Experts and Doctors on animals in Urbana, United States

Summary

Locale: Urbana, United States
Topic: animals

Top Publications

  1. Tomaszewski J, Joseph A, Archambeault D, Yao H. Essential roles of inhibin beta A in mouse epididymal coiling. Proc Natl Acad Sci U S A. 2007;104:11322-7 pubmed
    ..These results demonstrated that Inhba, a mesenchyme-specific gene, acts collectively with testosterone to facilitate epididymal coiling by stimulating epithelial proliferation. ..
  2. Holsberger D, Jirawatnotai S, Kiyokawa H, Cooke P. Thyroid hormone regulates the cell cycle inhibitor p27Kip1 in postnatal murine Sertoli cells. Endocrinology. 2003;144:3732-8 pubmed
    ..These results indicate that thyroid hormone status affects p27(Kip1) expression in neonatal Sertoli cells, suggesting that T(3) effects on Sertoli cell proliferation may be mediated through this CDKI. ..
  3. Schnulle P, Hurley W. Sequence and expression of the FcRn in the porcine mammary gland. Vet Immunol Immunopathol. 2003;91:227-31 pubmed
    ..These results indicate that the FcRn is expressed in porcine mammary tissue and are consistent with the hypothesis that FcRn may have a role in mammary gland immunoglobulin transport during colostrogenesis. ..
  4. Lueders T, Zou K, Huntsman H, Meador B, Mahmassani Z, Abel M, et al. The α7β1-integrin accelerates fiber hypertrophy and myogenesis following a single bout of eccentric exercise. Am J Physiol Cell Physiol. 2011;301:C938-46 pubmed publisher
    ..Further studies are necessary to elucidate the precise mechanism by which the α(7)-integrin can enhance muscle hypertrophy following exercise. ..
  5. Bai L, Livnat I, Romanova E, Alexeeva V, Yau P, Vilim F, et al. Characterization of GdFFD, a D-amino acid-containing neuropeptide that functions as an extrinsic modulator of the Aplysia feeding circuit. J Biol Chem. 2013;288:32837-51 pubmed publisher
    ..Our data indicate that the modification of an L-amino acid-containing neuropeptide to a DAACP is essential for peptide bioactivity in a motor circuit, and thus it provides a functional significance to this modification...
  6. Wolfe A, Henry J. Neuronal leucine-rich repeat 6 (XlNLRR-6) is required for late lens and retina development in Xenopus laevis. Dev Dyn. 2006;235:1027-41 pubmed
    ..These findings represent the first in vivo functional analysis of an NLRR family protein and establish a role for this protein during late differentiation of tissues in the developing eye. ..
  7. Wang Q, Xian W, Li S, Liu C, Padua G. Topography and biocompatibility of patterned hydrophobic/hydrophilic zein layers. Acta Biomater. 2008;4:844-51 pubmed publisher
    ..This property may be useful in controlling the spatial distribution of cells on patterned protein layers. ..
  8. Ford N, Clinton S, von Lintig J, Wyss A, Erdman J. Loss of carotene-9',10'-monooxygenase expression increases serum and tissue lycopene concentrations in lycopene-fed mice. J Nutr. 2010;140:2134-8 pubmed publisher
    ..In conclusion, the loss of CMO-II expression leads to increased serum and tissue concentrations of lycopene in tomato-fed mice. ..
  9. Wang L, Kamath A, Frye J, Iwamoto G, Chun J, Berry S. Aorta-derived mesoangioblasts differentiate into the oligodendrocytes by inhibition of the Rho kinase signaling pathway. Stem Cells Dev. 2012;21:1069-89 pubmed publisher
    ....
  10. Caliari S, Weisgerber D, Ramirez M, Kelkhoff D, Harley B. The influence of collagen-glycosaminoglycan scaffold relative density and microstructural anisotropy on tenocyte bioactivity and transcriptomic stability. J Mech Behav Biomed Mater. 2012;11:27-40 pubmed publisher
    ..Overall, this work demonstrates that relative density is a critical scaffold parameter, not only for insuring mechanical competence, but also for directing cell transcriptomic stability and behavior. ..

Locale

Detail Information

Publications62

  1. Tomaszewski J, Joseph A, Archambeault D, Yao H. Essential roles of inhibin beta A in mouse epididymal coiling. Proc Natl Acad Sci U S A. 2007;104:11322-7 pubmed
    ..These results demonstrated that Inhba, a mesenchyme-specific gene, acts collectively with testosterone to facilitate epididymal coiling by stimulating epithelial proliferation. ..
