Experts and Doctors on calpain in Atlanta, Georgia, United States
Locale: Atlanta, Georgia, United States
Glass J, Nash N, Dry I, Culver D, Levey A, Wesselingh S. Cloning of m-calpain 80 kD subunit from the axonal degeneration-resistant WLD(S) mouse mutant. J Neurosci Res. 1998;52:653-60 pubmed
..These data suggest that a defect in m-calpain 80 kD subunit does not likely underlie the WLD(S) phenotype, but raise questions about other subunits of calpain and possibly other proteases. ..
Li C, Chen S, Yue P, Deng X, Lonial S, Khuri F, et al
. Proteasome inhibitor PS-341 (bortezomib) induces calpain-dependent IkappaB(alpha) degradation. J Biol Chem. 2010;285:16096-104 pubmed publisher
..Collectively, these unexpected findings suggest not only a novel paradigm regarding the relationship between proteasome inhibition and NF-kappaB activity but also a strategy to enhance the anticancer efficacy of PS-341. ..
Wei G, Yin Y, Li W, Bito H, She H, Mao Z. Calpain-mediated degradation of myocyte enhancer factor 2D contributes to excitotoxicity by activation of extrasynaptic N-methyl-D-aspartate receptors. J Biol Chem. 2012;287:5797-805 pubmed publisher
..Collectively, these findings suggest that dysregulation of MEF2D by calpain may mediate excitotoxicity via an extrasynaptic NMDAR-dependent manner. ..
Ankala A, Kohn J, Dastur R, Gaitonde P, Khadilkar S, Hegde M. Ancestral founder mutations in calpain-3 in the Indian Agarwal community: historical, clinical, and molecular perspective. Muscle Nerve. 2013;47:931-7 pubmed publisher
..Founder mutations have immediate clinical application, at least in selected population groups. Clinically available gene panels may provide a definitive molecular diagnosis for heterogeneous disorders such as LGMD. ..
Montgomery D, Yu L, Ghazi Z, Thai T, Al Khalili O, Ma H, et al
. ENaC activity is regulated by calpain-2 proteolysis of MARCKS proteins. Am J Physiol Cell Physiol. 2017;313:C42-C53 pubmed publisher
Park J, Byrd A, Lee C, Morgan E. Nitric oxide stimulates cellular degradation of human CYP51A1, the highly conserved lanosterol 14?-demethylase. Biochem J. 2017;474:3241-3252 pubmed publisher
..NO donors also down-regulated CYP51A1 mRNA in Huh7 cells, but to a lesser degree, than the down-regulation of the protein. ..
Wang F, Xia P, Wu F, Wang D, Wang W, Ward T, et al
. Helicobacter pylori VacA disrupts apical membrane-cytoskeletal interactions in gastric parietal cells. J Biol Chem. 2008;283:26714-25 pubmed publisher
..pylori-induced inhibition of acid secretion. Our results indicate that VacA disrupts the apical membrane-cytoskeletal interactions in gastric parietal cells and thereby causes hypochlorhydria...
Liu F, Gamez G, Myers D, Clemmons W, Lam W, Jobe S. Mitochondrially mediated integrin ?IIb?3 protein inactivation limits thrombus growth. J Biol Chem. 2013;288:30672-81 pubmed publisher