Genomes and Genes
Experts and Doctors on transcription factors in Evanston, Illinois, United States
Locale: Evanston, Illinois, United States
Topic: transcription factors
Publications109 found, 100 shown here
- Sistonen L, Sarge K, Morimoto R. Human heat shock factors 1 and 2 are differentially activated and can synergistically induce hsp70 gene transcription. Mol Cell Biol. 1994;14:2087-99 pubmed
- Matulis C, Mayo K. The LIM domain protein FHL2 interacts with the NR5A family of nuclear receptors and CREB to activate the inhibin-? subunit gene in ovarian granulosa cells. Mol Endocrinol. 2012;26:1278-90 pubmed publisher..Collectively these results identify FHL2 as a novel coactivator of NR5A nuclear receptors in ovarian granulosa cells and suggest its involvement in regulating target genes important for mammalian reproduction...
- Abravaya K, Myers M, Murphy S, Morimoto R. The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression. Genes Dev. 1992;6:1153-64 pubmed..We suggest that hsp70 may negatively regulate the activation of HSF. ..
- Slusarski D, Motzny C, Holmgren R. Mutations that alter the timing and pattern of cubitus interruptus gene expression in Drosophila melanogaster. Genetics. 1995;139:229-40 pubmed..Thus, proper regulation of both the ci mRNA and protein appears to be critical for normal Drosophila development. ..
- Satyal S, Chen D, Fox S, Kramer J, Morimoto R. Negative regulation of the heat shock transcriptional response by HSBP1. Genes Dev. 1998;12:1962-74 pubmed..Alteration in the level of HSBP1 expression in C. elegans has severe effects on survival of the animals after thermal and chemical stress, consistent with a role for HSBP1 as a negative regulator of the heat shock response. ..
- Moyle Heyrman G, Tims H, Widom J. Structural constraints in collaborative competition of transcription factors against the nucleosome. J Mol Biol. 2011;412:634-46 pubmed publisher..These findings imply a special significance for TF binding sites that are spaced within one-half nucleosome length (74 bp) or less along the genome and may prove useful for prediction of cooperatively acting TFs genome wide. ..
- Outten C, Outten F, O Halloran T. DNA distortion mechanism for transcriptional activation by ZntR, a Zn(II)-responsive MerR homologue in Escherichia coli. J Biol Chem. 1999;274:37517-24 pubmed..The ZntR metalloregulatory protein is a direct Zn(II) sensor that catalyzes transcriptional activation of a zinc efflux gene, thus preventing intracellular Zn(II) from exceeding an optimal but as yet unknown concentration. ..
- Siepka S, Yoo S, Park J, Song W, Kumar V, Hu Y, et al. Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression. Cell. 2007;129:1011-23 pubmed..Thus, Fbxl3(Ovtm) defines a molecular link between CRY turnover and CLOCK/BMAL1-dependent circadian transcription to modulate circadian period. ..
- Song J, Takeda M, Morimoto R. Bag1-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth. Nat Cell Biol. 2001;3:276-82 pubmed..We propose that Bag1 functions in the heat-shock response to coordinate cell growth signals and mitogenesis, and that Hsp70 functions as a sensor in stress signalling. ..
- Terrell J, Shih S, Dunn R, Hicke L. A function for monoubiquitination in the internalization of a G protein-coupled receptor. Mol Cell. 1998;1:193-202 pubmed..Thus, we have defined a cellular function for monoubiquitination in alpha-factor receptor endocytosis. ..
- George K, Leonard M, Roth M, Lieuw K, Kioussis D, Grosveld F, et al. Embryonic expression and cloning of the murine GATA-3 gene. Development. 1994;120:2673-86 pubmed..Furthermore, this same region of the locus confers developmentally appropriate expression in transgenic mice, but only in a subset of the tissues that naturally express the gene. ..
- Outten C, O Halloran T. Femtomolar sensitivity of metalloregulatory proteins controlling zinc homeostasis. Science. 2001;292:2488-92 pubmed..Thus, cells exert tight control over cytosolic metal concentrations, even for relatively low-toxicity metals such as zinc...
