Experts and Doctors on serotonin in New York, United States


Locale: New York, United States
Topic: serotonin

Top Publications

  1. Broderick P, Kolodny E. Biosensors for brain trauma and dual laser doppler flowmetry: enoxaparin simultaneously reduces stroke-induced dopamine and blood flow while enhancing serotonin and blood flow in motor neurons of brain, in vivo. Sensors (Basel). 2011;11:138-61 pubmed publisher
  2. Chen J, Pan H, Rothman T, Wade P, Gershon M. Guinea pig 5-HT transporter: cloning, expression, distribution, and function in intestinal sensory reception. Am J Physiol. 1998;275:G433-48 pubmed publisher
    ..Inhibition of mucosal 5-HT uptake potentiates responses of submucosal neurons to mucosal stimulation. The epithelial reuptake of 5-HT thus appears to be responsible for terminating mucosal actions of 5-HT. ..
  3. Gershon M. Review article: serotonin receptors and transporters -- roles in normal and abnormal gastrointestinal motility. Aliment Pharmacol Ther. 2004;20 Suppl 7:3-14 pubmed
    ..The observation that molecular defects occur in the human gut in irritable bowel syndrome strengthens the hand of those seeking to legitimize the disease. At least it is not 'all in your head'. The bowel contributes. ..
  4. Liu M, Rayport S, Jiang Y, Murphy D, Gershon M. Expression and function of 5-HT3 receptors in the enteric neurons of mice lacking the serotonin transporter. Am J Physiol Gastrointest Liver Physiol. 2002;283:G1398-411 pubmed
    ..Adaptive changes thus occur in the subunit composition of enteric 5-HT(3) receptors of SERT -/- mice that are reflected in 5-HT(3) receptor affinity and desensitization. ..
  5. Leininger E, Kelley D. Distinct neural and neuromuscular strategies underlie independent evolution of simplified advertisement calls. Proc Biol Sci. 2013;280:20122639 pubmed publisher
    ..Temporally simple advertisement calls in genetically distant species of Xenopus have thus arisen independently via reconfigurations of central and peripheral vocal neuroeffectors. ..
  6. Hobert O. Behavioral plasticity in C. elegans: paradigms, circuits, genes. J Neurobiol. 2003;54:203-23 pubmed
    ..Lastly, the review outlines how reverse genetics and genomic approaches can guide the analysis of the role of genes in behavior and why and how they will complement the forward genetic analysis of behavior. ..
  7. Jones J, Hall F, Uhl G, Rice K, Riley A. Differential involvement of the norepinephrine, serotonin and dopamine reuptake transporter proteins in cocaine-induced taste aversion. Pharmacol Biochem Behav. 2009;93:75-81 pubmed publisher
  8. Hegde A, Inokuchi K, Pei W, Casadio A, Ghirardi M, Chain D, et al. Ubiquitin C-terminal hydrolase is an immediate-early gene essential for long-term facilitation in Aplysia. Cell. 1997;89:115-26 pubmed
    ..Thus, through induction of the hydrolase and the resulting up-regulation of the ubiquitin pathway, learning recruits a regulated form of proteolysis that removes inhibitory constraints on long-term memory storage...
  9. Yamada T, Placzek M, Tanaka H, Dodd J, Jessell T. Control of cell pattern in the developing nervous system: polarizing activity of the floor plate and notochord. Cell. 1991;64:635-47 pubmed
    ..These results suggest that the differentiation of neural cells is controlled, in part, by their position with respect to the notochord and floor plate. ..

More Information

Publications151 found, 100 shown here

  1. Sacktor T, Schwartz J. Sensitizing stimuli cause translocation of protein kinase C in Aplysia sensory neurons. Proc Natl Acad Sci U S A. 1990;87:2036-9 pubmed
  2. Julius D, Macdermott A, Axel R, Jessell T. Molecular characterization of a functional cDNA encoding the serotonin 1c receptor. Science. 1988;241:558-64 pubmed
  3. Gershon M. Review article: roles played by 5-hydroxytryptamine in the physiology of the bowel. Aliment Pharmacol Ther. 1999;13 Suppl 2:15-30 pubmed
  4. Gershon M, Liu M. Serotonin and neuroprotection in functional bowel disorders. Neurogastroenterol Motil. 2007;19 Suppl 2:19-24 pubmed
  5. MIKO I, Sanes D. Transient gain adjustment in the inferior colliculus is serotonin- and calcium-dependent. Hear Res. 2009;251:39-50 pubmed publisher
    ..These results suggest that 5-HT(3)R activation, coupled with increased intracellular calcium, can transiently alter postsynaptic excitability in IC neurons. ..
