Experts and Doctors on ribosomes in University Park, Florida, United States
Locale: University Park, Florida, United States
Spriggs K, Stoneley M, Bushell M, Willis A. Re-programming of translation following cell stress allows IRES-mediated translation to predominate. Biol Cell. 2008;100:27-38 pubmed
..Importantly, the genes identified in each of these studies do not show a significant amount of overlap, suggesting that 10-15% of all mRNAs have the capability for their initiation to occur via alternative mechanism(s). ..
Ramadoss N, Alumasa J, Cheng L, Wang Y, Li S, Chambers B, et al
. Small molecule inhibitors of trans-translation have broad-spectrum antibiotic activity. Proc Natl Acad Sci U S A. 2013;110:10282-7 pubmed publisher
..This unique target could play a key role in combating strains of pathogenic bacteria that are resistant to existing antibiotics. ..
Yakhnin H, Yakhnin A, Babitzke P. The trp RNA-binding attenuation protein (TRAP) of Bacillus subtilis regulates translation initiation of ycbK, a gene encoding a putative efflux protein, by blocking ribosome binding. Mol Microbiol. 2006;61:1252-66 pubmed publisher
..We also identified two dipeptide coding minigenes between the Shine-Dalgarno sequence and start codon of ycbK. Expression of one of the minigenes modestly interfered with translation of ycbK...
Baker C, Eöry L, Yakhnin H, Mercante J, Romeo T, Babitzke P. CsrA inhibits translation initiation of Escherichia coli hfq by binding to a single site overlapping the Shine-Dalgarno sequence. J Bacteriol. 2007;189:5472-81 pubmed
..The interaction of CsrA with hfq mRNA is the first example of a CsrA-regulated gene that contains only one CsrA binding site. ..
Yakhnin H, Pandit P, Petty T, Baker C, Romeo T, Babitzke P. CsrA of Bacillus subtilis regulates translation initiation of the gene encoding the flagellin protein (hag) by blocking ribosome binding. Mol Microbiol. 2007;64:1605-20 pubmed publisher
..Toeprint and cell-free translation studies demonstrate that bound CsrA prevents ribosome binding to the hag transcript, thereby inhibiting translation initiation and Hag synthesis...
Barakat A, Müller K, Sáenz de Miera L. Molecular evolutionary analyses of the Arabidopsis L7 ribosomal protein gene family. Gene. 2007;403:143-50 pubmed
..The probable evolution of an extra-ribosomal function of group 2 genes is discussed. ..
Han M, Cimen H, Miller Lee J, Koc H, Koc E. Purification of human mitochondrial ribosomal L7/L12 stalk proteins and reconstitution of functional hybrid ribosomes in Escherichia coli. Protein Expr Purif. 2011;78:48-54 pubmed publisher
..The goal is to demonstrate the homology between the mitochondrial and bacterial L7/L12 stalk proteins and to reconstitute a hybrid ribosome to be used in structural and functional studies of the mitochondrial stalk. ..
Hill S, Parmar M, Gheres K, Guignet M, Huang Y, Jackson F, et al
. Development of dendrite polarity in Drosophila neurons. Neural Dev. 2012;7:34 pubmed publisher
..Over time they mature to uniform microtubule polarity. Dendrite identity is established before the mature microtubule arrangement is attained, during the period of mixed microtubule polarity. ..
Döring K, Ahmed N, Riemer T, Suresh H, Vainshtein Y, Habich M, et al
. Profiling Ssb-Nascent Chain Interactions Reveals Principles of Hsp70-Assisted Folding. Cell. 2017;170:298-311.e20 pubmed publisher
..Ssb thus employs substrate-tailored dynamic nascent chain associations to coordinate co-translational protein folding, facilitate accelerated translation, and support membrane targeting of organellar proteins. ..