- Manaves V, Qin W, Bauer A, Rossie S, Kobayashi M, Rane S. Calcium and Vitamin D increase mRNA levels for the growth control hIK1 channel in human epidermal keratinocytes but functional channels are not observed. BMC Dermatol. 2004;4:7 pubmed..Further, the results indicate caution is required when interpreting experiments utilizing pharmacological hIK1 modulators in human keratinocytes. ..
- Westerheide S, Bosman J, Mbadugha B, Kawahara T, Matsumoto G, Kim S, et al. Celastrols as inducers of the heat shock response and cytoprotection. J Biol Chem. 2004;279:56053-60 pubmed..These results suggest that celastrols exhibit promise as a new class of pharmacologically active regulators of the heat shock response. ..
- Jones S, Paredes C, Tracy B, Cheng N, Sillers R, Senger R, et al. The transcriptional program underlying the physiology of clostridial sporulation. Genome Biol. 2008;9:R114 pubmed publisher..Elucidation of their sporulation program is critical for understanding important clostridial programs pertaining to their physiology and their industrial or environmental applications...
- Wang Q, Holmgren R. The subcellular localization and activity of Drosophila cubitus interruptus are regulated at multiple levels. Development. 1999;126:5097-106 pubmed..Finally, we propose that there are three levels of apparent Ci activity, corresponding to three zones along the AP axis with different sets of gene expression and different levels of Hh signaling. ..
- Menendez J, Vellon L, Colomer R, Lupu R. Effect of gamma-linolenic acid on the transcriptional activity of the Her-2/neu (erbB-2) oncogene. J Natl Cancer Inst. 2005;97:1611-5 pubmed..Concurrent treatments of Her-2/neu-overexpressing cancer cells with GLA and the anti-Her-2/neu antibody trastuzumab led to synergistic increases in apoptosis and reduced growth and colony formation. ..
- Prahlad V, Morimoto R. Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteins. Proc Natl Acad Sci U S A. 2011;108:14204-9 pubmed publisher..elegans to respond differently to acute stress such as heat shock, and chronic stress caused by the expression of misfolded proteins, suggesting that neuronal signaling determines the course of cellular proteotoxicity. ..
- Yamamoto M, Ko L, Leonard M, Beug H, Orkin S, Engel J. Activity and tissue-specific expression of the transcription factor NF-E1 multigene family. Genes Dev. 1990;4:1650-62 pubmed
- Schrader E, Harstad K, Holmgren R, Matouschek A. A three-part signal governs differential processing of Gli1 and Gli3 proteins by the proteasome. J Biol Chem. 2011;286:39051-8 pubmed publisher..These findings provide new insights into the molecular elements that regulate Gli protein processing by the proteasome. ..
- Brogaard K, Xi L, Wang J, Widom J. A chemical approach to mapping nucleosomes at base pair resolution in yeast. Methods Enzymol. 2012;513:315-34 pubmed publisher..Here we describe a new experimental approach that directly maps nucleosome center locations in vivo genome-wide at single base pair resolution. ..
- Sarge K, Murphy S, Morimoto R. Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress. Mol Cell Biol. 1993;13:1392-407 pubmed..These results demonstrate that HSF1 can be activated in the absence of physiological stress and also provide support for a model of regulation of HSF1 and HSF2 activity by a titratable negative regulatory factor. ..
- Shi Y, Mosser D, Morimoto R. Molecular chaperones as HSF1-specific transcriptional repressors. Genes Dev. 1998;12:654-66 pubmed
- Takahashi J. Circadian-clock regulation of gene expression. Curr Opin Genet Dev. 1993;3:301-9 pubmed..This review is an updated and extended version of a review first published in Current Opinion in Neurobiology 1991, 1:556-561. ..
- Bejsovec A. Wnt signalling shows its versatility. Curr Biol. 1999;9:R684-7 pubmed..Recent studies have revealed that regulatory interactions at several steps in the pathway can modify its outcome, helping to explain how the same pathway can, in different contexts, have very different characteristics and consequences. ..
