J Biol Chem. 2017;292:11021-11033 pubmed publisher
  11. Cala S, Jones L. Phosphorylation of cardiac and skeletal muscle calsequestrin isoforms by casein kinase II. Demonstration of a cluster of unique rapidly phosphorylated sites in cardiac calsequestrin. J Biol Chem. 1991;266:391-8 pubmed
    ..The endogenous Pi of cardiac calsequestrin was also localized to the distinct COOH terminus. Our results indicate that the cardiac isoform of calsequestrin is the preferred substrate for casein kinase II both in vivo and in vitro. ..
  12. Park I, Roach P, Bondor J, Fox S, DePaoli Roach A. Molecular mechanism of the synergistic phosphorylation of phosphatase inhibitor-2. Cloning, expression, and site-directed mutagenesis of inhibitor-2. J Biol Chem. 1994;269:944-54 pubmed
    ..Furthermore, acidic residues cannot substitute for the phosphate group either in enhancing GSK-3 phosphorylation or in activating the phosphatase. ..
  13. Klug M, Soonpaa M, Field L. DNA synthesis and multinucleation in embryonic stem cell-derived cardiomyocytes. Am J Physiol. 1995;269:H1913-21 pubmed
    ..Given these observations, as well as the genetic tractability of ES cells, ES-derived cardiogenesis might provide a useful in vitro system with which to assess the molecular regulation of the cardiomyocyte cell cycle. ..
  14. Blazer Yost B, Butterworth M, Hartman A, Parker G, Faletti C, Els W, et al. Characterization and imaging of A6 epithelial cell clones expressing fluorescently labeled ENaC subunits. Am J Physiol Cell Physiol. 2001;281:C624-32 pubmed
  15. Ingram D, Zhang L, McCarthy J, Wenning M, Fisher L, Yang F, et al. Lymphoproliferative defects in mice lacking the expression of neurofibromin: functional and biochemical consequences of Nf1 deficiency in T-cell development and function. Blood. 2002;100:3656-62 pubmed
    ..Collectively, these results identify neurofibromin as a GAP for Ras in T cells for maintaining immune homeostasis in vivo. ..
  16. Firulli A. A HANDful of questions: the molecular biology of the heart and neural crest derivatives (HAND)-subclass of basic helix-loop-helix transcription factors. Gene. 2003;312:27-40 pubmed
  17. Pinaire J, Chou W, Morton M, You M, Zeng Y, Cho W, et al. Identification of a retinoid receptor response element in the human aldehyde dehydrogenase-2 promoter. Alcohol Clin Exp Res. 2003;27:1860-6 pubmed
    ..This was confirmed in the case of RXRalpha using the RXR-specific ligand methoprene. The human aldehyde dehydrogenase-2 promoter contains a retinoid response element, which may contribute to regulation of the gene. ..
  18. Zhai L, Dietrich A, Skurat A, Roach P. Structure-function analysis of GNIP, the glycogenin-interacting protein. Arch Biochem Biophys. 2004;421:236-42 pubmed
    ..Heterologous interactions between GNIP1 and GNIP2 were also detected. Since glycogenin is also a dimer, higher order multimeric complexes between glycogenin and GNIPs would be possible. ..
  19. Zhong J, Deng J, Huang S, Yang X, Lee W. High K+ and IGF-1 protect cerebellar granule neurons via distinct signaling pathways. J Neurosci Res. 2004;75:794-806 pubmed
  20. Powrozek T, Zhou F. Effects of prenatal alcohol exposure on the development of the vibrissal somatosensory cortical barrel network. Brain Res Dev Brain Res. 2005;155:135-46 pubmed
  21. Li W, Kim M, Gourley T, McCarthy B, Sant Angelo D, Chang C. An alternate pathway for CD4 T cell development: thymocyte-expressed MHC class II selects a distinct T cell population. Immunity. 2005;23:375-86 pubmed
    ..Remarkably, the CD4 compartment in such mice is efficiently reconstituted with unique specificity, demonstrating a novel thymocyte-driven pathway of CD4 T cell selection. ..
  22. Zhou J, Hu G, Herring B. Smooth muscle-specific genes are differentially sensitive to inhibition by Elk-1. Mol Cell Biol. 2005;25:9874-85 pubmed
  23. Pelus L, Fukuda S. Chemokine-mobilized adult stem cells; defining a better hematopoietic graft. Leukemia. 2008;22:466-73 pubmed
    ..It remains to be determined if the chemokine mobilization axis can be harnessed to mobilize other populations of unique adult stem cells with clinical utility...