  6. Kinnally E, Capitanio J, Leibel R, Deng L, Leduc C, Haghighi F, et al. Epigenetic regulation of serotonin transporter expression and behavior in infant rhesus macaques. Genes Brain Behav. 2010;9:575-82 pubmed publisher
    ..5-HTT CpG methylation may be an important regulator of 5-HTT expression early in development and may contribute to the risk for mood disorders observed in 'high-risk'5-HTTLPR carriers. ..
  7. Bach H, Arango V, Huang Y, Leong S, Mann J, Underwood M. Neuronal tryptophan hydroxylase expression in BALB/cJ and C57Bl/6J mice. J Neurochem. 2011;118:1067-74 pubmed publisher
    ..Future studies quantifying expression per neuron are needed to determine whether less expression is explained by fewer neurons or also less expression per neuron, or both. ..
  8. Kode A, Mosialou I, Silva B, Rached M, Zhou B, Wang J, et al. FOXO1 orchestrates the bone-suppressing function of gut-derived serotonin. J Clin Invest. 2012;122:3490-503 pubmed publisher
    ..These observations identify FOXO1 as the molecular node of an intricate transcriptional machinery that confers the signal of duodenal-derived serotonin to inhibit bone formation. ..
  9. Gershon M. Serotonin is a sword and a shield of the bowel: serotonin plays offense and defense. Trans Am Clin Climatol Assoc. 2012;123:268-80; discussion 280 pubmed
    ..Mucosal 5-HT, therefore, may mobilize inflammatory effectors, which protect the gut from invasion, whereas neuronal 5-HT shields enteric neurons from inflammatory damage. ..
  10. Stimpson C, Barger N, Taglialatela J, Gendron Fitzpatrick A, Hof P, Hopkins W, et al. Differential serotonergic innervation of the amygdala in bonobos and chimpanzees. Soc Cogn Affect Neurosci. 2016;11:413-22 pubmed publisher
    ..These findings suggest that variation in serotonergic innervation of the amygdala may contribute to mediating the remarkable differences in social behavior exhibited by bonobos and chimpanzees. ..
  11. Lesauter J, Kriegsfeld L, Hon J, Silver R. Calbindin-D(28K) cells selectively contact intra-SCN neurons. Neuroscience. 2002;111:575-85 pubmed
    ..Our results reveal a highly specialized topographical organization of connections among suprachiasmatic nucleus cells. ..
  12. Skelton M, Koester J. The morphology, innervation and neural control of the anterior arterial system of Aplysia californica. J Comp Physiol A. 1992;171:141-55 pubmed
    ..By adjusting the length of the arteries during postural changes, the PAS neurons may prevent disturbances in blood flow due to bending or kinking of the arterial walls. ..
  13. Lages B, Weiss H. Enhanced increases in cytosolic Ca2+ in ADP-stimulated platelets from patients with delta-storage pool deficiency--a possible indicator of interactions between granule-bound ADP and the membrane ADP receptor. Thromb Haemost. 1997;77:376-82 pubmed
    ..Thus, in addition to enhancing platelet activation, dense granule ADP could also act to limit the ADP-mediated reactivity of platelets exposed in vivo to low levels of stimulation. ..
  14. Scott M, Brezina V, Weiss K. Ion currents and mechanisms of modulation in the radula opener muscles of Aplysia. J Neurophysiol. 1997;78:2372-87 pubmed
    ..By understanding the modulation in the opener muscles, as well as in the ARC, we are now in a position to understand how the behavior of the two muscles is coordinated under a variety of circumstances. ..