- Mathew A, Mathur S, Morimoto R. Heat shock response and protein degradation: regulation of HSF2 by the ubiquitin-proteasome pathway. Mol Cell Biol. 1998;18:5091-8 pubmed
- Roy H, Smyrk T, Koetsier J, Victor T, Wali R. The transcriptional repressor SNAIL is overexpressed in human colon cancer. Dig Dis Sci. 2005;50:42-6 pubmed..11). In conclusion, we demonstrate, for the first time, that SNAIL is upregulated in human colon cancer, which potentially may have significance in control of metastasis and possibly serve as a target for chemopreventive agents. ..
- Light W, Vernon A, Lasorella A, Iavarone A, LaBonne C. Xenopus Id3 is required downstream of Myc for the formation of multipotent neural crest progenitor cells. Development. 2005;132:1831-41 pubmed..These results shed new light on the mechanisms governing the formation and maintenance of a developmentally and clinically important cell population. ..
- Ng Y, George K, Engel J, Linzer D. GATA factor activity is required for the trophoblast-specific transcriptional regulation of the mouse placental lactogen I gene. Development. 1994;120:3257-66 pubmed
- Horvath C. Weapons of STAT destruction. Interferon evasion by paramyxovirus V protein. Eur J Biochem. 2004;271:4621-8 pubmed..Exposure of the viral weapons of STAT destruction may also be instructive for application to STAT-directed therapeutics for diseases characterized by STAT hyperactivity. ..
- Zheng L, Carthew R. Lola regulates cell fate by antagonizing Notch induction in the Drosophila eye. Mech Dev. 2008;125:18-29 pubmed..The predicted consequence of this mechanism is to sharpen a cell's responsiveness to Notch signaling by creating a threshold. ..
- Harney A, Lee J, Manus L, Wang P, Ballweg D, LaBonne C, et al. Targeted inhibition of Snail family zinc finger transcription factors by oligonucleotide-Co(III) Schiff base conjugate. Proc Natl Acad Sci U S A. 2009;106:13667-72 pubmed publisher..A complex targeted to inactivate their transcriptional activity could prove valuable as an experimental tool and a cancer therapeutic. ..
- Westerheide S, Kawahara T, Orton K, Morimoto R. Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death. J Biol Chem. 2006;281:9616-22 pubmed..The ability of triptolide to inhibit the heat shock response renders these cells sensitive to stress-induced cell death, which may be of great relevance to cancer treatments. ..
- Germaniuk Kurowska A, Nag A, Zhao X, Dimri M, Band H, Band V. Ada3 requirement for HAT recruitment to estrogen receptors and estrogen-dependent breast cancer cell proliferation. Cancer Res. 2007;67:11789-97 pubmed..Thus, our results show an important role of Ada3 in HAT recruitment to estrogen-responsive target gene promoters and for estrogen-dependent proliferation of breast cancer cells. ..
- Duina A, Kalton H, Gaber R. Requirement for Hsp90 and a CyP-40-type cyclophilin in negative regulation of the heat shock response. J Biol Chem. 1998;273:18974-8 pubmed..Our results reveal that Hsp90 and Cpr7 are required for negative regulation of the heat shock response under both stress and nonstress conditions and establish a specific endogenous role for the Hsp90 machinery in S. cerevisiae. ..
- Foley K, Engel J. Individual stage selector element mutations lead to reciprocal changes in beta- vs. epsilon-globin gene transcription: genetic confirmation of promoter competition during globin gene switching. Genes Dev. 1992;6:730-44 pubmed
- Dunn R, Hicke L. Domains of the Rsp5 ubiquitin-protein ligase required for receptor-mediated and fluid-phase endocytosis. Mol Biol Cell. 2001;12:421-35 pubmed..In addition, mutations in the C2 and WW1 domains had more severe defects on transport of fluid-phase markers to the vacuole than on receptor internalization, suggesting that Rsp5p functions at multiple steps in the endocytic pathway. ..
- Vernon A, LaBonne C. Slug stability is dynamically regulated during neural crest development by the F-box protein Ppa. Development. 2006;133:3359-70 pubmed..These results provide novel insight into the regulation of Slug, a protein that plays a central role in neural crest precursor formation, as well as in developmental and pathological epithelial to mesenchymal transitions. ..
