Experts and Doctors on tretinoin in University Park, Florida, United States


Locale: University Park, Florida, United States
Topic: tretinoin

Top Publications

  1. Tan L, Wray A, Green M, Ross A. Compartmental modeling of whole-body vitamin A kinetics in unsupplemented and vitamin A-retinoic acid-supplemented neonatal rats. J Lipid Res. 2014;55:1738-49 pubmed publisher
  2. Tan L, Wray A, Green M, Ross A. Retinol kinetics in unsupplemented and vitamin A-retinoic acid supplemented neonatal rats: a preliminary model. J Lipid Res. 2014;55:1077-86 pubmed publisher
    ..A VARA perturbation model indicated that the effect of VARA in stimulating VA uptake into tissues in neonates is both dramatic and transient. ..
  3. Chen Q, Ross A. Vitamin A and immune function: retinoic acid modulates population dynamics in antigen receptor and CD38-stimulated splenic B cells. Proc Natl Acad Sci U S A. 2005;102:14142-9 pubmed
  4. Chen Q, Ross A. Retinoic acid promotes mouse splenic B cell surface IgG expression and maturation stimulated by CD40 and IL-4. Cell Immunol. 2007;249:37-45 pubmed
    ..Overall, RA can promote B-cell maturation at the population level by increasing the number of sIgG1 and CD138 expressing cells, which may be related to the potentiation of humoral immunity in vivo. ..
  5. Wang Y, Baumrucker C. Retinoids, retinoid analogs, and lactoferrin interact and differentially affect cell viability of 2 bovine mammary cell types in vitro. Domest Anim Endocrinol. 2010;39:10-20 pubmed publisher
  6. Ross A. Vitamin A and retinoic acid in T cell-related immunity. Am J Clin Nutr. 2012;96:1166S-72S pubmed publisher
  7. Chen Q, Ross A. Retinoic acid regulates CD1d gene expression at the transcriptional level in human and rodent monocytic cells. Exp Biol Med (Maywood). 2007;232:488-94 pubmed
    ..These studies together provide evidence for a previously unknown mechanism of CD1d gene expression regulation by RA and suggest that RA is a significant modulator of NKT cell activation. ..
  8. Qian L, Zolfaghari R, Ross A. Liver-specific cytochrome P450 CYP2C22 is a direct target of retinoic acid and a retinoic acid-metabolizing enzyme in rat liver. J Lipid Res. 2010;51:1781-92 pubmed publisher
    ..Our studies demonstrate that CYP2C22 is a high-abundance, retinoid-inducible, hepatic P450 with the potential to metabolize at-RA, providing additional insight into the role of the CYP2C gene family in retinoid homeostasis. ..
  9. Tan L, Wray A, Ross A. Oral vitamin A and retinoic acid supplementation stimulates antibody production and splenic Stra6 expression in tetanus toxoid-immunized mice. J Nutr. 2012;142:1590-5 pubmed publisher
    ..Concomitantly, these treatments increased the systemic antigen-specific antibody response. The ability of oral retinoids to stimulate systemic immunity has implications for public health and therapeutic use of VA. ..

More Information


  1. Borland M, Khozoie C, Albrecht P, Zhu B, Lee C, Lahoti T, et al. Stable over-expression of PPAR?/? and PPAR? to examine receptor signaling in human HaCaT keratinocytes. Cell Signal. 2011;23:2039-50 pubmed publisher
  2. Borland M, Foreman J, Girroir E, Zolfaghari R, Sharma A, Amin S, et al. Ligand activation of peroxisome proliferator-activated receptor-beta/delta inhibits cell proliferation in human HaCaT keratinocytes. Mol Pharmacol. 2008;74:1429-42 pubmed publisher
  3. Shimada T, Ross A, Muccio D, Brouillette W, Shealy Y. Regulation of hepatic lecithin:retinol acyltransferase activity by retinoic acid receptor-selective retinoids. Arch Biochem Biophys. 1997;344:220-7 pubmed
    ..920). These data implicate the RARs in the induction of hepatic LRAT and suggest a predominant role for RAR-alpha-active ligands. ..
  4. Wu L, Ross A. Acidic retinoids synergize with vitamin A to enhance retinol uptake and STRA6, LRAT, and CYP26B1 expression in neonatal lung. J Lipid Res. 2010;51:378-87 pubmed publisher
    ..However, the pronounced and prolonged induction of CYP26B1 by Am580 may counteract lung RE accumulation after the absorption process is completed. ..
  5. Zhang Y, Zolfaghari R, Ross A. Multiple retinoic acid response elements cooperate to enhance the inducibility of CYP26A1 gene expression in liver. Gene. 2010;464:32-43 pubmed publisher
  6. Ross A, Zolfaghari R. Cytochrome P450s in the regulation of cellular retinoic acid metabolism. Annu Rev Nutr. 2011;31:65-87 pubmed publisher
    ..Thus, pharmacological approaches to limiting the activity of CYP26 enzymes may extend the half-life of RA and could be useful clinically in the future. ..
  7. Zhang Y, Wray A, Ross A. Perinatal exposure to vitamin A differentially regulates chondrocyte growth and the expression of aggrecan and matrix metalloprotein genes in the femur of neonatal rats. J Nutr. 2012;142:649-54 pubmed publisher
    ..These results suggest that moderately high maternal VA intake combined with neonatal VARA supplementation can reduce the ratio of aggrecan:MMP, which may unfavorably alter early bone development. ..
  8. Luo X, Ross A. Retinoic acid exerts dual regulatory actions on the expression and nuclear localization of interferon regulatory factor-1. Exp Biol Med (Maywood). 2006;231:619-31 pubmed
  9. Zhang Y, Ross A. Retinoic acid and the transcription factor MafB act together and differentially to regulate aggrecan and matrix metalloproteinase gene expression in neonatal chondrocytes. J Cell Biochem. 2013;114:471-9 pubmed publisher
    ..These results support a role for MafB as a regulator of chondrocyte gene expression and matrix formation via control of aggrecan, MMP3 and MMP13 expression, and indicate an important role for RA in the regulation of MafB. ..
  10. Zolfaghari R, Wang Y, Chen Q, Sancher A, Ross A. Cloning and molecular expression analysis of large and small lecithin:retinol acyltransferase mRNAs in the liver and other tissues of adult rats. Biochem J. 2002;368:621-31 pubmed
    ..The differential usage of these polyadenylation signals can explain the presence of multiple LRAT mRNA transcripts which are expressed in different tissue-specific patterns. ..
  11. Wang Y, Zolfaghari R, Ross A. Cloning of rat cytochrome P450RAI (CYP26) cDNA and regulation of its gene expression by all-trans-retinoic acid in vivo. Arch Biochem Biophys. 2002;401:235-43 pubmed
  12. Zolfaghari R, Ross A. Lecithin:retinol acyltransferase from mouse and rat liver. CDNA cloning and liver-specific regulation by dietary vitamin a and retinoic acid. J Lipid Res. 2000;41:2024-34 pubmed