Experts and Doctors on succinic acid in New York, United States
Locale: New York, United States
Topic: succinic acid
Bao L, Avshalumov M, Patel J, Lee C, Miller E, Chang C, et al
. Mitochondria are the source of hydrogen peroxide for dynamic brain-cell signaling. J Neurosci. 2009;29:9002-10 pubmed publisher
..These data provide the first demonstration that respiring mitochondria are the primary source of H(2)O(2) generation for dynamic neuronal signaling. ..
Eoh H, Rhee K. Multifunctional essentiality of succinate metabolism in adaptation to hypoxia in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2013;110:6554-9 pubmed publisher
..Isocitrate lyase-dependent production of succinate affords M. tuberculosis with a unique and bioenergetically efficient metabolic means of entry into and exit from hypoxia-induced quiescence. ..
Colas C, Schlessinger A, Pajor A. Mapping Functionally Important Residues in the Na+/Dicarboxylate Cotransporter, NaDC1. Biochemistry. 2017;56:4432-4441 pubmed publisher
..The results of this study improve our understanding of substrate and ion recognition in the mammalian members of the SLC13 family and provide a framework for developing conformationally specific inhibitors against these transporters. ..
Starkov A, Fiskum G, Chinopoulos C, Lorenzo B, Browne S, Patel M, et al
. Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species. J Neurosci. 2004;24:7779-88 pubmed
..The data strongly indicate that KGDHC is a primary site of ROS production in normally functioning mitochondria. ..
Sozer S, Wang X, Zhang W, Fiel M, Ishii T, Wang J, et al
. Circulating angiogenic monocyte progenitor cells are reduced in JAK2V617F high allele burden myeloproliferative disorders. Blood Cells Mol Dis. 2008;41:284-91 pubmed publisher
..These studies suggest that reduced numbers of circulating angiogenic monocyte progenitors contribute to the propensity to develop thrombotic complications in myeloproliferative disorder patients. ..