Genomes and Genes
Experts and Doctors on orthomyxoviridae infections in Atlanta, Georgia, United States
Locale: Atlanta, Georgia, United States
Topic: orthomyxoviridae infections
- Yoo D, Kim M, Park M, Song J, Quan F, Park K, et al. Protective effect of Korean red ginseng extract on the infections by H1N1 and H3N2 influenza viruses in mice. J Med Food. 2012;15:855-62 pubmed publisher..This study provides evidence that intake of ginseng extract will have beneficial effects on preventing lethal infection with newly emerging influenza viruses. ..
- Belser J, Katz J, Tumpey T. The ferret as a model organism to study influenza A virus infection. Dis Model Mech. 2011;4:575-9 pubmed publisher..We highlight the recent and emerging uses of this species in influenza virus research that are advancing our understanding of virus-host interactions. ..
- Sun X, Jayaraman A, Maniprasad P, Raman R, Houser K, Pappas C, et al. N-linked glycosylation of the hemagglutinin protein influences virulence and antigenicity of the 1918 pandemic and seasonal H1N1 influenza A viruses. J Virol. 2013;87:8756-66 pubmed publisher..These results demonstrate that glycosylation patterns of the 1918 and seasonal H1N1 viruses directly contribute to differences in virulence and are partially responsible for their distinct antigenicity. ..
- Biggerstaff M, Reed C, Epperson S, Jhung M, Gambhir M, Bresee J, et al. Estimates of the number of human infections with influenza A(H3N2) variant virus, United States, August 2011-April 2012. Clin Infect Dis. 2013;57 Suppl 1:S12-5 pubmed publisher..Illness from this variant influenza virus was more frequent than previously thought. Continued surveillance is needed to ensure timely detection and response to H3N2v virus infections. ..
- Skountzou I, Martin M, Wang B, Ye L, Koutsonanos D, Weldon W, et al. Salmonella flagellins are potent adjuvants for intranasally administered whole inactivated influenza vaccine. Vaccine. 2010;28:4103-12 pubmed publisher..Our results reveal a promising perspective for the use of both soluble monomeric and polymeric flagellin as mucosal vaccine adjuvants to improve protection against influenza epidemics as well as a range of other infectious diseases. ..
- Payungporn S, Crawford P, Kouo T, Chen L, Pompey J, Castleman W, et al. Influenza A virus (H3N8) in dogs with respiratory disease, Florida. Emerg Infect Dis. 2008;14:902-8 pubmed publisher..Continued surveillance and antigenic analyses should monitor possible emergence of antigenic variants of canine influenza virus. ..
- Yoo D, Kim M, Park M, Park K, Quan F, Song J, et al. Protective effect of ginseng polysaccharides on influenza viral infection. PLoS ONE. 2012;7:e33678 pubmed publisher..Daily treatment of vaccinated mice with GP improved their survival against heterosubtypic lethal challenge. This study demonstrates the first evidence that GP can be used as a remedy against influenza viral infection. ..
- Song J, Kim Y, Barlow P, Hossain M, Park K, Donis R, et al. Improved protection against avian influenza H5N1 virus by a single vaccination with virus-like particles in skin using microneedles. Antiviral Res. 2010;88:244-7 pubmed publisher..Thus, this study provides evidence that skin delivery of H5 VLP vaccines using microneedles designed for self-administration induces improved protection compared to conventional intramuscular immunization. ..
- Le T, Mironova E, Garcin D, Compans R. Induction of influenza-specific mucosal immunity by an attenuated recombinant Sendai virus. PLoS ONE. 2011;6:e18780 pubmed publisher..These results demonstrate that the GP42-H1 Sendai virus recombinant is able to confer full protection from lethal infection by influenza virus, supporting the conclusion that it is a safe and effective mucosal vaccine vector. ..
- Kim J, Liepkalns J, Reber A, Lu X, Music N, Jacob J, et al. Prior infection with influenza virus but not vaccination leaves a long-term immunological imprint that intensifies the protective efficacy of antigenically drifted vaccine strains. Vaccine. 2016;34:495-502 pubmed publisher..Therefore, influenza infection is a significant priming event that intensifies future vaccine responses against drift strains. ..