  24. Mellon M, Bae K, Steding C, Jimenez J, Kao C, Gardner T. Suppression of renal cell carcinoma growth and metastasis with sustained antiangiogenic gene therapy. Hum Gene Ther. 2008;19:487-95 pubmed publisher
    ..These results suggest that sustained EndoAngio gene therapy has effective antiangiogenic action against human RCC tumors and possesses potential as a novel treatment for metastatic renal cell carcinoma. ..
  25. Iwata T, Philipovskiy A, Fisher A, Presson R, Chiyo M, Lee J, et al. Anti-type V collagen humoral immunity in lung transplant primary graft dysfunction. J Immunol. 2008;181:5738-47 pubmed
    ..This study demonstrates a major role for anti-col(V) humoral immunity in PGD, and identifies the airway epithelium as a target in PGD. ..
  26. Yang Z, Kondo T, Voorhorst C, NABINGER S, Ndong L, Yin F, et al. Increased c-Jun expression and reduced GATA2 expression promote aberrant monocytic differentiation induced by activating PTPN11 mutants. Mol Cell Biol. 2009;29:4376-93 pubmed publisher
    ..1 complex at the Mcsfr promoter. Furthermore, JMML progenitors express higher levels of c-JUN than healthy controls, substantiating the disease relevance of these mechanistic findings. ..
  27. Franklin K, Engleman E, Ingraham C, McClaren J, Keith C, McBride W, et al. A single, moderate ethanol exposure alters extracellular dopamine levels and dopamine d receptor function in the nucleus accumbens of wistar rats. Alcohol Clin Exp Res. 2009;33:1721-30 pubmed publisher
    ..The present results indicate that a single EtOH pretreatment at a moderate dose can increase DA neurotransmission in the NAc due, in part, to reduced D(2) autoreceptor function. ..
  28. Dale R. Birth statistics for African (Loxodonta africana) and Asian (Elephas maximus) elephants in human care: history and implications for elephant welfare. Zoo Biol. 2010;29:87-103 pubmed publisher
    ..Confirming earlier anecdotal evidence, both African [N=47] and Asian [N=91] dams gave birth most often at night...
  29. Stocum D, Cameron J. Looking proximally and distally: 100 years of limb regeneration and beyond. Dev Dyn. 2011;240:943-68 pubmed publisher
  30. Tagliabracci V, Heiss C, Karthik C, Contreras C, Glushka J, Ishihara M, et al. Phosphate incorporation during glycogen synthesis and Lafora disease. Cell Metab. 2011;13:274-82 pubmed publisher
    ..We show that the phosphate in glycogen is present as C2 and C3 phosphomonoesters. Since hyperphosphorylation of glycogen causes Lafora disease, phosphate removal by laforin may thus be considered a repair or damage control mechanism. ..
  31. Wilkes D. Chronic lung allograft rejection and airway microvasculature: is HIF-1 the missing link?. J Clin Invest. 2011;121:2155-7 pubmed publisher
    ..Data showing that overexpressing HIF-1? restores the microvascular airway normoxia and prevents airway fibrosis highlight a novel role for vascular biology in OB pathogenesis. ..
  32. Wang E, Meier D, Sandoval R, Von Hendy Willson V, Pressler B, Bunch R, et al. A portable fiberoptic ratiometric fluorescence analyzer provides rapid point-of-care determination of glomerular filtration rate in large animals. Kidney Int. 2012;81:112-7 pubmed publisher
    ..Thus, our ratiometric technique allows for both measurement of plasma vascular volume and highly accurate real-time GFR determinations, enabling clinical decision making in real time...
  33. Chae H, Lee M, Broxmeyer H. 5-Aminoimidazole-4-carboxyamide ribonucleoside induces G(1)/S arrest and Nanog downregulation via p53 and enhances erythroid differentiation. Stem Cells. 2012;30:140-9 pubmed publisher
    ..Our results suggest that energy metabolism regulated by AMPK activity may control the balance of self-renewal and differentiation of ESCs. ..
  34. Ahlfeld S, Conway S. Aberrant signaling pathways of the lung mesenchyme and their contributions to the pathogenesis of bronchopulmonary dysplasia. Birth Defects Res A Clin Mol Teratol. 2012;94:3-15 pubmed publisher
    ..Finally, future areas of research to identify novel targets affected in arrested lung development and recovery are discussed. ..
