Experts and Doctors on cell line in Atlanta, Georgia, United States

Summary

Locale: Atlanta, Georgia, United States
Topic: cell line

Top Publications

  1. Kaiser W, Kaufman J, Offermann M. IFN-alpha sensitizes human umbilical vein endothelial cells to apoptosis induced by double-stranded RNA. J Immunol. 2004;172:1699-710 pubmed
  2. Ouko L, Ziegler T, Gu L, Eisenberg L, Yang V. Wnt11 signaling promotes proliferation, transformation, and migration of IEC6 intestinal epithelial cells. J Biol Chem. 2004;279:26707-15 pubmed
    ..These findings may help understand the molecular mechanisms that regulate proliferation and migration of intestinal epithelial cells. ..
  3. Kreiner L, Lee A. Endogenous and exogenous Ca2+ buffers differentially modulate Ca2+-dependent inactivation of Ca(v)2.1 Ca2+ channels. J Biol Chem. 2006;281:4691-8 pubmed
    ..We conclude that Ca2+-dependent inactivation of Ca(v)2.1 depends on a subplasmalemmal Ca2+ microdomain that is affected by the amplitude of the Ca2+ current and differentially modulated by distinct Ca2+ buffers. ..
  4. Massung R, Levin M, Munderloh U, Silverman D, Lynch M, Gaywee J, et al. Isolation and propagation of the Ap-Variant 1 strain of Anaplasma phagocytophilum in a tick cell line. J Clin Microbiol. 2007;45:2138-43 pubmed
    ..phagocytophilum with pleomorphic bacteria in membrane-bound vacuoles and both electron-dense and electron-lucent forms...
  5. Gross J, Long R, Constantinidis I, Sambanis A. Monitoring of dissolved oxygen and cellular bioenergetics within a pancreatic substitute. Biotechnol Bioeng. 2007;98:261-70 pubmed
    ..It is concluded that PFC incorporation and (19)F NMR measurements, in combination with a mechanistic model of the encapsulated system, allow the tracking of the state of a pancreatic substitute in vitro and potentially in vivo. ..
  6. Wu X, Franka R, Velasco Villa A, Rupprecht C. Are all lyssavirus genes equal for phylogenetic analyses?. Virus Res. 2007;129:91-103 pubmed
  7. Nisimoto Y, Jackson H, Ogawa H, Kawahara T, Lambeth J. Constitutive NADPH-dependent electron transferase activity of the Nox4 dehydrogenase domain. Biochemistry. 2010;49:2433-42 pubmed publisher
    ..These results indicate that the Nox4 DH domain exists in an intrinsically activated state and that electron transfer from NADPH to FAD is likely to be rate-limiting in the NADPH-dependent reduction of oxygen by holo-Nox4. ..
  8. Shelton M, Huang M, Ali S, Powell M, Bond V. Secretion modification region-derived peptide disrupts HIV-1 Nef's interaction with mortalin and blocks virus and Nef exosome release. J Virol. 2012;86:406-19 pubmed publisher
    ..Taken together, this work constitutes a significant step in understanding the underlying mechanism of exNef secretion, identifies a novel host-pathogen interaction, and introduces an HIV-derived peptide with antiviral properties. ..
  9. Leoni G, Alam A, Neumann P, Lambeth J, Cheng G, McCoy J, et al. Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J Clin Invest. 2013;123:443-54 pubmed publisher
    ..Our findings delineate a novel epithelial FPR1/NOX1-dependent redox signaling pathway that promotes mucosal wound repair. ..

More Information

Publications452 found, 100 shown here

  1. Reyes C, Garcia A. Engineering integrin-specific surfaces with a triple-helical collagen-mimetic peptide. J Biomed Mater Res A. 2003;65:511-23 pubmed
    ..Engineering surfaces that specifically target certain integrin-ligand interactions and signaling cascades provides a biomolecular strategy for optimizing cellular responses in biomaterials and tissue engineering applications. ..
  2. Qu Z, Wei R, Mann W, Hartzell H. Two bestrophins cloned from Xenopus laevis oocytes express Ca(2+)-activated Cl(-) currents. J Biol Chem. 2003;278:49563-72 pubmed
    ..We conclude that bestrophins are the first molecularly identified Cl- channels that are dependent on intracellular Ca2+ in a physiological range. ..
  3. Offe K, Dodson S, Shoemaker J, Fritz J, Gearing M, Levey A, et al. The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments. J Neurosci. 2006;26:1596-603 pubmed
    ..The robust correlation between reduced LR11 expression and AD neuropathology and its potent effects on extracellular Abeta levels suggest that this neuronal lipoprotein receptor could play an important role in AD pathogenesis. ..
  4. Ye L, Lin J, Sun Y, Bennouna S, Lo M, Wu Q, et al. Ebola virus-like particles produced in insect cells exhibit dendritic cell stimulating activity and induce neutralizing antibodies. Virology. 2006;351:260-70 pubmed publisher
    ..These results show that production of Ebola VLPs in insect cells using recombinant baculoviruses represents a promising approach for vaccine development against Ebola virus infection...