  2. Holsberger D, Jirawatnotai S, Kiyokawa H, Cooke P. Thyroid hormone regulates the cell cycle inhibitor p27Kip1 in postnatal murine Sertoli cells. Endocrinology. 2003;144:3732-8 pubmed
    ..These results indicate that thyroid hormone status affects p27(Kip1) expression in neonatal Sertoli cells, suggesting that T(3) effects on Sertoli cell proliferation may be mediated through this CDKI. ..
  3. Schnulle P, Hurley W. Sequence and expression of the FcRn in the porcine mammary gland. Vet Immunol Immunopathol. 2003;91:227-31 pubmed
    ..These results indicate that the FcRn is expressed in porcine mammary tissue and are consistent with the hypothesis that FcRn may have a role in mammary gland immunoglobulin transport during colostrogenesis. ..
  4. Lueders T, Zou K, Huntsman H, Meador B, Mahmassani Z, Abel M, et al. The α7β1-integrin accelerates fiber hypertrophy and myogenesis following a single bout of eccentric exercise. Am J Physiol Cell Physiol. 2011;301:C938-46 pubmed publisher
    ..Further studies are necessary to elucidate the precise mechanism by which the α(7)-integrin can enhance muscle hypertrophy following exercise. ..
  5. Bai L, Livnat I, Romanova E, Alexeeva V, Yau P, Vilim F, et al. Characterization of GdFFD, a D-amino acid-containing neuropeptide that functions as an extrinsic modulator of the Aplysia feeding circuit. J Biol Chem. 2013;288:32837-51 pubmed publisher
    ..Our data indicate that the modification of an L-amino acid-containing neuropeptide to a DAACP is essential for peptide bioactivity in a motor circuit, and thus it provides a functional significance to this modification...
  6. Wolfe A, Henry J. Neuronal leucine-rich repeat 6 (XlNLRR-6) is required for late lens and retina development in Xenopus laevis. Dev Dyn. 2006;235:1027-41 pubmed
    ..These findings represent the first in vivo functional analysis of an NLRR family protein and establish a role for this protein during late differentiation of tissues in the developing eye. ..
  7. Wang Q, Xian W, Li S, Liu C, Padua G. Topography and biocompatibility of patterned hydrophobic/hydrophilic zein layers. Acta Biomater. 2008;4:844-51 pubmed publisher
    ..This property may be useful in controlling the spatial distribution of cells on patterned protein layers. ..
  8. Ford N, Clinton S, von Lintig J, Wyss A, Erdman J. Loss of carotene-9',10'-monooxygenase expression increases serum and tissue lycopene concentrations in lycopene-fed mice. J Nutr. 2010;140:2134-8 pubmed publisher
    ..In conclusion, the loss of CMO-II expression leads to increased serum and tissue concentrations of lycopene in tomato-fed mice. ..
  9. Wang L, Kamath A, Frye J, Iwamoto G, Chun J, Berry S. Aorta-derived mesoangioblasts differentiate into the oligodendrocytes by inhibition of the Rho kinase signaling pathway. Stem Cells Dev. 2012;21:1069-89 pubmed publisher
    ....
  10. Caliari S, Weisgerber D, Ramirez M, Kelkhoff D, Harley B. The influence of collagen-glycosaminoglycan scaffold relative density and microstructural anisotropy on tenocyte bioactivity and transcriptomic stability. J Mech Behav Biomed Mater. 2012;11:27-40 pubmed publisher
    ..Overall, this work demonstrates that relative density is a critical scaffold parameter, not only for insuring mechanical competence, but also for directing cell transcriptomic stability and behavior. ..
  11. Crandall S, Cox C. Thalamic microcircuits: presynaptic dendrites form two feedforward inhibitory pathways in thalamus. J Neurophysiol. 2013;110:470-80 pubmed publisher
    ....
  12. Walker A, Budac D, Bisulco S, Lee A, Smith R, Beenders B, et al. NMDA receptor blockade by ketamine abrogates lipopolysaccharide-induced depressive-like behavior in C57BL/6J mice. Neuropsychopharmacology. 2013;38:1609-16 pubmed publisher
    ..These findings indicate that LPS-induced depressive-like behavior is mediated by NMDA receptor activation, probably as a consequence of formation of quinolinic acid. ..
