Experts and Doctors on skin abnormalities in New York, United States
Locale: New York, United States
Topic: skin abnormalities
Panteleyev A, Ahmad W, Malashenko A, Ignatieva E, Paus R, Sundberg J, et al
. Molecular basis for the rhino Yurlovo (hr(rhY)) phenotype: severe skin abnormalities and female reproductive defects associated with an insertion in the hairless gene. Exp Dermatol. 1998;7:281-8 pubmed
..These results, together with previous studies of hr(rhY)/hr(rhY) mutant mice, suggest that the rhino Yurlovo (hr(rhY)) mutation represents a third and potentially more severe variation of the hairless phenotype. ..
Gayraud B, Keene D, Sakai L, Ramirez F. New insights into the assembly of extracellular microfibrils from the analysis of the fibrillin 1 mutation in the tight skin mouse. J Cell Biol. 2000;150:667-80 pubmed
..Indirect in vitro evidence suggests that a potential mechanism for the dominant negative effects of incorporating Tsk fibrillin 1 into microfibrils is increased proteolytic susceptibility conferred by the duplicated Tsk region. ..
McGaha T, Saito S, Phelps R, Gordon R, Noben Trauth N, Paul W, et al
. Lack of skin fibrosis in tight skin (TSK) mice with targeted mutation in the interleukin-4R alpha and transforming growth factor-beta genes. J Invest Dermatol. 2001;116:136-43 pubmed
Kobielak K, Pasolli H, Alonso L, Polak L, Fuchs E. Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA. J Cell Biol. 2003;163:609-23 pubmed
Wang X, Bolotin D, Chu D, Polak L, Williams T, Fuchs E. AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis. J Cell Biol. 2006;172:409-21 pubmed
..These results provide insights into why elevated AP-2alpha levels are often associated with terminal differentiation and why tumor cells often display reduced AP-2alpha and elevated EGFR proteins. ..
Yi R, Pasolli H, Landthaler M, Hafner M, Ojo T, Sheridan R, et al
. DGCR8-dependent microRNA biogenesis is essential for skin development. Proc Natl Acad Sci U S A. 2009;106:498-502 pubmed publisher
..Our results underscore a specific importance of microRNAs in controlling mammalian skin development. ..
Wang Y, Zhou X, Oberoi K, Phelps R, COUWENHOVEN R, Sun M, et al
. p38 Inhibition ameliorates skin and skull abnormalities in Fgfr2 Beare-Stevenson mice. J Clin Invest. 2012;122:2153-64 pubmed publisher
..The demonstration of a pathogenic role for p38 activation may lead to the development of therapeutic strategies for BSS and related conditions, such as acanthosis nigricans or craniosynostosis. ..
Meyer A, Wang W, Qu J, Croft L, Degen J, Coller B, et al
. Platelet TGF-?1 contributions to plasma TGF-?1, cardiac fibrosis, and systolic dysfunction in a mouse model of pressure overload. Blood. 2012;119:1064-74 pubmed publisher