  5. Nava P, Laukoetter M, Hopkins A, Laur O, Gerner Smidt K, Green K, et al. Desmoglein-2: a novel regulator of apoptosis in the intestinal epithelium. Mol Biol Cell. 2007;18:4565-78 pubmed
    ..Our studies highlight a novel mechanism by which Dsg2 regulates IEC apoptosis driven by cysteine proteases during physiological differentiation and inflammation. ..
  6. Zimmer S, Liu J, Clayton J, Stephens D, Snyder J. Paclitaxel binding to human and murine MD-2. J Biol Chem. 2008;283:27916-26 pubmed publisher
    ..In particular, Phe(126) appears to operate as a bridge for TLR4.MD-2 dimerization in the mouse but not the human protein. ..
  7. Shaner R, Allegood J, Park H, Wang E, Kelly S, Haynes C, et al. Quantitative analysis of sphingolipids for lipidomics using triple quadrupole and quadrupole linear ion trap mass spectrometers. J Lipid Res. 2009;50:1692-707 pubmed publisher
    ..The application of these methods is illustrated with RAW264.7 cells, a mouse macrophage cell line. These methods should be useful for a wide range of focused (sphingo)lipidomic investigations. ..
  8. Cohen S, Haack K, Halstead Nussloch G, Bernard K, Hatt H, Kubanek J, et al. Identification of RL-TGR, a coreceptor involved in aversive chemical signaling. Proc Natl Acad Sci U S A. 2010;107:12339-44 pubmed publisher
    ..RL-TGR forms a coreceptor that responds to a chemical defense compound in the marine environment, and its discovery might lead the way to the identification of other receptors that mediate chemical defense signaling. ..
  9. Lee J, Komatsu K, Lee B, Lim J, Jono H, Xu H, et al. Phosphodiesterase 4B mediates extracellular signal-regulated kinase-dependent up-regulation of mucin MUC5AC protein by Streptococcus pneumoniae by inhibiting cAMP-protein kinase A-dependent MKP-1 phosphatase pathway. J Biol Chem. 2012;287:22799-811 pubmed publisher
    ..pneumoniae by inhibiting cAMP-PKA-dependent MKP-1 pathway. This study may lead to novel therapeutic strategy for inhibiting mucus overproduction. ..
  10. Dong S, Baranwal S, Garcia A, Serrano Gomez S, Eastlack S, Iwakuma T, et al. Nischarin inhibition alters energy metabolism by activating AMP-activated protein kinase. J Biol Chem. 2017;292:16833-16846 pubmed publisher
    ..As a result, these mice displayed decreased growth and body weight. Taken together, our results indicate that Nisch is an important AMPK inhibitor and a critical regulator of energy homeostasis, including lipid and glucose metabolism. ..
  11. Langley S, Lai K, Dembure P, Hjelm L, Elsas L. Molecular basis for Duarte and Los Angeles variant galactosemia. Am J Hum Genet. 1997;60:366-72 pubmed
    ..A favorable codon bias for the mutated codon with consequently increased translation rates is postulated as the mechanism...
  12. Dominguez G, Lakatos A, Kuhar M. Characterization of the cocaine- and amphetamine-regulated transcript (CART) peptide gene promoter and its activation by a cyclic AMP-dependent signaling pathway in GH3 cells. J Neurochem. 2002;80:885-93 pubmed
    ..These studies indicate that the CART proximal promoter lies within the 5'-most 641 bp and that in GH3 cells the CART gene is regulated via a cyclic AMP-dependent pathway. ..
  13. Edens H, Levi B, Jaye D, Walsh S, Reaves T, Turner J, et al. Neutrophil transepithelial migration: evidence for sequential, contact-dependent signaling events and enhanced paracellular permeability independent of transjunctional migration. J Immunol. 2002;169:476-86 pubmed
    ..We propose that regulation of PMN transepithelial migration is mediated, in part, by sequential signaling events between migrating PMN and the epithelium. ..
  14. Rivera Marrero C, Stewart J, Shafer W, Roman J. The down-regulation of cathepsin G in THP-1 monocytes after infection with Mycobacterium tuberculosis is associated with increased intracellular survival of bacilli. Infect Immun. 2004;72:5712-21 pubmed
    ..Therefore, the down-regulation of CatG in macrophages is advantageous to M. tuberculosis bacilli and possibly is an important mechanism by which M. tuberculosis is able to evade the host immune defenses. ..
  15. Tippens A, Lee A. Caldendrin, a neuron-specific modulator of Cav/1.2 (L-type) Ca2+ channels. J Biol Chem. 2007;282:8464-73 pubmed
    ..Our findings reveal functional diversity within related Ca2+-binding proteins, which may enhance the specificity of Ca2+ signaling by Cav1.2 channels in different cellular contexts. ..
