Experts and Doctors on connexins in Miami, Florida, United States

Summary

Locale: Miami, Florida, United States
Topic: connexins

Top Publications

  1. Dahl G, Keane R. Pannexin: from discovery to bedside in 11±4 years?. Brain Res. 2012;1487:150-9 pubmed publisher
    ..Since Panx1 inhibitors such as probenecid are already clinically tested in different settings they should be considered for therapy in stroke and CNS trauma. ..
  2. Ouyang X, Yan D, Aslan I, Du L, Tekin M, Liu X. Mutation screening of the GJA7 (Cx45) gene in a large international series of probands with nonsyndromic hearing impairment. Genet Test Mol Biomarkers. 2011;15:333-6 pubmed publisher
    ..889C>A (p.D297N), were found. None of the identified changes appeared to be pathogenic. Our data suggest that GJA7 alterations have no or low genetic relevance in nonsyndromic hearing loss in these populations. ..
  3. Hudder A, Werner R. Analysis of a Charcot-Marie-Tooth disease mutation reveals an essential internal ribosome entry site element in the connexin-32 gene. J Biol Chem. 2000;275:34586-91 pubmed
    ..A mutation in either of the first two elements investigated showed loss of IRES function, whereas mutation of a third element showed gain of function. ..
  4. Ransford G, Fregien N, Qiu F, Dahl G, Conner G, Salathe M. Pannexin 1 contributes to ATP release in airway epithelia. Am J Respir Cell Mol Biol. 2009;41:525-34 pubmed publisher
    ..These data not only show that Panx1 is expressed apically in differentiated airway epithelial cells but also that it contributes to ATP release in these cells. ..
  5. Angeli S. Phenotype/genotype correlations in a DFNB1 cohort with ethnical diversity. Laryngoscope. 2008;118:2014-23 pubmed publisher
    ..These data can be applied to direct the clinical evaluation and effectively counsel families of children with DFNB1. ..
  6. Silverman W, de Rivero Vaccari J, Locovei S, Qiu F, Carlsson S, Scemes E, et al. The pannexin 1 channel activates the inflammasome in neurons and astrocytes. J Biol Chem. 2009;284:18143-51 pubmed publisher
    ..Thus, in contrast to macrophages and monocytes in which low intracellular K(+) has been suggested to trigger inflammasome activation, in neural cells, high extracellular K(+) activates caspase-1 probably through pannexin 1. ..
  7. Dahl G, Muller K. Innexin and pannexin channels and their signaling. FEBS Lett. 2014;588:1396-402 pubmed publisher
  8. Huang Y, Stone L, Pereira E, Yang R, Kinnamon J, Dvoryanchikov G, et al. Knocking out P2X receptors reduces transmitter secretion in taste buds. J Neurosci. 2011;31:13654-61 pubmed publisher
    ..Importantly, we find that P2X2 is expressed in WT taste buds and appears to function as an autocrine, positive feedback signal to amplify taste-evoked ATP secretion. ..
  9. Bao L, Samuels S, Locovei S, Macagno E, Muller K, Dahl G. Innexins form two types of channels. FEBS Lett. 2007;581:5703-8 pubmed
    ..In addition, carbenoxolone reversibly blocked the loss of carboxyfluorescein dye into the bath from the giant glial cells in the connectives of the leech nerve cord, which are known to express the innexins we assayed...