- Quan F, Vunnava A, Compans R, Kang S. Virus-like particle vaccine protects against 2009 H1N1 pandemic influenza virus in mice. PLoS ONE. 2010;5:e9161 pubmed publisher..The results indicate that VLPs can be developed into an effective vaccine, which can be rapidly produced and avoid the need to isolate high growth reassortants for egg-based production. ..
- Wilson J, Belser J, DaSilva J, Guo Z, Sun X, Gansebom S, et al. An influenza A virus (H7N9) anti-neuraminidase monoclonal antibody protects mice from morbidity without interfering with the development of protective immunity to subsequent homologous challenge. Virology. 2017;511:214-221 pubmed publisher..Taken together, 3c10-3 highlights the potential use of anti-NA mAb to mitigate influenza virus infection. ..
- Pearce M, Belser J, Houser K, Katz J, Tumpey T. Efficacy of seasonal live attenuated influenza vaccine against virus replication and transmission of a pandemic 2009 H1N1 virus in ferrets. Vaccine. 2011;29:2887-94 pubmed publisher..The results demonstrate that prior immunization with seasonal LAIV or H1N1 virus infection provides some cross-protection against the 2009 H1N1 virus, but had no significant effect on the transmission efficiency of the 2009 H1N1 virus. ..
- Liu F, Sun X, Fairman J, Lewis D, Katz J, Levine M, et al. A cationic liposome-DNA complexes adjuvant (JVRS-100) enhances the immunogenicity and cross-protective efficacy of pre-pandemic influenza A (H5N1) vaccine in ferrets. Virology. 2016;492:197-203 pubmed publisher..JVRS-100 warrants further investigation as a potential adjuvant for influenza vaccines. ..
- Wong K, Gambhir M, Finelli L, Swerdlow D, Ostroff S, Reed C. Transmissibility of variant influenza from Swine to humans: a modeling approach. Clin Infect Dis. 2013;57 Suppl 1:S16-22 pubmed publisher..Although the risk of H3N2v virus infection is small for fair attendees with minimal swine contact, large populations attend agricultural events each year, and human cases will likely occur when infected swine are present. ..
- Tretyakova I, Hidajat R, Hamilton G, Horn N, Nickols B, Prather R, et al. Preparation of quadri-subtype influenza virus-like particles using bovine immunodeficiency virus gag protein. Virology. 2016;487:163-71 pubmed publisher..Electron microscopy showed that Bgag-based VLPs resembled influenza virions with the diameter of 150-200nm. This is the first report of quadri-subtype design for influenza VLP and the use of Bgag for influenza VLP preparation. ..
- Terebuh P, Olsen C, Wright J, Klimov A, Karasin A, Todd K, et al. Transmission of influenza A viruses between pigs and people, Iowa, 2002-2004. Influenza Other Respir Viruses. 2010;4:387-96 pubmed publisher..Influenza virus surveillance among pigs and SW should be encouraged to better understand cross-species transmission and diversity of influenza viruses at the human-swine interface. ..
- Quan F, Compans R, Nguyen H, Kang S. Induction of heterosubtypic immunity to influenza virus by intranasal immunization. J Virol. 2008;82:1350-9 pubmed..This study has significant implications for developing broadly cross-reactive vaccines against newly emerging pathogenic influenza viruses. ..
- Jeisy Scott V, Kim J, Davis W, Cao W, Katz J, Sambhara S. TLR7 recognition is dispensable for influenza virus A infection but important for the induction of hemagglutinin-specific antibodies in response to the 2009 pandemic split vaccine in mice. J Virol. 2012;86:10988-98 pubmed..Taken together, our data demonstrate that TLR7 plays an important role in vaccine-induced humoral immune responses to influenza virus through the interaction with viral RNA present in the split vaccine. ..
- Alymova I, Samarasinghe A, Vogel P, Green A, Weinlich R, McCullers J. A novel cytotoxic sequence contributes to influenza A viral protein PB1-F2 pathogenicity and predisposition to secondary bacterial infection. J Virol. 2014;88:503-15 pubmed publisher..Here we provide evidence suggesting that the newly identified cytotoxic sequence I68, L69, and V70 of A/Puerto Rico/8/34 PB1-F2 contributes to the pathogenesis of both primary viral and secondary bacterial infections. ..