  16. Dalmasso G, Nguyen H, Yan Y, Laroui H, Srinivasan S, Sitaraman S, et al. MicroRNAs determine human intestinal epithelial cell fate. Differentiation. 2010;80:147-54 pubmed publisher
    ..19A cell phenotype. In conclusion, our study shows that miRNAs might play a role in determining the unique physiological characteristics of IECs. ..
  17. Vijay Kumar M, Carvalho F, Aitken J, Fifadara N, Gewirtz A. TLR5 or NLRC4 is necessary and sufficient for promotion of humoral immunity by flagellin. Eur J Immunol. 2010;40:3528-34 pubmed publisher
    ..Such promotion of adaptive immunity can be effectively driven by either TLR5-mediated activation of NF-?B or NLRC4-mediated activation of the inflammasome. ..
  18. Elbahesh H, Scherbik S, Brinton M. West Nile virus infection does not induce PKR activation in rodent cells. Virology. 2011;421:51-60 pubmed publisher
    ..The results indicate that PKR phosphorylation is not actively suppressed in WNV-infected cells but that PKR is not activated by the viral dsRNA in infected cells. ..
  19. Scherbik S, Pulit Penaloza J, Basu M, Courtney S, Brinton M. Increased early RNA replication by chimeric West Nile virus W956IC leads to IPS-1-mediated activation of NF-?B and insufficient virus-mediated counteraction of the resulting canonical type I interferon signaling. J Virol. 2013;87:7952-65 pubmed publisher
  20. Cui L, Guo J, Zhang Q, Yin J, Li J, Zhou W, et al. Erythropoietin activates SIRT1 to protect human cardiomyocytes against doxorubicin-induced mitochondrial dysfunction and toxicity. Toxicol Lett. 2017;275:28-38 pubmed publisher
    ..Taken together, our results indicated that EPO may activate SIRT1 to enhance mitochondrial function and protect against DOX-induced cardiotoxicity. ..
  21. Rock B, Xin L, Niederhuber J. 71.67 T lymphocyte activation is accompanied by the down-regulation of three G alpha genes. Cell Immunol. 1995;164:316-21 pubmed
    ..These findings suggest that an important element in signal transduction through these G proteins in lymphocytes may include regulation of G alpha mRNA steady-state levels. ..
  22. Feng Y, Gutekunst C, Eberhart D, Yi H, Warren S, Hersch S. Fragile X mental retardation protein: nucleocytoplasmic shuttling and association with somatodendritic ribosomes. J Neurosci. 1997;17:1539-47 pubmed
  23. Shibahara T, Si Tahar M, Shaw S, Madara J. Adhesion molecules expressed on homing lymphocytes in model intestinal epithelia. Gastroenterology. 2000;118:289-98 pubmed
    ..We also show that phenotypic alteration of IELs is induced by close interaction with intestinal epithelia as a consequence of homing. ..
  24. Dobos K, Small P, Deslauriers M, Quinn F, King C. Mycobacterium ulcerans cytotoxicity in an adipose cell model. Infect Immun. 2001;69:7182-6 pubmed
    ..Apoptosis was likely due to secreted proteins, while necrosis was likely due to mycolactone. Our data suggest that additional factors in M. ulcerans may be involved in Buruli ulcer pathogenesis. ..
  25. Yang L, Lin C, Liu Z. P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from beta-catenin. Cell. 2006;127:139-55 pubmed
    ..These data demonstrated a novel mechanism of phosphor-p68 in mediating the growth factor-induced EMT and uncovered a new pathway to promote beta-catenin nuclear translocation. ..
  26. Kaiser W, Upton J, Mocarski E. Receptor-interacting protein homotypic interaction motif-dependent control of NF-kappa B activation via the DNA-dependent activator of IFN regulatory factors. J Immunol. 2008;181:6427-34 pubmed
  27. Hossain M, Perez S, Guo Z, Chen L, Donis R. Establishment and characterization of a Madin-Darby canine kidney reporter cell line for influenza A virus assays. J Clin Microbiol. 2010;48:2515-23 pubmed publisher
  28. Capaldo C, Koch S, Kwon M, Laur O, Parkos C, Nusrat A. Tight function zonula occludens-3 regulates cyclin D1-dependent cell proliferation. Mol Biol Cell. 2011;22:1677-85 pubmed publisher
    ..This study highlights an important new role for ZO family TJ proteins in regulating epithelial cell proliferation through stabilization of cyclin D1 during mitosis. ..
  29. Yeligar S, Harris F, Hart C, Brown L. Ethanol induces oxidative stress in alveolar macrophages via upregulation of NADPH oxidases. J Immunol. 2012;188:3648-57 pubmed publisher
    ..Ethanol induces AM oxidative stress initially through upregulation of Nox1 and Nox2 with downstream Nox4 upregulation and subsequent impairment of AM function. ..