  35. Wright R, Johnson B, Zhang C, Salhoff C, Kingston A, Calligaro D, et al. CNS distribution of metabotropic glutamate 2 and 3 receptors: transgenic mice and [³H]LY459477 autoradiography. Neuropharmacology. 2013;66:89-98 pubmed publisher
    ..This article is part of a Special Issue entitled 'Metabotropic Glutamate Receptors'...
  36. Lee J, Jin Y, He G, Zeng S, Wang Y, Wahl G, et al. Hypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3? inactivation of MDMX protein. J Biol Chem. 2012;287:20898-903 pubmed publisher
    ..These results demonstrate that hypoxia can activate p53 through inactivation of MDMX by the ATR-Chk1-MDMX-14-3-3? pathway. ..
  37. Xiong X, Tao R, Depinho R, Dong X. The autophagy-related gene 14 (Atg14) is regulated by forkhead box O transcription factors and circadian rhythms and plays a critical role in hepatic autophagy and lipid metabolism. J Biol Chem. 2012;287:39107-14 pubmed publisher
    ..In summary, our data suggest that Atg14 is a new target gene of FoxOs and the core clock machinery, and this gene plays an important role in hepatic lipid metabolism. ..
  38. Hoggatt J, Mohammad K, Singh P, Pelus L. Prostaglandin E2 enhances long-term repopulation but does not permanently alter inherent stem cell competitiveness. Blood. 2013;122:2997-3000 pubmed publisher
  39. Simon J, Ghetti B. Topographic distribution of dopamine uptake, choline uptake, choline acetyltransferase, and GABA uptake in the striata of weaver mutant mice. Neurochem Res. 1992;17:431-6 pubmed
    ..The results also indicate that the striatal cholinergic and GABAergic interneurons are not directly or indirectly affected by the weaver gene. ..
  40. Tauchi T, Feng G, Shen R, Hoatlin M, Bagby G, Kabat D, et al. Involvement of SH2-containing phosphotyrosine phosphatase Syp in erythropoietin receptor signal transduction pathways. J Biol Chem. 1995;270:5631-5 pubmed
    ..These results suggest that Syp may be an important signaling component downstream of the EpoR and may regulate the proliferation and differentiation of hematopoietic cells. ..
  41. Autry J, Jones L. Functional Co-expression of the canine cardiac Ca2+ pump and phospholamban in Spodoptera frugiperda (Sf21) cells reveals new insights on ATPase regulation. J Biol Chem. 1997;272:15872-80 pubmed
  42. Schmitzer P, Graupner P, Chapin E, Fields S, Gilbert J, Gray J, et al. Ribofuranosyl triazolone: a natural product herbicide with activity on adenylosuccinate synthetase following phosphorylation. J Nat Prod. 2000;63:777-81 pubmed
    ..Metabolite reversal studies suggested the target site was adenylosuccinate synthetase, which was confirmed by direct measurement of the activity of the 5'-phosphorylated derivative on the isolated enzyme. ..
  43. Rahman S, McBride W. D1-D2 dopamine receptor interaction within the nucleus accumbens mediates long-loop negative feedback to the ventral tegmental area (VTA). J Neurochem. 2001;77:1248-55 pubmed
  44. Robertson M. Role of chemokines in the biology of natural killer cells. J Leukoc Biol. 2002;71:173-83 pubmed
    ..Thus, chemokines appear to play an important role in afferent and efferent NK cell responses to infected and neoplastic cells. ..
  45. Torrungruang K, Shah R, Alvarez M, Bowen D, Gerard R, Pavalko F, et al. Osteoblast intracellular localization of Nmp4 proteins. Bone. 2002;30:931-6 pubmed
    ..These data necessarily enlarge the known Nmp4 family from nuclear matrix transcription factors to a more widely extended class of intracellular proteins. ..
  46. Xie X, Chan R, Johnson S, Starr M, McCarthy J, Kapur R, et al. Thrombopoietin promotes mixed lineage and megakaryocytic colony-forming cell growth but inhibits primitive and definitive erythropoiesis in cells isolated from early murine yolk sacs. Blood. 2003;101:1329-35 pubmed
    ..Thus, under certain growth factor conditions, Tpo directly inhibits early yolk sac erythroid CFU growth but facilitates megakaryocyte and mixed lineage colony formation. ..
