Experts and Doctors on dna transposable elements in Atlanta, Georgia, United States

Summary

Locale: Atlanta, Georgia, United States
Topic: dna transposable elements

Top Publications

  1. Krajmalnik Brown R, Sung Y, Ritalahti K, Saunders F, Löffler F. Environmental distribution of the trichloroethene reductive dehalogenase gene (tceA) suggests lateral gene transfer among Dehalococcoides. FEMS Microbiol Ecol. 2007;59:206-14 pubmed
    ..Sequence identity was interrupted downstream of tceB and upstream or downstream of the PTE, suggesting that intrachromosomal or interchromosomal transfer of tceAB had occurred...
  2. Diehl W, Johnson W, Hunter E. Elevated rate of fixation of endogenous retroviral elements in Haplorhini TRIM5 and TRIM22 genomic sequences: impact on transcriptional regulation. PLoS ONE. 2013;8:e58532 pubmed publisher
    ..To our knowledge, this represents the first report of persistent evolutionary pressure for the capture of retroviral LTR insertions. ..
  3. Tatti K, Sparks K, Boney K, Tondella M. Novel multitarget real-time PCR assay for rapid detection of Bordetella species in clinical specimens. J Clin Microbiol. 2011;49:4059-66 pubmed publisher
    ..In conclusion, the use of this multitarget RT-PCR approach increases specificity, while it decreases the amount of time, reagents, and specimen necessary for RT-PCRs used for accurate diagnosis of pertussis-like illness...
  4. Wang J, Bowen N, Mariño Ramírez L, Jordan I. A c-Myc regulatory subnetwork from human transposable element sequences. Mol Biosyst. 2009;5:1831-9 pubmed publisher
    ..These data point to a substantial contribution of TEs to the regulation of human genes by c-Myc. Genes that are regulated by TE-derived c-Myc binding sites appear to form a distinct c-Myc regulatory subnetwork. ..
  5. Polavarapu N, Mariño Ramírez L, Landsman D, McDonald J, Jordan I. Evolutionary rates and patterns for human transcription factor binding sites derived from repetitive DNA. BMC Genomics. 2008;9:226 pubmed publisher
    ..Thus, the very TFBS that are most likely to yield human-specific characteristics will be neglected by the comparative genomic techniques that are currently de rigeur for the identification of novel regulatory sites. ..
  6. Piriyapongsa J, Polavarapu N, Borodovsky M, McDonald J. Exonization of the LTR transposable elements in human genome. BMC Genomics. 2007;8:291 pubmed
  7. Alexander S, Woodling N, Yedvobnick B. Insertional inactivation of the L13a ribosomal protein gene of Drosophila melanogaster identifies a new Minute locus. Gene. 2006;368:46-52 pubmed
    ..The insert in the RpL13A coding region creates a classic Minute mutation which enhances Notch pathway wing phenotypes. This report adds RpL13A to the list of Drosophila ribosomal protein genes that cause Minute phenotypes when mutated. ..
  8. Joloba M, Clemmer K, Sledjeski D, Rather P. Activation of the gab operon in an RpoS-dependent manner by mutations that truncate the inner core of lipopolysaccharide in Escherichia coli. J Bacteriol. 2004;186:8542-6 pubmed
    ..This study reveals a stress-induced pathway, mediated by loss of the LPS inner core, that increases RpoS translation and gab operon expression in E. coli. ..
  9. Froehlich B, Holtzapple E, Read T, Scott J. Horizontal transfer of CS1 pilin genes of enterotoxigenic Escherichia coli. J Bacteriol. 2004;186:3230-7 pubmed
    ..We conclude that when R64-like plasmids are transmitted to an ETEC strain containing pCoo, their recombination may allow for spread of the pCoo plasmid to other enteric bacteria...