  15. Pan H, Gershon M. Activation of intrinsic afferent pathways in submucosal ganglia of the guinea pig small intestine. J Neurosci. 2000;20:3295-309 pubmed
    ..Slow EPSPs are necessary for excitation to spread within the submucosal plexus. Because some second-order neurons contain also CGRP, primary afferent neurons may be multifunctional and also serve as interneurons. ..
  16. Doherty M, Pickel V. Ultrastructural localization of the serotonin 2A receptor in dopaminergic neurons in the ventral tegmental area. Brain Res. 2000;864:176-85 pubmed
    ..These results also implicate 5-HT2A receptors in the postsynaptic activation of non-dopaminergic neurons and possibly the presynaptic release from terminals of axons originating in, or passing through, these regions. ..
  17. Schacher S, Wu F, Sun Z, Wang D. Cell-specific changes in expression of mRNAs encoding splice variants of aplysia cell adhesion molecule accompany long-term synaptic plasticity. J Neurobiol. 2000;45:152-61 pubmed
    ..The results suggest that rapid cell-specific regulation of splice variant expression may contribute to different forms of long-term synaptic plasticity. ..
  18. Si K, Giustetto M, Etkin A, Hsu R, Janisiewicz A, Miniaci M, et al. A neuronal isoform of CPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in aplysia. Cell. 2003;115:893-904 pubmed
    ..We suggest that Aplysia CPEB is one of the stabilizing components of the synaptic mark. ..
  19. McEwen B, Magarinos A, Reagan L. Structural plasticity and tianeptine: cellular and molecular targets. Eur Psychiatry. 2002;17 Suppl 3:318-30 pubmed
    ..In studying these actions, we hope to better understand the molecular and cellular targets of action of tianeptine in relation to its role in influencing structural plasticity of the hippocampus. ..
  20. Oquendo M, Krunic A, Parsey R, Milak M, Malone K, Anderson A, et al. Positron emission tomography of regional brain metabolic responses to a serotonergic challenge in major depressive disorder with and without borderline personality disorder. Neuropsychopharmacology. 2005;30:1163-72 pubmed
    ..Controlling for the presence of BPD in future imaging studies of mood disorders may elucidate similarities and differences in regional serotonergic function in these two often comorbid disorders. ..
  21. Underwood M, Mann J, Arango V. Morphometry of dorsal raphe nucleus serotonergic neurons in alcoholism. Alcohol Clin Exp Res. 2007;31:837-45 pubmed
  22. Yadav V, Oury F, Suda N, Liu Z, Gao X, Confavreux C, et al. A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure. Cell. 2009;138:976-89 pubmed publisher
    ..For a video summary of this article, see the PaperFlick file with the Supplemental Data available online. ..
  23. Kullyev A, Dempsey C, Miller S, Kuan C, Hapiak V, Komuniecki R, et al. A genetic survey of fluoxetine action on synaptic transmission in Caenorhabditis elegans. Genetics. 2010;186:929-41 pubmed publisher
    ..Epistatic analyses suggest that SER-7 and SER-5 act upstream of AMPA receptor GLR-1 signaling. Our work provides genetic evidence that fluoxetine may influence neuronal functions and behavior by directly targeting serotonin receptors. ..
  24. Gershon M. 5-Hydroxytryptamine (serotonin) in the gastrointestinal tract. Curr Opin Endocrinol Diabetes Obes. 2013;20:14-21 pubmed publisher
    ..New studies show that enteric 5-HT is a polyfunctional signalling molecule, acting both in developing and mature animals as a neurotransmitter paracrine factor, endocrine hormone and growth factor. ..
  25. Garcia García A, Meng Q, Richardson Jones J, Dranovsky A, Leonardo E. Disruption of 5-HT1A function in adolescence but not early adulthood leads to sustained increases of anxiety. Neuroscience. 2016;321:210-221 pubmed publisher
    ..These data suggest the possibility that brief interventions in the serotonergic system during adolescence could lead to profound and enduring changes in physiology and behavior. ..
  26. Pranzatelli M, Dollison A, Hlibczuk V. Intracisternal 5,7-dihydroxytryptamine lesions in neonatal and adult rats: comparison of response to 5-hydroxytryptophan. Dev Neurosci. 1989;11:205-11 pubmed
    ..They suggest that recovery mechanisms did not occur or failed to reverse the neurochemical or behavioral consequences of early 5,7-DHT lesions. ..