- Rivailler P, Perry I, Jang Y, Davis C, Chen L, Dubovi E, et al. Evolution of canine and equine influenza (H3N8) viruses co-circulating between 2005 and 2008. Virology. 2010;408:71-9 pubmed publisher..Analysis of a limited number of equine influenza viruses suggested substantial separation in the transmission of viruses causing clinically apparent influenza in dogs and horses. ..
- Song J, Wang B, Park K, Van Rooijen N, Quan F, Kim M, et al. Influenza virus-like particles containing M2 induce broadly cross protective immunity. PLoS ONE. 2011;6:e14538 pubmed publisher..These results suggest that presenting M2 on VLPs in a membrane-anchored form is a promising approach for developing broadly cross protective influenza vaccines. ..
- Quan F, Compans R, Cho Y, Kang S. Ginseng and Salviae herbs play a role as immune activators and modulate immune responses during influenza virus infection. Vaccine. 2007;25:272-82 pubmed..Therefore, these results indicate that both ginseng and Salviae play a role as mucosal adjuvants against influenza virus as well as immuno-modulators during influenza virus infection. ..
- Pulit Penaloza J, Simpson N, Yang H, Creager H, Jones J, Carney P, et al. Assessment of Molecular, Antigenic, and Pathological Features of Canine Influenza A(H3N2) Viruses That Emerged in the United States. J Infect Dis. 2017;216:S499-S507 pubmed publisher..Since then, this CIV has caused thousands of infections in dogs in multiple states...
- Langley W, Bradley K, Li Z, Talekar G, Galloway S, Steinhauer D. The effects of preexisting immunity to influenza on responses to influenza vectors in mice. Vaccine. 2010;28:6305-13 pubmed publisher..These CD8(+) T cells were further shown to protect mice from a lethal challenge by a heterologous influenza subtype. The implication of these data for the use of influenza virus vectors and influenza vaccination in general are discussed...
- Kim Y, Quan F, Yoo D, Compans R, Kang S, Prausnitz M. Improved influenza vaccination in the skin using vaccine coated microneedles. Vaccine. 2009;27:6932-8 pubmed publisher..These findings suggest that vaccination in the skin using a microneedle patch can improve protective immunity, and simplify delivery of influenza and possibly other vaccines. ..
- Deng L, Kim J, Chang T, Zhang H, Mohan T, Champion J, et al. Protein nanoparticle vaccine based on flagellin carrier fused to influenza conserved epitopes confers full protection against influenza A virus challenge. Virology. 2017;509:82-89 pubmed publisher..It was also found that the incorporation of the H1 HA2 domain into f4M2e/fHApr8 nanoparticles boosted M2e specific antibody responses. Immunized mice were fully protected against lethal doses of virus challenge. ..
- Chen X, Seth S, Yue G, Kamat P, Compans R, Guidot D, et al. Influenza virus inhibits ENaC and lung fluid clearance. Am J Physiol Lung Cell Mol Physiol. 2004;287:L366-73 pubmed
- Belser J, Johnson A, Pulit Penaloza J, Pappas C, Pearce M, Tzeng W, et al. Pathogenicity testing of influenza candidate vaccine viruses in the ferret model. Virology. 2017;511:135-141 pubmed publisher..While the magnitude of virus attenuation varied between virus subtypes, collectively we show the reliable and reproducible attenuation of CVVs that have the A/Puerto Rico/9/1934 backbone in a mammalian model. ..
- Pearce M, Belser J, Gustin K, Pappas C, Houser K, Sun X, et al. Seasonal trivalent inactivated influenza vaccine protects against 1918 Spanish influenza virus infection in ferrets. J Virol. 2012;86:7118-25 pubmed publisher..These findings suggest that exposure to A(H1N1)pdm09 through immunization may provide protection against the reconstructed 1918 virus which, as a select agent, is considered to pose both biosafety and biosecurity threats...
- Kamal R, Blanchfield K, Belser J, Music N, Tzeng W, Holiday C, et al. Inactivated H7 Influenza Virus Vaccines Protect Mice despite Inducing Only Low Levels of Neutralizing Antibodies. J Virol. 2017;91: pubmed publisher..Vaccines against H7 avian influenza viruses may be more effective than HI and virus neutralization assays suggest, and such vaccines may need other methods for evaluation. ..
