Experts and Doctors on rats in California, United States

Summary

Locale: California, United States
Topic: rats

Top Publications

  1. Thomas E, Cravatt B, Danielson P, Gilula N, Sutcliffe J. Fatty acid amide hydrolase, the degradative enzyme for anandamide and oleamide, has selective distribution in neurons within the rat central nervous system. J Neurosci Res. 1997;50:1047-52 pubmed
    ..The FAAH distribution in the CNS suggests that degradation of neuromodulatory fatty acid amides at their sites of action influences their effects on sleep, euphoria, and analgesia. ..
  2. Peden A, Park G, Scheller R. The Di-leucine motif of vesicle-associated membrane protein 4 is required for its localization and AP-1 binding. J Biol Chem. 2001;276:49183-7 pubmed
    ..Mutation of the di-leucine motif inhibits AP-1 binding in vitro and affects the steady state distribution of VAMP4 in vivo...
  3. Smith H, Reporter R, Rood M, Linscott A, Mascola L, Hogrefe W, et al. Prevalence study of antibody to ratborne pathogens and other agents among patients using a free clinic in downtown Los Angeles. J Infect Dis. 2002;186:1673-6 pubmed
    ..6%; to Bartonella elizabethae, 12.5%; to B. quintana, 9.5%; to B. henselae, 3.5%; to Seoul virus, 0.5%; and to Rickettsia typhi, 0.0%. This study found that patients and locally trapped rats had antibodies to some of the same agents. ..
  4. Porcello D, Smith S, Huguenard J. Actions of U-92032, a T-type Ca2+ channel antagonist, support a functional linkage between I(T) and slow intrathalamic rhythms. J Neurophysiol. 2003;89:177-85 pubmed
    ..This suggests that U-92032 or other specific T-channel antagonists may provide effective drug treatments for absence epilepsy. ..
  5. Willis B, Kim K, Li X, Liebler J, Crandall E, Borok Z. Modulation of ion conductance and active transport by TGF-beta 1 in alveolar epithelial cell monolayers. Am J Physiol Lung Cell Mol Physiol. 2003;285:L1192-200 pubmed
    ..These results demonstrate that TGF-beta 1 modulates ion conductance and active transport characteristics of the alveolar epithelium, associated with increased Na+-K+-ATPase, but without a change in alpha-rENaC. ..
  6. Chen Y, Zhuang S, Cassenaer S, Casteel D, Gudi T, Boss G, et al. Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires cooperation between CREB and C/EBP-beta. Mol Cell Biol. 2003;23:4066-82 pubmed
    ..We conclude that calcium and cGMP transcriptional synergism requires cooperation of CREB and C/EBP-beta, with calcium and cGMP modulating the phosphorylation states of CREB and C/EBP-beta, respectively. ..
  7. Dayas C, Liu X, Simms J, Weiss F. Distinct patterns of neural activation associated with ethanol seeking: effects of naltrexone. Biol Psychiatry. 2007;61:979-89 pubmed
    ..In addition, the data implicate the hippocampus, amygdala, and PVN as potential substrates for the inhibitory effects of NTX on conditioned reinstatement. ..
  8. Alirezaei M, Watry D, Flynn C, Kiosses W, Masliah E, Williams B, et al. Human immunodeficiency virus-1/surface glycoprotein 120 induces apoptosis through RNA-activated protein kinase signaling in neurons. J Neurosci. 2007;27:11047-55 pubmed
    ..Together, these results identify PKR as a critical mediator of gp120 neurotoxicity, suggesting that activation of PKR contributes to the neuronal injury and cell death observed in HAD. ..
  9. Liu J, Almaguel F, Bu L, DE LEON D, De Leon M. Expression of E-FABP in PC12 cells increases neurite extension during differentiation: involvement of n-3 and n-6 fatty acids. J Neurochem. 2008;106:2015-29 pubmed publisher
    ..These findings are consistent with the scenario that neurite extension of differentiating PC12 cells, including further stimulation by DHA and EPA, requires sufficient cellular levels of E-FABP. ..

More Information

Publications406 found, 100 shown here

  1. Kim Y, Remacle A, Chernov A, Liu H, Shubayev I, Lai C, et al. The MMP-9/TIMP-1 axis controls the status of differentiation and function of myelin-forming Schwann cells in nerve regeneration. PLoS ONE. 2012;7:e33664 pubmed publisher
    ..Our findings of the MMP-dependent regulation of Na(v) channels, which we document here for the first time, provide a basis for therapeutic intervention in sensorimotor pathologies and pain. ..
