Genomes and Genes
Experts and Doctors on animals in Atlanta, Georgia, United States
Locale: Atlanta, Georgia, United States
Publications1624 found, 100 shown here
- Altun A, Yokoyama S, Morokuma K. Color tuning in short wavelength-sensitive human and mouse visual pigments: ab initio quantum mechanics/molecular mechanics studies. J Phys Chem A. 2009;113:11685-92 pubmed publisher..There is no charge transfer between the SB and beta-ionone terminals of 11-cis-retinal in the ground and first excited states. ..
- Ovat A, Muindi F, Fagan C, Brouner M, Hansell E, Dvorak J, et al. Aza-peptidyl Michael acceptor and epoxide inhibitors--potent and selective inhibitors of Schistosoma mansoni and Ixodes ricinus legumains (asparaginyl endopeptidases). J Med Chem. 2009;52:7192-210 pubmed publisher..Given the central functions of these enzymes in both parasites, the data presented here may facilitate the eventual design of selective antiparasitic drugs. ..
- Hadjipanayis C, Van Meir E. Brain cancer propagating cells: biology, genetics and targeted therapies. Trends Mol Med. 2009;15:519-30 pubmed publisher..Ultimately, treatments that include specific targeting of BCPCs might potentially be more effective at treating the entire tumor mass, translating to improved patient survival and quality of life...
- Roberts Wilson T, Reddy R, Bailey J, Zheng B, Ordas R, Gooch J, et al. Calcineurin signaling and PGC-1alpha expression are suppressed during muscle atrophy due to diabetes. Biochim Biophys Acta. 2010;1803:960-7 pubmed publisher..These findings demonstrate that Cn activity is a major determinant of PGC-1alpha expression in skeletal muscle during diabetes and possibly other conditions associated with loss of muscle mass. ..
- Mistry A, Mallick R, Klein J, Sands J, Fröhlich O. Functional characterization of the central hydrophilic linker region of the urea transporter UT-A1: cAMP activation and snapin binding. Am J Physiol Cell Physiol. 2010;298:C1431-7 pubmed publisher..In addition, the Lc segment also gave UT-A2 the ability to bind snapin and, in Xenopus oocytes, to be stimulated in its urea transport activity by snapin and syntaxins 3 and 4, in the same way as UT-A1. ..
- Verma K, Gu J, Werner E. Tumor endothelial marker 8 amplifies canonical Wnt signaling in blood vessels. PLoS ONE. 2011;6:e22334 pubmed publisher..We postulate that the developmentally controlled expression of TEM8 modulates endothelial cell response to canonical Wnt signaling to regulate vessel patterning and density. ..
- Bossart G, Mignucci Giannoni A, Rivera Guzman A, Jimenez Marrero N, Camus A, Bonde R, et al. Disseminated toxoplasmosis in Antillean manatees Trichechus manatus manatus from Puerto Rico. Dis Aquat Organ. 2012;101:139-44 pubmed publisher..The documentation of 4 cases of toxoplasmosis within one year and the extremely low seroprevalence to T. gondii suggest that toxoplasmosis may be an emerging disease in Antillean manatees from Puerto Rico...
- Traber P, Chou H, Zomer E, Hong F, Klyosov A, Fiel M, et al. Regression of fibrosis and reversal of cirrhosis in rats by galectin inhibitors in thioacetamide-induced liver disease. PLoS ONE. 2013;8:e75361 pubmed publisher..These findings suggest a potential role of these drugs in human liver fibrosis and cirrhosis. ..
- Stimpson C, Barger N, Taglialatela J, Gendron Fitzpatrick A, Hof P, Hopkins W, et al. Differential serotonergic innervation of the amygdala in bonobos and chimpanzees. Soc Cogn Affect Neurosci. 2016;11:413-22 pubmed publisher..These findings suggest that variation in serotonergic innervation of the amygdala may contribute to mediating the remarkable differences in social behavior exhibited by bonobos and chimpanzees. ..