  27. Luine V, Thornton J, Frankfurt M, MacLusky N. Effects of hypothalamic serotonin depletion on lordosis behavior and gonadal hormone receptors. Brain Res. 1987;426:47-54 pubmed
    ..Thus, serotonergic influences on lordosis do not appear to involve changes in the expression of steroid receptor levels in preoptic-hypothalamic nuclei known to mediate hormone-dependent neuroendocrine processes. ..
  28. Kaang B, Kandel E, Grant S. Activation of cAMP-responsive genes by stimuli that produce long-term facilitation in Aplysia sensory neurons. Neuron. 1993;10:427-35 pubmed
    ..These data provide direct evidence for CREB-modulated transcriptional activation with long-term facilitation. ..
  29. Mathew S, Coplan J, Smith E, Scharf B, Owens M, Nemeroff C, et al. Cerebrospinal fluid concentrations of biogenic amines and corticotropin-releasing factor in adolescent non-human primates as a function of the timing of adverse early rearing. Stress. 2002;5:185-93 pubmed
    ..Thus, the timing of exposure to VFD conditions early in life evidently determines whether CSF CRF was found to be elevated or decreased, within the context of increased serotonin metabolism, during the course of primate maturation. ..
  30. Giustetto M, Hegde A, Si K, Casadio A, Inokuchi K, Pei W, et al. Axonal transport of eukaryotic translation elongation factor 1alpha mRNA couples transcription in the nucleus to long-term facilitation at the synapse. Proc Natl Acad Sci U S A. 2003;100:13680-5 pubmed
    ..The transport of eEF1A protein and its mRNA to nerve terminals suggests that the translation factor plays a role in the local protein synthesis that is essential for maintaining newly formed synapses. ..
  31. Hu J, Chen Y, Schacher S. Protein kinase C regulates local synthesis and secretion of a neuropeptide required for activity-dependent long-term synaptic plasticity. J Neurosci. 2007;27:8927-39 pubmed
    ..Thus, different stimuli activating different signaling pathways converge by regulating the synthesis and release of a neuropeptide to produce long-term synaptic plasticity. ..
  32. Jing J, Vilim F, Cropper E, Weiss K. Neural analog of arousal: persistent conditional activation of a feeding modulator by serotonergic initiators of locomotion. J Neurosci. 2008;28:12349-61 pubmed publisher
  33. Mann J, Arango V, Avenevoli S, Brent D, Champagne F, Clayton P, et al. Candidate endophenotypes for genetic studies of suicidal behavior. Biol Psychiatry. 2009;65:556-63 pubmed publisher
    ..Other candidate endophenotypes requiring further investigation include serotonergic neurotransmission, second messenger systems, and borderline personality disorder traits. ..
  34. Gonzalez Maeso J, Sealfon S. Psychedelics and schizophrenia. Trends Neurosci. 2009;32:225-32 pubmed publisher
    ..Recent results on the receptor, signalling and circuit mechanisms underlying the response to psychedelic and antipsychotic drugs might lead to unification of the serotonin and glutamate neurochemical hypotheses of schizophrenia. ..
  35. Smith G, Kramer E, Hermann C, Ma Y, Dhawan V, Chaly T, et al. Serotonin modulation of cerebral glucose metabolism in depressed older adults. Biol Psychiatry. 2009;66:259-66 pubmed publisher
    ..These findings suggest both blunted and compensatory cerebral metabolic responses to citalopram in depressed older adults. ..
  36. Richardson Jones J, Craige C, Guiard B, Stephen A, Metzger K, Kung H, et al. 5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants. Neuron. 2010;65:40-52 pubmed publisher
    ..These results establish a causal relationship between 5-HT(1A) autoreceptor levels, resilience under stress, and response to antidepressants. ..