- Zhao Y, Katzman R, Delmolino L, Bhat I, Zhang Y, Gurumurthy C, et al. The notch regulator MAML1 interacts with p53 and functions as a coactivator. J Biol Chem. 2007;282:11969-81 pubmed..elegans p53 homolog Cep-1. Thus, we present evidence for a novel coactivator function of MAML1 for p53, independent of its function as a coactivator of Notch signaling pathway. ..
- Prahlad V, Cornelius T, Morimoto R. Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons. Science. 2008;320:811-4 pubmed publisher..We propose a model whereby this loss of cell autonomy serves to integrate behavioral, metabolic, and stress-related responses to establish an organismal response to environmental change. ..
- Bommi P, Dimri M, Sahasrabuddhe A, Khandekar J, Dimri G. The polycomb group protein BMI1 is a transcriptional target of HDAC inhibitors. Cell Cycle. 2010;9:2663-73 pubmed..In summary, our findings suggest that BMI1 is an important therapy target of HDACi, and that HDACi can be used alone or in combination with other therapies to inhibit growth of tumors that overexpress PcG proteins such as BMI1. ..
- Lander R, Nordin K, LaBonne C. The F-box protein Ppa is a common regulator of core EMT factors Twist, Snail, Slug, and Sip1. J Cell Biol. 2011;194:17-25 pubmed publisher..Together, these results indicate that despite the structural diversity of the core transcriptional regulatory factors implicated in EMT, a common mechanism has evolved for controlling their stability and therefore their function...
- Buggele W, Horvath C. MicroRNA profiling of Sendai virus-infected A549 cells identifies miR-203 as an interferon-inducible regulator of IFIT1/ISG56. J Virol. 2013;87:9260-70 pubmed publisher..Results indicate that miR-203 is an IFN-inducible miRNA that can negatively regulate a number of cellular mRNAs, including an IFN-stimulated gene target, IFIT1/ISG56, by destabilizing its mRNA transcript. ..
- Lum L, Sultzman L, Kaufman R, Linzer D, Wu B. A cloned human CCAAT-box-binding factor stimulates transcription from the human hsp70 promoter. Mol Cell Biol. 1990;10:6709-17 pubmed..CCAAT-binding factor shows no homology to the previously identified human CCAAT transcription factor or rat CCAAT/enhancer-binding protein. ..
- Brickner D, Ahmed S, Meldi L, Thompson A, Light W, Young M, et al. Transcription factor binding to a DNA zip code controls interchromosomal clustering at the nuclear periphery. Dev Cell. 2012;22:1234-46 pubmed publisher..These results suggest that zip-code-mediated clustering of genes at the nuclear periphery influences the three-dimensional arrangement of the yeast genome. ..
- Lander R, Nasr T, Ochoa S, Nordin K, Prasad M, LaBonne C. Interactions between Twist and other core epithelial-mesenchymal transition factors are controlled by GSK3-mediated phosphorylation. Nat Commun. 2013;4:1542 pubmed publisher..Together, these findings elucidate a mechanism for coordinated control of a group of structurally diverse factors that function as a regulatory unit in both developmental and pathological epithelial-mesenchymal transitions...
- Ko L, Yamamoto M, Leonard M, George K, Ting P, Engel J. Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer. Mol Cell Biol. 1991;11:2778-84 pubmed..We infer that the murine and human GATA-3 proteins play a central and highly conserved role in vertebrate T-cell-specific transcriptional regulation. ..
- Dash A, Orrico F, Ness S. The EVES motif mediates both intermolecular and intramolecular regulation of c-Myb. Genes Dev. 1996;10:1858-69 pubmed..Our results suggest that Myb is regulated by a novel mechanism in which intramolecular interactions and conformational changes control the intermolecular associations among Myb, p100, and the transcriptional apparatus. ..
- Cotto J, Fox S, Morimoto R. HSF1 granules: a novel stress-induced nuclear compartment of human cells. J Cell Sci. 1997;110 ( Pt 23):2925-34 pubmed
- Changela A, Chen K, Xue Y, Holschen J, Outten C, O Halloran T, et al. Molecular basis of metal-ion selectivity and zeptomolar sensitivity by CueR. Science. 2003;301:1383-7 pubmed publisher..This binding mode is rare among metalloproteins but well suited for an ultrasensitive genetic switch...
