Experts and Doctors on cell cycle proteins in Tallahassee, Florida, United States


Locale: Tallahassee, Florida, United States
Topic: cell cycle proteins

Top Publications

  1. de Kloet R, de Kloet S. Evolution of the spindlin gene in birds: independent cessation of the recombination of sex chromosomes at the spindlin locus in neognathous birds and tinamous, a palaeognathous avian family. Genetica. 2003;119:333-42 pubmed
    ..This suggests that cessation of recombination at the spindlin locus of the ancestral W and Z chromosomes of the paleognathous tinamiformes and the neognathous avian species were independent events. ..
  2. Lu J, Gilbert D. Cell cycle regulated transcription of heterochromatin in mammals vs. fission yeast: functional conservation or coincidence?. Cell Cycle. 2008;7:1907-10 pubmed
    ..However, there are still fundamental differences between these two systems that preclude the identification of a functional or mechanistic link. ..
  3. Bruck I, Dhingra N, Martinez M, Kaplan D. Dpb11 may function with RPA and DNA to initiate DNA replication. PLoS ONE. 2017;12:e0177147 pubmed publisher
    ..We also propose an alternative model, wherein Dpb11-DNA interaction is required for some other function in DNA replication initiation, such as helicase activation. ..
  4. Liu H, Wang Y. The function and regulation of budding yeast Swe1 in response to interrupted DNA synthesis. Mol Biol Cell. 2006;17:2746-56 pubmed
    ..Therefore, S-phase accumulated Swe1 prevents Clb2-Cdk1-mediated mitotic activities, but has little effects on Clb5-Cdk1-associated S-phase progression. ..
  5. Jin F, Richmond D, Wang Y. The multilayer regulation of the metaphase-to-anaphase transition. Cell Cycle. 2009;8:700-4 pubmed
  6. Jin F, Liu H, Liang F, Rizkallah R, Hurt M, Wang Y. Temporal control of the dephosphorylation of Cdk substrates by mitotic exit pathways in budding yeast. Proc Natl Acad Sci U S A. 2008;105:16177-82 pubmed publisher
    ..Our data also indicate that FEAR-induced dephosphorylation of S-phase Cdk substrates facilitates anaphase progression, revealing an extra layer of mitotic regulation. ..
  7. Kuipers M, Stasevich T, Sasaki T, Wilson K, Hazelwood K, McNally J, et al. Highly stable loading of Mcm proteins onto chromatin in living cells requires replication to unload. J Cell Biol. 2011;192:29-41 pubmed publisher
    ..These results provide in vivo evidence for an exceptionally stable lockdown mechanism to retain all loaded Mcm proteins on chromatin throughout prolonged cell cycles. ..
  8. Shyu L, Sun J, Chung H, Huang Y, Deng W. Notch signaling and developmental cell-cycle arrest in Drosophila polar follicle cells. Mol Biol Cell. 2009;20:5064-73 pubmed publisher
    ..Notch signaling is probably involved in down-regulating String in polar cells, thus inducing the G2 cell-cycle arrest. ..
  9. Jin H, Guacci V, Yu H. Pds5 is required for homologue pairing and inhibits synapsis of sister chromatids during yeast meiosis. J Cell Biol. 2009;186:713-25 pubmed publisher
    ..These data suggest that Pds5 modulates the Rec8 activity to facilitate chromosome morphological changes required for homologue synapsis, DSB repair, and meiotic chromosome segregation...

