Experts and Doctors on biological tumor markers in Miami, Florida, United States


Locale: Miami, Florida, United States
Topic: biological tumor markers

Top Publications

  1. Kramer M, Golshani R, Merseburger A, Knapp J, Garcia A, Hennenlotter J, et al. HYAL-1 hyaluronidase: a potential prognostic indicator for progression to muscle invasion and recurrence in bladder cancer. Eur Urol. 2010;57:86-93 pubmed publisher
    ..001; 76.8% accuracy) and recurrence (p=0.01; 67.8% accuracy). HYAL-1 is a potential prognostic marker for predicting progression to muscle invasion and recurrence. ..
  2. Jorda M, Gomez Fernandez C, Garcia M, Mousavi F, Walker G, Mejias A, et al. P63 differentiates subtypes of nonsmall cell carcinomas of lung in cytologic samples: implications in treatment selection. Cancer. 2009;117:46-50 pubmed publisher
    ..001). Therefore, p63 immunocytochemistry may be used in pulmonary cytologic samples of nonsmall cell carcinomas to identify squamous differentiation and to improve therapeutic selection of patients with lung cancer. ..
  3. Weed D, Gomez Fernandez C, Pacheco J, Ruiz J, Hamilton Nelson K, Arnold D, et al. MUC4 and ERBB2 expression in major and minor salivary gland mucoepidermoid carcinoma. Head Neck. 2004;26:353-64 pubmed
    ..This study investigates MUC4 and ErbB2 receptor expression in major and minor salivary gland mucoepidermoid carcinoma and correlates patterns of expression with clinical outcomes...
  4. Alvarez A, Lokeshwar V. Bladder cancer biomarkers: current developments and future implementation. Curr Opin Urol. 2007;17:341-6 pubmed
    ..Biomarkers for bladder cancer have been intensively scrutinized over the last decade, but despite new findings and good performance characteristics, they are currently not accepted in clinical practice. ..
  5. Wykoff C, Lam B, Brathwaite C, Biegel J, McKeown C, Rosenblum M, et al. Atypical teratoid/rhabdoid tumor arising from the third cranial nerve. J Neuroophthalmol. 2008;28:207-11 pubmed publisher
    ..Despite aggressive chemotherapy, the patient died within 6 months of presentation. This is the first report of an AT/RT presenting as an isolated third cranial nerve palsy caused by tumor arising from within the nerve...
  6. Helfman D, Flynn P, Khan P, Saeed A. Tropomyosin as a regulator of cancer cell transformation. Adv Exp Med Biol. 2008;644:124-31 pubmed
  7. Germani R, Civantos F, Elgart G, Roberts B, Franzmann E. Molecular markers of micrometastasis in oral cavity carcinomas. Otolaryngol Head Neck Surg. 2009;141:52-8 pubmed publisher
    ..016, RR=7.33). Preliminary results suggest that MT1-MMP positivity in primary tumor specimens may identify aggressive tumor types, evidenced by the presence of micrometastasis or PNI. ..
  8. Iorns E, Hnatyszyn H, Seo P, Clarke J, Ward T, Lippman M. The role of SATB1 in breast cancer pathogenesis. J Natl Cancer Inst. 2010;102:1284-96 pubmed publisher
    ..80, 95% confidence interval = 0.62 to 1.03, P = .10). In contrast to previous studies, we found that SATB1 expression did not promote breast cancer progression and was not associated with breast cancer outcome. ..
  9. Weed D, Gomez Fernandez C, Yasin M, Hamilton Nelson K, Rodriguez M, Zhang J, et al. MUC4 and ErbB2 expression in squamous cell carcinoma of the upper aerodigestive tract: correlation with clinical outcomes. Laryngoscope. 2004;114:1-32 pubmed
    ..The hypotheses of the study were that MUC4 expression would correlate with ErbB2 expression and that MUC4 expression would correlate with clinical outcomes in squamous cell carcinoma of the upper aerodigestive tract...

More Information


  1. Shirodkar S, Lokeshwar V. Bladder tumor markers: from hematuria to molecular diagnostics--where do we stand?. Expert Rev Anticancer Ther. 2008;8:1111-23 pubmed publisher
    ..Studies continue to refine the role of these markers in clinical practice, but their ultimate efficacy will need to be borne out in large-scale clinical trials in a multitude of settings...
  2. Franzmann E, Schroeder G, Goodwin W, Weed D, Fisher P, Lokeshwar V. Expression of tumor markers hyaluronic acid and hyaluronidase (HYAL1) in head and neck tumors. Int J Cancer. 2003;106:438-45 pubmed
    ..Furthermore, HA and HAase may be sensitive and specific markers for detecting HNSCC and monitoring its recurrence. Further studies are needed to confirm these preliminary studies. ..
  3. Caruso D, Carmack A, Lokeshwar V, Duncan R, Soloway M, Lokeshwar B. Osteopontin and interleukin-8 expression is independently associated with prostate cancer recurrence. Clin Cancer Res. 2008;14:4111-8 pubmed publisher
    ..5%; 73.6%) and specificity (76%; 70.6%). In prostatectomy specimens, osteopontin expression is independently associated with biochemical recurrence. Both osteopontin and IL-8 may be predictors of early disease progression. ..
  4. Khor L, Bae K, Paulus R, Al Saleem T, Hammond M, Grignon D, et al. MDM2 and Ki-67 predict for distant metastasis and mortality in men treated with radiotherapy and androgen deprivation for prostate cancer: RTOG 92-02. J Clin Oncol. 2009;27:3177-84 pubmed publisher
    ..CONCLUSION Combined MDM2 and Ki-67 expression levels were independently related to distant metastasis and mortality and, if validated, could be considered for risk stratification of patients with prostate cancer in clinical trials. ..
  5. Kozloski G, Carraway C, Carraway K. Mechanistic and signaling analysis of Muc4-ErbB2 signaling module: new insights into the mechanism of ligand-independent ErbB2 activity. J Cell Physiol. 2010;224:649-57 pubmed publisher
    ..Our microarray analysis indicates that Muc4 expression promotes cell migration by increasing the phosphorylation of the focal adhesion kinase and also through an increase in the levels of beta-catenin. ..
  6. Calfa C, Lossos I, Ruiz P, Davis J. Ocular involvement as the initial manifestation of T-cell chronic lymphocytic leukemia. Am J Ophthalmol. 2007;144:326-9 pubmed
    ..Systemic evaluation established diagnosis of T-cell CLL. T-CLL is a rare disease with an aggressive clinical course. We present a case of T-cell intraocular lymphoma as the initial manifestation of an otherwise asymptomatic T-CLL. ..