Experts and Doctors on stem cells in Scotland, United Kingdom


Locale: Scotland, United Kingdom
Topic: stem cells

Top Publications

  1. Tsimbouri P, McMurray R, Burgess K, Alakpa E, Reynolds P, Murawski K, et al. Using nanotopography and metabolomics to identify biochemical effectors of multipotency. ACS Nano. 2012;6:10239-49 pubmed publisher
    ..We then show that these signaling effectors regulate functional multipotency. ..
  2. Williams M, Clouston A, Forbes S. Links between hepatic fibrosis, ductular reaction, and progenitor cell expansion. Gastroenterology. 2014;146:349-56 pubmed publisher
    ..Understanding the interactions between progenitor cells and matrix is critical for the development of novel regenerative and antifibrotic therapies. ..
  3. Dalby M, Gadegaard N, Oreffo R. Harnessing nanotopography and integrin-matrix interactions to influence stem cell fate. Nat Mater. 2014;13:558-69 pubmed publisher
  4. Guest R, Boulter L, Kendall T, Minnis Lyons S, Walker R, Wigmore S, et al. Cell lineage tracing reveals a biliary origin of intrahepatic cholangiocarcinoma. Cancer Res. 2014;74:1005-10 pubmed publisher
    ..These data prove that in the context of chronic inflammation and p53 loss, frequent occurrences in human disease, biliary epithelia are a target of transformation and an origin of intrahepatic cholangiocarcinoma. ..
  5. Forsyth N, Musio A, Vezzoni P, Simpson A, Noble B, McWhir J. Physiologic oxygen enhances human embryonic stem cell clonal recovery and reduces chromosomal abnormalities. Cloning Stem Cells. 2006;8:16-23 pubmed
    ..These results clearly demonstrate that physiologic oxygen culture conditions are indispensable for robust hES clone recovery and may enhance the isolation of novel hES lines and transgenic clones. ..
  6. Hay D, Sutherland L, Clark J, Burdon T. Oct-4 knockdown induces similar patterns of endoderm and trophoblast differentiation markers in human and mouse embryonic stem cells. Stem Cells. 2004;22:225-35 pubmed
    ..Moreover, the upregulation of endoderm-associated markers in both mouse and human ES cells points to overlap between development of trophoblast and endoderm differentiation. ..
  7. Brodeur J, Calvo J, Johnston I. Proliferation of myogenic progenitor cells following feeding in the sub-antarctic notothenioid fish Harpagifer bispinis. J Exp Biol. 2003;206:163-9 pubmed
    ..These results show that the proliferation of myogenic progenitor cells can be induced by feeding in teleost fishes and that temperature and photoperiod influence the expression of myogenic regulatory factors. ..
  8. Gao S, Gasparrini B, McGarry M, Ferrier T, Fletcher J, Harkness L, et al. Germinal vesicle material is essential for nucleus remodeling after nuclear transfer. Biol Reprod. 2002;67:928-34 pubmed
    ..3% of transferred embryos developed to term. These results indicate that GV material is essential for nucleus remodeling after nuclear transfer. ..
  9. Zhang H, Jarjour A, Boyd A, Williams A. Central nervous system remyelination in culture--a tool for multiple sclerosis research. Exp Neurol. 2011;230:138-48 pubmed publisher

