Experts and Doctors on trypsin in Pennsylvania, United States
Locale: Pennsylvania, United States
Xu Y, Mehl J, Bakhtiar R, Woolf E. Immunoaffinity purification using anti-PEG antibody followed by two-dimensional liquid chromatography/tandem mass spectrometry for the quantification of a PEGylated therapeutic peptide in human plasma. Anal Chem. 2010;82:6877-86 pubmed publisher
..A cross comparison, performed using clinical samples, showed that the values obtained from IAP assay were about 15-30% lower than those from PPT method, which supports more specific PEG recognition provided by IAP. ..
Draper D, Donohoe W, Mortimer L, Heine R. Cysteine proteases of Trichomonas vaginalis degrade secretory leukocyte protease inhibitor. J Infect Dis. 1998;178:815-9 pubmed
..Median levels of SLPI from infected patients were 26% of those of controls (P <.005). The degradation of SLPI in association with trichomonal infection may increase the risk of HIV acquisition. ..
Shetty V, Nickens Z, Shah P, Sinnathamby G, Semmes O, Philip R. Investigation of sialylation aberration in N-linked glycopeptides by lectin and tandem labeling (LTL) quantitative proteomics. Anal Chem. 2010;82:9201-10 pubmed publisher
..Thus, LTL quantitative technique is potentially an useful method for obtaining simultaneous unambiguous identification and reliable quantification of N-linked glycopeptides. ..
Gonzales L, Angampalli S, Guttentag S, Beers M, Feinstein S, Matlapudi A, et al
. Maintenance of differentiated function of the surfactant system in human fetal lung type II epithelial cells cultured on plastic. Pediatr Pathol Mol Med. 2001;20:387-412 pubmed
Novak J, Trnka F. Proenzyme therapy of cancer. Anticancer Res. 2005;25:1157-77 pubmed
..In conclusion, we have discovered that proenzyme therapy, mandated first by John Beard nearly one hundred years ago, shows remarkable selective effects that result in growth inhibition of tumor cells with metastatic potential. ..
Neeper M, Schmidt A, Brett J, Yan S, Wang F, Pan Y, et al
. Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. J Biol Chem. 1992;267:14998-5004 pubmed
..These results suggest that RAGE functions as a cell surface receptor for AGEs, which could potentially mediate cellular effects of this class of glycosylated proteins. ..
Yan Y, Lagenaur C, Narayanan V. Molecular cloning of M6: identification of a PLP/DM20 gene family. Neuron. 1993;11:423-31 pubmed
..The identification of a gene family including neuron-specific M6 and glia-specific PLP/DM20 in CNS suggests a broader functional role for these molecules than myelination. ..
Whitcomb D, Gorry M, Preston R, Furey W, Sossenheimer M, Ulrich C, et al
. Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat Genet. 1996;14:141-5 pubmed
..Cleavage at this site is probably part of a fail-safe mechanism by which trypsin, which is activated within the pancreas, may be inactivated; loss of this cleavage site would permit autodigestion resulting in pancreatitis. ..
Nunez A, Fishman M, Fortis L, Cooke P, Hotchkiss A. Identification of extensin protein associated with sugar beet pectin. J Agric Food Chem. 2009;57:10951-8 pubmed publisher
..Atomic force microscopy established that the number of rod-like elements decreased following protease treatment compared to the untreated sample. ..