  30. Markowski M, Brown A, Barker T. Directing epithelial to mesenchymal transition through engineered microenvironments displaying orthogonal adhesive and mechanical cues. J Biomed Mater Res A. 2012;100:2119-27 pubmed publisher
    ..Suppressing cell-contractility was sufficient to maintain an epithelial phenotype. Our results suggest that integrin-specific engagement of fibronectin adhesive domains and the mechanics of the ECM act synergistically to direct EMT. ..
  31. Krumm S, Takeda M, Plemper R. The measles virus nucleocapsid protein tail domain is dispensable for viral polymerase recruitment and activity. J Biol Chem. 2013;288:29943-53 pubmed publisher
    ..Dispensable for polymerase recruitment, N-MoRE binding to P-tail stabilizes the advancing polymerase-RNP complex and may rearrange unstructured central tail sections to facilitate polymerase access to the template. ..
  32. Sitaraman S, Wang L, Wong M, Bruewer M, Hobert M, Yun C, et al. The adenosine 2b receptor is recruited to the plasma membrane and associates with E3KARP and Ezrin upon agonist stimulation. J Biol Chem. 2002;277:33188-95 pubmed
    ..We speculate that such an interaction may not only anchor the A2bR to the plasma membrane but may also function to stabilize the receptor in a signaling complex in the plasma membrane. ..
  33. Montero A, Uda S, Kelavkar U, Yoshimura A, Badr K, Munger K. Increased 5-lipoxygenase activating protein in immune-mediated experimental nephritis. J Nephrol. 2003;16:682-90 pubmed
  34. Chen G, Huang H, Fröhlich O, Yang Y, Klein J, Price S, et al. MDM2 E3 ubiquitin ligase mediates UT-A1 urea transporter ubiquitination and degradation. Am J Physiol Renal Physiol. 2008;295:F1528-34 pubmed publisher
    ..The mechanism is likely to be physiologically important as UT-A1 ubiquitination was identified in kidney inner medullary tissue. The ubiquitin-proteasome degradation pathway provides an important novel mechanism for UT-A1 regulation. ..
  35. Yang Q, She H, Gearing M, Colla E, Lee M, Shacka J, et al. Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy. Science. 2009;323:124-7 pubmed publisher
    ..Thus, chaperone-mediated autophagy modulates the neuronal survival machinery, and dysregulation of this pathway is associated with Parkinson's disease...
  36. Skountzou I, Martin M, Wang B, Ye L, Koutsonanos D, Weldon W, et al. Salmonella flagellins are potent adjuvants for intranasally administered whole inactivated influenza vaccine. Vaccine. 2010;28:4103-12 pubmed publisher
    ..Our results reveal a promising perspective for the use of both soluble monomeric and polymeric flagellin as mucosal vaccine adjuvants to improve protection against influenza epidemics as well as a range of other infectious diseases. ..
  37. Turner D, Moshkelani D, Shemesh C, Luc D, Zhang H. Near-infrared image-guided delivery and controlled release using optimized thermosensitive liposomes. Pharm Res. 2012;29:2092-103 pubmed publisher
    ..In vivo studies suggest that liposomal encapsulation of ICG permits reliable, real-time monitoring of liposome biodistribution through non-invasive NIR imaging. ..
  38. Belser J, Pulit Penaloza J, Sun X, Brock N, Pappas C, Creager H, et al. A Novel A(H7N2) Influenza Virus Isolated from a Veterinarian Caring for Cats in a New York City Animal Shelter Causes Mild Disease and Transmits Poorly in the Ferret Model. J Virol. 2017;91: pubmed publisher
    ..These data highlight the promiscuity of influenza viruses and the need for diligent surveillance across multiple species to quickly identify an emerging strain with pandemic potential. ..
  39. Kaytor M, Wilkinson K, Warren S. Modulating huntingtin half-life alters polyglutamine-dependent aggregate formation and cell toxicity. J Neurochem. 2004;89:962-73 pubmed
    ..Polyglutamine-induced neurotoxicity may therefore be triggered by non-aggregated protein, and aggregate formation itself may be a cellular defense mechanism. ..
  40. Olzmann J, Li L, Chudaev M, Chen J, Perez F, Palmiter R, et al. Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6. J Cell Biol. 2007;178:1025-38 pubmed
  41. Giles L, Chen J, Li L, Chin L. Dystonia-associated mutations cause premature degradation of torsinA protein and cell-type-specific mislocalization to the nuclear envelope. Hum Mol Genet. 2008;17:2712-22 pubmed publisher
  42. Mistry A, Mallick R, Klein J, Weimbs T, Sands J, Fröhlich O. Syntaxin specificity of aquaporins in the inner medullary collecting duct. Am J Physiol Renal Physiol. 2009;297:F292-300 pubmed publisher
    ..Snapin plays an important role as a linker between the water channel and the t-SNARE complex, leading to the fusion event, and the pairing with specific t-SNAREs is essential for the specificity of membrane recognition and fusion. ..