  13. Nagy D, Tyler J, Stoker A, Kleiboeker S. Association between the strength of serologic recognition of bovine leukosis virus and lymphocyte count in bovine leukosis virus-infected cows. J Am Vet Med Assoc. 2002;220:1681-4 pubmed
    ..To determine whether strength of serologic recognition of bovine leukosis virus (BLV) by use of ELISA is associated with blood lymphocyte counts...
  14. Smith S, Choi S, Collins J, Travers R, Cooley B, Morrissey J. Inhibition of polyphosphate as a novel strategy for preventing thrombosis and inflammation. Blood. 2012;120:5103-10 pubmed publisher
    ..This study provides proof of principle for polyphosphate inhibitors as antithrombotic/anti-inflammatory agents in vitro and in vivo, with a novel mode of action compared with conventional anticoagulants. ..
  15. Li L, Moroz T, Garden R, Floyd P, Weiss K, Sweedler J. Mass spectrometric survey of interganglionically transported peptides in Aplysia. Peptides. 1998;19:1425-33 pubmed
    ..Furthermore, novel processing products of the L5-67 precursor peptide and the APGWamide/cerebral peptide 1 prohormone are strongly suggested, and their interganglionic transport demonstrated...
  16. Vester B, Beloshapka A, Middelbos I, Burke S, Dikeman C, Simmons L, et al. Evaluation of nutrient digestibility and fecal characteristics of exotic felids fed horse- or beef-based diets: use of the domestic cat as a model for exotic felids. Zoo Biol. 2010;29:432-48 pubmed publisher
    ..Decreased nutrient digestibility by tigers and jaguars should be considered when developing feeding recommendations for these species based on domestic cat data. ..
  17. Valero M, Huntsman H, Liu J, Zou K, Boppart M. Eccentric exercise facilitates mesenchymal stem cell appearance in skeletal muscle. PLoS ONE. 2012;7:e29760 pubmed publisher
    ..The results from this study also support a role for the α7 integrin and/or mMSCs in molecular- and cellular-based therapeutic strategies that can effectively combat disuse muscle atrophy. ..
  18. Bionaz M, Loor J. Gene networks driving bovine milk fat synthesis during the lactation cycle. BMC Genomics. 2008;9:366 pubmed publisher
    ..g., SCD). Longitudinal mRNA expression allowed development of transcriptional regulation networks and an updated model of milk fat synthesis regulation. ..
  19. Brown R, McDonnell C, Berenbaum M, Schuler M. Regulation of an insect cytochrome P450 monooxygenase gene (CYP6B1) by aryl hydrocarbon and xanthotoxin response cascades. Gene. 2005;358:39-52 pubmed
    ....
  20. Simon L, Ekman G, Kostereva N, Zhang Z, Hess R, Hofmann M, et al. Direct transdifferentiation of stem/progenitor spermatogonia into reproductive and nonreproductive tissues of all germ layers. Stem Cells. 2009;27:1666-75 pubmed publisher
    ..The ability of stem/progenitor spermatogonia to directly generate various epithelia emphasizes their clinical potential, and if adult human SSCs have similar properties, this may have applications in human regenerative medicine...
  21. Niu G, Siegel J, Schuler M, Berenbaum M. Comparative toxicity of mycotoxins to navel orangeworm (Amyelois transitella) and corn earworm (Helicoverpa zea). J Chem Ecol. 2009;35:951-7 pubmed publisher
    ..zea. Our studies indicate that A. transitella, although a hostplant generalist, may well be highly specialized for mycotoxin detoxification. ..
  22. Kadirvel G, Machado S, Korneli C, Collins E, Miller P, Bess K, et al. Porcine sperm bind to specific 6-sialylated biantennary glycans to form the oviduct reservoir. Biol Reprod. 2012;87:147 pubmed publisher
    ..These results demonstrate that sperm binding to oviduct 6-sialylated biantennary glycans is necessary for normal adhesion to the oviduct. ..
  23. Schultz J, Loven M, Melvin V, Edwards D, Nardulli A. Differential modulation of DNA conformation by estrogen receptors alpha and beta. J Biol Chem. 2002;277:8702-7 pubmed
    ....