- Croker J, Ziegenhorn S, Holmgren R. Regulation of the Drosophila transcription factor, Cubitus interruptus, by two conserved domains. Dev Biol. 2006;291:368-81 pubmed..Analysis of the amino acid sequence of this domain identifies 11 perfectly conserved serines and one tyrosine. We propose that this region may be modified, possibly by phosphorylation, to regulate Ci nuclear import. ..
- Sisson B, Ziegenhorn S, Holmgren R. Regulation of Ci and Su(fu) nuclear import in Drosophila. Dev Biol. 2006;294:258-70 pubmed..Finally, we demonstrate that Ci can bring Su(fu) with it to a multimerized Ci DNA binding site. These results provide a basis for understanding the dual roles played by Su(fu) in the regulation of Ci. ..
- Fox M, Billings S, Gleason B, Thomas A, Cibull T. Cutaneous meningioma: a potential diagnostic pitfall in p63 positive cutaneous neoplasms. J Cutan Pathol. 2013;40:891-5 pubmed publisher..On the basis of our small study, it is unlikely that p63 expression would be helpful in distinguishing between type II and type III meningioma, as both may be p63-positive. ..
- Motzny C, Holmgren R. The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways. Mech Dev. 1995;52:137-50 pubmed..The role of ci in cell-cell signaling and pattern formation was examined in double mutants of ci with patched and zeste-white3/shaggy. ..
- Mazanka E, Weiss E. Sequential counteracting kinases restrict an asymmetric gene expression program to early G1. Mol Biol Cell. 2010;21:2809-20 pubmed publisher..Overall, these findings show how sequential opposing kinases limit a daughter cell specific transcriptional program to a brief period during the cell cycle and suggest that CDKs may function as cytoplasmic sequestration factors. ..
- Buhr E, Yoo S, Takahashi J. Temperature as a universal resetting cue for mammalian circadian oscillators. Science. 2010;330:379-85 pubmed publisher..These results suggest that the evolutionarily ancient temperature resetting response can be used in homeothermic animals to enhance internal circadian synchronization. ..
- Xie T, Graveline R, Kumar G, Zhang Y, Krishnan A, David G, et al. Structural basis for molecular interactions involving MRG domains: implications in chromatin biology. Structure. 2012;20:151-60 pubmed publisher..Multiple MRG15 interactors share an FxLP motif in the extended segment, but equivalent sequence/helical motifs are not readily evident, implying potential diversity in MRG-recognition mechanisms...
- Ma G, Roth M, Groskopf J, Tsai F, Orkin S, Grosveld F, et al. GATA-2 and GATA-3 regulate trophoblast-specific gene expression in vivo. Development. 1997;124:907-14 pubmed
- Wang Q, Holmgren R. Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation. Development. 2000;127:3131-9 pubmed..Finally, we show that cos2 and pka, two molecules that have been characterized primarily as negative regulators of Ci activity, also have positive roles in the activation of Ci in response to Hh. ..
- Kroft T, Patterson J, Won Yoon J, Doglio L, Walterhouse D, Iannaccone P, et al. GLI1 localization in the germinal epithelial cells alternates between cytoplasm and nucleus: upregulation in transgenic mice blocks spermatogenesis in pachytene. Biol Reprod. 2001;65:1663-71 pubmed
- Tian L, Holmgren R, Matouschek A. A conserved processing mechanism regulates the activity of transcription factors Cubitus interruptus and NF-kappaB. Nat Struct Mol Biol. 2005;12:1045-53 pubmed..These findings suggest that the mechanism is conserved evolutionarily and that processing signals may be widespread in regulatory proteins. ..
- Vitaterna M, Ko C, Chang A, Buhr E, Fruechte E, Schook A, et al. The mouse Clock mutation reduces circadian pacemaker amplitude and enhances efficacy of resetting stimuli and phase-response curve amplitude. Proc Natl Acad Sci U S A. 2006;103:9327-32 pubmed..The increased efficacy of resetting stimuli and decreased PER expression amplitude can be explained in a unified manner by a model in which the Clock mutation reduces circadian pacemaker amplitude in the suprachiasmatic nuclei. ..