  47. Zaretskaia M, Zaretsky D, DiMicco J. Role of the dorsomedial hypothalamus in thermogenesis and tachycardia caused by microinjection of prostaglandin E2 into the preoptic area in anesthetized rats. Neurosci Lett. 2003;340:1-4 pubmed
    ..Therefore, thermogenic and tachycardic actions of PGE2 in the POA are at least in part a consequence of neuronal activity in the region of the DMH. ..
  48. Cao J, Burn P, Shi Y. Properties of the mouse intestinal acyl-CoA:monoacylglycerol acyltransferase, MGAT2. J Biol Chem. 2003;278:25657-63 pubmed
    ..The elucidation of properties of MGAT2 will facilitate future development of compounds that inhibit dietary fat absorption as a means to treat obesity. ..
  49. Sen S, Sperry A, Childress M, Hannemann D. Juvenile hormone biosynthesis in moths: synthesis and evaluation of farnesol homologs as alternate substrates of farnesol oxidase. Insect Biochem Mol Biol. 2003;33:601-7 pubmed
  50. Yang N, Kays J, Skillman T, Burris L, Seng T, Hammond C. C75 [4-methylene-2-octyl-5-oxo-tetrahydro-furan-3-carboxylic acid] activates carnitine palmitoyltransferase-1 in isolated mitochondria and intact cells without displacement of bound malonyl CoA. J Pharmacol Exp Ther. 2005;312:127-33 pubmed
    ..We conclude that CPT-1 is an activator of human CPT-1beta and other CPT-1 isoforms but that it does not activate CPT-1 through antagonism of malonyl CoA binding. ..
  51. Chun T, Pratt J. Aldosterone increases plasminogen activator inhibitor-1 synthesis in rat cardiomyocytes. Mol Cell Endocrinol. 2005;239:55-61 pubmed
    ..In summary, aldosterone directly increased PAI-1 expression in two different cardiac muscle cell types, an effect that was dependent on MR. In the neonatal cells, there appeared to be a requirement for transforming growth factor-beta1. ..
  52. Quilliam L. New insights into the mechanisms of SOS activation. Sci STKE. 2007;2007:pe67 pubmed
    ..These studies not only enable us to better appreciate the complexity of the regulation of GEFs but also prompt us to reevaluate our current understanding of pathways that lead to Ras activation. ..
  53. McCarthy R, Spurlin B, Wright M, Breite A, Sturdevant L, Dwulet C, et al. Development and characterization of a collagen degradation assay to assess purified collagenase used in islet isolation. Transplant Proc. 2008;40:339-42 pubmed publisher
    ..A collagen degradation activity (CDA) assay was developed to improve the biochemical characterization of purified collagenase used for islet isolation...
  54. Mead L, Prater D, Yoder M, Ingram D. Isolation and characterization of endothelial progenitor cells from human blood. Curr Protoc Stem Cell Biol. 2008;Chapter 2:Unit 2C.1 pubmed publisher
    ..In this unit, we describe detailed methodologies for isolation and characterization of ECFCs from both human peripheral and umbilical cord blood. ..
  55. Reinwald S, Peterson R, Allen M, Burr D. Skeletal changes associated with the onset of type 2 diabetes in the ZDF and ZDSD rodent models. Am J Physiol Endocrinol Metab. 2009;296:E765-74 pubmed publisher
    ..Because the metabolic origin of the T2D-like state that develops in the ZDSD rat strain is highly relevant to adult-onset diabetes, it is a particularly attractive novel model for future preclinical research. ..
  56. Alley G, Bailey J, Chen D, Ray B, Puli L, Tanila H, et al. Memantine lowers amyloid-beta peptide levels in neuronal cultures and in APP/PS1 transgenic mice. J Neurosci Res. 2010;88:143-54 pubmed publisher
    ..Memantine's ability to preserve neuronal cells against neurodegeneration, to increase metabolic activity, and to lower Abeta level has therapeutic implications for neurodegenerative disorders. ..
  57. Park K, Fehrenbacher J, Thompson E, Duarte D, Hingtgen C, Vasko M. Signaling pathways that mediate nerve growth factor-induced increase in expression and release of calcitonin gene-related peptide from sensory neurons. Neuroscience. 2010;171:910-23 pubmed publisher
  58. Rayapureddi J, Tomamichel W, Walton S, Payne R. TAT fusion protein transduction into isolated mitochondria is accelerated by sodium channel inhibitors. Biochemistry. 2010;49:9470-9 pubmed publisher
    ..The mechanism of TAT transduction into mitochondria therefore is distinctly different from transduction across the cell membrane. ..