  24. Schoenherr C, Levorse J, Tilghman S. CTCF maintains differential methylation at the Igf2/H19 locus. Nat Genet. 2003;33:66-9 pubmed
    ..Conversely, maternal H19 expression is reduced, suggesting a positive role for CTCF in the transcription of that gene. This study constitutes the first in vivo demonstration of the multiple functions of CTCF in an ICR. ..
  25. DeLucia E, Nabity P, Zavala J, Berenbaum M. Climate change: resetting plant-insect interactions. Plant Physiol. 2012;160:1677-85 pubmed publisher
  26. MacNeill A, Moldawer L, Moyer R. The role of the cowpox virus crmA gene during intratracheal and intradermal infection of C57BL/6 mice. Virology. 2009;384:151-60 pubmed publisher
    ..d. inoculation. This suggests that the host immune response differs in the two routes of infection and emphasizes the need to consider the effect of route of infection when examining functions of virulence factors in vivo...
  27. Vasenkova I, Luginbuhl D, Chiba A. Gliopodia extend the range of direct glia-neuron communication during the CNS development in Drosophila. Mol Cell Neurosci. 2006;31:123-30 pubmed
    ..We propose that gliopodia extend the range of direct glia-neuron communication during CNS development. ..
  28. Bergmann K, Landvatter S, Rocque P, Carlson K, Welch M, Katzenellenbogen J. Oxohexestrol derivatives labeled with fluorine-18. Synthesis, receptor binding and in vivo distribution of two non-steroidal estrogens as potential breast tumor imaging agents. Nucl Med Biol. 1994;21:25-39 pubmed
    ..The specific and non-specific components of target tissue uptake of these two compounds appear to be directly related to their non-specific binding and their binding selectivity. ..
  29. Wilund K, Feeney L, Tomayko E, Chung H, Kim K. Endurance exercise training reduces gallstone development in mice. J Appl Physiol (1985). 2008;104:761-5 pubmed publisher
    ..This suggests a mechanism by which exercise improves cholesterol clearance from the circulation while simultaneously inhibiting gallstone formation...
  30. Stein H, Seve B, Fuller M, Moughan P, de Lange C. Invited review: Amino acid bioavailability and digestibility in pig feed ingredients: terminology and application. J Anim Sci. 2007;85:172-80 pubmed
    ..It is suggested that SID values should be used for feed formulation, at least until more information on TID values becomes available. ..
  31. Wilund K, Rosenblat M, Chung H, Volkova N, Kaplan M, Woods J, et al. Macrophages from alpha 7 nicotinic acetylcholine receptor knockout mice demonstrate increased cholesterol accumulation and decreased cellular paraoxonase expression: a possible link between the nervous system and atherosclerosis development. Biochem Biophys Res Commun. 2009;390:148-54 pubmed publisher
    ..The above results suggest an anti-atherogenic role for the macrophage alpha7nAchr, through a mechanism that involves attenuated macrophage oxidative stress and decreased uptake of oxidized LDL. ..
  32. Che T, Adeola O, Azain M, Carter S, Cromwell G, Hill G, et al. Effect of dietary acids on growth performance of nursery pigs: a cooperative study. J Anim Sci. 2012;90:4408-13 pubmed publisher
    ..05). In summary, under the conditions of this experiment, the acid treatments had no effect but the antibiotic improved growth performance...
  33. Valdez R, Gelberg H, Morin D, Zuckermann F. Use of corticosteroids and aurothioglucose in a pygmy goat with pemphigus foliaceus. J Am Vet Med Assoc. 1995;207:761-5 pubmed
    ....
  34. Boppart M, Burkin D, Kaufman S. Alpha7beta1-integrin regulates mechanotransduction and prevents skeletal muscle injury. Am J Physiol Cell Physiol. 2006;290:C1660-5 pubmed
    ..These experiments provide the first evidence that alpha7beta1-integrin is a negative regulator of mechanotransduction in vivo and provides resistance to exercise-induced muscle damage. ..
  35. Lasker M, Gajjar M, Nair S. Cutting edge: molecular structure of the IL-1R-associated kinase-4 death domain and its implications for TLR signaling. J Immunol. 2005;175:4175-9 pubmed
    ..This structure can be used as a framework for future mutation and deletion studies and potential drug design. ..