- Fair P, Schaefer A, Houser D, Bossart G, Romano T, Champagne C, et al. The environment as a driver of immune and endocrine responses in dolphins (Tursiops truncatus). PLoS ONE. 2017;12:e0176202 pubmed publisher..While the underlying mechanisms are likely multiple and complex, the marked differences observed in the immune and endocrine systems of wild and managed-care care dolphins appear to be shaped by their environment. ..
- Huang R, Yi P, Tang Y. Probing the interactions of organic molecules, nanomaterials, and microbes with solid surfaces using quartz crystal microbalances: methodology, advantages, and limitations. Environ Sci Process Impacts. 2017;19:793-811 pubmed publisher..It serves to help researchers gain deeper insights into the fundamentals and applications of QCMs, and provides new perspectives on future research directions. ..
- Boyan B, Dean D, Sylvia V, Schwartz Z. Steroid hormone action in musculoskeletal cells involves membrane receptor and nuclear receptor mechanisms. Connect Tissue Res. 2003;44 Suppl 1:130-5 pubmed
- Collins R, Cheng X. Structural domains in RNAi. FEBS Lett. 2005;579:5841-9 pubmed..We present a review of recent structures that illustrate the molecular mechanisms contributing to these two related functions, highlighting models of Drosha, Dicer, and RISC function. ..
- Chavan R, Marfatia K, An I, Garber D, Feinberg M. Expression of CCL20 and granulocyte-macrophage colony-stimulating factor, but not Flt3-L, from modified vaccinia virus ankara enhances antiviral cellular and humoral immune responses. J Virol. 2006;80:7676-87 pubmed..Our results demonstrate that a strategy to express specific genetic adjuvants from rMVA vectors can be successfully applied to enhance the immunogenicity of MVA-based vaccines. ..
- Zhang X, Cassis Ghavami F, Eller M, Currier J, Slike B, Chen X, et al. Direct comparison of antigen production and induction of apoptosis by canarypox virus- and modified vaccinia virus ankara-human immunodeficiency virus vaccine vectors. J Virol. 2007;81:7022-33 pubmed..These results reveal differences in poxvirus vector-host cell interactions that should be relevant to their use as immunization vehicles...
- Tran T, Sneed B, Haider J, Blavo D, White A, Aiyejorun T, et al. Automated, quantitative screening assay for antiangiogenic compounds using transgenic zebrafish. Cancer Res. 2007;67:11386-92 pubmed..5 and 0.36 micromol/L, respectively). It is therefore the first antiangiogenic compound discovered initially in a zebrafish assay that also has demonstrable activity in human endothelial cell-based angiogenesis assays. ..
- Bramlett J, Perdue B, Evans T, Beran M. Capuchin monkeys (Cebus apella) let lesser rewards pass them by to get better rewards. Anim Cogn. 2012;15:963-9 pubmed publisher..These data confirm that the mechanisms necessary for self-control are present in capuchin monkeys and indicate that the methodology can be useful for broader comparative assessments of self-control...
- Bastaki M, Farrell T, Bhusari S, Pant K, Kulkarni R. Lack of genotoxicity in vivo for food color additive Tartrazine. Food Chem Toxicol. 2017;105:278-284 pubmed publisher..Negative findings in parallel genotoxicity studies on Allura Red AC and Ponceau 4R (published separately) are consistent with lack of genotoxicity for azo dyes used as food colors. ..
- Bozja J, Yi K, Shafer W, Stojiljkovic I. Porphyrin-based compounds exert antibacterial action against the sexually transmitted pathogens Neisseria gonorrhoeae and Haemophilus ducreyi. Int J Antimicrob Agents. 2004;24:578-84 pubmed
- Duprey Z, Steurer F, Rooney J, Kirchhoff L, Jackson J, Rowton E, et al. Canine visceral leishmaniasis, United States and Canada, 2000-2003. Emerg Infect Dis. 2006;12:440-6 pubmed
- Berns G, Capra C, Noussair C. Receptor theory and biological constraints on value. Ann N Y Acad Sci. 2007;1104:301-9 pubmed..From the laws of mass action and receptor occupancy, we show how behaviorally observed forms of nonlinear value functions can arise. ..