- Mueller S, Langley W, Li G, Garcia Sastre A, Webby R, Ahmed R. Qualitatively different memory CD8+ T cells are generated after lymphocytic choriomeningitis virus and influenza virus infections. J Immunol. 2010;185:2182-90 pubmed publisher..These findings suggest that qualitatively different memory CD8(+) T cells are generated after respiratory or systemic virus infections...
- Perrone L, Szretter K, Katz J, Mizgerd J, Tumpey T. Mice lacking both TNF and IL-1 receptors exhibit reduced lung inflammation and delay in onset of death following infection with a highly virulent H5N1 virus. J Infect Dis. 2010;202:1161-70 pubmed publisher..The combined signaling from the TNF or IL-1 receptors promotes maximal lung inflammation that may contribute to the severity of disease caused by H5N1 virus infection. ..
- Campbell P, Danzy S, Kyriakis C, Deymier M, Lowen A, Steel J. The M segment of the 2009 pandemic influenza virus confers increased neuraminidase activity, filamentous morphology, and efficient contact transmissibility to A/Puerto Rico/8/1934-based reassortant viruses. J Virol. 2014;88:3802-14 pubmed publisher..Thus, our data demonstrate the surprising result that functions encoded by the influenza A virus M segment impact neuraminidase activity and, perhaps through this mechanism, have a potent effect on transmissibility...
- Belser J, Gustin K, Pearce M, Maines T, Zeng H, Pappas C, et al. Pathogenesis and transmission of avian influenza A (H7N9) virus in ferrets and mice. Nature. 2013;501:556-9 pubmed publisher..Our results indicate that H7N9 viruses have the capacity for efficient replication in mammals and human airway cells and highlight the need for continued public health surveillance of this emerging virus. ..
- Liu F, Veguilla V, Gross F, Gillis E, Rowe T, Xu X, et al. Effect of Priming With Seasonal Influenza A(H3N2) Virus on the Prevalence of Cross-Reactive Hemagglutination-Inhibition Antibodies to Swine-Origin A(H3N2) Variants. J Infect Dis. 2017;216:S539-S547 pubmed publisher..We estimated the levels of serologic cross-reactivity among humans primed with seasonal influenza A(H3N2) (sH3N2), using postinfection ferret antisera. We also explored age-related HI antibody responses to 2012-2013 H3N2v viruses...
- Hon H, Rucker E, Hennighausen L, Jacob J. bcl-xL is critical for dendritic cell survival in vivo. J Immunol. 2004;173:4425-32 pubmed..Taken together, our work demonstrates that the bcl-x(L) isoform is critical for survival of skin-derived, Ag-bearing DC in vivo. ..
- Szretter K, Gangappa S, Lu X, Smith C, Shieh W, Zaki S, et al. Role of host cytokine responses in the pathogenesis of avian H5N1 influenza viruses in mice. J Virol. 2007;81:2736-44 pubmed..These results suggest that TNF-alpha may contribute to morbidity during H5N1 influenza virus infection, while IL-1 may be important for effective virus clearance in nonlethal H5N1 disease. ..
- Matsuoka Y, Swayne D, Thomas C, Rameix Welti M, Naffakh N, Warnes C, et al. Neuraminidase stalk length and additional glycosylation of the hemagglutinin influence the virulence of influenza H5N1 viruses for mice. J Virol. 2009;83:4704-8 pubmed publisher..The presence of additional HA glycosylation sites had less of an effect on virulence than did NA stalk length. The short-stalk NA of H5N1 viruses circulating in Asia may contribute to virulence in humans...
- Shinde V, Bridges C, Uyeki T, Shu B, Balish A, Xu X, et al. Triple-reassortant swine influenza A (H1) in humans in the United States, 2005-2009. N Engl J Med. 2009;360:2616-25 pubmed publisher..Although all the patients recovered, severe illness of the lower respiratory tract and unusual influenza signs such as diarrhea were observed in some patients, including those who had been previously healthy. ..
- Hossain M, Bourgeois M, Quan F, Lipatov A, Song J, Chen L, et al. Virus-like particle vaccine containing hemagglutinin confers protection against 2009 H1N1 pandemic influenza. Clin Vaccine Immunol. 2011;18:2010-7 pubmed publisher..n. vaccination with VLPs has the potential for highly efficacious vaccination against influenza. ..
