Experts and Doctors on colonic neoplasms in Evanston, Illinois, United States


Locale: Evanston, Illinois, United States
Topic: colonic neoplasms

Top Publications

  1. Kunte D, Wali R, Koetsier J, Roy H. Antiproliferative effect of sulindac in colonic neoplasia prevention: role of COOH-terminal Src kinase. Mol Cancer Ther. 2008;7:1797-806 pubmed publisher
    ..01). Thus, this is the first demonstration that the antiproliferative activity of NSAID is modulated, at least partly, through the Csk/Src axis. ..
  2. Roy H, Koetsier J, Tiwari A, Joshi S, Kunte D, Ward T, et al. Involvement of p21cip1/waf1 in the anti-proliferative effects of polyethylene glycol in colon carcinogenesis. Int J Oncol. 2011;38:529-36 pubmed publisher
    ..These results demonstrate for the first time that PEG is involved in p21 regulation concomitant with G1S phase cell cycle arrest and it is through these effects that it can exert its anti-proliferative and hence chemopreventive role. ..
  3. Tiwari A, Crawford S, Radosevich A, Wali R, Stypula Y, Kunte D, et al. Neo-angiogenesis and the premalignant micro-circulatory augmentation of early colon carcinogenesis. Cancer Lett. 2011;306:205-13 pubmed publisher
    ..This finding has potential implications as a biomarker for risk-stratification and target for chemoprevention. ..
  4. Gomes A, Ruderman S, Delacruz M, Wali R, Roy H, Backman V. In vivo measurement of the shape of the tissue-refractive-index correlation function and its application to detection of colorectal field carcinogenesis. J Biomed Opt. 2012;17:047005 pubmed publisher
    ..These results suggest that noninvasive measurement of the shape of the refractive-index correlation function could be a promising marker of early cancer development. ..
  5. Mutyal N, Radosevich A, Tiwari A, Stypula Y, Wali R, Kunte D, et al. Biological mechanisms underlying structural changes induced by colorectal field carcinogenesis measured with low-coherence enhanced backscattering (LEBS) spectroscopy. PLoS ONE. 2013;8:e57206 pubmed publisher
  6. Gomes A, Backman V. Algorithm for automated selection of application-specific fiber-optic reflectance probes. J Biomed Opt. 2013;18:27012 pubmed publisher
    ..The software has been applied to biological case studies. ..
  7. Qi W, Fitchev P, Cornwell M, Greenberg J, Cabe M, Weber C, et al. FOXO3 growth inhibition of colonic cells is dependent on intraepithelial lipid droplet density. J Biol Chem. 2013;288:16274-81 pubmed publisher
    ..Taken together, FOXO3 and LDs might serve as new targets for therapeutic intervention of colon cancer. ..
  8. Roy H, Smyrk T, Koetsier J, Victor T, Wali R. The transcriptional repressor SNAIL is overexpressed in human colon cancer. Dig Dis Sci. 2005;50:42-6 pubmed
    ..11). In conclusion, we demonstrate, for the first time, that SNAIL is upregulated in human colon cancer, which potentially may have significance in control of metastasis and possibly serve as a target for chemopreventive agents. ..
  9. Wali R, Roy H, Kim Y, Liu Y, Koetsier J, Kunte D, et al. Increased microvascular blood content is an early event in colon carcinogenesis. Gut. 2005;54:654-60 pubmed
    ..These findings may provide novel insights into early biological events in colorectal carcinogenesis and have potential applicability for screening. ..

More Information


  1. Kunte D, Wali R, Koetsier J, Hart J, Kostjukova M, Kilimnik A, et al. Down-regulation of the tumor suppressor gene C-terminal Src kinase: an early event during premalignant colonic epithelial hyperproliferation. FEBS Lett. 2005;579:3497-502 pubmed
    ..Thus, we demonstrate, for the first time, that Csk suppression is an important early event in colorectal cancer pathogenesis. ..
  2. Roy H, Kim Y, Wali R, Liu Y, Koetsier J, Kunte D, et al. Spectral markers in preneoplastic intestinal mucosa: an accurate predictor of tumor risk in the MIN mouse. Cancer Epidemiol Biomarkers Prev. 2005;14:1639-45 pubmed
    ..Moreover, the reversal of spectral markers by celecoxib treatment supports the neoplastic relevance. ..
  3. Brand R, Jones D, Lynch H, Brand R, Watson P, Ashwathnayaran R, et al. Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling: Influence of smoking. World J Gastroenterol. 2006;12:4485-91 pubmed
    ..These data demonstrate that fuzzy modeling may enable formulation of clinical risk scores, thereby allowing individualization of CRC prevention strategies. ..
  4. Roy H, Wali R, Kim Y, Liu Y, Hart J, Kunte D, et al. Inducible nitric oxide synthase (iNOS) mediates the early increase of blood supply (EIBS) in colon carcinogenesis. FEBS Lett. 2007;581:3857-62 pubmed
    ..These data indicate that iNOS induction may have a critical role in augmenting the predysplastic mucosal blood supply and thereby fostering colon carcinogenesis. ..
  5. Qi W, Weber C, Wasland K, Savkovic S. Genistein inhibits proliferation of colon cancer cells by attenuating a negative effect of epidermal growth factor on tumor suppressor FOXO3 activity. BMC Cancer. 2011;11:219 pubmed publisher
    ..These novel anti-proliferative mechanisms of genistein suggest a possible role of combining genistein with other chemoreceptive agents for the treatment of colon cancer. ..
  6. Rubinstein W, Acheson L, O Neill S, Ruffin M, Wang C, Beaumont J, et al. Clinical utility of family history for cancer screening and referral in primary care: a report from the Family Healthware Impact Trial. Genet Med. 2011;13:956-65 pubmed publisher
    ..Engagement of clinicians and patients, integration with clinical decision support, and inclusion of nonfamilial risk factors may be necessary to achieve the full potential of computerized risk assessment. ..
  7. Kunte D, Delacruz M, Wali R, Menon A, Du H, Stypula Y, et al. Dysregulation of microRNAs in colonic field carcinogenesis: implications for screening. PLoS ONE. 2012;7:e45591 pubmed publisher
    ..Based on our results, we propose an accurate, inexpensive, non-invasive miRNA test for CRC risk stratification based on rectal brushings or from abraded fecal colonocytes. ..