- Regnery R. Poxviruses and the passive quest for novel hosts. Curr Top Microbiol Immunol. 2007;315:345-61 pubmed..The remaining bulk of the discussion involves examples of members of the genus Orthopoxvirus, which are known to be (have been) involved with human disease, and their zoonotic origins...
- Guzik T, Hoch N, Brown K, McCann L, Rahman A, Dikalov S, et al. Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction. J Exp Med. 2007;204:2449-60 pubmed..T cells might represent a novel therapeutic target for the treatment of high blood pressure. ..
- Calvert J, Coetzee W, Lefer D. Novel insights into hydrogen sulfide--mediated cytoprotection. Antioxid Redox Signal. 2010;12:1203-17 pubmed publisher..This review also provides a detailed description of the current signaling mechanisms shown to be responsible for these cardioprotective actions. ..
- Saxena N, Fu P, Nagalingam A, Wang J, Handy J, Cohen C, et al. Adiponectin modulates C-jun N-terminal kinase and mammalian target of rapamycin and inhibits hepatocellular carcinoma. Gastroenterology. 2010;139:1762-73, 1773.e1-5 pubmed publisher..Adiponectin protects against liver tumorigenesis; its reduced expression is associated with poor prognosis in obese patients with HCC. ..
- Turner A, Shaffer V, Araki K, Martens C, Turner P, Gangappa S, et al. Sirolimus enhances the magnitude and quality of viral-specific CD8+ T-cell responses to vaccinia virus vaccination in rhesus macaques. Am J Transplant. 2011;11:613-8 pubmed publisher..These data elucidate new mechanistic characteristics of sirolimus and suggest immune applications extending beyond its role as an immunosuppressant...
- Koch S, Nava P, Addis C, Kim W, Denning T, Li L, et al. The Wnt antagonist Dkk1 regulates intestinal epithelial homeostasis and wound repair. Gastroenterology. 2011;141:259-68, 268.e1-8 pubmed publisher..Depletion of Dkk1 induces a strong proliferative response that promotes wound repair after colitis. ..
- Mutuku F, King C, Bustinduy A, Mungai P, Muchiri E, Kitron U. Impact of drought on the spatial pattern of transmission of Schistosoma haematobium in coastal Kenya. Am J Trop Med Hyg. 2011;85:1065-70 pubmed publisher..The implications of extreme weather and climate conditions on risk and transmission of S. haematobium and their relevance to control strategies are discussed...
- Stehouwer J. Fluorinated tropanes. Curr Top Med Chem. 2013;13:920-35 pubmed..This review provides an overview of the efforts devoted to developing fluorine-18 radiolabeled tropanes for imaging use with positron emission tomography. ..
- Hansen L, Parker I, Roberts L, Sutliff R, Platt M, Gleason R. Azidothymidine (AZT) leads to arterial stiffening and intima-media thickening in mice. J Biomech. 2013;46:1540-7 pubmed publisher..Thus, this study suggests the drug AZT has significant effects on the development of subclinical markers of atherosclerosis. ..
- Jiang Y, Qi X, Chrenek M, Gardner C, Boatright J, Grossniklaus H, et al. Functional principal component analysis reveals discriminating categories of retinal pigment epithelial morphology in mice. Invest Ophthalmol Vis Sci. 2013;54:7274-83 pubmed publisher..We conclude that an RPE cell's area and aspect ratio are very early quantitative indicators that predict progression to advanced RPE disease as manifested in rd10. ..
- Whitney E, Massung R, Kersh G, Fitzpatrick K, Mook D, Taylor D, et al. Survey of laboratory animal technicians in the United States for Coxiella burnetii antibodies and exploration of risk factors for exposure. J Am Assoc Lab Anim Sci. 2013;52:725-31 pubmed..Physicians should consider the risk of infection with C. burnetii when treating LAT with potential occupational exposures. ..
