Experts and Doctors on phospholipids in Princeton, Florida, United States
Locale: Princeton, Florida, United States
Malinverni J, Silhavy T. An ABC transport system that maintains lipid asymmetry in the gram-negative outer membrane. Proc Natl Acad Sci U S A. 2009;106:8009-14 pubmed publisher
..We propose that the Mla pathway constitutes a bacterial intermembrane PL trafficking system...
Kamphorst J, Cross J, Fan J, de Stanchina E, Mathew R, White E, et al
. Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids. Proc Natl Acad Sci U S A. 2013;110:8882-7 pubmed publisher
..This renders Ras-driven cells, both in culture and in allografts, resistant to SCD1 inhibition. Thus, a mechanism by which oncogenic Ras confers metabolic robustness is through lipid scavenging. ..
Wang B, Zhao A, Novick R, Muir T. Activation and inhibition of the receptor histidine kinase AgrC occurs through opposite helical transduction motions. Mol Cell. 2014;53:929-40 pubmed publisher
..Binding of agonist or inverse-agonist peptides results in twisting of the linker in different directions. These two observations provide a view of the molecular motions triggered by ligand binding in an intact membrane-bound RHK. ..
Hickman M, Petti A, Ho Shing O, Silverman S, McIsaac R, Lee T, et al
. Coordinated regulation of sulfur and phospholipid metabolism reflects the importance of methylation in the growth of yeast. Mol Biol Cell. 2011;22:4192-204 pubmed publisher
..Our results show that rapidly growing cells require significant methylation, likely for the biosynthesis of phospholipids. ..