  2. Zhao L, Donaldson C, Smith G, Vale W. The structures of the mouse and human urocortin genes (Ucn and UCN). Genomics. 1998;50:23-33 pubmed
  3. Leo C, Hsu S, McGee E, Salanova M, Hsueh A. DEFT, a novel death effector domain-containing molecule predominantly expressed in testicular germ cells. Endocrinology. 1998;139:4839-48 pubmed
    ..In conclusion, we have identified a novel DED-containing protein with high expression in testis germ cells. This protein may be important in the regulation of death factor-induced apoptosis in the testis and other tissues. ..
  4. Leal A, Takabe K, Wang L, Donaldson C, Macconell L, Bilezikjian L, et al. Effect of adenovirus-mediated overexpression of follistatin and extracellular domain of activin receptor type II on gonadotropin secretion in vitro and in vivo. Endocrinology. 2002;143:964-9 pubmed
  5. Hayashi T, Saito A, Okuno S, Ferrand Drake M, Chan P. Induction of GRP78 by ischemic preconditioning reduces endoplasmic reticulum stress and prevents delayed neuronal cell death. J Cereb Blood Flow Metab. 2003;23:949-61 pubmed
    ..Immunoprecipitation and double staining demonstrated involvement of GRP78 in prevention of PERK phosphorylation. These results suggest that GRP78 induced by preconditioning may reduce ER stress and eventual DND after ischemia. ..
  6. Austin J, Buckmaster P. Recurrent excitation of granule cells with basal dendrites and low interneuron density and inhibitory postsynaptic current frequency in the dentate gyrus of macaque monkeys. J Comp Neurol. 2004;476:205-18 pubmed
    ..These primate characteristics may contribute to the susceptibility of the human dentate gyrus to epileptogenic injuries. ..
  7. Zhao H, Sapolsky R, Steinberg G. Interrupting reperfusion as a stroke therapy: ischemic postconditioning reduces infarct size after focal ischemia in rats. J Cereb Blood Flow Metab. 2006;26:1114-21 pubmed
    ..In conclusion, postconditioning reduced infarct size, most plausibly by blocking apoptosis and free radical generation. With further study it may eventually be clinically applicable for stroke treatment. ..
  8. Schiltz J, Sawchenko P. Specificity and generality of the involvement of catecholaminergic afferents in hypothalamic responses to immune insults. J Comp Neurol. 2007;502:455-67 pubmed
    ..Residual Fos induction seen in lesioned animals in response to higher doses of LPS provides a basis for probing additional circuits that may be recruited in a hierarchical manner in response to more strenuous or complex immune insults. ..
  9. Jessberger S, Aigner S, Clemenson G, Toni N, Lie D, Karalay O, et al. Cdk5 regulates accurate maturation of newborn granule cells in the adult hippocampus. PLoS Biol. 2008;6:e272 pubmed publisher
    ..The data presented here also suggest a mechanistic dissociation between accurate dendritic targeting and subsequent synapse formation. ..
  10. Brar B, Helgeland E, Mahata S, Zhang K, O Connor D, Helle K, et al. Human catestatin peptides differentially regulate infarct size in the ischemic-reperfused rat heart. Regul Pept. 2010;165:63-70 pubmed publisher
    ..3%) increased myocardial infarct size via a mechanism involving dephosphorylation of Akt and the two downstream targets during ischemic reperfusion in the isolated rat heart. ..
  11. Zhang W, Huguenard J, Buckmaster P. Increased excitatory synaptic input to granule cells from hilar and CA3 regions in a rat model of temporal lobe epilepsy. J Neurosci. 2012;32:1183-96 pubmed publisher
    ..The aberrant development of these additional positive-feedback circuits might contribute to epileptogenesis in temporal lobe epilepsy. ..
  12. Marquez Lona E, Torres Machorro A, Gonzales F, Pillus L, Patrick G. Phosphorylation of the 19S regulatory particle ATPase subunit, Rpt6, modifies susceptibility to proteotoxic stress and protein aggregation. PLoS ONE. 2017;12:e0179893 pubmed publisher
    ..Together, these data suggest that Rpt6 phosphorylation at S119 may play an important function in proteasome-dependent relief of proteotoxic stress that can be critical in protein aggregation pathologies. ..