- Xu K, Chen G, Qiu Y, Yuan Z, Li H, Yuan X, et al. miR-503-5p confers drug resistance by targeting PUMA in colorectal carcinoma. Oncotarget. 2017;8:21719-21732 pubmed publisher..These results indicate that a p53/miR-503-5p/PUMA signaling axis regulates the CRC response to chemotherapy, and suggest that miR-503-5p plays an important role in the development of MDR in CRC by modulating PUMA expression. ..
- Suk H, van Welie I, Kodandaramaiah S, Allen B, Forest C, Boyden E. Closed-Loop Real-Time Imaging Enables Fully Automated Cell-Targeted Patch-Clamp Neural Recording In Vivo. Neuron. 2017;95:1037-1047.e11 pubmed publisher..Our "imagepatching" robot is easy to implement and will help enable scalable characterization of identified cell types in intact neural circuits. ..
- Holtzman S. Opioid- and phencyclidine-like discriminative effects of ditolylguanidine, a selective sigma ligand. J Pharmacol Exp Ther. 1989;248:1054-62 pubmed
- Dusenbery D. Performance of basic strategies for following gradients in two dimensions. J Theor Biol. 2001;208:345-60 pubmed..The modeling demonstrates the need to obtain quantitative estimates for a number of parameters (relating costs and noise levels) for a more rigorous understanding of the relative advantages of these different strategies. ..
- Bough K, Schwartzkroin P, Rho J. Calorie restriction and ketogenic diet diminish neuronal excitability in rat dentate gyrus in vivo. Epilepsia. 2003;44:752-60 pubmed..These data suggest that CR, by itself, can be anticonvulsant, and treatment with a KCR diet may be both anticonvulsant and antiepileptogenic. ..
- Ismail M, Brun R, Wenzler T, Tanious F, Wilson W, Boykin D. Novel dicationic imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines as antiprotozoal agents. J Med Chem. 2004;47:3658-64 pubmed..The oral activity of the prodrugs was modest with only one showing 2/4 cures in the same mouse model. ..
- Prusak A, O Neal J, Kubanek J. Prevalence of chemical defenses among freshwater plants. J Chem Ecol. 2005;31:1145-60 pubmed..However, we found no relationship between soluble protein concentration and deterrence of plant extracts...
- Hopkins A, Pineda A, Winfree L, Brown G, Laukoetter M, Nusrat A. Organized migration of epithelial cells requires control of adhesion and protrusion through Rho kinase effectors. Am J Physiol Gastrointest Liver Physiol. 2007;292:G806-17 pubmed
- Hill E, Katz P. Role of membrane potential in calcium signaling during rhythmic bursting in tritonia swim interneurons. J Neurophysiol. 2007;97:2204-14 pubmed..Therefore in VSI, the cytoplasmic Ca(2+) signal during the SMP can be accounted for by its membrane potential excursions, whereas in C2 the membrane potential excursions can account for most of the SMP Ca(2+) signal. ..
- Ono K, Yu R, Ono S. Structural components of the nonstriated contractile apparatuses in the Caenorhabditis elegans gonadal myoepithelial sheath and their essential roles for ovulation. Dev Dyn. 2007;236:1093-105 pubmed..Our results provide basic information that helps understanding the mechanism of sheath contraction during ovulation and establishing a new model to study morphogenesis of nonstriated muscle. ..
- Wang X, Yue P, Chan C, Ye K, Ueda T, Watanabe Fukunaga R, et al. Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation. Mol Cell Biol. 2007;27:7405-13 pubmed..In addition, we also suggest an effective therapeutic strategy for enhancing mTOR-targeted cancer therapy by cotargeting mTOR signaling and Mnk/eIF4E phosphorylation. ..