  37. Yadav V, Arantes H, Barros E, Lazaretti Castro M, Ducy P. Genetic analysis of Lrp5 function in osteoblast progenitors. Calcif Tissue Int. 2010;86:382-8 pubmed publisher
    ..These results rule out a direct function of Lrp5 in osteoblast progenitor cells and add further support to the notion that dysregulation of serotonin synthesis is involved in bone mass abnormalities observed in OPPG patients. ..
  38. Li Z, Caron M, Blakely R, Margolis K, Gershon M. Dependence of serotonergic and other nonadrenergic enteric neurons on norepinephrine transporter expression. J Neurosci. 2010;30:16730-40 pubmed publisher
    ..NET expression is essential for development and/or survival of some (5-HT- and calretinin-expressing), but not all (nNOS-expressing), of these neurons. ..
  39. Till S, Li H, Miniaci M, Kandel E, Choi Y. A presynaptic role for FMRP during protein synthesis-dependent long-term plasticity in Aplysia. Learn Mem. 2011;18:39-48 pubmed publisher
  40. Hu J, Baussi O, Levine A, Chen Y, Schacher S. Persistent long-term synaptic plasticity requires activation of a new signaling pathway by additional stimuli. J Neurosci. 2011;31:8841-50 pubmed publisher
    ..Thus, additional stimuli make preexisting plasticity labile as they recruit a new signaling cascade to regulate the synthesis of a neurotrophin-like peptide required for persistent alterations in synaptic efficacy. ..
  41. Bevilacqua L, Goldman D. Genetics of impulsive behaviour. Philos Trans R Soc Lond B Biol Sci. 2013;368:20120380 pubmed publisher
    ..Via deep sequencing an uncommon HTR2B stop codon, common in one population, was discovered, with implications for understanding impulsive behaviour in both humans and rodents and for future gene discovery. ..
  42. Wakayama T, Tabar V, Rodriguez I, Perry A, Studer L, Mombaerts P. Differentiation of embryonic stem cell lines generated from adult somatic cells by nuclear transfer. Science. 2001;292:740-3 pubmed
    ..Cloning by transfer of ntES cell nuclei could result in normal development of fertile adults. These studies demonstrate the full pluripotency of ntES cells. ..
  43. Gershon M. Serotonin and its implication for the management of irritable bowel syndrome. Rev Gastroenterol Disord. 2003;3 Suppl 2:S25-34 pubmed
    ..The way in which these findings have implicated serotonin in irritable bowel syndrome is discussed. ..
  44. Huang J, Pickel V. Serotonin transporters (SERTs) within the rat nucleus of the solitary tract: subcellular distribution and relation to 5HT2A receptors. J Neurocytol. 2002;31:667-79 pubmed
    ..Our results suggest that in the mNTS 5HT activates 5HT2A receptors at a distance from SERT-mediated uptake sites in diverse cell types including some that express both 5HT2A receptors and SERTs. ..
  45. Broderick P. Studies of oxidative stress mechanisms using a morphine / ascorbate animal model and novel N-stearoyl cerebroside and laurate sensors. J Neural Transm (Vienna). 2008;115:7-17 pubmed
    ..Thus, oxidative stress mechanisms and novel N-stearoyl cerebroside and laurate sensors, which selectively detect and separate neuromolecules involved in these mechanisms, may be potentially clinically relevant. ..
  46. McNamara I, Borella A, Bialowas L, Whitaker Azmitia P. Further studies in the developmental hyperserotonemia model (DHS) of autism: social, behavioral and peptide changes. Brain Res. 2008;1189:203-14 pubmed
  47. Wiste A, Arango V, Ellis S, Mann J, Underwood M. Norepinephrine and serotonin imbalance in the locus coeruleus in bipolar disorder. Bipolar Disord. 2008;10:349-59 pubmed publisher
    ..Studies during manic or euthymic states will determine whether these changes are mood state dependent. ..
  48. Rajasethupathy P, Fiumara F, Sheridan R, Betel D, Puthanveettil S, Russo J, et al. Characterization of small RNAs in Aplysia reveals a role for miR-124 in constraining synaptic plasticity through CREB. Neuron. 2009;63:803-17 pubmed publisher
    ..We therefore present direct evidence that a modulatory neurotransmitter important for learning can regulate the levels of small RNAs and present a role for miR-124 in long-term plasticity of synapses in the mature nervous system. ..
