Experts and Doctors on drosophila proteins in Tallahassee, Florida, United States


Locale: Tallahassee, Florida, United States
Topic: drosophila proteins

Top Publications

  1. De Nobrega A, Lyons L. Circadian Modulation of Alcohol-Induced Sedation and Recovery in Male and Female Drosophila. J Biol Rhythms. 2016;31:142-60 pubmed publisher
    ..These studies provide a framework outlining how the circadian clock modulates alcohol-induced behaviors in Drosophila and identifies sexual dimorphisms in the circadian modulation of alcohol behaviors. ..
  2. Zouaz A, Auradkar A, Delfini M, Macchi M, Barthez M, Ela Akoa S, et al. The Hox proteins Ubx and AbdA collaborate with the transcription pausing factor M1BP to regulate gene transcription. EMBO J. 2017;36:2887-2906 pubmed publisher
  3. Tian A, Deng W. Lgl and its phosphorylation by aPKC regulate oocyte polarity formation in Drosophila. Development. 2008;135:463-71 pubmed
    ..Our studies suggest that Lgl and its phosphorylation by aPKC may form a conserved regulatory circuitry in polarization of various cell types. ..
  4. Jia D, Tamori Y, Pyrowolakis G, Deng W. Regulation of broad by the Notch pathway affects timing of follicle cell development. Dev Biol. 2014;392:52-61 pubmed publisher
    ..Our findings suggest an important role of br in the timing of follicle cell development, and its transcriptional regulation by the Notch pathway. ..
  5. Sun J, Smith L, Armento A, Deng W. Regulation of the endocycle/gene amplification switch by Notch and ecdysone signaling. J Cell Biol. 2008;182:885-96 pubmed publisher
  6. Hollis B, Fierst J, Houle D. Sexual selection accelerates the elimination of a deleterious mutant in Drosophila melanogaster. Evolution. 2009;63:324-33 pubmed publisher
    ..In contrast to recent experiments employing monogamy/polygamy designs, our results demonstrate a fitness benefit to sexual selection. This is consistent with the operation of good-genes female choice. ..
  7. Shyu L, Sun J, Chung H, Huang Y, Deng W. Notch signaling and developmental cell-cycle arrest in Drosophila polar follicle cells. Mol Biol Cell. 2009;20:5064-73 pubmed publisher
    ..Notch signaling is probably involved in down-regulating String in polar cells, thus inducing the G2 cell-cycle arrest. ..
  8. Li Y, Liu X, Wu Y, Xu Z, Li H, Griffith L, et al. Intracellular regions of the Eag potassium channel play a critical role in generation of voltage-dependent currents. J Biol Chem. 2011;286:1389-99 pubmed publisher
    ..Synthesis and assembly of Eag at high temperature disrupt the ability of these domains to carry out their function. These results suggest an important role of the intracellular regions in the generation of Eag currents. ..
  9. Klusza S, Deng W. poly is required for nurse-cell chromosome dispersal and oocyte polarity in Drosophila. Fly (Austin). 2010;4:128-36 pubmed
    ..In addition, our interaction data suggest that poly is probably a member of the characterized mRNP complex that mediates both processes. ..