- Vidal M, Gaber R. RPD3 encodes a second factor required to achieve maximum positive and negative transcriptional states in Saccharomyces cerevisiae. Mol Cell Biol. 1991;11:6317-27 pubmed..The effects of mutations in RPD1 and RPD3 are not additive, suggesting that these genes are involved in the same transcriptional regulatory function or pathway. ..
- Winick J, Abel T, Leonard M, Michelson A, Chardon Loriaux I, Holmgren R, et al. A GATA family transcription factor is expressed along the embryonic dorsoventral axis in Drosophila melanogaster. Development. 1993;119:1055-65 pubmed..The pattern of expression in a variety of dorsoventral polarity mutants indicates that dGATAa lies downstream of the zygotic patterning genes decapentaplegic and zerknüllt. ..
- Zhou Y, Yamamoto M, Engel J. GATA2 is required for the generation of V2 interneurons. Development. 2000;127:3829-38 pubmed..The identification of a V2-specific enhancer should allow fundamental new insight into the genetic hierarchy of regulatory events that govern neurogenesis in a well-defined cell lineage. ..
- Lefers M, Wang Q, Holmgren R. Genetic dissection of the Drosophila Cubitus interruptus signaling complex. Dev Biol. 2001;236:411-20 pubmed..Fu participates in two partially redundant pathways to regulate Ci nuclear import; the kinase function plays a positive role by inhibiting Su(fu), and the regulatory domain plays a negative role in conjunction with Cos2. ..
- Kennerdell J, Yamaguchi S, Carthew R. RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine and spindle-E. Genes Dev. 2002;16:1884-9 pubmed
- Allada R. Circadian clocks: a tale of two feedback loops. Cell. 2003;112:284-6 pubmed..In Drosophila, the first loop has been well characterized and controls rhythmic period expression. In this issue of Cell, define a role for a transcriptional activator and a repressor in the second feedback loop. ..
- Morley J, Morimoto R. Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones. Mol Biol Cell. 2004;15:657-64 pubmed..The interaction of ILS with HSF-1 could represent an important molecular strategy to couple the regulation of longevity with an ancient genetic switch that governs the ability of cells to sense and respond to stress. ..
- Alsaker K, Spitzer T, Papoutsakis E. Transcriptional analysis of spo0A overexpression in Clostridium acetobutylicum and its effect on the cell's response to butanol stress. J Bacteriol. 2004;186:1959-71 pubmed
- Paul S, Beitel G. Tubulogenesis: zipping up your fly. Curr Biol. 2005;15:R70-2 pubmed..In animals, rearrangements of the junctions between cells are fundamental to morphogenesis. Recent work has revealed the acrobatics that Drosophila tracheal cells perform as they intercalate to form unicellular tubes. ..
- Little T, Zhang Y, Matulis C, Weck J, Zhang Z, Ramachandran A, et al. Sequence-specific deoxyribonucleic acid (DNA) recognition by steroidogenic factor 1: a helix at the carboxy terminus of the DNA binding domain is necessary for complex stability. Mol Endocrinol. 2006;20:831-43 pubmed..We propose that the FTZ-F1 helix along with the core DBD serves as a platform for interactions with coactivators and other DNA-bound factors in the vicinity. ..
- Weck J, Mayo K. Switching of NR5A proteins associated with the inhibin alpha-subunit gene promoter after activation of the gene in granulosa cells. Mol Endocrinol. 2006;20:1090-103 pubmed
- McDearmon E, Patel K, Ko C, Walisser J, Schook A, Chong J, et al. Dissecting the functions of the mammalian clock protein BMAL1 by tissue-specific rescue in mice. Science. 2006;314:1304-8 pubmed..In contrast, muscle-rescued Bmal1-/- mice exhibited normal activity levels and body weight yet remained behaviorally arrhythmic. Thus, Bmal1 has distinct tissue-specific functions that regulate integrative physiology. ..
- Silva M, Amaral M, Morimoto R. Neuronal reprograming of protein homeostasis by calcium-dependent regulation of the heat shock response. PLoS Genet. 2013;9:e1003711 pubmed publisher..This demonstrates that the heat shock response (HSR) can be activated in muscle cells by neuronal signaling across the NMJ to protect proteome health. ..