  36. Lee H, Zhao S, Fields P, Sherwood O. The extent to which relaxin promotes proliferation and inhibits apoptosis of cervical epithelial and stromal cells is greatest during late pregnancy in rats. Endocrinology. 2005;146:511-8 pubmed
    ..In conclusion, this study provides evidence that the extent to which relaxin promotes proliferation and inhibits apoptosis of cervical epithelial and stromal cells is greatest during late pregnancy. ..
  37. Polk J. Influences of limb proportions and body size on locomotor kinematics in terrestrial primates and fossil hominins. J Hum Evol. 2004;47:237-52 pubmed
    ..Such differences may also have characterized the gait of Homo sapiens in comparison to Neanderthals, but more experimental data on humans that vary in limb proportions are necessary in order to evaluate this question more thoroughly...
  38. Grimm J, Grimm K, Kneller S, Tranquilli W, Crochik S, Bischoff M, et al. The effect of a combination of medetomidine-butorphanol and medetomidine, butorphanol, atropine on glomerular filtration rate in dogs. Vet Radiol Ultrasound. 2001;42:458-62 pubmed
    ....
  39. Liu Z, Wiedmeyer C, Sisson D, Solter P. Cloning and characterization of feline brain natriuretic peptide. Gene. 2002;292:183-90 pubmed
    ..Based on the similarity of BNP prepropeptide sequences, a phylogenetic relationship is presented for mammalian species including human, cat, cattle, dog, mouse, rat, sheep and swine. ..
  40. Uebing Czipura A, Dawson H, Rutherford M, Scherba G. Transcriptome profile and cytogenetic analysis of immortalized neuronally restricted progenitor cells derived from the porcine olfactory bulb. Anim Biotechnol. 2009;20:186-215 pubmed publisher
    ....
  41. Broadus J, Skeath J, Spana E, Bossing T, Technau G, Doe C. New neuroblast markers and the origin of the aCC/pCC neurons in the Drosophila central nervous system. Mech Dev. 1995;53:393-402 pubmed
    ..These results are supported by DiI cell lineage analysis of neuroblasts identified in vivo. ..
  42. Chun T, Hermel E, Aldrich C, Gaskins H. Pig lmp7 proteasome subunit cDNA cloning and expression analysis. Immunogenetics. 1999;49:72-7 pubmed
  43. Tripathy D. Swinepox virus as a vaccine vector for swine pathogens. Adv Vet Med. 1999;41:463-80 pubmed
    ....
  44. Montano M, Ekena K, Delage Mourroux R, Chang W, Martini P, Katzenellenbogen B. An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens. Proc Natl Acad Sci U S A. 1999;96:6947-52 pubmed
    ....
  45. Toma D, Bloch G, Moore D, Robinson G. Changes in period mRNA levels in the brain and division of labor in honey bee colonies. Proc Natl Acad Sci U S A. 2000;97:6914-9 pubmed
    ..These results extend the regulation of a "clock gene" to a social context and suggest that there are connections at the molecular level between division of labor and chronobiology in social insects. ..
  46. Wang Y, Zayas R, Guo T, Newmark P. nanos function is essential for development and regeneration of planarian germ cells. Proc Natl Acad Sci U S A. 2007;104:5901-6 pubmed
    ..Our results reveal a conserved function of nanos in germ cell development in planarians and suggest that these animals will serve as useful models for dissecting the molecular basis of epigenetic germ cell specification...
  47. Kim J, Yoon M, Chen J. Signal transducer and activator of transcription 3 (STAT3) mediates amino acid inhibition of insulin signaling through serine 727 phosphorylation. J Biol Chem. 2009;284:35425-32 pubmed publisher
    ....
  48. McAllister R, Singh Y, du Bois W, Potter M, Boehm T, Meeker N, et al. Susceptibility to anthrax lethal toxin is controlled by three linked quantitative trait loci. Am J Pathol. 2003;163:1735-41 pubmed
    ..Additionally, to recapitulate dominant resistance to mortality as seen in (BALB/c x DBA/2) F(1) hybrids, DBA/2 alleles are required at all three QTL. ..
  49. Cheng H, Clayton D. Activation and habituation of extracellular signal-regulated kinase phosphorylation in zebra finch auditory forebrain during song presentation. J Neurosci. 2004;24:7503-13 pubmed publisher
    ....