- He M, Cai J, Go Y, Johnson J, Martin W, Hansen J, et al. Identification of thioredoxin-2 as a regulator of the mitochondrial permeability transition. Toxicol Sci. 2008;105:44-50 pubmed publisher..Unexpectedly, Trx2 also protected against the MPT induced by Ca(2+) in the absence of added peroxide. The results indicate that in addition to protecting against oxidative stress, Trx2 is an endogenous regulator of the MPT. ..
- Collins W, Sullivan J, Nace D, Williams T, Williams A, Barnwell J. Transmission of different strains of Plasmodium cynomolgi to Aotus nancymaae monkeys and relapse. J Parasitol. 2009;95:349-52 pubmed publisher..Importantly, relapse was demonstrated in 5 of 5 sporozoite-induced infections with the Rossan strain following treatment with chloroquine...
- Miller A. Norman Cousins Lecture. Mechanisms of cytokine-induced behavioral changes: psychoneuroimmunology at the translational interface. Brain Behav Immun. 2009;23:149-58 pubmed publisher..Depending on the relative balance between these behavioral accoutrements of an activated innate immune response, clinical presentations may be distinct and warrant individualized therapeutic approaches. ..
- Tamin A, Harcourt B, Lo M, Roth J, Wolf M, Lee B, et al. Development of a neutralization assay for Nipah virus using pseudotype particles. J Virol Methods. 2009;160:1-6 pubmed publisher..Therefore, this new method has the potential to be a rapid and cost-effective diagnostic method, especially in locations that lack high containment facilities, and will provide a valuable tool for basic research and vaccine development...
- Banyai K, Esona M, Liu A, Wang Y, Tu X, Jiang B. Molecular detection of novel adenoviruses in fecal specimens of captive monkeys with diarrhea in China. Vet Microbiol. 2010;142:416-9 pubmed publisher..A better understanding of the epidemiology of SAdVs and their potential role in gastroenteritis is critical to the implementation of advanced prevention strategies against AdV infection in captive primates...
- Guo J, Rainnie D. Presynaptic 5-HT(1B) receptor-mediated serotonergic inhibition of glutamate transmission in the bed nucleus of the stria terminalis. Neuroscience. 2010;165:1390-401 pubmed publisher..This study illustrates a new pathway by which the activity of BNST neurons can be indirectly modulated by 5-HT, and suggests a potential new target for the development of novel treatments for depression and anxiety disorders. ..
- Song J, Kim Y, Lipatov A, Pearton M, Davis C, Yoo D, et al. Microneedle delivery of H5N1 influenza virus-like particles to the skin induces long-lasting B- and T-cell responses in mice. Clin Vaccine Immunol. 2010;17:1381-9 pubmed publisher..Microneedle vaccination in the skin with H5 VLPs represents a promising approach for a self-administered vaccine against viruses with pandemic potential...
- Altincicek B, Kovacs J, Gerardo N. Horizontally transferred fungal carotenoid genes in the two-spotted spider mite Tetranychus urticae. Biol Lett. 2012;8:253-7 pubmed publisher..As carotenoids are associated with diapause induction in these animals, our results add to recent findings highlighting the importance of eukaryotic horizontal gene transfer in the ecology and evolution of higher animals...
- Zhang L, Agravat S, Derado G, Chen S, McIntosh B, Bowman F. BSMac: a MATLAB toolbox implementing a Bayesian spatial model for brain activation and connectivity. J Neurosci Methods. 2012;204:133-143 pubmed publisher..The toolbox can be downloaded from http://www.sph.emory.edu/bios/CBIS/. We illustrate the BSMac toolbox through an application to an fMRI study of working memory in patients with schizophrenia. ..
- Qurashi A, Liu H, Ray L, Nelson D, Duan R, Jin P. Chemical screen reveals small molecules suppressing fragile X premutation rCGG repeat-mediated neurodegeneration in Drosophila. Hum Mol Genet. 2012;21:2068-75 pubmed publisher..Our results demonstrate the utility of Drosophila models for unbiased small molecule screens and point to PLA(2) as a possible therapeutic target to treat FXTAS. ..
