Experts and Doctors on hyaluronoglucosaminidase in Miami, Florida, United States
Locale: Miami, Florida, United States
Lokeshwar V, Estrella V, Lopez L, Kramer M, Gomez P, Soloway M, et al
. HYAL1-v1, an alternatively spliced variant of HYAL1 hyaluronidase: a negative regulator of bladder cancer. Cancer Res. 2006;66:11219-27 pubmed
..Therefore, HYAL-v1 expression may negatively regulate bladder tumor growth, infiltration, and angiogenesis. ..
Monzon M, Manzanares D, Schmid N, Casalino Matsuda S, Forteza R. Hyaluronidase expression and activity is regulated by pro-inflammatory cytokines in human airway epithelial cells. Am J Respir Cell Mol Biol. 2008;39:289-95 pubmed publisher
Kramer M, Golshani R, Merseburger A, Knapp J, Garcia A, Hennenlotter J, et al
. HYAL-1 hyaluronidase: a potential prognostic indicator for progression to muscle invasion and recurrence in bladder cancer. Eur Urol. 2010;57:86-93 pubmed publisher
..001; 76.8% accuracy) and recurrence (p=0.01; 67.8% accuracy). HYAL-1 is a potential prognostic marker for predicting progression to muscle invasion and recurrence. ..
Lokeshwar V, Schroeder G, Carey R, Soloway M, Iida N. Regulation of hyaluronidase activity by alternative mRNA splicing. J Biol Chem. 2002;277:33654-63 pubmed
..These results demonstrate that alternative mRNA splicing controls cellular expression of enzymatically active hyaluronidase and may explain the elevated hyaluronidase levels in bladder/prostate cancer. ..
Franzmann E, Schroeder G, Goodwin W, Weed D, Fisher P, Lokeshwar V. Expression of tumor markers hyaluronic acid and hyaluronidase (HYAL1) in head and neck tumors. Int J Cancer. 2003;106:438-45 pubmed
..Furthermore, HA and HAase may be sensitive and specific markers for detecting HNSCC and monitoring its recurrence. Further studies are needed to confirm these preliminary studies. ..
Lokeshwar V, Cerwinka W, Isoyama T, Lokeshwar B. HYAL1 hyaluronidase in prostate cancer: a tumor promoter and suppressor. Cancer Res. 2005;65:7782-9 pubmed
..This study shows that, depending on the concentration, HYAL1 functions as a tumor promoter and as a suppressor and provides a basis for anti-hyaluronidase and high-hyaluronidase treatments for cancer. ..
Alvarez A, Lokeshwar V. Bladder cancer biomarkers: current developments and future implementation. Curr Opin Urol. 2007;17:341-6 pubmed
..Biomarkers for bladder cancer have been intensively scrutinized over the last decade, but despite new findings and good performance characteristics, they are currently not accepted in clinical practice. ..
Lokeshwar V, Gomez P, Kramer M, Knapp J, McCornack M, Lopez L, et al
. Epigenetic regulation of HYAL-1 hyaluronidase expression. identification of HYAL-1 promoter. J Biol Chem. 2008;283:29215-27 pubmed publisher
..Thus, HYAL-1 expression is epigenetically regulated by the binding of different transcription factors to the methylated and unmethylated HYAL-1 promoter. ..
Monzon M, Fregien N, Schmid N, Falcon N, Campos M, Casalino Matsuda S, et al
. Reactive oxygen species and hyaluronidase 2 regulate airway epithelial hyaluronan fragmentation. J Biol Chem. 2010;285:26126-34 pubmed publisher
..In summary, this work provides evidence that ROS induce Hyal2, suggesting that Hyal2 is likely responsible for the sustained HA fragmentation in the airway lumen observed in inflammatory conditions associated with oxidative stress. ..