Experts and Doctors on adenosine triphosphate in Miami, Florida, United States


Locale: Miami, Florida, United States
Topic: adenosine triphosphate

Top Publications

  1. Slepak V, Hurley J. Mechanism of light-induced translocation of arrestin and transducin in photoreceptors: interaction-restricted diffusion. IUBMB Life. 2008;60:2-9 pubmed publisher
    ..The directionality and light dependence of this movement is achieved by the interactions of arrestin and transducin with their spatially restricted binding partners. ..
  2. Xi H, Barredo J, Merchan J, Lampidis T. Endoplasmic reticulum stress induced by 2-deoxyglucose but not glucose starvation activates AMPK through CaMKK? leading to autophagy. Biochem Pharmacol. 2013;85:1463-77 pubmed publisher
    ..Taken together, our data support a model where under normoxia therapeutic (2-DG) and physiologic (GS) glucose restriction differentially activate autophagy, while under hypoxia they similarly inhibit it. ..
  3. Silverman W, Locovei S, Dahl G. Probenecid, a gout remedy, inhibits pannexin 1 channels. Am J Physiol Cell Physiol. 2008;295:C761-7 pubmed publisher
    ..Probenecid did not affect channels formed by connexins. Thus probenecid allows for discrimination between channels formed by connexins and pannexins. ..
  4. Tran M, Neary J. Purinergic signaling induces thrombospondin-1 expression in astrocytes. Proc Natl Acad Sci U S A. 2006;103:9321-6 pubmed
  5. Dweck D, Reyes Alfonso A, Potter J. Expanding the range of free calcium regulation in biological solutions. Anal Biochem. 2005;347:303-15 pubmed
    ..These findings demonstrate that EGTA, when used in conjunction with NTA, improves and expands the regulation of free calcium in solution. ..
  6. White M, Saleh O, Nonner D, Barrett E, Moraes C, Barrett J. Mitochondrial dysfunction induced by heat stress in cultured rat CNS neurons. J Neurophysiol. 2012;108:2203-14 pubmed publisher
    ..Post-stress ΔΨ(m) depolarization and/or delayed neuronal death were modestly reduced/postponed by nicotinamide adenine dinucleotide, a calpain inhibitor, and increased expression of Bcl-xL. ..
  7. Maher J, Wangpaichitr M, Savaraj N, Kurtoglu M, Lampidis T. Hypoxia-inducible factor-1 confers resistance to the glycolytic inhibitor 2-deoxy-D-glucose. Mol Cancer Ther. 2007;6:732-41 pubmed
    ..Moreover, because 2-DG is now in phase I clinical trials, our results suggest that glycolytic inhibitors may be more effective clinically when combined with agents that inhibit HIF. ..
  8. Dahl G, Qiu F, Wang J. The bizarre pharmacology of the ATP release channel pannexin1. Neuropharmacology. 2013;75:583-93 pubmed publisher
    ..This article is part of the Special Issue Section entitled 'Current Pharmacology of Gap Junction Channels and Hemichannels'. ..
  9. Lenz G, Gottfried C, Luo Z, Avruch J, Rodnight R, Nie W, et al. P(2Y) purinoceptor subtypes recruit different mek activators in astrocytes. Br J Pharmacol. 2000;129:927-36 pubmed

More Information


  1. Mittal R, Chan B, Grati M, Mittal J, Patel K, Debs L, et al. Molecular Structure and Regulation of P2X Receptors With a Special Emphasis on the Role of P2X2 in the Auditory System. J Cell Physiol. 2016;231:1656-70 pubmed publisher
    ..J. Cell. Physiol. 231: 1656-1670, 2016. © 2015 Wiley Periodicals, Inc. ..
  2. Xi H, Kurtoglu M, Liu H, Wangpaichitr M, You M, Liu X, et al. 2-Deoxy-D-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion. Cancer Chemother Pharmacol. 2011;67:899-910 pubmed publisher
    ..Furthermore, autophagy plays a protective role against 2-DG-elicited cell death apparently by relieving ER stress. These data suggest that combining autophagy inhibitors with 2-DG may be useful clinically. ..
  3. Zhai R, Rizzi M, Garavaglia S. Nicotinamide/nicotinic acid mononucleotide adenylyltransferase, new insights into an ancient enzyme. Cell Mol Life Sci. 2009;66:2805-18 pubmed publisher
    ..The resultant wealth of biochemical data has built a robust framework upon which design of NMNAT activators, inhibitors or enzyme variants of potential medical interest can be based. ..
  4. Jin X, Zhang Z, Beer Stolz D, Zimmers T, Koniaris L. Interleukin-6 inhibits oxidative injury and necrosis after extreme liver resection. Hepatology. 2007;46:802-12 pubmed
    ..IL-6 improves recovery and survival from extreme liver resection by enhancing pro-growth pathways, reducing oxidative stress, and maintaining mitochondrial function. ..