More Information


  1. Jackson M, Watt A, Gautier P, Gilchrist D, Driehaus J, Graham G, et al. A murine specific expansion of the Rhox cluster involved in embryonic stem cell biology is under natural selection. BMC Genomics. 2006;7:212 pubmed
    ..Moreover, this unique cluster may explain species differences in ES cell derivation and maintenance between mouse, rat and human. ..
  2. Moore R, Redhead N, Selfridge J, Hope J, Manson J, Melton D. Double replacement gene targeting for the production of a series of mouse strains with different prion protein gene alterations. Biotechnology (N Y). 1995;13:999-1004 pubmed
    ..We anticipate that this procedure will have applications to the study of human inherited diseases and the development of therapies. ..
  3. Finlay D, Sinclair L, Feijoo C, Waugh C, Hagenbeek T, Spits H, et al. Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes. J Exp Med. 2009;206:2441-54 pubmed publisher
    ..Second, PDK1 determines the cohort of chemokine and adhesion receptors expressed by PTEN-null cells, thereby controlling their migratory capacity. ..
  4. Jackson M, Baird J, Nichols J, Wilkie R, Ansell J, Graham G, et al. Expression of a novel homeobox gene Ehox in trophoblast stem cells and pharyngeal pouch endoderm. Dev Dyn. 2003;228:740-4 pubmed
  5. McClive P, Pall G, Newton K, Lee M, Mullins J, Forrester L. Gene trap integrations expressed in the developing heart: insertion site affects splicing of the PT1-ATG vector. Dev Dyn. 1998;212:267-76 pubmed
    ..One of these exon integrations results in a lethal neonatal phenotype. ..
  6. Chambers I, Smith A. Self-renewal of teratocarcinoma and embryonic stem cells. Oncogene. 2004;23:7150-60 pubmed
    ..Nanog function also requires Oct4. Here, we review recent progress in ES cell self-renewal, relate this to the biology of teratocarcinomas and offer testable hypotheses to expose the mechanics of ES cell self-renewal...
  7. Middleton G, Pinon L, Wyatt S, Davies A. Bcl-2 accelerates the maturation of early sensory neurons. J Neurosci. 1998;18:3344-50 pubmed
    ..These findings indicate that Bcl-2 expression is required for the normal progression of a particular early maturational change in embryonic sensory neurons. ..
  8. Stacey A, Schnieke A, McWhir J, Cooper J, Colman A, Melton D. Use of double-replacement gene targeting to replace the murine alpha-lactalbumin gene with its human counterpart in embryonic stem cells and mice. Mol Cell Biol. 1994;14:1009-16 pubmed
    ..A typical strategy for future use would be to generate a null mutation which could then be used to produce multiple second-step alterations at the same locus. ..
  9. Dunlop C, Telfer E, Anderson R. Ovarian stem cells--potential roles in infertility treatment and fertility preservation. Maturitas. 2013;76:279-83 pubmed publisher
    ..This review summarises our current understanding of OSCs and discusses their potential clinical application in infertility treatment and fertility preservation. ..
  10. Lund K, Adams P, Copland M. EZH2 in normal and malignant hematopoiesis. Leukemia. 2014;28:44-9 pubmed publisher
    ..This review examines the role of EZH2 in normal and malignant hematopoiesis and recent developments in harnessing the therapeutic potential of EZH2 inhibition. ..
  11. Keller T, Abbott J, Moritz T, Doerner P. Arabidopsis REGULATOR OF AXILLARY MERISTEMS1 controls a leaf axil stem cell niche and modulates vegetative development. Plant Cell. 2006;18:598-611 pubmed
    ..RAX1 thus defines a novel activity that links the specification of AM formation with the modulation of the rate of progression through developmental phases. ..
  12. Maxwell S, Ho H, Kuehner E, Zhao S, Li M. Pitx3 regulates tyrosine hydroxylase expression in the substantia nigra and identifies a subgroup of mesencephalic dopaminergic progenitor neurons during mouse development. Dev Biol. 2005;282:467-79 pubmed
    ..Such an expression pattern may provide the molecular basis for the specific dependence of substantia nigra DA neurons on Pitx3. ..
  13. McHugh B, Krause S, Yu B, Deans A, Heasman S, McLaughlin P, et al. Invadolysin: a novel, conserved metalloprotease links mitotic structural rearrangements with cell migration. J Cell Biol. 2004;167:673-86 pubmed
    ..Thus, invadolysin identifies a new family of conserved metalloproteases whose activity appears to be essential for the coordination of mitotic progression, but which also plays an unexpected role in cell migration. ..
  14. Ying Q, Nichols J, Chambers I, Smith A. BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell. 2003;115:281-92 pubmed