  43. Makarova N, Zhao C, Zhang Y, Bhosle S, Suppiah S, Rhea J, et al. Antibody responses against xenotropic murine leukemia virus-related virus envelope in a murine model. PLoS ONE. 2011;6:e18272 pubmed publisher
    ..The low level of immunogenicity observed in the present study may be characteristic of a natural XMRV infection in humans. ..
  44. Nezami B, Mwangi S, Lee J, Jeppsson S, Anitha M, Yarandi S, et al. MicroRNA 375 mediates palmitate-induced enteric neuronal damage and high-fat diet-induced delayed intestinal transit in mice. Gastroenterology. 2014;146:473-83.e3 pubmed publisher
    ..This effect is mediated by Mir375 and is associated with reduced levels of Pdk1. Mir375 might be targeted to increase survival of enteric neurons and gastrointestinal motility. ..
  45. Müller M, Lee C, Gasiunas G, Davis T, Cradick T, Siksnys V, et al. Streptococcus thermophilus CRISPR-Cas9 Systems Enable Specific Editing of the Human Genome. Mol Ther. 2016;24:636-44 pubmed publisher
    ..In conclusion, our results show that Cas9 proteins with longer or more restrictive PAM requirements provide a safe alternative to SpCas9-based RGNs and hence a valuable option for future human gene therapy applications. ..
  46. Richmond A, Balentien E, Thomas H, Flaggs G, Barton D, Spiess J, et al. Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin. EMBO J. 1988;7:2025-33 pubmed
    ..This same region also contains genes for two of the structurally related factors, for c-kit, a receptor for an as yet unidentified ligand, and for 'piebald trait', an inherited skin pigmentation disorder. ..
  47. Nagarajan U, Peijnenburg A, Gobin S, Boss J, van den Elsen P. Novel mutations within the RFX-B gene and partial rescue of MHC and related genes through exogenous class II transactivator in RFX-B-deficient cells. J Immunol. 2000;164:3666-74 pubmed
    ..Transfection of CIITA into Ramia cells, a B cell line that does not produce a stable RFX-B mRNA, resulted in induction of an MHC class II reporter, suggesting that CIITA overexpression may partially override the RFX-B defect. ..
  48. Marfatia K, Harreman M, Fanara P, Vertino P, Corbett A. Identification and characterization of the human MOG1 gene. Gene. 2001;266:45-56 pubmed
    ..Taken together, our findings suggest that MOG1 is an evolutionarily conserved Ran binding protein that could play a role in regulating nuclear protein trafficking. ..
  49. Pavlova I, Virgin H, Speck S. Disruption of gammaherpesvirus 68 gene 50 demonstrates that Rta is essential for virus replication. J Virol. 2003;77:5731-9 pubmed
    ..This work lays the foundation for characterizing the role of Rta in gamma HV68 chronic infection of mice. ..
  50. Swimm A, Bommarius B, Li Y, Cheng D, Reeves P, Sherman M, et al. Enteropathogenic Escherichia coli use redundant tyrosine kinases to form actin pedestals. Mol Biol Cell. 2004;15:3520-9 pubmed
    ..Our results raise the possibility that PD may be useful in treating EPEC infections, and because PD affects host and not bacterium, selecting resistant strains may be far less likely than with conventional antibiotics. ..
  51. Cheng G, Ritsick D, Lambeth J. Nox3 regulation by NOXO1, p47phox, and p67phox. J Biol Chem. 2004;279:34250-5 pubmed
    ..The unique regulation of Nox3 supports a model in which multiple interactions with regulatory subunits stabilize an active conformation of the catalytic subunit. ..
  52. Eremeeva M, Bosserman E, Demma L, Zambrano M, Blau D, Dasch G. Isolation and identification of Rickettsia massiliae from Rhipicephalus sanguineus ticks collected in Arizona. Appl Environ Microbiol. 2006;72:5569-77 pubmed publisher
    ..Whether R. massiliae AZT80 is pathogenic or infectious for dogs and humans or can cause seroconversion to spotted fever group antigens in the United States is unknown...
  53. Williamson Y, Gowrisankar R, Longo D, Facklam R, Gipson I, Ades E, et al. Adherence of nontypeable Streptococcus pneumoniae to human conjunctival epithelial cells. Microb Pathog. 2008;44:175-85 pubmed
  54. Go Y, Halvey P, Hansen J, Reed M, Pohl J, Jones D. Reactive aldehyde modification of thioredoxin-1 activates early steps of inflammation and cell adhesion. Am J Pathol. 2007;171:1670-81 pubmed
    ..Chemical modification of Trx1 by common environmental and endogenously generated reactive aldehydes can contribute to atherosclerosis development by interfering with antioxidant and redox signaling functions of Trx1. ..
  55. McCall I, Betanzos A, Weber D, Nava P, Miller G, Parkos C. Effects of phenol on barrier function of a human intestinal epithelial cell line correlate with altered tight junction protein localization. Toxicol Appl Pharmacol. 2009;241:61-70 pubmed publisher
    ..Overall, these findings suggest that phenol may affect transiently the lipid bilayer of the cell membrane, thus destabilizing TJ-containing microdomains. ..