  49. Gross E, Gershon M, Margolis K, Gertsberg Z, Li Z, Cowles R. Neuronal serotonin regulates growth of the intestinal mucosa in mice. Gastroenterology. 2012;143:408-17.e2 pubmed publisher
    ..Surprisingly, these processes appear to be mediated by neuronal, rather than mucosal, 5-HT. The 5-HT(2A) receptor activates cholinergic neurons, which provide a muscarinic innervation to epithelial effectors. ..
  50. Müller C, Anacker A, Veenstra Vanderweele J. The serotonin system in autism spectrum disorder: From biomarker to animal models. Neuroscience. 2016;321:24-41 pubmed publisher
    ..Collectively, these data point to the serotonin system as a prime candidate for treatment development in a subgroup of children defined by a robust, heritable biomarker. ..
  51. Li H, Huang B, Vishwasrao H, Sutedja N, Chen W, Jin I, et al. Dscam mediates remodeling of glutamate receptors in Aplysia during de novo and learning-related synapse formation. Neuron. 2009;61:527-40 pubmed publisher
    ..Taken together, these findings suggest that learning-induced synapse formation recapitulates, at least in part, aspects of the mechanisms that govern de novo synaptogenesis. ..
  52. Kandel E. The molecular biology of memory storage: a dialog between genes and synapses. Biosci Rep. 2004;24:475-522 pubmed
    ..The biology of learning, and short-term and long-term memory, as revealed by Aplysia and other organisms, is reviewed. ..
  53. Mitropoulou V, Trestman R, New A, Flory J, Silverman J, Siever L. Neurobiologic function and temperament in subjects with personality disorders. CNS Spectr. 2003;8:725-30 pubmed
    ..Limited support was provided for a relationship between monoamines, particularly dopamine and novelty-seeking as well as norepinephrine and reward dependence but other hypothesized relationships were not supported by these measures. ..
  54. Hu J, Schacher S. Persistent long-term facilitation at an identified synapse becomes labile with activation of short-term heterosynaptic plasticity. J Neurosci. 2014;34:4776-85 pubmed publisher
    ..Activity-selective induction of a labile state at synapses expressing persistent plasticity may facilitate the development of therapies for reversing inappropriate memories. ..
  55. Govorunova E, Moussaif M, Kullyev A, Nguyen K, McDonald T, Hall D, et al. A homolog of FHM2 is involved in modulation of excitatory neurotransmission by serotonin in C. elegans. PLoS ONE. 2010;5:e10368 pubmed publisher
    ..The role of eat-6 in modulation of excitatory neurotransmission by 5-HT may provide a genetic explanation for the therapeutic effects of the drugs targeting 5-HT receptors in the treatment of migraine patients. ..
  56. Sublette M, Galfalvy H, Fuchs D, Lapidus M, Grunebaum M, Oquendo M, et al. Plasma kynurenine levels are elevated in suicide attempters with major depressive disorder. Brain Behav Immun. 2011;25:1272-8 pubmed publisher
    ..These preliminary results suggest that KYN and related molecular pathways may be implicated in the pathophysiology of suicidal behavior. ..
  57. Yadav V, Ducy P. Lrp5 and bone formation : A serotonin-dependent pathway. Ann N Y Acad Sci. 2010;1192:103-9 pubmed publisher
    ..These findings may have important therapeutic implications for the treatment of low bone-mass disorders. ..
  58. Yadav V, Oury F, Tanaka K, Tanaka K, Thomas T, Wang Y, et al. Leptin-dependent serotonin control of appetite: temporal specificity, transcriptional regulation, and therapeutic implications. J Exp Med. 2011;208:41-52 pubmed publisher
  59. Weiss H, Lages B, Vicic W, Tsung L, White J. Heterogeneous abnormalities of platelet dense granule ultrastructure in 20 patients with congenital storage pool deficiency. Br J Haematol. 1993;83:282-95 pubmed
    ..Additional defects may account for the more extensive granule abnormalities observed in alpha delta-SPD. ..