  5. Huang Y, Maruyama Y, Lu K, Pereira E, Plonsky I, Baur J, et al. Using biosensors to detect the release of serotonin from taste buds during taste stimulation. Arch Ital Biol. 2005;143:87-96 pubmed
    ..Sour- and depolarization-evoked release of 5HT from taste buds is triggered by Ca2+ influx from the extracellular fluid. In contrast, bitter- and sweet-evoked release of 5HT is triggered by Ca2+ derived from intracellular stores. ..
  6. Washburn K, Neary J. P2 purinergic receptors signal to STAT3 in astrocytes: Difference in STAT3 responses to P2Y and P2X receptor activation. Neuroscience. 2006;142:411-23 pubmed
    ..We conclude that P2 receptors stimulate STAT3 activation and suggest that P2 receptor/STAT3 signaling may play an important role in astrocyte proliferation and reactive astrogliosis. ..
  7. Guy J, Qi X, Koilkonda R, Arguello T, Chou T, Ruggeri M, et al. Efficiency and safety of AAV-mediated gene delivery of the human ND4 complex I subunit in the mouse visual system. Invest Ophthalmol Vis Sci. 2009;50:4205-14 pubmed publisher
  8. Dvoriantchikova G, Barakat D, Hernandez E, Shestopalov V, Ivanov D. Liposome-delivered ATP effectively protects the retina against ischemia-reperfusion injury. Mol Vis. 2010;16:2882-90 pubmed
    ..ATP-liposome treatment of IR-challenged neural tissues suppressed necrosis and correlated with a significantly reduced level of inflammation and retinal damage. ..
  9. Ding D, Enriquez Algeciras M, Dave K, Perez Pinzon M, Bhattacharya S. The role of deimination in ATP5b mRNA transport in a transgenic mouse model of multiple sclerosis. EMBO Rep. 2012;13:230-6 pubmed publisher
    ..Impaired deimination of REF and defect in mitochondrial mRNA transport are critical factors in mitochondrial dysfunction in ND4 mice. ..
  10. Dando R, Dvoryanchikov G, Pereira E, Chaudhari N, Roper S. Adenosine enhances sweet taste through A2B receptors in the taste bud. J Neurosci. 2012;32:322-30 pubmed publisher
    ..Our findings suggest that ATP released during taste reception is degraded to adenosine to exert positive modulation particularly on sweet taste. ..
  11. Ngu E, Sahley C, Muller K. Reduced axon sprouting after treatment that diminishes microglia accumulation at lesions in the leech CNS. J Comp Neurol. 2007;503:101-9 pubmed
    ..There was a significant reduction in total sprout lengths compared with controls when microglial accumulation was reduced. The results suggest that microglial cells are necessary for the usual sprouting of injured axons...
  12. Tran T, Andreka P, Rodrigues C, Webster K, Bishopric N. Jun kinase delays caspase-9 activation by interaction with the apoptosome. J Biol Chem. 2007;282:20340-50 pubmed
    ..We propose that this interaction delays formation of the active apoptosome, promoting cell survival during short bursts of oxidative stress. ..
  13. Ohta Y, Powis S, Coadwell W, Haliniewski D, Liu Y, Li H, et al. Identification and genetic mapping of Xenopus TAP2 genes. Immunogenetics. 1999;49:171-82 pubmed
    ..Similar to LMP7 and class Ia,TAP2 is expressed ubiquitously with highest levels in intestine and spleen...
  14. Dahl G, Muller K. Innexin and pannexin channels and their signaling. FEBS Lett. 2014;588:1396-402 pubmed publisher
  15. De Silva D, Fontanesi F, Barrientos A. The DEAD box protein Mrh4 functions in the assembly of the mitochondrial large ribosomal subunit. Cell Metab. 2013;18:712-25 pubmed publisher
    ..We conclude that Mrh4 plays an essential role during the late stages of mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. ..
  16. Minkiewicz J, de Rivero Vaccari J, Keane R. Human astrocytes express a novel NLRP2 inflammasome. Glia. 2013;61:1113-21 pubmed publisher
    ..Our findings suggest that the astrocytic NLRP2 inflammasome is an important component of the CNS inflammatory response and that the NLRP2 inflammasome may be a therapeutic target to inhibit inflammation induced by CNS injury. ..
  17. Huang Y, Roper S. Intracellular Ca(2+) and TRPM5-mediated membrane depolarization produce ATP secretion from taste receptor cells. J Physiol. 2010;588:2343-50 pubmed publisher
  18. Zhao X, Jain C. DEAD-box proteins from Escherichia coli exhibit multiple ATP-independent activities. J Bacteriol. 2011;193:2236-41 pubmed publisher
  19. Tran M. P2 receptor stimulation induces amyloid precursor protein production and secretion in rat cortical astrocytes. Neurosci Lett. 2011;492:155-9 pubmed publisher
    ..These results indicate that APP production and secretion can be regulated by activation of P2Y2/4 receptors coupled to protein kinase signaling pathways and suggest that astrocytes can be a potential source of APP. ..