More Information

Publications24

  1. Locovei S, Bao L, Dahl G. Pannexin 1 in erythrocytes: function without a gap. Proc Natl Acad Sci U S A. 2006;103:7655-9 pubmed
    ..Furthermore, under conditions of ATP release, erythrocytes took up fluorescent tracer molecules permeant to gap junction channels. ..
  2. Dvoriantchikova G, Ivanov D, Panchin Y, Shestopalov V. Expression of pannexin family of proteins in the retina. FEBS Lett. 2006;580:2178-82 pubmed
    ..Our results indicated that Panx1 and Panx2 are abundantly expressed in the retina, and may therefore contribute to the electrical and metabolic coupling, or to signaling between retinal neurons via the secondary messengers. ..
  3. Anderson C, Zundel M, Werner R. Variable promoter usage and alternative splicing in five mouse connexin genes. Genomics. 2005;85:238-44 pubmed
    ..The expression of alternative 5' UTRs suggests that connexins, like many genes involved in development, require complex regulation at both transcriptional and translational levels. ..
  4. Liu X, Yuan Y, Yan D, Ding E, Ouyang X, Fei Y, et al. Digenic inheritance of non-syndromic deafness caused by mutations at the gap junction proteins Cx26 and Cx31. Hum Genet. 2009;125:53-62 pubmed publisher
    ..Together, our data indicate that a genetic interaction between these two connexin genes can lead to hearing loss. ..
  5. Locovei S, Scemes E, Qiu F, Spray D, Dahl G. Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complex. FEBS Lett. 2007;581:483-8 pubmed
    ..Thus, pannexin1 appears to be the molecular substrate for the permeabilization pore (or death receptor channel) recruited into the P2X(7)R signaling complex. ..
  6. Dvoriantchikova G, Ivanov D, Pestova A, Shestopalov V. Molecular characterization of pannexins in the lens. Mol Vis. 2006;12:1417-26 pubmed
    ..Despite similarity in detergent solubility of pannexins and connexins, the lack of spatial co-localization in the lens membranes suggested a distinct, non-redundant to connexin function for these proteins in the membrane. ..
  7. Lipan M, Ouyang X, Yan D, Angeli S, Du L, Liu X. Clinical comparison of hearing-impaired patients with DFNB1 against heterozygote carriers of connexin 26 mutations. Laryngoscope. 2011;121:811-4 pubmed publisher
    ..Therefore, genetic counseling should consider the complexity of their genetic factors and the limitations of current screening. ..
  8. Qiu F, Wang J, Spray D, Scemes E, Dahl G. Two non-vesicular ATP release pathways in the mouse erythrocyte membrane. FEBS Lett. 2011;585:3430-5 pubmed publisher
    ..Thus, in erythrocytes, two independent pathways mediate the release of ATP. We also show that glyburide is a strong inhibitor of Panx1 channels...
  9. Dvoriantchikova G, Ivanov D, Barakat D, Grinberg A, Wen R, Slepak V, et al. Genetic ablation of Pannexin1 protects retinal neurons from ischemic injury. PLoS ONE. 2012;7:e31991 pubmed publisher
    ..Thus, our work presents the in vivo evidence for neurotoxicity elicited by neuronal Panx1, and identifies this channel as a new therapeutic target in ischemic pathologies. ..
  10. McKuen M, Dahl G, Fields K. Assessing a potential role of host Pannexin 1 during Chlamydia trachomatis infection. PLoS ONE. 2013;8:e63732 pubmed publisher
    ..Therefore, probenecid may inhibit C. trachomatis growth by an as yet unresolved mechanism...
  11. Qiu F, Dahl G. A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP. Am J Physiol Cell Physiol. 2009;296:C250-5 pubmed publisher
    ..Mutational analysis identified R75 in pannexin 1 to be critical for ATP inhibition of pannexin 1 currents. ..
  12. Huang Y, Maruyama Y, Dvoryanchikov G, Pereira E, Chaudhari N, Roper S. The role of pannexin 1 hemichannels in ATP release and cell-cell communication in mouse taste buds. Proc Natl Acad Sci U S A. 2007;104:6436-41 pubmed
    ..They also indicate a route for cell-cell communication and signal processing within the taste bud. ..
  13. Tekin M, Xia X, Erdenetungalag R, Cengiz F, White T, Radnaabazar J, et al. GJB2 mutations in Mongolia: complex alleles, low frequency, and reduced fitness of the deaf. Ann Hum Genet. 2010;74:155-64 pubmed publisher
    ..We found a lower frequency of assortative mating (37.5%) and decreased genetic fitness (62%) of the deaf in Mongolia as compared to the western populations, which provides an explanation for lower frequency of GJB2 deafness in Mongolia. ..
  14. Wang J, Jackson D, Dahl G. The food dye FD&C Blue No. 1 is a selective inhibitor of the ATP release channel Panx1. J Gen Physiol. 2013;141:649-56 pubmed publisher
  15. Minkiewicz J, de Rivero Vaccari J, Keane R. Human astrocytes express a novel NLRP2 inflammasome. Glia. 2013;61:1113-21 pubmed publisher
    ..Our findings suggest that the astrocytic NLRP2 inflammasome is an important component of the CNS inflammatory response and that the NLRP2 inflammasome may be a therapeutic target to inhibit inflammation induced by CNS injury. ..