  60. Santarelli L, Gobbi G, Blier P, Hen R. Behavioral and physiologic effects of genetic or pharmacologic inactivation of the substance P receptor (NK1). J Clin Psychiatry. 2002;63 Suppl 11:11-7 pubmed
    ..Future studies will attempt to delineate the interaction between the SP-NK1R system and various neurotransmitter pathways in greater detail and to address the specific role(s) of this system in different brain regions. ..
  61. Kolevzon A, Newcorn J, Kryzak L, Chaplin W, Watner D, Hollander E, et al. Relationship between whole blood serotonin and repetitive behaviors in autism. Psychiatry Res. 2010;175:274-6 pubmed publisher
    ..No significant associations were found between serotonin level and the primary behavioral outcome measures. However, a significant inverse relationship between serotonin level and self-injury was demonstrated. ..
  62. Zhai J, Gershon M, Walsh J, Wong H, Kirchgessner A. Inward currents in neurons from newborn guinea pig intestine: mediation by 5-hydroxytryptamine type 3 receptors. J Pharmacol Exp Ther. 1999;291:374-82 pubmed
    ..It is concluded that alosetron is a potent and noncompetitive 5-HT(3) antagonist on myenteric neurons. ..
  63. Alvarez L, Turner H, Zamudio A, Candia O. Serotonin-elicited inhibition of Cl(-) secretion in the rabbit conjunctival epithelium. Am J Physiol Cell Physiol. 2001;280:C581-92 pubmed
    ..Briefly, the conjunctiva harbors the only known Cl(-)-secreting epithelium in which 5-HT evokes Cl(-) transport inhibition; receptor subtype and signal transduction mechanism were not determined...
  64. Hern ndez A, Wolk J, Hu J, Liu J, Kurosu T, Schwartz J, et al. Poly-(ADP-ribose) polymerase-1 is necessary for long-term facilitation in Aplysia. J Neurosci. 2009;29:9553-62 pubmed publisher
    ..Thus, our results suggest that 5-HT, in part by regulating PARP-1 activity, alters the expression of transcripts required for the synthesis of new ribosomes necessary for LTF...
  65. Ducy P, Karsenty G. The two faces of serotonin in bone biology. J Cell Biol. 2010;191:7-13 pubmed publisher
    ..The effect of serotonin on bone biology could be harnessed pharmacologically to treat diseases such as osteoporosis. ..
  66. Pranzatelli M, Huang Y, Dollison A, Stanley M. Brainstem serotonergic hyperinnervation modifies behavioral supersensitivity to 5-hydroxytryptophan in the rat. Brain Res Dev Brain Res. 1989;50:89-99 pubmed
    ..To the extent that the 5-HT syndrome is mediated by 5-HT1A receptors and shaking behavior by 5-HT2 sites, differential responses to injury of 5-HT1A and 5-HT2 receptors may contribute to these behavioral differences. ..
  67. Mann J, Currier D. A review of prospective studies of biologic predictors of suicidal behavior in mood disorders. Arch Suicide Res. 2007;11:3-16 pubmed
    ..The most promising biologic predictors are low CSF 5-HIAA and HPA axis dysfunction as demonstrated by dexamethasone non-suppression that are each associated with about 4.5 fold greater risk of suicide. ..
  68. Oury F, Yadav V, Wang Y, Zhou B, Liu X, Guo X, et al. CREB mediates brain serotonin regulation of bone mass through its expression in ventromedial hypothalamic neurons. Genes Dev. 2010;24:2330-42 pubmed publisher
  69. Karsenty G, Yadav V. Regulation of bone mass by serotonin: molecular biology and therapeutic implications. Annu Rev Med. 2011;62:323-31 pubmed publisher
    ..Exploiting these findings in the pharmacological arena led to the demonstration that inhibiting synthesis of gut-derived serotonin could be an effective means to treat low-bone-mass diseases such as osteoporosis. ..
  70. Kalsner S, Abdali S. Rate-independent inhibition by norepinephrine of 5-HT release from the somadendritic region of serotonergic neurons. Brain Res Bull. 2001;55:761-5 pubmed
  71. Grabham P, Wu F, Schacher S, Goldberg D. Initiating morphological changes associated with long-term facilitation in Aplysia is independent of transcription or translation in the cell body. J Neurobiol. 2005;64:202-12 pubmed
    ..Macromolecular synthesis in the cell body is, however, required to maintain the enlarged arbor. ..