  20. Jacques Silva M, Correa Medina M, Cabrera O, Rodriguez Diaz R, Makeeva N, Fachado A, et al. ATP-gated P2X3 receptors constitute a positive autocrine signal for insulin release in the human pancreatic beta cell. Proc Natl Acad Sci U S A. 2010;107:6465-70 pubmed publisher
    ..This may explain how the human pancreatic beta cell can respond so effectively to relatively modest changes in glucose concentration under physiological conditions in vivo. ..
  21. Yan D, Zhu Y, Walsh T, Xie D, Yuan H, Sirmaci A, et al. Mutation of the ATP-gated P2X(2) receptor leads to progressive hearing loss and increased susceptibility to noise. Proc Natl Acad Sci U S A. 2013;110:2228-33 pubmed publisher
    ..V60L, noise exposure exacerbated high-frequency hearing loss in young adulthood. Our results suggest that P2X(2) function is required for life-long normal hearing and for protection from exposure to noise. ..
  22. Dey R, Moraes C. Lack of oxidative phosphorylation and low mitochondrial membrane potential decrease susceptibility to apoptosis and do not modulate the protective effect of Bcl-x(L) in osteosarcoma cells. J Biol Chem. 2000;275:7087-94 pubmed
    ..It also reinforces a model in which Bcl-x(L) can exert an antiapoptotic effect by stimulating oxidative phosphorylation and/or inhibiting caspase activation. ..
  23. Ransford G, Fregien N, Qiu F, Dahl G, Conner G, Salathe M. Pannexin 1 contributes to ATP release in airway epithelia. Am J Respir Cell Mol Biol. 2009;41:525-34 pubmed publisher
    ..These data not only show that Panx1 is expressed apically in differentiated airway epithelial cells but also that it contributes to ATP release in these cells. ..
  24. Luo X, Ribeiro M, Bray E, Lee D, Yungher B, Mehta S, et al. Enhanced Transcriptional Activity and Mitochondrial Localization of STAT3 Co-induce Axon Regrowth in the Adult Central Nervous System. Cell Rep. 2016;15:398-410 pubmed publisher
  25. Huang Y, Maruyama Y, Dvoryanchikov G, Pereira E, Chaudhari N, Roper S. The role of pannexin 1 hemichannels in ATP release and cell-cell communication in mouse taste buds. Proc Natl Acad Sci U S A. 2007;104:6436-41 pubmed
    ..They also indicate a route for cell-cell communication and signal processing within the taste bud. ..
  26. Neary J, Kang Y. P2 purinergic receptors signal to glycogen synthase kinase-3beta in astrocytes. J Neurosci Res. 2006;84:515-24 pubmed
    ..These findings suggest that purinergic signaling contributes to the regulation of GSK3beta functions, one of which may be the response of astrocytes to CNS injury on release of ATP. ..
  27. Tillotson J, Kedzior M, Guimarães L, Ross A, Peters T, Ambrose A, et al. ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A. Bioorg Med Chem Lett. 2017;27:4082-4085 pubmed publisher
    ..However, only compound 2 showed potent inhibition of helicase activity congruent with its ATPase inhibitory activity. ..
  28. Dahl G, Keane R. Pannexin: from discovery to bedside in 11±4 years?. Brain Res. 2012;1487:150-9 pubmed publisher
    ..Since Panx1 inhibitors such as probenecid are already clinically tested in different settings they should be considered for therapy in stroke and CNS trauma. ..
  29. Koilkonda R, Chou T, Porciatti V, Hauswirth W, Guy J. Induction of rapid and highly efficient expression of the human ND4 complex I subunit in the mouse visual system by self-complementary adeno-associated virus. Arch Ophthalmol. 2010;128:876-83 pubmed publisher
  30. Smith A, Meyer P, Asthana D, Ashman M, Scott W. Intracellular substrates for the primer-unblocking reaction by human immunodeficiency virus type 1 reverse transcriptase: detection and quantitation in extracts from quiescent- and activated-lymphocyte subpopulations. Antimicrob Agents Chemother. 2005;49:1761-9 pubmed
    ..While PP(i)-dependent excision may contribute to AZT resistance in vivo, it is likely that selection of AZT-resistant mutants occurs primarily in an environment where the ATP-dependent reaction predominates...