  56. Rosenthal K, Edwards L, Sabatino J, Hood J, Wasserman H, Zhu C, et al. Low 2-dimensional CD4 T cell receptor affinity for myelin sets in motion delayed response kinetics. PLoS ONE. 2012;7:e32562 pubmed publisher
    ..Taken together, these data demonstrate that time can offset low TCR affinity to attain full activation and suggest a mechanism by which low affinity T cells participate in autoimmune disease. ..
  57. Liu D, Lin Y, Kang T, Huang B, Xu W, Garcia Barrio M, et al. Mitochondrial dysfunction and adipogenic reduction by prohibitin silencing in 3T3-L1 cells. PLoS ONE. 2012;7:e34315 pubmed publisher
    ..Our results suggest that PHBs are critical mediators in promoting 3T3-L1 adipocyte differentiation and may be the potential targets for obesity therapies. ..
  58. Howell J, Chun E, Farrell A, Hur E, Caroti C, Iuvone P, et al. Global microRNA expression profiling: curcumin (diferuloylmethane) alters oxidative stress-responsive microRNAs in human ARPE-19 cells. Mol Vis. 2013;19:544-60 pubmed
    ..The results demonstrated that curcumin alters the expression of H?O?-modulated miRNAs that are putative regulators of antioxidant defense and renin-angiotensin systems, which have been reported to be linked to ocular diseases. ..
  59. Ban K, Wile B, Kim S, Park H, Byun J, Cho K, et al. Purification of cardiomyocytes from differentiating pluripotent stem cells using molecular beacons that target cardiomyocyte-specific mRNA. Circulation. 2013;128:1897-909 pubmed publisher
    ..MBs are nanoscale probes that emit a fluorescence signal when hybridized to target mRNAs...
  60. Shi P, Li W, Brinton M. Cell proteins bind specifically to West Nile virus minus-strand 3' stem-loop RNA. J Virol. 1996;70:6278-87 pubmed
    ..It is possible that the increased binding activity of one of the resistant cell proteins for the flavivirus minus-strand RNA could result in a reduced synthesis of plus-strand RNA as observed with the flavivirus resistance phenotype...
  61. Ceman S, Brown V, Warren S. Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex. Mol Cell Biol. 1999;19:7925-32 pubmed
  62. Bagnasco S, Peng T, Janech M, Karakashian A, Sands J. Cloning and characterization of the human urea transporter UT-A1 and mapping of the human Slc14a2 gene. Am J Physiol Renal Physiol. 2001;281:F400-6 pubmed
    ..We determined the organization of the human Slc14a2 gene and identified 20 exons distributed over approximately 67.5 kb on chromosome 18, from which hUT-A1 and the other human urea transporter, hUT-A2, are transcribed...
  63. Yue G, Merlin D, Selsted M, Lencer W, Madara J, Eaton D. Cryptdin 3 forms anion selective channels in cytoplasmic membranes of human embryonic kidney cells. Am J Physiol Gastrointest Liver Physiol. 2002;282:G757-65 pubmed
    ..1, 1.6, 4.2, and 12.5 ms. These results suggest that cryptdin 3 forms anion-selective channels on the cytoplasmic membrane of HEK cells and that the kinetics of one such channel are affected by its interaction with other such channels. ..
  64. Banke T, Dravid S, Traynelis S. Protons trap NR1/NR2B NMDA receptors in a nonconducting state. J Neurosci. 2005;25:42-51 pubmed
    ..From these data, we propose a physical model of proton inhibition that can describe macroscopic and single-channel properties of NMDA receptor function over a range of pH values. ..
  65. Papaharalambus C, Sajjad W, Syed A, Zhang C, Bergo M, Alexander R, et al. Tumor necrosis factor alpha stimulation of Rac1 activity. Role of isoprenylcysteine carboxylmethyltransferase. J Biol Chem. 2005;280:18790-6 pubmed
    ..These results suggest that ICMT regulates Rac1 activity by controlling the interaction of Rac1 with RhoGDI. We hypothesize that ICMT regulates the release of Rac1 from RhoGDI. ..
  66. Clark K, Lin S, Humphrey C, Foytich K, Esona M, Wang Y, et al. Expression and characterization of human group C rotavirus virus-like particles in insect cells. Virology. 2009;387:267-72 pubmed publisher
  67. Wei J, Yerokun T, Leipelt M, Haynes C, Radhakrishna H, Momin A, et al. Serine palmitoyltransferase subunit 1 is present in the endoplasmic reticulum, nucleus and focal adhesions, and functions in cell morphology. Biochim Biophys Acta. 2009;1791:746-56 pubmed publisher
    ..Thus, in addition to its "traditional" localization in the ER for de novo sphingolipid biosynthesis, SPT1 is present in other cellular compartments, including focal adhesions where it is associated with cell morphology...