  72. Caldarone B, Paterson N, Zhou J, Brunner D, Kozikowski A, Westphal K, et al. The novel triple reuptake inhibitor JZAD-IV-22 exhibits an antidepressant pharmacological profile without locomotor stimulant or sensitization properties. J Pharmacol Exp Ther. 2010;335:762-70 pubmed publisher
    ..These findings may have implications for the potential for abuse liability in humans. ..
  73. Simon R, Britsch S, Bergemann A. Ablation of Sax2 gene expression prevents diet-induced obesity. FEBS J. 2011;278:371-82 pubmed publisher
    ..Sax2 gene expression may be required to allow the coordinated crosstalk of factors involved in the maintenance of energy homeostasis, possibly regulating the transcription of specific factors involved in energy balance. ..
  74. Bansal R, Peterson B, Gingrich J, Hao X, Odgerel Z, Warner V, et al. Serotonin signaling modulates the effects of familial risk for depression on cortical thickness. Psychiatry Res Neuroimaging. 2016;248:83-93 pubmed publisher
    ..The opposing gene effects across the two risk groups were likely due to either epistatic effects and/or differing modulation of the neural plasticity by the altered 5-HT signaling in utero. ..
  75. Martin K, Michael D, Rose J, Barad M, Casadio A, Zhu H, et al. MAP kinase translocates into the nucleus of the presynaptic cell and is required for long-term facilitation in Aplysia. Neuron. 1997;18:899-912 pubmed
    ..This mechanism for long-term plasticity may be quite general: cAMP also activated MAPK in mouse hippocampal neurons, suggesting that MAPK may play a role in hippocampal long-term potentiation. ..
  76. Peerschke E, Murphy T, Ghebrehiwet B. Activation-dependent surface expression of gC1qR/p33 on human blood platelets. Thromb Haemost. 2003;89:331-9 pubmed
    ..aureus protein A, supports the hypothesis that gC1qR expressed on activated platelets may contribute directly to thrombosis, inflammation, and endovascular infections. ..
  77. Hu J, Glickman L, Wu F, Schacher S. Serotonin regulates the secretion and autocrine action of a neuropeptide to activate MAPK required for long-term facilitation in Aplysia. Neuron. 2004;43:373-85 pubmed
    ..Thus, long-term synaptic plasticity is produced when stimuli activate kinases in a specific sequence by regulating the secretion and autocrine action of a neuropeptide. ..
  78. Bach Mizrachi H, Underwood M, Tin A, Ellis S, Mann J, Arango V. Elevated expression of tryptophan hydroxylase-2 mRNA at the neuronal level in the dorsal and median raphe nuclei of depressed suicides. Mol Psychiatry. 2008;13:507-13, 465 pubmed publisher
  79. Bhansali P, Dunning J, Singer S, David L, Schmauss C. Early life stress alters adult serotonin 2C receptor pre-mRNA editing and expression of the alpha subunit of the heterotrimeric G-protein G q. J Neurosci. 2007;27:1467-73 pubmed
  80. Broderick P, Olabisi O, Rahni D, Zhou Y. Cocaine acts on accumbens monoamines and locomotor behavior via a 5-HT2A/2C receptor mechanism as shown by ketanserin: 24-h follow-up studies. Prog Neuropsychopharmacol Biol Psychiatry. 2004;28:547-57 pubmed
    ..The data suggest that presynaptic 5-HT(2A/2C) receptor mechanisms may be important during withdrawal from single injection of cocaine. ..
  81. Ramboz S, Oosting R, Amara D, Kung H, Blier P, Mendelsohn M, et al. Serotonin receptor 1A knockout: an animal model of anxiety-related disorder. Proc Natl Acad Sci U S A. 1998;95:14476-81 pubmed
  82. Nautiyal K, Dailey C, Jahn J, Rodriquez E, Son N, Sweedler J, et al. Serotonin of mast cell origin contributes to hippocampal function. Eur J Neurosci. 2012;36:2347-59 pubmed publisher
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