    ..Upon LIF withdrawal, Id-expressing ES cells differentiate but do not give rise to neural lineages. We conclude that blockade of lineage-specific transcription factors by Id proteins enables the self-renewal response to LIF/STAT3. ..
  15. Aubert J, Stavridis M, Tweedie S, O Reilly M, Vierlinger K, Li M, et al. Screening for mammalian neural genes via fluorescence-activated cell sorter purification of neural precursors from Sox1-gfp knock-in mice. Proc Natl Acad Sci U S A. 2003;100 Suppl 1:11836-41 pubmed
    ..Whole mount in situ hybridization against two genes of previously unknown embryonic expression, Lrrn1 and Musashi2, confirmed the selectivity of this screen for early neuroectodermal markers. ..
  16. Jackson M, Baird J, Cambray N, Ansell J, Forrester L, Graham G. Cloning and characterization of Ehox, a novel homeobox gene essential for embryonic stem cell differentiation. J Biol Chem. 2002;277:38683-92 pubmed
    ..We therefore conclude that Ehox is a novel homeobox-containing gene that is essential for the earliest stages of murine ES cell differentiation. ..
  17. Hendrich B, Guy J, Ramsahoye B, Wilson V, Bird A. Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development. Genes Dev. 2001;15:710-23 pubmed
    ..Genetic and biochemical data together favor the view that MBD3 is a key component of the Mi-2/NuRD corepressor complex, whereas MBD2 may be one of several factors that can recruit this complex to DNA. ..
  18. Tate P, Lee M, Tweedie S, Skarnes W, Bickmore W. Capturing novel mouse genes encoding chromosomal and other nuclear proteins. J Cell Sci. 1998;111 ( Pt 17):2575-85 pubmed
    ..Motifs in two of the isolated genes suggest new links between cellular regulatory mechanisms (ubiquitination and phosphorylation) and mRNA splicing and chromosome structure/function. ..
  19. Chambers I, Cozens A, Broadbent J, Robertson M, Lee M, Li M, et al. Structure of the mouse leukaemia inhibitory factor receptor gene: regulated expression of mRNA encoding a soluble receptor isoform from an alternative 5' untranslated region. Biochem J. 1997;328 ( Pt 3):879-88 pubmed
  20. Wu C, Melton D. Production of a model for Lesch-Nyhan syndrome in hypoxanthine phosphoribosyltransferase-deficient mice. Nat Genet. 1993;3:235-40 pubmed
    ..This combined genetic and biochemical model will facilitate the study of Lesch-Nyhan syndrome and the evaluation of novel therapies. ..
  21. Mountford P, Zevnik B, Duwel A, Nichols J, Li M, Dani C, et al. Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression. Proc Natl Acad Sci U S A. 1994;91:4303-7 pubmed
    ..This has allowed visualization of putative "stem-cell niches" in which sources of elevated expression of differentiation-inhibiting activity were localized to the differentiated cells surrounding colonies of stem cells. ..
  22. Robertson M, Stenhouse F, Colby D, Marland J, Nichols J, Tweedie S, et al. Nanog retrotransposed genes with functionally conserved open reading frames. Mamm Genome. 2006;17:732-43 pubmed
    ..caroli and M. spretus and indicates that Nanog retrotransposition events continue to occur at a high frequency, a property likely to extend to other germ-line transcripts. ..
  23. MacLaine N, Hupp T. How phosphorylation controls p53. Cell Cycle. 2011;10:916-21 pubmed
    ..Finally, we discuss how changes in the specific activity of p53 can have profound effects not only on cancer development, but also on organism aging. ..
  24. Douvaras P, Webb S, Whitaker D, DorĂ  N, Hill R, Dorin J, et al. Rare corneal clones in mice suggest an age-related decrease of stem cell activity and support the limbal epithelial stem cell hypothesis. Stem Cell Res. 2012;8:109-19 pubmed publisher
    ..Pax6(+/-), KRT5(LacZ/-) corneas had small patches rather than stripes, which confirms that corneal maintenance is abnormal in Pax6(+/-) mice...
  25. Dani C, Chambers I, Johnstone S, Robertson M, Ebrahimi B, Saito M, et al. Paracrine induction of stem cell renewal by LIF-deficient cells: a new ES cell regulatory pathway. Dev Biol. 1998;203:149-62 pubmed
    ..Operation of this pathway in vivo could play an important role in the regulation of pluripotency in the epiblast and account for the viability of lifr -/- and gp130 -/- embryos. ..
  26. Huels D, Sansom O. R-spondin Is More Than Just Wnt's Sidekick. Dev Cell. 2017;41:456-458 pubmed publisher
    ..2017) show that Wnts and Wnt signaling potentiator R-spondins have non-interchangeable roles. Both are necessary for intestinal stem cell (ISC) maintenance, and R-spondins are the limiting factor that defines ISC number. ..