Experts and Doctors on micrornas in Evanston, Illinois, United States


Locale: Evanston, Illinois, United States
Topic: micrornas

Top Publications

  1. Lee Y, Pressman S, Andress A, Kim K, White J, Cassidy J, et al. Silencing by small RNAs is linked to endosomal trafficking. Nat Cell Biol. 2009;11:1150-6 pubmed publisher
    ..It may provide a means to enhance the dynamics of RNA silencing in the cytoplasm. ..
  2. Sontheimer E, Carthew R. Silence from within: endogenous siRNAs and miRNAs. Cell. 2005;122:9-12 pubmed
    ..Bioinformatic analyses indicate that target genes in vertebrate species may number in the thousands. ..
  3. Nakahara K, Kim K, Sciulli C, Dowd S, Minden J, Carthew R. Targets of microRNA regulation in the Drosophila oocyte proteome. Proc Natl Acad Sci U S A. 2005;102:12023-8 pubmed
    ..The preponderance of genes that control global protein abundance suggests this process is under tight control by miRNAs at the onset of fertilization. ..
  4. Preall J, Sontheimer E. RNAi: RISC gets loaded. Cell. 2005;123:543-5 pubmed
    ..2005) reveal the fate of the rejected passenger siRNA strand. Additionally, Gregory et al. (2005) define a heterotrimeric complex from humans that appears to execute dsRNA loading, strand selection, and target mRNA cleavage activities. ..
  5. Carthew R, Sontheimer E. Origins and Mechanisms of miRNAs and siRNAs. Cell. 2009;136:642-55 pubmed publisher
    ..Our understanding of siRNA- and miRNA-based regulation has direct implications for fundamental biology as well as disease etiology and treatment. ..
  6. Su H, Meng S, Lu Y, Trombly M, Chen J, Lin C, et al. Mammalian hyperplastic discs homolog EDD regulates miRNA-mediated gene silencing. Mol Cell. 2011;43:97-109 pubmed publisher
    ..Among the PABC-interactors, DDX6 and Tob1/2 are both required and sufficient for silencing mRNA targets. Taken together, these data demonstrate a critical function for EDD in miRNA silencing. ..
  7. Kunte D, Delacruz M, Wali R, Menon A, Du H, Stypula Y, et al. Dysregulation of microRNAs in colonic field carcinogenesis: implications for screening. PLoS ONE. 2012;7:e45591 pubmed publisher
    ..Based on our results, we propose an accurate, inexpensive, non-invasive miRNA test for CRC risk stratification based on rectal brushings or from abraded fecal colonocytes. ..
  8. Wu P, Isaji M, Carthew R. Functionally diverse microRNA effector complexes are regulated by extracellular signaling. Mol Cell. 2013;52:113-23 pubmed publisher
    ..Taken together, these results indicate that mitogenic signaling regulates the miRNA effector machinery to attenuate its repressive activities. ..
  9. Lee Y, Nakahara K, Pham J, Kim K, He Z, Sontheimer E, et al. Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways. Cell. 2004;117:69-81 pubmed
    ..However, Dicer-1 but not Dicer-2 is essential for miRISC-directed translation repression. Thus, siRISCs and miRISCs are different with respect to Dicers in Drosophila. ..

More Information


  1. Li X, Carthew R. A microRNA mediates EGF receptor signaling and promotes photoreceptor differentiation in the Drosophila eye. Cell. 2005;123:1267-77 pubmed
    ..Expression is switched when EGFR signaling transiently triggers Yan degradation. This two-tiered mechanism explains how signal transduction activity can robustly generate a stable change in gene-expression patterns. ..
  2. Su H, Trombly M, Chen J, Wang X. Essential and overlapping functions for mammalian Argonautes in microRNA silencing. Genes Dev. 2009;23:304-17 pubmed publisher
    ..Thus, our results demonstrate that mammalian Agos all contribute to miRNA silencing, and individual Agos have largely overlapping functions in this process. ..
  3. Li X, Cassidy J, Reinke C, Fischboeck S, Carthew R. A microRNA imparts robustness against environmental fluctuation during development. Cell. 2009;137:273-82 pubmed publisher
    ..We suggest that some conserved microRNAs like miR-7 may enter into novel genetic relationships to buffer developmental programs against variation and impart robustness to diverse regulatory networks. ..
  4. Marques J, Kim K, Wu P, Alleyne T, Jafari N, Carthew R. Loqs and R2D2 act sequentially in the siRNA pathway in Drosophila. Nat Struct Mol Biol. 2010;17:24-30 pubmed publisher
    ..Loqs is primarily required for dsRNA processing, whereas R2D2 is essential for the subsequent loading of siRNAs into effector Ago-RISC complexes. ..
  5. Buggele W, Horvath C. MicroRNA profiling of Sendai virus-infected A549 cells identifies miR-203 as an interferon-inducible regulator of IFIT1/ISG56. J Virol. 2013;87:9260-70 pubmed publisher
    ..Results indicate that miR-203 is an IFN-inducible miRNA that can negatively regulate a number of cellular mRNAs, including an IFN-stimulated gene target, IFIT1/ISG56, by destabilizing its mRNA transcript. ..
  6. Buggele W, Krause K, Horvath C. Small RNA profiling of influenza A virus-infected cells identifies miR-449b as a regulator of histone deacetylase 1 and interferon beta. PLoS ONE. 2013;8:e76560 pubmed publisher
  7. Cassidy J, Jha A, Posadas D, Giri R, Venken K, Ji J, et al. miR-9a minimizes the phenotypic impact of genomic diversity by buffering a transcription factor. Cell. 2013;155:1556-67 pubmed publisher
    ..These findings reveal that microRNA-target interactions may be a key mechanism by which the impact of genomic diversity on cell behavior is dampened...