- Zhou Y, Lim K, Onodera K, Takahashi S, Ohta J, Minegishi N, et al. Rescue of the embryonic lethal hematopoietic defect reveals a critical role for GATA-2 in urogenital development. EMBO J. 1998;17:6689-700 pubmed..These findings reveal that GATA-2 plays equally vital roles in urogenital and hematopoietic development. ..
- Hayashi T, Xu C, Carthew R. Cell-type-specific transcription of prospero is controlled by combinatorial signaling in the Drosophila eye. Development. 2008;135:2787-96 pubmed publisher..The activity level, therefore, is dictated by the proper combination of highly cooperative selector and pre-pattern factors present in the cell...
- Ramsey K, Yoshino J, Brace C, Abrassart D, Kobayashi Y, Marcheva B, et al. Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science. 2009;324:651-4 pubmed publisher..In turn, the circadian transcription factor CLOCK binds to and up-regulates Nampt, thus completing a feedback loop involving NAMPT/NAD+ and SIRT1/CLOCK:BMAL1. ..
- Duina A, Marsh J, Gaber R. Identification of two CyP-40-like cyclophilins in Saccharomyces cerevisiae, one of which is required for normal growth. Yeast. 1996;12:943-52 pubmed..Neither CPR6 nor CPR7 is essential but deletion of CPR7 results in a significant impairment of the rate of cell division. This is the first demonstration that a member of the cyclophilin family is required for normal cell growth. ..
- Morimoto R, Kline M, Bimston D, Cotto J. The heat-shock response: regulation and function of heat-shock proteins and molecular chaperones. Essays Biochem. 1997;32:17-29 pubmed
- Vitaterna M, Selby C, Todo T, Niwa H, Thompson C, Fruechte E, et al. Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2. Proc Natl Acad Sci U S A. 1999;96:12114-9 pubmed..The differential regulation of mPer1 and mPer2 by light in Cry double mutants reveals a surprising complexity in the role of cryptochromes in mammals. ..
- Tanimoto K, Liu Q, Grosveld F, Bungert J, Engel J. Context-dependent EKLF responsiveness defines the developmental specificity of the human epsilon-globin gene in erythroid cells of YAC transgenic mice. Genes Dev. 2000;14:2778-94 pubmed..We conclude that the suppression of epsilon-globin transcription during definitive erythropoiesis is mediated by the binding of a repressor that prevents EKLF from activating the epsilon-globin gene. ..
- Calamini B, Silva M, Madoux F, Hutt D, Khanna S, Chalfant M, et al. Small-molecule proteostasis regulators for protein conformational diseases. Nat Chem Biol. 2011;8:185-96 pubmed publisher..We suggest that modulation of the proteostasis network by proteostasis regulators may be a promising therapeutic approach for the treatment of a variety of protein conformational diseases. ..
- Cassidy J, Jha A, Posadas D, Giri R, Venken K, Ji J, et al. miR-9a minimizes the phenotypic impact of genomic diversity by buffering a transcription factor. Cell. 2013;155:1556-67 pubmed publisher..These findings reveal that microRNA-target interactions may be a key mechanism by which the impact of genomic diversity on cell behavior is dampened...
- Burkart A, Mukherjee A, Sterneck E, Johnson P, Mayo K. Repression of the inhibin alpha-subunit gene by the transcription factor CCAAT/enhancer-binding protein-beta. Endocrinology. 2005;146:1909-21 pubmed..Thus, there are two distinct mechanisms by which C/EBPbeta represses inhibin alpha-subunit gene expression in ovarian granulosa cells. ..
- Brace J, Hsu J, Weiss E. Mitotic exit control of the Saccharomyces cerevisiae Ndr/LATS kinase Cbk1 regulates daughter cell separation after cytokinesis. Mol Cell Biol. 2011;31:721-35 pubmed publisher..Thus, we propose that Cdc14 coordinates cell separation with mitotic exit via FEAR-initiated phosphorylation of the Cbk1 HM site and MEN-activated reversal of mitotic CDK phosphorylations that block both Cbk1 and Ace2 function. ..