  68. Xiao Q, Yu K, Cui Y, Hartzell H. Dysregulation of human bestrophin-1 by ceramide-induced dephosphorylation. J Physiol. 2009;587:4379-91 pubmed publisher
    ..Our results support a model in which ceramide accumulation during early stages of retinopathy inhibits hBest1 function, leading to abnormal fluid transport across the retina, and enhanced inflammation. ..
  69. Poulos S, Dodson M, Hausman G. Cell line models for differentiation: preadipocytes and adipocytes. Exp Biol Med (Maywood). 2010;235:1185-93 pubmed publisher
    ..The focus of this brief review is to highlight similarities and differences in adipocyte models to aid in appropriate model selection and data interpretation for successful advancement of our understanding of adipocyte biology...
  70. Nguyen H, Trujillo A, Sheu T, Levine M, Mishin V, Shaw M, et al. Analysis of influenza viruses from patients clinically suspected of infection with an oseltamivir resistant virus during the 2009 pandemic in the United States. Antiviral Res. 2012;93:381-6 pubmed publisher
    ..These data suggest that pyrosequencing is a powerful tool for timely detection of NAI resistant viruses and that NI assays are needed for comprehensive testing to detect novel resistance substitutions. ..
  71. Tretyakova I, Hidajat R, Hamilton G, Horn N, Nickols B, Prather R, et al. Preparation of quadri-subtype influenza virus-like particles using bovine immunodeficiency virus gag protein. Virology. 2016;487:163-71 pubmed publisher
    ..Electron microscopy showed that Bgag-based VLPs resembled influenza virions with the diameter of 150-200nm. This is the first report of quadri-subtype design for influenza VLP and the use of Bgag for influenza VLP preparation. ..
  72. Su Z, Klein J, Du J, Franch H, Zhang L, Hassounah F, et al. Chronic kidney disease induces autophagy leading to dysfunction of mitochondria in skeletal muscle. Am J Physiol Renal Physiol. 2017;312:F1128-F1140 pubmed publisher
    ..However, myofibrillar protein is not directly broken down through autophagy. Instead, CKD-induced upregulation of autophagy leads to dysfunction of mitochondria and decrease of ATP production. ..
  73. Kishore A, Hall R. Disease-associated extracellular loop mutations in the adhesion G protein-coupled receptor G1 (ADGRG1; GPR56) differentially regulate downstream signaling. J Biol Chem. 2017;292:9711-9720 pubmed publisher
  74. Si Tahar M, Sitaraman S, Shibahara T, Madara J. Negative regulation of epithelium-neutrophil interactions via activation of CD44. Am J Physiol Cell Physiol. 2001;280:C423-32 pubmed
    ..Together, these results suggest that CD44 of PMN may potentially serve as a negative regulator of leukocyte migration across biological surfaces such as columnar epithelia...
  75. Corchero J, Mar E, Spira T, Pellett P, Inoue N. Comparison of serologic assays for detection of antibodies against human herpesvirus 8. Clin Diagn Lab Immunol. 2001;8:913-21 pubmed
    ..Because the K8.1-based IFA provides sensitivity similar to that of lytic PEL-based IFAs and improved specificity, it can be a useful alternative to the PEL-based IFAs. ..
  76. Calkins C, Hoepner B, Law C, Novak M, Setzer S, Hatzfeld M, et al. The Armadillo family protein p0071 is a VE-cadherin- and desmoplakin-binding protein. J Biol Chem. 2003;278:1774-83 pubmed
  77. Crary S, Towner J, Honig J, Shoemaker T, Nichol S. Analysis of the role of predicted RNA secondary structures in Ebola virus replication. Virology. 2003;306:210-8 pubmed
  78. Duan R, Pak C, Jin P. Single nucleotide polymorphism associated with mature miR-125a alters the processing of pri-miRNA. Hum Mol Genet. 2007;16:1124-31 pubmed
    ..Thus, our study reveals an additional structural requirement for pri-miRNA processing and emphasizes the importance of identifying new miRNA SNPs and their contributions to miRNA biogenesis and human genetic disease. ..
  79. Stansell E, Apkarian R, Haubova S, Diehl W, Tytler E, Hunter E. Basic residues in the Mason-Pfizer monkey virus gag matrix domain regulate intracellular trafficking and capsid-membrane interactions. J Virol. 2007;81:8977-88 pubmed publisher
    ..All mutants that released virions exhibited near-wild-type infectivity in a single-round assay. Thus, basic amino acids in the M-PMV MA define both cellular location and efficiency of virus release...
  80. Samarin S, Ivanov A, Flatau G, Parkos C, Nusrat A. Rho/Rho-associated kinase-II signaling mediates disassembly of epithelial apical junctions. Mol Biol Cell. 2007;18:3429-39 pubmed
    ..Thus, our findings demonstrate a central role of the GEF-H1/Rho/ROCK-II signaling pathway in the disassembly of AJC in epithelial cells. ..
  81. Olson V, Karem K, Smith S, Hughes C, Damon I. Smallpox virus plaque phenotypes: genetic, geographical and case fatality relationships. J Gen Virol. 2009;90:792-8 pubmed publisher
    ..The mechanisms for variola virus pathogenicity probably involves multiple host and pathogen factors...
