Experts and Doctors on superoxides in Chicago, Illinois, United States


Locale: Chicago, Illinois, United States
Topic: superoxides

Top Publications

  1. Morgan D, Cherny V, Price M, Dinauer M, DeCoursey T. Absence of proton channels in COS-7 cells expressing functional NADPH oxidase components. J Gen Physiol. 2002;119:571-80 pubmed
    ..PMA or AA did not elicit detectable H(+) current in COS(WT) or COS(phox) cells. Therefore, gp91(phox) does not function as a proton channel in unstimulated cells or in activated cells with a demonstrably functional oxidase. ..
  2. Nanamori M, Cheng X, Mei J, Sang H, Xuan Y, Zhou C, et al. A novel nonpeptide ligand for formyl peptide receptor-like 1. Mol Pharmacol. 2004;66:1213-22 pubmed
    ..Quin-C1 is a prototype of substituted quinazolinones based on which further structural modifications may be made to improve its efficacy and potency for FPRL1. ..
  3. He R, Nanamori M, Sang H, Yin H, Dinauer M, Ye R. Reconstitution of chemotactic peptide-induced nicotinamide adenine dinucleotide phosphate (reduced) oxidase activation in transgenic COS-phox cells. J Immunol. 2004;173:7462-70 pubmed
  4. Lin P, Welch E, Gao X, Malik A, Ye R. Lysophosphatidylcholine modulates neutrophil oxidant production through elevation of cyclic AMP. J Immunol. 2005;174:2981-9 pubmed
    ..A similar mechanism of inhibition may be used for the control of neutrophil-mediated tissue injury. ..
  5. Phillips S, Pechman K, Leonard E, Friedrich J, Bian J, Beal A, et al. Increased ANG II sensitivity following recovery from acute kidney injury: role of oxidant stress in skeletal muscle resistance arteries. Am J Physiol Regul Integr Comp Physiol. 2010;298:R1682-91 pubmed publisher
    ..Taken together, this study demonstrates that AKI alters peripheral vascular responses by increasing oxidant stress, likely in the endothelium, via an undefined mechanism. ..
  6. Rajamohan S, Raghuraman G, Prabhakar N, Kumar G. NADPH oxidase-derived H(2)O(2) contributes to angiotensin II-induced aldosterone synthesis in human and rat adrenal cortical cells. Antioxid Redox Signal. 2012;17:445-59 pubmed publisher
    ..Our results suggest that Ang II facilitates CYP11B2 activity and the ensuing aldosterone production via activation of AT(1)R-Nox-H(2)O(2) signaling pathway. ..
  7. Kamp D, Bauer K, Knap A, Dunn M. Contrasting effects of inflammatory stimuli on neutrophil and monocyte adherence to endothelial cells. J Appl Physiol (1985). 1989;67:556-62 pubmed
    ..abstract truncated at 250 words) ..
  8. Wainwright M, Kohli R, Whitington P, Chace D. Carnitine treatment inhibits increases in cerebral carnitine esters and glutamate detected by mass spectrometry after hypoxia-ischemia in newborn rats. Stroke. 2006;37:524-30 pubmed
    ..Carnitine metabolic pathways are compromised in HI and hypoxia. The protective effect of carnitine treatment on HI injury may be attributable to maintaining mitochondrial function. ..
  9. Bhalla S, Gordon L. Functional characterization of NAD dependent de-acetylases SIRT1 and SIRT2 in B-Cell Chronic Lymphocytic Leukemia (CLL). Cancer Biol Ther. 2016;17:300-9 pubmed publisher
    ..Furthermore, studies in nutrient deprived conditions suggest a role of SIRT in metabolism in CLL. These results demonstrate that the inhibition of SIRT1 and SIRT2 activity may be a new therapeutic approach for CLL. ..