  13. Jackson A, Parham P. Structure of human clathrin light chains. Conservation of light chain polymorphism in three mammalian species. J Biol Chem. 1988;263:16688-95 pubmed
    ..The faithful preservation of clathrin light chain polymorphism in three mammalian species provides evidence supporting a functional diversification of the brain and non-brain forms of LCa and LCb. ..
  14. Shahbaz M, Hoch J, Trach K, Hural J, Webber S, Whiteley J. Structural studies and isolation of cDNA clones providing the complete sequence of rat liver dihydropteridine reductase. J Biol Chem. 1987;262:16412-6 pubmed
    ..In contrast, the sequence shows little homology with that of mammalian dihydrofolate reductase: reduced pyridine nucleotide-requiring enzymes with superficial mechanistic similarities. ..
  15. Orend G, Hunter T, Ruoslahti E. Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cells. Oncogene. 1998;16:2575-83 pubmed publisher
  16. Siegel J. Narcolepsy: a key role for hypocretins (orexins). Cell. 1999;98:409-12 pubmed
  17. Xu C, Lee S, Singh T, Sho E, Li X, Sho M, et al. Molecular mechanisms of aortic wall remodeling in response to hypertension. J Vasc Surg. 2001;33:570-8 pubmed
    ..Cell proliferation precedes apoptosis by 2 weeks in this procedure. ..
  18. Liu X, Weiss F. Reversal of ethanol-seeking behavior by D1 and D2 antagonists in an animal model of relapse: differences in antagonist potency in previously ethanol-dependent versus nondependent rats. J Pharmacol Exp Ther. 2002;300:882-9 pubmed
    ..The results also indicate that chronic ethanol exposure produces changes in D1 and D2 receptor function that lead to enhanced sensitivity to the behavioral effects of antagonists for these receptors. ..
  19. Zhang Y, Okada A, Lew C, McConnell S. Regulated nuclear trafficking of the homeodomain protein otx1 in cortical neurons. Mol Cell Neurosci. 2002;19:430-46 pubmed
    ..These results suggest that ventricular cells actively sequester Otx1 in the cytoplasm, either by preventing nuclear import or by promoting a balance of export over import signals. ..
  20. Liao J, Schultz P. Three sweet receptor genes are clustered in human chromosome 1. Mamm Genome. 2003;14:291-301 pubmed
    ..All three hT1Rs genes are expressed selectively in human taste receptor cells in the fungiform papillae, consistent with their role in taste perception. ..
  21. Dosanjh A, Ikonen T, Morris R. Respiratory epithelial expression of integrin alphaVbeta6 in chronic progressive allograft rejection. J Heart Lung Transplant. 2004;23:456-60 pubmed
    ..Integrin alphaVbeta6 is readily detectable in healing isografts. Integrin alphaVbeta6 may be crucial in maintaining a viable epithelial cell layer, which is related to slowed progression of airway obliteration in OB. ..
  22. Markou A, Paterson N, Semenova S. Role of gamma-aminobutyric acid (GABA) and metabotropic glutamate receptors in nicotine reinforcement: potential pharmacotherapies for smoking cessation. Ann N Y Acad Sci. 2004;1025:491-503 pubmed
    ..Thus, compounds that increase GABAergic neurotransmission and antagonists at mGluR5 have potential as anti-smoking medications for humans. ..
  23. Christopherson K, Ullian E, Stokes C, Mullowney C, Hell J, Agah A, et al. Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis. Cell. 2005;120:421-33 pubmed
  24. Kutschka I, Chen I, Kofidis T, von Degenfeld G, Sheikh A, Hendry S, et al. In vivo optical bioluminescence imaging of collagen-supported cardiac cell grafts. J Heart Lung Transplant. 2007;26:273-80 pubmed
    ..Optical bioluminescence is a powerful method for assessment of cardiac cell graft survival in vivo. Collagen matrices support early survival of cardiomyoblasts after transplantation into injured musculature. ..
  25. Smart F, Aschrafi A, Atkins A, Owens G, Pilotte J, Cunningham B, et al. Two isoforms of the cold-inducible mRNA-binding protein RBM3 localize to dendrites and promote translation. J Neurochem. 2007;101:1367-79 pubmed
    ..These data suggest that RBM3 plays a distinctive role in enhancing translation in neurons. ..