  82. Yoon J, Krumm S, Ndungu J, Hoffman V, Bankamp B, Rota P, et al. Target analysis of the experimental measles therapeutic AS-136A. Antimicrob Agents Chemother. 2009;53:3860-70 pubmed publisher
    ..Taken together, these data support the hypothesis that acquiring mutations in these L domains may reduce virus fitness. ..
  83. Quan F, Kim Y, Compans R, Prausnitz M, Kang S. Dose sparing enabled by skin immunization with influenza virus-like particle vaccine using microneedles. J Control Release. 2010;147:326-32 pubmed publisher
    ..Therefore, this study demonstrates that microneedle vaccination in the skin confers more effective protective immunity at a lower dose, thus providing vaccine dose-sparing effects. ..
  84. Lu X, Bijli K, Ramirez A, Murphy T, Kleinhenz J, Hart C. Hypoxia downregulates PPAR? via an ERK1/2-NF-?B-Nox4-dependent mechanism in human pulmonary artery smooth muscle cells. Free Radic Biol Med. 2013;63:151-60 pubmed publisher
    ..These results also indicate that restoration of PPAR? activity with pharmacological ligands may provide a novel therapeutic approach in selected forms of PH. ..
  85. Yates M, Raje M, Chatterjee P, Spiropoulou C, Bavari S, Flint M, et al. Flex-nucleoside analogues - Novel therapeutics against filoviruses. Bioorg Med Chem Lett. 2017;27:2800-2802 pubmed publisher
    ..The Flex-nucleoside was the most potent against recombinant Ebola virus in Huh7 cells with an EC50=2μM, while the McGuigan prodrug was most active against Sudan virus-infected HeLa cells with an EC50 of 7μM. ..
  86. Allen R, Dezalia M, Speck S. Identification of an Rta responsive promoter involved in driving gammaHV68 v-cyclin expression during virus replication. Virology. 2007;365:250-9 pubmed
  87. Ganguly S, Liu J, Pillai V, Mittler R, Amara R. Adjuvantive effects of anti-4-1BB agonist Ab and 4-1BBL DNA for a HIV-1 Gag DNA vaccine: different effects on cellular and humoral immunity. Vaccine. 2010;28:1300-9 pubmed publisher
    ..Collectively, our data suggest that for a HIV-1 vaccine where both antigen-specific cellular and humoral immunity are desirable, 4-1BBL expressed by a DNA vaccine is a superior adjuvant than anti-4-1BB agonistic Ab. ..
  88. Richter P, Li A, Polzin G, Roy S. Cytotoxicity of eight cigarette smoke condensates in three test systems: comparisons between assays and condensates. Regul Toxicol Pharmacol. 2010;58:428-36 pubmed publisher
    ..Overall, cigarettes made with flue-cured tobacco were the most cytotoxic across the assays. When results were expressed on a per-mg of nicotine basis, lower tar cigarettes were the most cytotoxic in primary human respiratory cells. ..
  89. Cong M, Youngpairoj A, Zheng Q, Aung W, Mitchell J, Sweeney E, et al. Protection against rectal transmission of an emtricitabine-resistant simian/human immunodeficiency virus SHIV162p3M184V mutant by intermittent prophylaxis with Truvada. J Virol. 2011;85:7933-6 pubmed publisher
    ..Increased susceptibility to tenofovir due to M184V and other factors, including residual antiviral activity by FTC and/or reduced virus fitness due to M184V, may all have contributed to the observed protection. ..
  90. Votaw J, Byas Smith M, Hua J, Voll R, Martarello L, Levey A, et al. Interaction of isoflurane with the dopamine transporter. Anesthesiology. 2003;98:404-11 pubmed
    ..Thus, [18F]FECNT appears to be an excellent agent for measuring plasma membrane-expressed DAT and evaluating DAT trafficking. ..
  91. Lakatos A, Prinster S, Vicentic A, Hall R, Kuhar M. Cocaine- and amphetamine-regulated transcript (CART) peptide activates the extracellular signal-regulated kinase (ERK) pathway in AtT20 cells via putative G-protein coupled receptors. Neurosci Lett. 2005;384:198-202 pubmed
    ..Overall, these data strongly support the existence of a specific receptor for CART peptide that is a G-protein coupled receptor utilizing a Gi/o mechanism involving MEK1 and 2. ..
  92. Han S, Ritzenthaler J, Rivera H, Roman J. Peroxisome proliferator-activated receptor-gamma ligands suppress fibronectin gene expression in human lung carcinoma cells: involvement of both CRE and Sp1. Am J Physiol Lung Cell Mol Physiol. 2005;289:L419-28 pubmed
    ..In summary, our results demonstrate that PPARgamma ligands inhibit Fn gene expression in NSCLC cells through PPARgamma-dependent and -independent pathways that affect both CREB and Sp1. ..