  31. Nair K, Hanson S, Mendez A, Gurevich E, Kennedy M, Shestopalov V, et al. Light-dependent redistribution of arrestin in vertebrate rods is an energy-independent process governed by protein-protein interactions. Neuron. 2005;46:555-67 pubmed
    ..These results indicate that the distribution of arrestin in rods is controlled by its dynamic interactions with rhodopsin in the OS and microtubules in the IS and that its movement occurs by simple diffusion...
  32. Della Morte D, Dave K, DeFazio R, Bao Y, Raval A, Perez Pinzon M. Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathway. Neuroscience. 2009;159:993-1002 pubmed publisher
    ..In conclusion, in vivo resveratrol pretreatment confers neuroprotection similar to IPC via the SIRT1-UCP2 pathway. ..
  33. Duan Y, Sahley C, Muller K. ATP and NO dually control migration of microglia to nerve lesions. Dev Neurobiol. 2009;69:60-72 pubmed publisher
    ..Taken together, the experiments support the hypothesis that ATP released directly or indirectly by injury activates microglia to move, whereas NO that activates sGC directs migration of microglia to CNS lesions...
  34. Qiu F, Dahl G. A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP. Am J Physiol Cell Physiol. 2009;296:C250-5 pubmed publisher
    ..Mutational analysis identified R75 in pannexin 1 to be critical for ATP inhibition of pannexin 1 currents. ..
  35. Panickar K, Nonner D, Barrett J. Overexpression of Bcl-xl protects septal neurons from prolonged hypoglycemia and from acute ischemia-like stress. Neuroscience. 2005;135:73-80 pubmed
    ..Bcl-xl's protective effects may require an intact electron transport chain. ..
  36. Locovei S, Bao L, Dahl G. Pannexin 1 in erythrocytes: function without a gap. Proc Natl Acad Sci U S A. 2006;103:7655-9 pubmed
    ..Furthermore, under conditions of ATP release, erythrocytes took up fluorescent tracer molecules permeant to gap junction channels. ..
  37. Huang Y, Stone L, Pereira E, Yang R, Kinnamon J, Dvoryanchikov G, et al. Knocking out P2X receptors reduces transmitter secretion in taste buds. J Neurosci. 2011;31:13654-61 pubmed publisher
    ..Importantly, we find that P2X2 is expressed in WT taste buds and appears to function as an autocrine, positive feedback signal to amplify taste-evoked ATP secretion. ..
  38. Qiu F, Wang J, Spray D, Scemes E, Dahl G. Two non-vesicular ATP release pathways in the mouse erythrocyte membrane. FEBS Lett. 2011;585:3430-5 pubmed publisher
    ..Thus, in erythrocytes, two independent pathways mediate the release of ATP. We also show that glyburide is a strong inhibitor of Panx1 channels...
  39. Wei J, Wang W, Chopra I, Li H, Dougherty C, Adi J, et al. c-Jun N-terminal kinase (JNK-1) confers protection against brief but not extended ischemia during acute myocardial infarction. J Biol Chem. 2011;286:13995-4006 pubmed publisher
    ..The studies define a novel role for JNK-1 as a conditional survival kinase that protects the heart against brief but not protracted ischemia. ..
  40. Huang Y, Dando R, Roper S. Autocrine and paracrine roles for ATP and serotonin in mouse taste buds. J Neurosci. 2009;29:13909-18 pubmed publisher
    ..These results begin to sort out how purinergic and aminergic transmitters function within the taste bud to modulate gustatory signaling in these peripheral sensory organs...
  41. Wen Y, Xu Y, Wang Y, Pinto J, Potter J, Kerrick W. Functional effects of a restrictive-cardiomyopathy-linked cardiac troponin I mutation (R145W) in transgenic mice. J Mol Biol. 2009;392:1158-67 pubmed publisher
    ..These functional results help to explain the mechanisms by which these mutations give rise to a restrictive phenotype. ..
  42. Neary J, Kang Y, Shi Y. Signaling from nucleotide receptors to protein kinase cascades in astrocytes. Neurochem Res. 2004;29:2037-42 pubmed
  43. Locovei S, Scemes E, Qiu F, Spray D, Dahl G. Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complex. FEBS Lett. 2007;581:483-8 pubmed
    ..Thus, pannexin1 appears to be the molecular substrate for the permeabilization pore (or death receptor channel) recruited into the P2X(7)R signaling complex. ..
  44. Neary J, Kang Y, Tran M, Feld J. Traumatic injury activates protein kinase B/Akt in cultured astrocytes: role of extracellular ATP and P2 purinergic receptors. J Neurotrauma. 2005;22:491-500 pubmed
    ..This suggests that P2 receptor/Akt signaling promotes astrocyte survival and growth, and this process may play a role in the generation of reactive gliosis after TBI. ..
  45. Wang J, Jackson D, Dahl G. The food dye FD&C Blue No. 1 is a selective inhibitor of the ATP release channel Panx1. J Gen Physiol. 2013;141:649-56 pubmed publisher