- Maines T, Chen L, Belser J, Van Hoeven N, Smith E, Donis R, et al. Multiple genes contribute to the virulent phenotype observed in ferrets of an H5N1 influenza virus isolated from Thailand in 2004. Virology. 2011;413:226-30 pubmed publisher..Our results demonstrate that H5N1 virus virulence determinants are polygenic and that there is an important correlation between polymerase adaptation, efficient replication in the host, and virulence...
- Smith G, Sun X, Bai Y, Liu Y, Massare M, Pearce M, et al. Neuraminidase-based recombinant virus-like particles protect against lethal avian influenza A(H5N1) virus infection in ferrets. Virology. 2017;509:90-97 pubmed publisher..In contrast, ferrets administered control N2 NA VLPs were not protected against H5N1 virus challenge. These results provide support for continued development of NA-based vaccines against influenza H5N1 viruses. ..
- Garten R, Davis C, Russell C, Shu B, Lindstrom S, Balish A, et al. Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans. Science. 2009;325:197-201 pubmed publisher..Antigenically the viruses are homogeneous and similar to North American swine A(H1N1) viruses but distinct from seasonal human A(H1N1)...
- Go Y, Kang S, ROEDE J, Orr M, Jones D. Increased inflammatory signaling and lethality of influenza H1N1 by nuclear thioredoxin-1. PLoS ONE. 2011;6:e18918 pubmed publisher..Increased Trx1 in cell nuclei can increase severity of disease responses by potentiation of redox-sensitive transcription factor activation. ..
- Barlow P, Svoboda P, Mackellar A, Nash A, York I, Pohl J, et al. Antiviral activity and increased host defense against influenza infection elicited by the human cathelicidin LL-37. PLoS ONE. 2011;6:e25333 pubmed publisher..These data suggest that treatment of influenza-infected individuals with cathelicidin-derived therapeutics, or modulation of endogenous cathelicidin production may provide significant protection against disease. ..
- Wang B, Gill H, Kang S, Wang L, Wang Y, Vassilieva E, et al. Enhanced influenza virus-like particle vaccines containing the extracellular domain of matrix protein 2 and a Toll-like receptor ligand. Clin Vaccine Immunol. 2012;19:1119-25 pubmed publisher..These results indicate that a combination of M2e antigens and TLR ligand adjuvants in VLPs has potential for development of a broadly protective influenza A virus vaccine...
- Gustin K, Katz J, Tumpey T, Maines T. Comparison of the levels of infectious virus in respirable aerosols exhaled by ferrets infected with influenza viruses exhibiting diverse transmissibility phenotypes. J Virol. 2013;87:7864-73 pubmed publisher..Our findings improve our understanding of the ferret transmission model and provide support for the potential for influenza virus aerosol transmission. ..
- Dong L, Liu F, Fairman J, Hong D, Lewis D, Monath T, et al. Cationic liposome-DNA complexes (CLDC) adjuvant enhances the immunogenicity and cross-protective efficacy of a pre-pandemic influenza A H5N1 vaccine in mice. Vaccine. 2012;30:254-64 pubmed publisher..Thus, JVRS-100 adjuvanted H5N1 vaccine elicited enhanced humoral and T-cell responses, dose-sparing, and cross-clade protection in mice. CLDC holds promise as an adjuvant for human pre-pandemic inactivated H5N1 vaccines. ..
- Pappas C, Matsuoka Y, Swayne D, Donis R. Development and evaluation of an Influenza virus subtype H7N2 vaccine candidate for pandemic preparedness. Clin Vaccine Immunol. 2007;14:1425-32 pubmed..These studies indicate that H7N2-PR8 is immunogenic, safe, and protective in animal models; these are the essential attributes to qualify for phase I human clinical trials as a prepandemic vaccine. ..
- Iskander J, Strikas R, Gensheimer K, Cox N, Redd S. Pandemic influenza planning, United States, 1978-2008. Emerg Infect Dis. 2013;19:879-85 pubmed publisher..Preparedness planning will enhance the collective, multilevel response to future public health crises. ..