More Information

Publications24

  1. Wang X, Preston J, Romeo T. The pgaABCD locus of Escherichia coli promotes the synthesis of a polysaccharide adhesin required for biofilm formation. J Bacteriol. 2004;186:2724-34 pubmed
    ..The pgaABCD operon exhibits features of a horizontally transferred locus and is present in a variety of eubacteria. Therefore, we propose that PGA serves as an adhesin that stabilizes biofilms of E. coli and other bacteria. ..
  2. Weigel L, Clewell D, Gill S, Clark N, McDougal L, Flannagan S, et al. Genetic analysis of a high-level vancomycin-resistant isolate of Staphylococcus aureus. Science. 2003;302:1569-71 pubmed
    ..Genetic analyses suggest that the long-anticipated transfer of vancomycin resistance to a methicillin-resistant S. aureus occurred in vivo by interspecies transfer of Tn1546 from a co-isolate of Enterococcus faecalis. ..
  3. Swartley J, Stephens D. Identification of a genetic locus involved in the biosynthesis of N-acetyl-D-mannosamine, a precursor of the (alpha 2-->8)-linked polysialic acid capsule of serogroup B Neisseria meningitidis. J Bacteriol. 1994;176:1530-4 pubmed
    ..The transposon insertion interrupts a capsule biosynthesis gene, synX, which is involved in the production of N-acetyl-D-mannosamine, a precursor of the (alpha 2-->8)-linked polysialic acid capsule of serogroup B meningococci. ..
  4. Houghton J, Brown T, Appel A, Hughes E, Ornston L. Discontinuities in the evolution of Pseudomonas putida cat genes. J Bacteriol. 1995;177:401-12 pubmed
    ..Properties of the palindromic genetic element suggest that it may serve functions analogous to those of repetitive extragenic palindromic sequences and enteric repetitive intergenic consensus sequences in enteric bacteria...
  5. Rouquette Loughlin C, Balthazar J, Hill S, Shafer W. Modulation of the mtrCDE-encoded efflux pump gene complex of Neisseria meningitidis due to a Correia element insertion sequence. Mol Microbiol. 2004;54:731-41 pubmed publisher
    ..We conclude that the mtr efflux system in meningococci is subject to transcriptional regulation by IHF and post-transcriptional regulation by cleavage in the inverted repeat of the Correia element...
  6. Wong S, Abdelal A. Unorthodox expression of an enzyme: evidence for an untranslated region within carA from Pseudomonas aeruginosa. J Bacteriol. 1990;172:630-42 pubmed
    ..The mRNA sequence was also deduced by in vitro synthesis of cDNA, enzymatic amplification, and sequencing, confirming that 12 nucleotides in the 5' terminal of carA are transcribed but are not translated. ..
  7. Shih G, Kahler C, Carlson R, Rahman M, Stephens D. gmhX, a novel gene required for the incorporation of L-glycero-D-manno-heptose into lipooligosaccharide in Neisseria meningitidis. Microbiology. 2001;147:2367-77 pubmed
    ..GmhX is a novel enzyme required for the incorporation of L-glycero-D-manno-heptose into meningococcal LOS, and is a candidate for the 2-D-glycero-manno-heptose phosphatase of the heptose biosynthesis pathway. ..
  8. De B, Stauffer L, Koylass M, Sharp S, Gee J, Helsel L, et al. Novel Brucella strain (BO1) associated with a prosthetic breast implant infection. J Clin Microbiol. 2008;46:43-9 pubmed
    ..confirms that the isolate is much more closely related to Brucella than to Ochrobactrum spp., and thus the isolate likely represents an atypical and novel strain within the genus Brucella. ..
  9. Tatti K, Wu K, Tondella M, Cassiday P, Cortese M, Wilkins P, et al. Development and evaluation of dual-target real-time polymerase chain reaction assays to detect Bordetella spp. Diagn Microbiol Infect Dis. 2008;61:264-72 pubmed publisher
    ..Guidelines for use of PCR testing and interpretation of results during cough-illness outbreaks are discussed...
  10. Kahler C, Blum E, Miller Y, Ryan D, Popovic T, Stephens D. exl, an exchangeable genetic island in Neisseria meningitidis. Infect Immun. 2001;69:1687-96 pubmed publisher
    ..The structure of these cassettes and their correlation with clonal groups emphasize the extensive gene pool and frequent horizontal DNA transfer events that contribute to the evolution and virulence of N. meningitidis...
  11. Huda A, Jordan I. Analysis of transposable element sequences using CENSOR and RepeatMasker. Methods Mol Biol. 2009;537:323-36 pubmed publisher
    ..We briefly consider the strengths and weaknesses of these different classes of methods with an emphasis on their complementary utility for the analysis of repetitive DNA in eukaryotes. ..
  12. Zhong J, Yedvobnick B. Targeted gain-of-function screening in Drosophila using GAL4-UAS and random transposon insertions. Genet Res (Camb). 2009;91:243-58 pubmed publisher
    ..In this article, we summarize studies that have utilized GAL4-UAS overexpression or misexpression of random loci to screen for candidates involved in specific developmental processes. ..
  13. Hebert M, Houghton J. Regulation of ornithine utilization in Pseudomonas aeruginosa (PAO1) is mediated by a transcriptional regulator, OruR. J Bacteriol. 1997;179:7834-42 pubmed
    ..aeruginosa may have a significant impact upon how the cell is able to monitor and regulate the use of arginine and glutamate as sources of either carbon or nitrogen. ..
  14. Wang J, Huda A, Lunyak V, Jordan I. A Gibbs sampling strategy applied to the mapping of ambiguous short-sequence tags. Bioinformatics. 2010;26:2501-8 pubmed publisher
    ..http://esbg.gatech.edu/jordan/software/map king.jordan@biology.gatech.edu Supplementary data are available at Bioinformatics online. ..
  15. Huda A, Tyagi E, Mariño Ramírez L, Bowen N, Jjingo D, Jordan I. Prediction of transposable element derived enhancers using chromatin modification profiles. PLoS ONE. 2011;6:e27513 pubmed publisher