  26. Conboy M, Karasov A, Rando T. High incidence of non-random template strand segregation and asymmetric fate determination in dividing stem cells and their progeny. PLoS Biol. 2007;5:e102 pubmed
  27. Vaingankar S, Li Y, Biswas N, Gayen J, Choksi S, Rao F, et al. Effects of chromogranin A deficiency and excess in vivo: biphasic blood pressure and catecholamine responses. J Hypertens. 2010;28:817-25 pubmed publisher
    ..Thus, across mammalian species, an optimal amount of CHGA may be required to establish appropriate catecholamine storage and release, and hence BP homeostasis. ..
  28. Martin Fardon R, Strong E, Weiss F. Effect of ?? receptor antagonism on ethanol and natural reward seeking. Neuroreport. 2012;23:809-13 pubmed publisher
  29. Whitfield T, Schlosburg J, Wee S, Gould A, George O, Grant Y, et al. κ Opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake. J Neurosci. 2015;35:4296-305 pubmed publisher
  30. Klein E, Simmons D, Swanson L, Rosenfeld M. Tissue-specific RNA splicing generates an ankyrin-like domain that affects the dimerization and DNA-binding properties of a bHLH protein. Genes Dev. 1993;7:55-71 pubmed
    ..Thus, REB alpha and REB beta represent a novel example of a regulated formation of an ankyrin-like domain within a bHLH protein, thereby mediating control of protein-protein interactions. ..
  31. Wender P, Jankowski O, Longcore K, Tabet E, Seto H, Tomikawa T. Correlation of F0F1-ATPase inhibition and antiproliferative activity of apoptolidin analogues. Org Lett. 2006;8:589-92 pubmed
    ..Potent F(0)F(1)-ATPase inhibition was not a sufficient determinant of antiproliferative activity for several analogues, suggesting the existence of a secondary biological target or more complex mode of action for apoptolidin. ..
  32. Shimasaki S, Uchiyama F, Shimonaka M, Ling N. Molecular cloning of the cDNAs encoding a novel insulin-like growth factor-binding protein from rat and human. Mol Endocrinol. 1990;4:1451-8 pubmed
    ..6-kilobase IGFBP-4 mRNA band was detectable in all tissues examined, including adrenal, testis, spleen, heart, lung, kidney, liver, stomach, hypothalamus, and brain cortex. ..
  33. Rivier C, Meunier H, Roberts V, Vale W. Possible involvement of inhibin in altered follicle-stimulating hormone (FSH) secretion during dissociated luteinizing hormone (LH) and FSH release: unilateral castration and experimental cryptorchidism. Biol Reprod. 1989;41:967-81 pubmed
    ..abstract truncated at 400 words) ..
  34. Richieri G, Ogata R, Kleinfeld A. Equilibrium constants for the binding of fatty acids with fatty acid-binding proteins from adipocyte, intestine, heart, and liver measured with the fluorescent probe ADIFAB. J Biol Chem. 1994;269:23918-30 pubmed
    ..These results provide a framework with which to understand better the biological function of FABPs and the FA-FABP interaction. ..
  35. Kim D, Zhang L, Dzau V, Pratt R. H19, a developmentally regulated gene, is reexpressed in rat vascular smooth muscle cells after injury. J Clin Invest. 1994;93:355-60 pubmed
    ..The vascular injury model may be a useful system to use in examining the function of H19. ..
  36. Iyer R, Bando J, Jenkinson C, Vockley J, Kim P, Kern R, et al. Cloning and characterization of the mouse and rat type II arginase genes. Mol Genet Metab. 1998;63:168-75 pubmed
    ..Sequence homology to the human type II arginase, arginase activity data, and immunoprecipitation with an anti-AII antibody confirm the identity of these cloned genes as rodent extrahepatic type II arginases. ..
  37. Le Niculescu H, Bonfoco E, Kasuya Y, Claret F, Green D, Karin M. Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death. Mol Cell Biol. 1999;19:751-63 pubmed
    ..Hence, the JNK-to-c-Jun-to-FasL pathway is an important mediator of stress-induced neuronal apoptosis. ..