More Information


  1. Brennan L, Steinhorn R, Wedgwood S, Mata Greenwood E, Roark E, Russell J, et al. Increased superoxide generation is associated with pulmonary hypertension in fetal lambs: a role for NADPH oxidase. Circ Res. 2003;92:683-91 pubmed
  2. Mora J, Riggs E, Fu J, Macglashan D, Fox S, Yu B, et al. Expression of the high affinity IgE receptor by neutrophils of individuals with allergic asthma is both minimal and insensitive to regulation by serum IgE. Clin Immunol. 2009;132:132-40 pubmed publisher
  3. Sudhahar V, Urao N, Oshikawa J, McKinney R, Llanos R, Mercer J, et al. Copper transporter ATP7A protects against endothelial dysfunction in type 1 diabetic mice by regulating extracellular superoxide dismutase. Diabetes. 2013;62:3839-50 pubmed publisher
    ..Thus, restoring copper transporter function is an essential therapeutic approach for oxidant stress-dependent vascular and metabolic diseases. ..
  4. Chen J, He R, Minshall R, Dinauer M, Ye R. Characterization of a mutation in the Phox homology domain of the NADPH oxidase component p40phox identifies a mechanism for negative regulation of superoxide production. J Biol Chem. 2007;282:30273-84 pubmed
    ..Both functions require the association of p40(phox) with p67(phox). ..
  5. Gordon L, Weiss D, Prachand S, Weitzman S. Scavenging of superoxide anion by phosphorylethanolamine: studies in human neutrophils and in a cell free system. Free Radic Res Commun. 1991;15:65-71 pubmed
    ..These data underscore the importance of identifying the mechanism of inhibition of superoxide generation by putative inhibitors as being due to a direct cellular effect or to a scavenging property. ..
  6. Waypa G, Marks J, Guzy R, Mungai P, Schriewer J, Dokic D, et al. Superoxide generated at mitochondrial complex III triggers acute responses to hypoxia in the pulmonary circulation. Am J Respir Crit Care Med. 2013;187:424-32 pubmed publisher
    ..Acute hypoxia induces superoxide release from Complex III of smooth muscle cells. These oxidant signals diffuse into the cytosol and trigger increases in [Ca(2+)](i) that cause acute hypoxic pulmonary vasoconstriction. ..
  7. Ansenberger Fricano K, Ganini D, Mao M, Chatterjee S, Dallas S, Mason R, et al. The peroxidase activity of mitochondrial superoxide dismutase. Free Radic Biol Med. 2013;54:116-24 pubmed publisher
    ..Here we report that MnSOD indeed possesses peroxidase activity that manifests in mitochondria when the enzyme is overexpressed. ..
  8. Saad M, Eom W, Hu G, Kim S, Crystal G. Persistency and pathway of isoflurane-induced inhibition of superoxide production by neutrophils. Can J Anaesth. 2010;57:50-7 pubmed publisher
  9. Guzman J, Sanchez Padilla J, Wokosin D, Kondapalli J, Ilijic E, Schumacker P, et al. Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1. Nature. 2010;468:696-700 pubmed publisher
    ..Because drugs approved for human use can antagonize calcium entry through L-type channels, these results point to a novel neuroprotective strategy for both idiopathic and familial forms of Parkinson's disease. ..
  10. Hu G, Ye R, Dinauer M, Malik A, Minshall R. Neutrophil caveolin-1 expression contributes to mechanism of lung inflammation and injury. Am J Physiol Lung Cell Mol Physiol. 2008;294:L178-86 pubmed
    ..Thus caveolin-1 expression in PMNs plays a key role in mediating PMN activation, adhesion, and transendothelial migration and in PMN activation-induced lung inflammation and vascular injury. ..
  11. Ghadge G, Lee J, Bindokas V, Jordan J, Ma L, Miller R, et al. Mutant superoxide dismutase-1-linked familial amyotrophic lateral sclerosis: molecular mechanisms of neuronal death and protection. J Neurosci. 1997;17:8756-66 pubmed
    ..The results support the hypothesis that mutant SOD induced-neurodegeneration is associated with disturbances of neuronal free radical homeostasis. ..
  12. Qian F, Deng J, Gantner B, Flavell R, Dong C, Christman J, et al. Map kinase phosphatase 5 protects against sepsis-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2012;302:L866-74 pubmed publisher
    ..Taken together, these results suggest that MKP5 is crucial to homeostatic regulation of MAPK activation in inflammatory responses. ..