- Chen J, Dosier C, Park J, De S, Guldberg R, Boyan B, et al. Mineralization of three-dimensional osteoblast cultures is enhanced by the interaction of 1?,25-dihydroxyvitamin D3 and BMP2 via two specific vitamin D receptors. J Tissue Eng Regen Med. 2016;10:40-51 pubmed publisher..These data indicate a synergistic crosstalk between 1?,25(OH)2D3 and BMP2 toward osteogenesis and mineral deposition, involving both VDR and Pdia3. ..
- Liu Y, Olanrewaju Y, Zhang X, Cheng X. DNA recognition of 5-carboxylcytosine by a Zfp57 mutant at an atomic resolution of 0.97 Å. Biochemistry. 2013;52:9310-7 pubmed publisher..Furthermore, introducing a positively charged arginine at position 182 resulted in a mutant (E182R) having higher selectivity for the negatively charged 5caC. ..
- Krachun C, Lurz R, Russell J, Hopkins W. Smoke and mirrors: Testing the scope of chimpanzees' appearance-reality understanding. Cognition. 2016;150:53-67 pubmed publisher..The findings thus support the hypothesis that chimpanzees are capable of making AR discriminations with a range of illusory stimuli. ..
- Sharer J, Kahn R. The ARF-like 2 (ARL2)-binding protein, BART. Purification, cloning, and initial characterization. J Biol Chem. 1999;274:27553-61 pubmed..The lack of ARL2 GTPase-activating protein activity in BART led us to conclude that the specific interaction with ARL2.GTP is most consistent with BART being the first identified ARL2-specific effector. ..
- Bhat K, van Beers E, Bhat P. Sloppy paired acts as the downstream target of wingless in the Drosophila CNS and interaction between sloppy paired and gooseberry inhibits sloppy paired during neurogenesis. Development. 2000;127:655-65 pubmed..This mechanism appears to be responsible for specifying NB5-3 identity to a row 5 neuroblast and preventing Wg from specifying NB4-2 identity to that cell. ..
- Igietseme J, Murdin A. Induction of protective immunity against Chlamydia trachomatis genital infection by a vaccine based on major outer membrane protein-lipophilic immune response-stimulating complexes. Infect Immun. 2000;68:6798-806 pubmed..Altogether, the results suggested that IM delivery of MOMP-ISCOMs may be a suitable vaccine regimen potentially capable of inducing protective mucosal immunity against C. trachomatis infection. ..
- Borges K, Dingledine R. Functional organization of the GluR1 glutamate receptor promoter. J Biol Chem. 2001;276:25929-38 pubmed..In contrast to the GluR2 promoter the regulatory regions are mainly located outside of the GluR1 initiation region. ..
- Sharma A, Valadi N, Miller A, Pearce B. Neonatal viral infection decreases neuronal progenitors and impairs adult neurogenesis in the hippocampus. Neurobiol Dis. 2002;11:246-56 pubmed..The LCMV model could be exploited to examine pathophysiological mechanisms of neurodegeneration and to test pharmacological strategies aimed at increasing neurogenesis or rescuing multipotent progenitors. ..
- Silvestri G, Sodora D, Koup R, Paiardini M, O Neil S, McClure H, et al. Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia. Immunity. 2003;18:441-52 pubmed..Rather, attenuated immune activation enables SIV-infected mangabeys to avoid the bystander damage seen in pathogenic infections and protects them from developing AIDS...
- Novak C, Ehlen J, Huhman K, Albers H. GABA(B) receptor activation in the suprachiasmatic nucleus of diurnal and nocturnal rodents. Brain Res Bull. 2004;63:531-5 pubmed..Taken together with previous data from our laboratory, these results demonstrate that, in both hamsters and grass rats, GABAB receptor activation in the SCN significantly affects circadian phase during the night, but not during the day. ..
