Experts and Doctors on genetic transduction in Chicago, Illinois, United States


Locale: Chicago, Illinois, United States
Topic: genetic transduction

Top Publications

  1. DeKoter R, Lee H, Singh H. PU.1 regulates expression of the interleukin-7 receptor in lymphoid progenitors. Immunity. 2002;16:297-309 pubmed
    ..1 in early B cell development, it is not required. These results demonstrate that PU.1 functions to regulate early B cell development in part by controlling the expression of the IL-7Ralpha gene. ..
  2. Mahmud N, Pang W, Cobbs C, Alur P, Borneman J, Dodds R, et al. Studies of the route of administration and role of conditioning with radiation on unrelated allogeneic mismatched mesenchymal stem cell engraftment in a nonhuman primate model. Exp Hematol. 2004;32:494-501 pubmed
  3. Lee K, Bhawan S, Majima T, Wei H, Nishimura M, Yagita H, et al. Cutting edge: the NK cell receptor 2B4 augments antigen-specific T cell cytotoxicity through CD48 ligation on neighboring T cells. J Immunol. 2003;170:4881-5 pubmed
    ..Therefore, 2B4 functions as a costimulator of CD8(+) T cells in MHC-restricted cytotoxicity. We conclude that 2B4/CD48 interactions among T cells themselves can augment CTL lysis of their specific targets. ..
  4. Alappat E, Volkland J, Peter M. Cell cycle effects by C-FADD depend on its C-terminal phosphorylation site. J Biol Chem. 2003;278:41585-8 pubmed
    ..Our data suggest that C-FADD may affect apoptosis sensitivity of cells by interfering with cell cycle progression and not only by binding to death receptors. ..
  5. Mutlu G, Dumasius V, Burhop J, McShane P, Meng F, Welch L, et al. Upregulation of alveolar epithelial active Na+ transport is dependent on beta2-adrenergic receptor signaling. Circ Res. 2004;94:1091-100 pubmed
    ..These findings indicate that betaAR signaling may not be necessary for basal AFC, and that beta2AR is essential for the adaptive physiological response needed to clear excess fluid from the alveolar airspace of normal and injured lungs. ..
  6. Horvat Switzer R, Thompson A. HOXA11 mutation in amegakaryocytic thrombocytopenia with radio-ulnar synostosis syndrome inhibits megakaryocytic differentiation in vitro. Blood Cells Mol Dis. 2006;37:55-63 pubmed
    ..Taken together, these data begin to give us insight into the molecular mechanisms by which HoxA11 may be involved in regulating megakaryocytic differentiation...
  7. Merrill B. Develop-WNTs in somatic cell reprogramming. Cell Stem Cell. 2008;3:465-6 pubmed publisher
    ..2008) show that Wnt-beta-catenin signaling stimulates nuclear reprogramming. These two studies, using distinct reprogramming methods, offer insights into the mechanisms underlying acquisition and maintenance of pluripotency. ..
  8. Hakansson S, Caffrey M. Structural and dynamic properties of the HIV-1 tat transduction domain in the free and heparin-bound states. Biochemistry. 2003;42:8999-9006 pubmed
    ..69 in the presence of heparin). A model for the first step of TTD-mediated entry into cells is presented. ..
  9. Cabana V, Feng N, Reardon C, Lukens J, Webb N, de Beer F, et al. Influence of apoA-I and apoE on the formation of serum amyloid A-containing lipoproteins in vivo and in vitro. J Lipid Res. 2004;45:317-25 pubmed
    ..In the absence of both apoA-I and apoE, SAA-HDL is not formed and SAA associates with any available lipoprotein. ..

More Information


  1. Yu P, Lee Y, Liu W, Chin R, Wang J, Wang Y, et al. Priming of naive T cells inside tumors leads to eradication of established tumors. Nat Immunol. 2004;5:141-9 pubmed
    ..Our study indicates that targeting the tumor barrier may be an effective strategy for cancer immunotherapy. ..
  2. Zhang C, Chaturvedi D, Jaggar L, Magnuson D, Lee J, Patel T. Regulation of vascular smooth muscle cell proliferation and migration by human sprouty 2. Arterioscler Thromb Vasc Biol. 2005;25:533-8 pubmed
    ..We conclude that TAT-tagged proteins are efficiently transduced into VSMCs in vitro and in vivo, that hSPRY2 inhibits growth and migration of VSMCs, and that this protein can decrease neointimal growth after blood vessel injury. ..
  3. Markovitz A. A new in vivo termination function for DNA polymerase I of Escherichia coli K12. Mol Microbiol. 2005;55:1867-82 pubmed
    ..To explain these results we propose a new in vivo function for wild-type DNA polymerase I in chromosome termination at site(s) not yet identified. ..
  4. Poon A, Gu H, Roizman B. ICP0 and the US3 protein kinase of herpes simplex virus 1 independently block histone deacetylation to enable gene expression. Proc Natl Acad Sci U S A. 2006;103:9993-8 pubmed
    ..We conclude that the U(S)3 protein kinase blocks histone deacetylation by a mechanism distinct from that of ICP0 and that debilitated histone deacetylation contributes to the permissiveness of U2OS cells for DeltaICP0 mutants. ..
  5. Benetti L, Roizman B. In transduced cells, the US3 protein kinase of herpes simplex virus 1 precludes activation and induction of apoptosis by transfected procaspase 3. J Virol. 2007;81:10242-8 pubmed
  6. Kaufman H, Kim D, DeRaffele G, Mitcham J, Coffin R, Kim Schulze S. Local and distant immunity induced by intralesional vaccination with an oncolytic herpes virus encoding GM-CSF in patients with stage IIIc and IV melanoma. Ann Surg Oncol. 2010;17:718-30 pubmed publisher
    ..Direct injection of Oncovex(GM-CSF) induces local and systemic antigen-specific T cell responses and decreases Treg, Ts, and MDSC in patients exhibiting therapeutic responses. ..