  50. Gal A, Ridge T, Graves T. Cloning and sequencing of the calcium-sensing receptor from the feline parathyroid gland. Domest Anim Endocrinol. 2010;38:57-61 pubmed publisher
    ..The fCaSR has 96%, 96%, and 94% homology to the canine, human, and bovine amino acid sequences, respectively. ..
  51. Liu J, Gurpur P, Kaufman S. Genetically determined proteolytic cleavage modulates alpha7beta1 integrin function. J Biol Chem. 2008;283:35668-78 pubmed publisher
    ....
  52. Murnane R, Wright R, Ahern Rindell A, Prieur D. Prenatal lesions in an ovine fetus with GM1 gangliosidosis. Am J Med Genet. 1991;39:106-11 pubmed
    ....
  53. McCusker R, Novakofski J. Zinc partitions insulin-like growth factors (IGFs) from soluble IGF binding protein (IGFBP)-5 to the cell surface receptors of BC3H-1 muscle cells. J Cell Physiol. 2003;197:388-99 pubmed
    ..Zn(2+) was active at physiological doses depressing IGF binding to IGFBP-5 and the IGF-2R at 15-20 microM. Hence, a novel mechanism is further characterized by which the trace micronutrient Zn(2+) could regulate IGF activity. ..
  54. Kuzminov A. DNA replication meets genetic exchange: chromosomal damage and its repair by homologous recombination. Proc Natl Acad Sci U S A. 2001;98:8461-8 pubmed
    ..In vitro properties of the eukaryotic recombinases suggest a bigger role for single-strand annealing in the eukaryotic recombinational repair. ..
  55. Hess R, Nakai M. Histopathology of the male reproductive system induced by the fungicide benomyl. Histol Histopathol. 2000;15:207-24 pubmed publisher
    ..Lesions in the male track that cause blockage may induce permanent testicular damage and a decrease in sperm production...
  56. Everts van der Wind A, Larkin D, Green C, Elliott J, Olmstead C, Chiu R, et al. A high-resolution whole-genome cattle-human comparative map reveals details of mammalian chromosome evolution. Proc Natl Acad Sci U S A. 2005;102:18526-31 pubmed
    ....
  57. Mantena S, Kannan A, Cheon Y, Li Q, Johnson P, Bagchi I, et al. C/EBPbeta is a critical mediator of steroid hormone-regulated cell proliferation and differentiation in the uterine epithelium and stroma. Proc Natl Acad Sci U S A. 2006;103:1870-5 pubmed
    ..Collectively, our studies established that C/EBPbeta is a key mediator of steroid responsiveness of the epithelium and stroma in the mouse uterus. ..
  58. Meyers S, RODRIGUEZ ZAS S, Beever J. Fine-mapping of a QTL influencing pork tenderness on porcine chromosome 2. BMC Genet. 2007;8:69 pubmed
    ..Furthermore, additional resources have been generated for the targeted investigation of other putative QTL on SSC2q, which may lead to further advancements in pork quality. ..
  59. Roberts Galbraith R, Newmark P. Follistatin antagonizes activin signaling and acts with notum to direct planarian head regeneration. Proc Natl Acad Sci U S A. 2013;110:1363-8 pubmed publisher
    ....
  60. Messick J, Berent L, Cooper S. Development and evaluation of a PCR-based assay for detection of Haemobartonella felis in cats and differentiation of H. felis from related bacteria by restriction fragment length polymorphism analysis. J Clin Microbiol. 1998;36:462-6 pubmed
    ..felis from closely related bacteria was examined. This is the first report of the utility of PCR-facilitated diagnosis and discrimination of H. felis infection in cats...
  61. Mao W, Schuler M, Berenbaum M. Honey constituents up-regulate detoxification and immunity genes in the western honey bee Apis mellifera. Proc Natl Acad Sci U S A. 2013;110:8842-6 pubmed publisher
    ..The widespread apicultural use of honey substitutes, including high-fructose corn syrup, may thus compromise the ability of honey bees to cope with pesticides and pathogens and contribute to colony losses. ..
  62. Doane D, Lawson M, Meade J, Kotz C, Beverly J. Orexin-induced feeding requires NMDA receptor activation in the perifornical region of the lateral hypothalamus. Am J Physiol Regul Integr Comp Physiol. 2007;293:R1022-6 pubmed
    ..2 +/- 0.5 g). There was no effect of d-AP5 alone on food intake. These data support glutamatergic systems in the LH/PFA mediating the feeding response to orexin-A through NMDA receptors. ..