  13. Musset B, Clark R, DeCoursey T, Petheo G, Geiszt M, Chen Y, et al. NOX5 in human spermatozoa: expression, function, and regulation. J Biol Chem. 2012;287:9376-88 pubmed publisher
    ..Collectively, our findings show that NOX5 is a major source of ROS in human spermatozoa and indicate a role for NOX5-dependent ROS generation in human spermatozoa motility. ..
  14. Murley J, Kataoka Y, Miller R, Li J, Woloschak G, Grdina D. SOD2-mediated effects induced by WR1065 and low-dose ionizing radiation on micronucleus formation in RKO human colon carcinoma cells. Radiat Res. 2011;175:57-65 pubmed publisher
    ..SOD2 played an important role in the adaptive/delayed radioprotective response by inhibiting the initiation of a superoxide anion-induced ROS cascade leading to enhanced mitochondrial and nuclear damages...
  15. Pendyala S, Moitra J, Kalari S, Kleeberger S, Zhao Y, Reddy S, et al. Nrf2 regulates hyperoxia-induced Nox4 expression in human lung endothelium: identification of functional antioxidant response elements on the Nox4 promoter. Free Radic Biol Med. 2011;50:1749-59 pubmed publisher
    ..Collectively, these results demonstrate, for the first time, a novel role for Nrf2 in regulating hyperoxia-induced Nox4 transcription via AREs in lung endothelium. ..
  16. Fukai T, Ushio Fukai M. Superoxide dismutases: role in redox signaling, vascular function, and diseases. Antioxid Redox Signal. 2011;15:1583-606 pubmed publisher
    ..Finally, we will discuss the development of future SOD-dependent therapeutic strategies. ..
  17. Wedgwood S, Lakshminrusimha S, Farrow K, Czech L, Gugino S, Soares F, et al. Apocynin improves oxygenation and increases eNOS in persistent pulmonary hypertension of the newborn. Am J Physiol Lung Cell Mol Physiol. 2012;302:L616-26 pubmed publisher
    ..NADPH oxidase inhibition with apocynin may improve oxygenation, in part, by attenuating ROS-mediated vasoconstriction and by increasing NOS activity. ..
  18. Shenoy N, Gleich G, Thomas L. Eosinophil major basic protein stimulates neutrophil superoxide production by a class IA phosphoinositide 3-kinase and protein kinase C-zeta-dependent pathway. J Immunol. 2003;171:3734-41 pubmed
  19. Chalupsky K, Cai H. Endothelial dihydrofolate reductase: critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase. Proc Natl Acad Sci U S A. 2005;102:9056-61 pubmed
    ..This signaling cascade may represent a universal mechanism underlying eNOS dysfunction under pathophysiological conditions associated with oxidant stress. ..
  20. Chen J, Tang H, Hay N, Xu J, Ye R. Akt isoforms differentially regulate neutrophil functions. Blood. 2010;115:4237-46 pubmed publisher
    ..These results demonstrate a predominant role of Akt2 in regulating neutrophil functions and provide evidence for differential activation of the 2 Akt isoforms in neutrophils. ..
  21. Qian F, Deng J, Cheng N, Welch E, Zhang Y, Malik A, et al. A non-redundant role for MKP5 in limiting ROS production and preventing LPS-induced vascular injury. EMBO J. 2009;28:2896-907 pubmed publisher
    ..Collectively, these results show an earlier unrecognized and non-redundant function of MKP5 in restraining p38 MAPK-mediated neutrophil oxidant production, thereby preventing LPS-induced vascular injury. ..
  22. Papatheofanis F, Barmada R. Increased superoxide anion production in polymorphonuclear leucocytes on exposure to isobutyl-2-cyanoacrylate. Biomaterials. 1992;13:403-7 pubmed
    ..These findings suggested that the cytotoxicity of this class of adhesives may be associated with the formation of reactive oxygen intermediates...
  23. Cheng N, He R, Tian J, Dinauer M, Ye R. A critical role of protein kinase C delta activation loop phosphorylation in formyl-methionyl-leucyl-phenylalanine-induced phosphorylation of p47(phox) and rapid activation of nicotinamide adenine dinucleotide phosphate oxidase. J Immunol. 2007;179:7720-8 pubmed
    ..We conclude that agonist-induced PKCdelta phosphorylation is a novel mechanism for NADPH oxidase activation. The ability to induce PKCdelta phosphorylation may distinguish a full agonist from a partial agonist for superoxide production. ..
  24. Gao X, Zhu X, Fu J, Liu Q, Frey R, Malik A. Blockade of class IA phosphoinositide 3-kinase in neutrophils prevents NADPH oxidase activation- and adhesion-dependent inflammation. J Biol Chem. 2007;282:6116-25 pubmed