- Maines T, Belser J, Gustin K, Van Hoeven N, Zeng H, Svitek N, et al. Local innate immune responses and influenza virus transmission and virulence in ferrets. J Infect Dis. 2012;205:474-85 pubmed publisher..Our findings point to a link between localized innate immunity and influenza virus transmission and disease progression...
- Belser J, Pulit Penaloza J, Sun X, Brock N, Pappas C, Creager H, et al. A Novel A(H7N2) Influenza Virus Isolated from a Veterinarian Caring for Cats in a New York City Animal Shelter Causes Mild Disease and Transmits Poorly in the Ferret Model. J Virol. 2017;91: pubmed publisher..These data highlight the promiscuity of influenza viruses and the need for diligent surveillance across multiple species to quickly identify an emerging strain with pandemic potential. ..
- Belser J, Maines T, Katz J, Tumpey T. Considerations regarding appropriate sample size for conducting ferret transmission experiments. Future Microbiol. 2013;8:961-5 pubmed publisher..A closer examination of previously published studies utilizing this model as it is currently employed reveals that the 'sample size' of these studies is not always as small as it may appear. ..
- Sun H, Kaplan B, Guan M, Zhang G, Ye J, Long L, et al. Pathogenicity and transmission of a swine influenza A(H6N6) virus. Emerg Microbes Infect. 2017;6:e17 pubmed publisher..These findings suggest H6N6 swine IAV (SIV) currently poses a moderate risk to public health, but its evolution and spread should be closely monitored. ..
- Song J, Hossain J, Yoo D, Lipatov A, Davis C, Quan F, et al. Protective immunity against H5N1 influenza virus by a single dose vaccination with virus-like particles. Virology. 2010;405:165-75 pubmed publisher..This study provides insights into the potential mechanisms of improved immunogenicity by H5 VLP vaccines as an approach to improve the protective efficacy against potential pandemic viruses. ..
- Zeng H, Pappas C, Katz J, Tumpey T. The 2009 pandemic H1N1 and triple-reassortant swine H1N1 influenza viruses replicate efficiently but elicit an attenuated inflammatory response in polarized human bronchial epithelial cells. J Virol. 2011;85:686-96 pubmed publisher..In addition, their less efficient replication at human upper airway temperatures has implications for the understanding of pandemic H1N1 virus adaptation to humans. ..
- Belser J, Lu X, Maines T, Smith C, Li Y, Donis R, et al. Pathogenesis of avian influenza (H7) virus infection in mice and ferrets: enhanced virulence of Eurasian H7N7 viruses isolated from humans. J Virol. 2007;81:11139-47 pubmed..Therefore, in general, the relative virulence and cell tropism of the H7 viruses in these animal models correlated with the observed virulence in humans. ..
- Perrone L, Belser J, Wadford D, Katz J, Tumpey T. Inducible nitric oxide contributes to viral pathogenesis following highly pathogenic influenza virus infection in mice. J Infect Dis. 2013;207:1576-84 pubmed publisher..This study demonstrates that NO contributes to the pathogenic outcome of H5N1 and 1918 viral infections in the mouse model. ..
- Houser K, Katz J, Tumpey T. Seasonal trivalent inactivated influenza vaccine does not protect against newly emerging variants of influenza A (H3N2v) virus in ferrets. J Virol. 2013;87:1261-3 pubmed publisher..The complete absence of specific hemagglutination inhibition antibody response to A(H3N2)v is consistent with the poor cross-protection observed among TIV-immune animals. ..
- Epperson S, Jhung M, Richards S, QUINLISK P, Ball L, Moll M, et al. Human infections with influenza A(H3N2) variant virus in the United States, 2011-2012. Clin Infect Dis. 2013;57 Suppl 1:S4-S11 pubmed publisher..With minimal preexisting immunity in children and the limited cross-protective effect from seasonal influenza vaccine, the majority of children are susceptible to infection with this novel influenza virus. ..
- Marshall N, Priyamvada L, Ende Z, Steel J, Lowen A. Influenza virus reassortment occurs with high frequency in the absence of segment mismatch. PLoS Pathog. 2013;9:e1003421 pubmed publisher..Overall, our results indicate that reassortment between two like influenza viruses is efficient but also strongly dependent on dose and timing of the infections...