  59. Stritesky G, Muthukrishnan R, Sehra S, Goswami R, Pham D, Travers J, et al. The transcription factor STAT3 is required for T helper 2 cell development. Immunity. 2011;34:39-49 pubmed publisher
    ..Thus, STAT3 cooperates with STAT6 in promoting Th2 cell development. These results demonstrate that differentiating T helper cells integrate multiple STAT protein signals during Th2 cell development. ..
  60. Chua S, Chang P, Maruyama M, Turker I, Shinohara T, Shen M, et al. Small-conductance calcium-activated potassium channel and recurrent ventricular fibrillation in failing rabbit ventricles. Circ Res. 2011;108:971-9 pubmed publisher
    ..002). Heart failure heterogeneously increases the sensitivity of I(KAS) to intracellular Ca(2+), leading to upregulation of I(KAS), postshock APD shortening, and recurrent SVF. ..
  61. Chi X, Amet T, Byrd D, Chang K, Shah K, Hu N, et al. Direct effects of HIV-1 Tat on excitability and survival of primary dorsal root ganglion neurons: possible contribution to HIV-1-associated pain. PLoS ONE. 2011;6:e24412 pubmed publisher
    ..Together, this work indicates that HIV-1 proteins are capable of producing pain signaling through direct actions on excitability and survival of sensory neurons. ..
  62. Ichikawa S, Austin A, Gray A, Econs M. A Phex mutation in a murine model of X-linked hypophosphatemia alters phosphate responsiveness of bone cells. J Bone Miner Res. 2012;27:453-60 pubmed publisher
    ..These data suggest that Phex mutations alter the responsiveness of bone cells to extracellular phosphate concentrations and may create a lower set point for "normal" phosphate levels. ..
  63. Schwarz A, Gass N, Sartorius A, Risterucci C, Spedding M, Schenker E, et al. Anti-correlated cortical networks of intrinsic connectivity in the rat brain. Brain Connect. 2013;3:503-11 pubmed publisher
  64. Zimmers T, Jin X, Zhang Z, Jiang Y, Koniaris L. Epidermal growth factor receptor restoration rescues the fatty liver regeneration in mice. Am J Physiol Endocrinol Metab. 2017;313:E440-E449 pubmed publisher
    ..Loss of EGFR expression is rate limiting for liver regeneration in obesity. Therapies directed at increasing EGFR in steatosis might promote liver regeneration and survival following hepatic resection or transplantation. ..
  65. Hall S, Hassanzadeh Khayyat M, Knadler M, Mayer P. Pulmonary inversion of 2-arylpropionic acids: influence of protein binding. Chirality. 1992;4:349-52 pubmed
  66. Ghetti B, Triarhou L, Alyea C, Dlouhy S, Karn R. Unique cerebellar phenotype combining granule and Purkinje cell loss: morphological evidence for weaver* pcd double mutant mice. J Neurocytol. 1991;20:27-38 pubmed
    ..We propose that (1) wv/wv*pcd/pcd double mutant mice are viable, and (2) the anatomical phenotype of such mice is a combined expression of the component phenotypes. ..
  67. Byers T, Beggs A, McNally E, Kunkel L. Novel actin crosslinker superfamily member identified by a two step degenerate PCR procedure. FEBS Lett. 1995;368:500-4 pubmed
    ..Sequence comparisons argue that ACF7 does not fit into one of the existing families, but represents a new class within the superfamily. ..
  68. Fox N, Schrementi J, Nishi M, Ohagi S, Chan S, Heisserman J, et al. Human islet amyloid polypeptide transgenic mice as a model of non-insulin-dependent diabetes mellitus (NIDDM). FEBS Lett. 1993;323:40-4 pubmed
    ..These animals provide a unique model for exploring this hypothesis and other proposed functions of IAPP. ..
