Experts and Doctors on virion in Evanston, Illinois, United States
Locale: Evanston, Illinois, United States
Rossman J, Jing X, Leser G, Balannik V, Pinto L, Lamb R. Influenza virus m2 ion channel protein is necessary for filamentous virion formation. J Virol. 2010;84:5078-88 pubmed publisher
..We found that an amphipathic helix located within the M2 cytoplasmic tail is able to bind cholesterol, and we speculate that M2 cholesterol binding is essential for both filament formation and the stability of existing viral filaments. ..
Zebedee S, Lamb R. Influenza A virus M2 protein: monoclonal antibody restriction of virus growth and detection of M2 in virions. J Virol. 1988;62:2762-72 pubmed
Zhang J, Pekosz A, Lamb R. Influenza virus assembly and lipid raft microdomains: a role for the cytoplasmic tails of the spike glycoproteins. J Virol. 2000;74:4634-44 pubmed
..The data indicate that deletion of both the HA and NA cytoplasmic tails results in reduced DIG association and changes in both virus polypeptide and lipid composition. ..
Paterson R, Leser G, Shaughnessy M, Lamb R. The paramyxovirus SV5 V protein binds two atoms of zinc and is a structural component of virions. Virology. 1995;208:121-31 pubmed
..The V protein has been purified from V recombinant baculovirus-infected insect cells and by using inductively coupled argon plasma atomic emission spectroscopy it was found that each molecule of V binds two zinc atoms. ..
Schmitt A, Leser G, Waning D, Lamb R. Requirements for budding of paramyxovirus simian virus 5 virus-like particles. J Virol. 2002;76:3952-64 pubmed
..Taken together, these data suggest that multiple viral components, including assembled nucleocapsids, have important roles in the paramyxovirus budding process. ..
Vega R, Maspoch D, Salaita K, Mirkin C. Nanoarrays of single virus particles. Angew Chem Int Ed Engl. 2005;44:6013-5 pubmed