- Kajita M, McClinic K, Wade P. Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress. Mol Cell Biol. 2004;24:7559-66 pubmed..Thus, aberrant expression of Snail or Slug may promote tumorigenesis through increased resistance to programmed cell death. ..
- Keen Rhinehart E, Bartness T. Peripheral ghrelin injections stimulate food intake, foraging, and food hoarding in Siberian hamsters. Am J Physiol Regul Integr Comp Physiol. 2005;288:R716-22 pubmed..Collectively, these data suggest that exogenous ghrelin, similar to fasting, increases appetitive behaviors (foraging, hoarding) by Siberian hamsters, but dissimilar to fasting in this species, stimulates food intake. ..
- Westerman L, McClure H, Jiang B, Almond J, Glass R. Serum IgG mediates mucosal immunity against rotavirus infection. Proc Natl Acad Sci U S A. 2005;102:7268-73 pubmed..The observation that passively transferred antibodies can suppress or delay viral infection in rotavirus-challenged pigtailed macaques has important implications for the design and testing of parenteral candidate rotavirus vaccines...
- Hu Y, Yao J, Liu Z, Liu X, Fu H, Ye K. Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation. EMBO J. 2005;24:3543-54 pubmed..Thus, Akt inhibits chromatin condensation during apoptosis by phosphorylating acinus in the nucleus, revealing a specific mechanism by which nuclear Akt promotes cell survival. ..
- Vezys V, Masopust D, Kemball C, Barber D, O Mara L, Larsen C, et al. Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection. J Exp Med. 2006;203:2263-9 pubmed..These findings reveal a novel role for antigen in maintaining virus-specific CD8 T cells during persistent infection and provide insight toward understanding T cell differentiation in chronic infection. ..
- Sengupta A, Baker T, Chakrabarti N, Whittaker J, Sridaran R. Localization of immunoreactive gonadotropin-releasing hormone and relative expression of its mRNA in the oviduct during pregnancy in rats. J Histochem Cytochem. 2007;55:525-34 pubmed
- Zhang B, Maris C, Foell J, Whitmire J, Niu L, Song J, et al. Immune suppression or enhancement by CD137 T cell costimulation during acute viral infection is time dependent. J Clin Invest. 2007;117:3029-41 pubmed..These data show that anti-CD137 mAbs can induce T cell activation-induced cell death or enhance antiviral immunity depending on the timing of treatment, which may be important for vaccine development. ..
- Hancock K, Narang S, Pattabhi S, Yushak M, Khan A, Lin S, et al. False positive reactivity of recombinant, diagnostic, glycoproteins produced in High Five insect cells: effect of glycosylation. J Immunol Methods. 2008;330:130-6 pubmed
- Clark M, Khan R, Baro D. Crustacean dopamine receptors: localization and G protein coupling in the stomatogastric ganglion. J Neurochem. 2008;104:1006-19 pubmed..All three receptors are localized exclusively to the synaptic neuropil and most likely generate global biochemical signals that alter ion channels in distant compartments, as well as local signals...
- Andrews N, Pack C, Lukacher A. Generation of antiviral major histocompatibility complex class I-restricted T cells in the absence of CD8 coreceptors. J Virol. 2008;82:4697-705 pubmed publisher..These findings provide a possible explanation for the resistance of CD8-deficient mice to PyV-induced tumors and have implications for the maintenance of virus-specific MHC-I-restricted T cells during persistent infection. ..
- Hutson C, Abel J, Carroll D, Olson V, Braden Z, Hughes C, et al. Comparison of West African and Congo Basin monkeypox viruses in BALB/c and C57BL/6 mice. PLoS ONE. 2010;5:e8912 pubmed publisher..In addition, such a model can be utilized to test antivirals and the next generation of orthopoxvirus vaccines for their ability to alter the course of disease. ..