More Information


  1. Singh R, Kabbaj M, Paik J, Gunjan A. Histone levels are regulated by phosphorylation and ubiquitylation-dependent proteolysis. Nat Cell Biol. 2009;11:925-33 pubmed publisher
    ..Regulated histone proteolysis has major implications for the maintenance of epigenetic marks on chromatin, genomic stability and the packaging of sperm DNA. ..
  2. de Kloet R, de Kloet S. The evolution of the spindlin gene in birds: sequence analysis of an intron of the spindlin W and Z gene reveals four major divisions of the Psittaciformes. Mol Phylogenet Evol. 2005;36:706-21 pubmed
    ..The results support a Gondwanan origin of the Psittaciformes and the suggestion that paleogeographic events were a major force in psittacine divergence...
  3. Jin F, Wang Y. The signaling network that silences the spindle assembly checkpoint upon the establishment of chromosome bipolar attachment. Proc Natl Acad Sci U S A. 2013;110:21036-41 pubmed publisher
    ..Therefore, Sgo1, Ipl1 kinase, Dam1, and protein phosphatase 1 comprise the SAC silencing network that ensures the correct timing for anaphase onset...
  4. Tang X, Wang Y. Pds1/Esp1-dependent and -independent sister chromatid separation in mutants defective for protein phosphatase 2A. Proc Natl Acad Sci U S A. 2006;103:16290-5 pubmed
    ..These data suggest that PP2A regulates sister chromatid cohesion in Pds1-dependent and -independent manners. ..
  5. Sellix M, Egli M, Poletini M, McKee D, Bosworth M, Fitch C, et al. Anatomical and functional characterization of clock gene expression in neuroendocrine dopaminergic neurons. Am J Physiol Regul Integr Comp Physiol. 2006;290:R1309-23 pubmed
    ..These data suggest that clock gene expression, particularly PER1 and PER2, within NDNs may act to modulate diurnal rhythms of DA release from NDNs in the OVX rat. ..
  6. Klusza S, Deng W. At the crossroads of differentiation and proliferation: precise control of cell-cycle changes by multiple signaling pathways in Drosophila follicle cells. Bioessays. 2011;33:124-34 pubmed publisher
  7. Rizkallah R, Alexander K, Kassardjian A, Luscher B, Hurt M. The transcription factor YY1 is a substrate for Polo-like kinase 1 at the G2/M transition of the cell cycle. PLoS ONE. 2011;6:e15928 pubmed publisher
    ..We show that this phosphorylation is cell cycle regulated and peaks at G2/M. This is the first report identifying a kinase for which YY1 is a substrate. ..
  8. Bruck I, Kaplan D. The replication initiation protein Sld2 regulates helicase assembly. J Biol Chem. 2014;289:1948-59 pubmed publisher
    ..We also study a mutant of Sld2 that is defective in binding DNA, sld2-DNA, and find that sld2-DNA cells exhibit no GINS-Mcm2-7 interaction. These data suggest that Sld2 association with DNA is required for CMG assembly in S phase...
  9. Sasaki T, Li A, Gillespie P, Blow J, Gilbert D. Evidence for a mammalian late-G1 phase inhibitor of replication licensing distinct from geminin or Cdk activity. Nucleus. 2011;2:455-64 pubmed publisher
    ..Our hybrid system should permit the identification of this and other novel cell cycle regulatory activities. ..
  10. Pérez Arnaiz P, Bruck I, Colbert M, Kaplan D. An intact Mcm10 coiled-coil interaction surface is important for origin melting, helicase assembly and the recruitment of Pol-? to Mcm2-7. Nucleic Acids Res. 2017;45:7261-7275 pubmed publisher
    ..We also detected diminished GINS and pol-? recruitment to the Mcm2-7 complex. We conclude that an intact Mcm10 coiled-coil interaction surface is important for origin melting, helicase assembly, and the recruitment of pol ? to Mcm2-7. ..
  11. Siersbæk R, Madsen J, Javierre B, Nielsen R, Bagge E, Cairns J, et al. Dynamic Rewiring of Promoter-Anchored Chromatin Loops during Adipocyte Differentiation. Mol Cell. 2017;66:420-435.e5 pubmed publisher
  12. Liang F, Richmond D, Wang Y. Coordination of chromatid separation and spindle elongation by antagonistic activities of mitotic and S-phase CDKs. PLoS Genet. 2013;9:e1003319 pubmed publisher
    ..Therefore, the tight temporal control of spindle elongation and cohesin cleavage assure orchestrated chromosome separation and spindle elongation. ..
  13. Sun J, Deng W. Hindsight mediates the role of notch in suppressing hedgehog signaling and cell proliferation. Dev Cell. 2007;12:431-42 pubmed
    ..Our studies suggest that Hindsight bridges the two antagonistic pathways, Notch and Hedgehog, in the temporal regulation of follicle-cell proliferation and differentiation. ..
  14. Rashid R, Liang B, Baker D, Youssef O, He Y, Phipps K, et al. Crystal structure of a Cbf5-Nop10-Gar1 complex and implications in RNA-guided pseudouridylation and dyskeratosis congenita. Mol Cell. 2006;21:249-60 pubmed publisher
    ..We have also identified a dyskeratosis congenita mutation cluster site within a modeled dyskerin structure...
  15. Wang Y, Ng T. Phosphatase 2A negatively regulates mitotic exit in Saccharomyces cerevisiae. Mol Biol Cell. 2006;17:80-9 pubmed
    ..All the evidence suggests the negative role of PP2A in mitotic exit. Finally, our genetic and biochemical data suggest that PP2A regulates the phosphorylation of Tem1, which acts at the very top of MEN pathway. ..
  16. Singh R, Gonzalez M, Kabbaj M, Gunjan A. Novel E3 ubiquitin ligases that regulate histone protein levels in the budding yeast Saccharomyces cerevisiae. PLoS ONE. 2012;7:e36295 pubmed publisher
    ..Overall, our results highlight the importance of posttranslational histone regulatory mechanisms that employ multiple E3 ubiquitin ligases to ensure excess histone degradation and thus contribute to the maintenance of genomic stability. ..
  17. Lin W, Jin H, Liu X, Hampton K, Yu H. Scc2 regulates gene expression by recruiting cohesin to the chromosome as a transcriptional activator during yeast meiosis. Mol Biol Cell. 2011;22:1985-96 pubmed publisher
    ..Finally, we provide evidence that chromosomal binding of cohesin is sufficient for target-gene activation during meiosis. Our data support a noncanonical role for cohesin as a transcriptional activator during cell differentiation. ..
  18. Lin W, Wang M, Jin H, Yu H. Cohesin plays a dual role in gene regulation and sister-chromatid cohesion during meiosis in Saccharomyces cerevisiae. Genetics. 2011;187:1041-51 pubmed publisher
    ..Our results suggest that the cohesin complex plays a dual role in gene regulation and sister-chromatid cohesion during meiotic differentiation in yeast. ..
  19. Sun J, Deng W. Notch-dependent downregulation of the homeodomain gene cut is required for the mitotic cycle/endocycle switch and cell differentiation in Drosophila follicle cells. Development. 2005;132:4299-308 pubmed
    ..Our data suggest that Cut functions in regulating both cell differentiation and the cell cycle, and that downregulation of Cut by Notch contributes to the mitotic cycle/endocycle switch and cell differentiation in follicle cells. ..