  69. Quilliam L, Rebhun J, Castro A. A growing family of guanine nucleotide exchange factors is responsible for activation of Ras-family GTPases. Prog Nucleic Acid Res Mol Biol. 2002;71:391-444 pubmed
  70. Engleman E, McBride W, Li T, Lumeng L, Murphy J. Ethanol drinking experience attenuates (-)sulpiride-induced increases in extracellular dopamine levels in the nucleus accumbens of alcohol-preferring (P) rats. Alcohol Clin Exp Res. 2003;27:424-31 pubmed
  71. Liang T, Spence J, Liu L, Strother W, Chang H, Ellison J, et al. alpha-Synuclein maps to a quantitative trait locus for alcohol preference and is differentially expressed in alcohol-preferring and -nonpreferring rats. Proc Natl Acad Sci U S A. 2003;100:4690-5 pubmed
    ..These results suggest that differential expression of the alpha-synuclein gene may contribute to alcohol preference in the iP rats. ..
  72. Chen H, Shi S, Acosta L, Li W, Lu J, Bao S, et al. BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. Development. 2004;131:2219-31 pubmed
    ..This may provide an underlying mechanism for understanding the pathogenesis of both structural and functional congenital heart defects. ..
  73. Spence J, Liang T, Habegger K, Carr L. Effect of polymorphism on expression of the neuropeptide Y gene in inbred alcohol-preferring and -nonpreferring rats. Neuroscience. 2005;131:871-6 pubmed
    ..These results suggest that differential expression of the NPY gene resulting from the D4mit7 marker polymorphism may contribute to reduced levels of NPY in discrete brain regions in the iP rats. ..
  74. Myers C, Boyd J, Presson R, Vijay P, Coats A, Brown J, et al. Neonatal cavopulmonary assist: pulsatile versus steady-flow pulmonary perfusion. Ann Thorac Surg. 2006;81:257-63 pubmed
    ..These results suggest that there is no benefit to pulsatile flow in this model. ..
  75. Herman R, Storer N, Gao Y. Digestion assays in allergenicity assessment of transgenic proteins. Environ Health Perspect. 2006;114:1154-7 pubmed
  76. Meng H, Gao R, Dai Q, Qiao X. Differential regulation of glutamate receptor-mediated BDNF mRNA expression in the cerebellum and its defects in stargazer mice. Neuropharmacology. 2007;53:81-91 pubmed
    ..It indicates that the BDNF expression defect in the stg cerebellum is attributable to the AMPA receptor defect caused by the stargazin mutation. ..
  77. Zhu W, Xu P, Cuascut F, Hall A, Oxford G. Activin acutely sensitizes dorsal root ganglion neurons and induces hyperalgesia via PKC-mediated potentiation of transient receptor potential vanilloid I. J Neurosci. 2007;27:13770-80 pubmed
    ..These data suggest that activin signals through its own receptor, involves PKCepsilon signaling to sensitize the TRPV1 channel, and contributes to acute thermal hyperalgesia. ..
  78. Richardson M, Gupta A, O Brien L, Berg D, Gerlitz B, Syed S, et al. Treatment of sepsis-induced acquired protein C deficiency reverses Angiotensin-converting enzyme-2 inhibition and decreases pulmonary inflammatory response. J Pharmacol Exp Ther. 2008;325:17-26 pubmed publisher
  79. Renukaradhya G, Khan M, Shaji D, Brutkiewicz R. Vesicular stomatitis virus matrix protein impairs CD1d-mediated antigen presentation through activation of the p38 MAPK pathway. J Virol. 2008;82:12535-42 pubmed publisher
    ..Thus, the VSV-M protein plays an important role in permitting the virus to evade important components of the innate immune response by regulating specific MAPK pathways. ..
  80. Pu X, Kamendulis L, Klaunig J. Acrylonitrile-induced oxidative stress and oxidative DNA damage in male Sprague-Dawley rats. Toxicol Sci. 2009;111:64-71 pubmed publisher
    ..Since oxidative DNA damage in brain correlated with oxidative damage in WBC, these results suggest that monitoring WBC DNA damage maybe a useful tool to assess acrylonitrile-induced oxidative stress in humans. ..
  81. Liu N, Wang X, Lu Q, Xu X. Altered microRNA expression following traumatic spinal cord injury. Exp Neurol. 2009;219:424-9 pubmed publisher
    ..These findings suggest that abnormal expression of miRNAs may contribute to the pathogenesis of SCI and are potential targets for therapeutic interventions following SCI. ..
  82. Chang H, Han L, Jabeen R, Carotta S, Nutt S, Kaplan M. PU.1 regulates TCR expression by modulating GATA-3 activity. J Immunol. 2009;183:4887-94 pubmed publisher
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