Experts and Doctors on amiloride in Atlanta, Georgia, United States
Locale: Atlanta, Georgia, United States
Chen X, Eaton D, Jain L. Beta-adrenergic regulation of amiloride-sensitive lung sodium channels. Am J Physiol Lung Cell Mol Physiol. 2002;282:L609-20 pubmed
..PKA increases HSC number and increases intracellular calcium. The increase in calcium increases NSC P(o). Thus increased cAMP levels are likely to increase lung sodium transport regardless of which channel type is present...
Pech V, Thumová M, Kim Y, Agazatian D, Hummler E, Rossier B, et al
. ENaC inhibition stimulates Cl- secretion in the mouse cortical collecting duct through an NKCC1-dependent mechanism. Am J Physiol Renal Physiol. 2012;303:F45-55 pubmed publisher
..Finally, benzamil-sensitive Cl(-) flux occurs, at least in part, through transcellular transport through a pathway that depends on NKCC1. ..
Pech V, Thumová M, Dikalov S, Hummler E, Rossier B, Harrison D, et al
. Nitric oxide reduces Cl? absorption in the mouse cortical collecting duct through an ENaC-dependent mechanism. Am J Physiol Renal Physiol. 2013;304:F1390-7 pubmed publisher
..We conclude that NO reduces Cl? absorption in the CCD through a mechanism that is ENaC-dependent. ..
Kelly O, Lin C, Ramkumar M, Saxena N, Kleyman T, Eaton D. Characterization of an amiloride binding region in the alpha-subunit of ENaC. Am J Physiol Renal Physiol. 2003;285:F1279-90 pubmed
..These data provide new insight into the relative position of the extracellular loop with respect to the pore of ENaC and its role in amiloride binding and channel gating. ..
Kim Y, Pech V, Spencer K, Beierwaltes W, Everett L, Green E, et al
. Reduced ENaC protein abundance contributes to the lower blood pressure observed in pendrin-null mice. Am J Physiol Renal Physiol. 2007;293:F1314-24 pubmed
..The reduced ENaC protein abundance and function observed in Slc26a4-null mice contribute to their lower blood pressure and reduced ability to conserve Na(+) during NaCl restriction. ..
Montgomery D, Yu L, Ghazi Z, Thai T, Al Khalili O, Ma H, et al
. ENaC activity is regulated by calpain-2 proteolysis of MARCKS proteins. Am J Physiol Cell Physiol. 2017;313:C42-C53 pubmed publisher