- Price S, Gooch J, Donaldson S, Roberts Wilson T. Muscle atrophy in chronic kidney disease results from abnormalities in insulin signaling. J Ren Nutr. 2010;20:S24-8 pubmed publisher..In this review, the proteolytic systems that are activated during chronic kidney disease and the key insulin signaling pathways that regulate the protein degradative processes are described. ..
- Albarino C, Bird B, Chakrabarti A, Dodd K, White D, Bergeron E, et al. Reverse genetics generation of chimeric infectious Junin/Lassa virus is dependent on interaction of homologous glycoprotein stable signal peptide and G2 cytoplasmic domains. J Virol. 2011;85:112-22 pubmed publisher..These recombinant chimeric viruses shed light on the fundamental requirements of arenavirus GPC maturation and may serve as a strategy for the development of bivalent JUNV and LASV vaccine candidates...
- Parr L, Heintz M, Lonsdorf E, Wroblewski E. Visual kin recognition in nonhuman primates: (Pan troglodytes and Macaca mulatta): inbreeding avoidance or male distinctiveness?. J Comp Psychol. 2010;124:343-50 pubmed publisher..This suggests that for the rhesus monkey, inbreeding avoidance involves something other than facial phenotypic matching but that among chimpanzees, the visual recognition of facial similarities may play an important role. ..
- Mitchell C, Lee R. Cargo distributions differentiate pathological axonal transport impairments. J Theor Biol. 2012;300:277-91 pubmed publisher..For example, using the model-predicted defect signatures, we identify the defect candidates, which are most likely to be responsible for the axonal transport impairments in the G93A SOD1 mouse model of ALS. ..
- Fournier B, Andargachew R, Robin A, Laur O, Voelker D, Lee W, et al. Surfactant protein D (Sp-D) binds to membrane-proximal domain (D3) of signal regulatory protein ? (SIRP?), a site distant from binding domain of CD47, while also binding to analogous region on signal regulatory protein ? (SIRP?). J Biol Chem. 2012;287:19386-98 pubmed publisher
- Wongtrakool C, Grooms K, Ping X, Rivera H, Ward J, Roser Page S, et al. In utero nicotine exposure promotes M2 activation in neonatal mouse alveolar macrophages. Pediatr Res. 2012;72:147-53 pubmed..These findings have important implications for immune responses in the nicotine-exposed neonatal lung. ..
- Bettler D, Pearson S, Yedvobnick B. The nuclear protein encoded by the Drosophila neurogenic gene mastermind is widely expressed and associates with specific chromosomal regions. Genetics. 1996;143:859-75 pubmed..Immunohistochemical detection of Mam on polytene chromosomes revealed binding at > 100 sites. Chromosome colocalization studies with RNA polymerase and the groucho corepressor protein implicate Mam in transcriptional regulation. ..
- Clemens S, Katz P. Identified serotonergic neurons in the Tritonia swim CPG activate both ionotropic and metabotropic receptors. J Neurophysiol. 2001;85:476-9 pubmed..A similar synaptic activation of metabotropic receptors might also be found within the CPG itself, where it could exert a direct influence onto motor pattern generation...
- Krebs J, Mondul A, Rupprecht C, Childs J. Rabies surveillance in the United States during 2000. J Am Vet Med Assoc. 2001;219:1687-99 pubmed..One case of human rabies acquired outside the United States that resulted from a dog bite was caused by the canine variant of the rabies virus...
- Tong S, Li M, Vincent A, Compans R, Fritsch E, Beier R, et al. Regulation of fusion activity by the cytoplasmic domain of a paramyxovirus F protein. Virology. 2002;301:322-333 pubmed..These results demonstrate that an elongated CT of a paramyxovirus F protein suppresses its membrane fusion activity. ..
- Xu H, Whelan P, Wenner P. Development of an inhibitory interneuronal circuit in the embryonic spinal cord. J Neurophysiol. 2005;93:2922-33 pubmed..The R-interneuron projects three or more segments both rostrally and caudally through the ventrolateral funiculus. The distribution of this circuit may become more locally focused between E7.5 and E15. ..