More Information


  1. Liu X, Wu Y, Zhou Y. Intracellular linkers are involved in Mg2+-dependent modulation of the Eag potassium channel. Channels (Austin). 2010;4:311-8 pubmed publisher
    ..Together, these results suggest an important role of the intracellular linker regions in gating processes of Eag channels. ..
  2. Tamori Y, Bialucha C, Tian A, Kajita M, Huang Y, Norman M, et al. Involvement of Lgl and Mahjong/VprBP in cell competition. PLoS Biol. 2010;8:e1000422 pubmed publisher
    ..As far as we are aware, this is the first report that cell competition can occur in a mammalian cell culture system. ..
  3. Tamori Y, Deng W. Tissue repair through cell competition and compensatory cellular hypertrophy in postmitotic epithelia. Dev Cell. 2013;25:350-63 pubmed publisher
  4. Klusza S, Deng W. At the crossroads of differentiation and proliferation: precise control of cell-cycle changes by multiple signaling pathways in Drosophila follicle cells. Bioessays. 2011;33:124-34 pubmed publisher
  5. Gladstein N, McKeon M, Horabin J. Requirement of male-specific dosage compensation in Drosophila females--implications of early X chromosome gene expression. PLoS Genet. 2010;6:e1001041 pubmed publisher
    ..Our data suggest that before the female state is set, the ground state is male and female X chromosome expression is elevated. Females thus utilize the male dosage compensation process to amplify the signal which determines their fate. ..
  6. Tian A, Deng W. Par-1 and Tau regulate the anterior-posterior gradient of microtubules in Drosophila oocytes. Dev Biol. 2009;327:458-64 pubmed publisher
  7. Sun J, Deng W. Hindsight mediates the role of notch in suppressing hedgehog signaling and cell proliferation. Dev Cell. 2007;12:431-42 pubmed
    ..Our studies suggest that Hindsight bridges the two antagonistic pathways, Notch and Hedgehog, in the temporal regulation of follicle-cell proliferation and differentiation. ..
  8. Hock T, Cottrill T, Keegan J, Garza D. The E23 early gene of Drosophila encodes an ecdysone-inducible ATP-binding cassette transporter capable of repressing ecdysone-mediated gene activation. Proc Natl Acad Sci U S A. 2000;97:9519-24 pubmed
    ..Our results suggest the existence of a previously unrecognized regulatory mechanism for modulating steroid hormone signaling in Drosophila...
  9. Yu J, Zheng Y, Dong J, Klusza S, Deng W, Pan D. Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded. Dev Cell. 2010;18:288-99 pubmed publisher
    ..These results shed light on the mechanism of Ex and Mer function and implicate Kibra as a potential tumor suppressor with relevance to neurofibromatosis. ..
  10. Poulton J, Huang Y, Smith L, Sun J, Leake N, Schleede J, et al. The microRNA pathway regulates the temporal pattern of Notch signaling in Drosophila follicle cells. Development. 2011;138:1737-45 pubmed publisher
    ..Here we have uncovered a complex regulatory process in which the microRNA pathway promotes Notch activation by repressing Delta-mediated inhibition of Notch in follicle cells. ..
  11. Tian A, Tamori Y, Huang Y, Melendez N, Deng W. Efficient EGFR signaling and dorsal-ventral axis patterning requires syntaxin dependent Gurken trafficking. Dev Biol. 2013;373:349-58 pubmed publisher
    ..Our studies reveal that the Syx1A dependent trafficking of Grk protein is required for efficient EGFR signaling during DV patterning. ..
  12. Huang Y, Smith L, Poulton J, Deng W. The microRNA miR-7 regulates Tramtrack69 in a developmental switch in Drosophila follicle cells. Development. 2013;140:897-905 pubmed publisher
    ..Our studies reveal the important role miR-7 plays in developmental decision-making in association with signal-transduction pathways. ..
  13. Yu J, Poulton J, Huang Y, Deng W. The hippo pathway promotes Notch signaling in regulation of cell differentiation, proliferation, and oocyte polarity. PLoS ONE. 2008;3:e1761 pubmed publisher
  14. Dalton J, Fear J, Knott S, Baker B, McIntyre L, Arbeitman M. Male-specific Fruitless isoforms have different regulatory roles conferred by distinct zinc finger DNA binding domains. BMC Genomics. 2013;14:659 pubmed publisher
    ..These results add to our understanding of sex chromosome biology and further support the hypothesis that in some cell-types genes with male-biased expression are enriched on the X chromosome. ..
  15. Klusza S, Novak A, Figueroa S, Palmer W, Deng W. Prp22 and spliceosome components regulate chromatin dynamics in germ-line polyploid cells. PLoS ONE. 2013;8:e79048 pubmed publisher
  16. Yan Y, Wang H, Hu M, Jiang L, Wang Y, Liu P, et al. HDAC6 Suppresses Age-Dependent Ectopic Fat Accumulation by Maintaining the Proteostasis of PLIN2 in Drosophila. Dev Cell. 2017;43:99-111.e5 pubmed publisher
    ..Our study suggests that manipulation of proteostasis could be an alternative approach to the treatment of age-related metabolic diseases such as obesity and diabetes...
  17. Tomaiuolo M, Bertram R, Houle D. Enzyme isoforms may increase phenotypic robustness. Evolution. 2008;62:2884-93 pubmed publisher
    ..Thus, we show that controlling isoform proportion can be a powerful mechanism for reducing the effects of variations in the values of system parameters, increasing system robustness. ..
  18. Sun J, Deng W. Notch-dependent downregulation of the homeodomain gene cut is required for the mitotic cycle/endocycle switch and cell differentiation in Drosophila follicle cells. Development. 2005;132:4299-308 pubmed
    ..Our data suggest that Cut functions in regulating both cell differentiation and the cell cycle, and that downregulation of Cut by Notch contributes to the mitotic cycle/endocycle switch and cell differentiation in follicle cells. ..