  38. Kim J, Noskov V, Lu X, Bergmann A, Ren X, Warth T, et al. Discovery of a novel, paternally expressed ubiquitin-specific processing protease gene through comparative analysis of an imprinted region of mouse chromosome 7 and human chromosome 19q13.4. Genome Res. 2000;10:1138-47 pubmed
    ..This identification of a third imprinted gene, Usp29, from the Peg3/Zim1-region confirms the presence of a conserved imprinted domain spanning at least 500 kb in the proximal portion of mouse chromosome 7 (Mmu7). ..
  39. Hawley S, Tamura T, Miles L. Purification, cloning, and characterization of a profibrinolytic plasminogen-binding protein, TIP49a. J Biol Chem. 2001;276:179-86 pubmed
    ..These results suggest that TIP49a is a previously unrecognized plasminogen-binding protein on the U937 cell surface. ..
  40. Chin G, Lee S, Hsu M, Liu W, Kim W, Levinson H, et al. Discoidin domain receptors and their ligand, collagen, are temporally regulated in fetal rat fibroblasts in vitro. Plast Reconstr Surg. 2001;107:769-76 pubmed
    ..Future studies will involve the characterization of the biomolecular functions of these receptor kinases during fetal wound repair. ..
  41. Kumagai J, Hsu S, Matsumi H, Roh J, Fu P, Wade J, et al. INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent. J Biol Chem. 2002;277:31283-6 pubmed
    ..Demonstration of INSL3 as the ligand for LGR8 facilitates understanding of the mechanism of testis descent and allows studies on the role of INSL3 in gonadal and other physiological processes. ..
  42. Kaufer D, Ogle W, Pincus Z, Clark K, Nicholas A, Dinkel K, et al. Restructuring the neuronal stress response with anti-glucocorticoid gene delivery. Nat Neurosci. 2004;7:947-53 pubmed
    ..Our findings elucidate three principal steps in the neuronal stress-response pathway, all of which are amenable to therapeutic intervention. ..
  43. Nacamuli R, Fong K, Lenton K, Song H, Fang T, Salim A, et al. Expression and possible mechanisms of regulation of BMP3 in rat cranial sutures. Plast Reconstr Surg. 2005;116:1353-62 pubmed
    ..The authors investigated the expression pattern of the bone morphogenetic protein antagonist BMP3 in rat cranial sutures and the factors regulating its expression in vitro...
  44. Brignole E, Smith S, Asturias F. Conformational flexibility of metazoan fatty acid synthase enables catalysis. Nat Struct Mol Biol. 2009;16:190-7 pubmed publisher
    ..Concomitant rearrangement of the beta-carbon-processing domains synchronizes acyl chain reduction in one chamber with acyl chain elongation in the other. ..
  45. Slater B, Kwan M, Gupta D, Lee J, Longaker M. The role of regional posterior frontal dura mater in the overlying suture morphology. Plast Reconstr Surg. 2009;123:463-9 pubmed publisher
    ..The differential expression pattern of TGF-beta signaling from the dura mater further supports the regional paracrine effect of the dura mater. ..
  46. Wu Zhang A, Schramm C, Nabavi S, Malinow R, Newton A. Cellular pharmacology of protein kinase M? (PKM?) contrasts with its in vitro profile: implications for PKM? as a mediator of memory. J Biol Chem. 2012;287:12879-85 pubmed publisher
  47. Wright M, Angrish D, Aarde S, Barlow D, Buczynski M, Creehan K, et al. Effect of ambient temperature on the thermoregulatory and locomotor stimulant effects of 4-methylmethcathinone in Wistar and Sprague-Dawley rats. PLoS ONE. 2012;7:e44652 pubmed publisher
  48. Gomez Ospina N, Panagiotakos G, Portmann T, Paşca S, Rabah D, Budzillo A, et al. A promoter in the coding region of the calcium channel gene CACNA1C generates the transcription factor CCAT. PLoS ONE. 2013;8:e60526 pubmed publisher
    ..This study provides new insights into the regulation of CACNA1C, and provides an example of how exonic promoters contribute to the complexity of mammalian genomes. ..
  49. Apara A, Galvão J, Wang Y, Blackmore M, Trillo A, Iwao K, et al. KLF9 and JNK3 Interact to Suppress Axon Regeneration in the Adult CNS. J Neurosci. 2017;37:9632-9644 pubmed publisher
  50. Hughes S, Blau H. Muscle fiber pattern is independent of cell lineage in postnatal rodent development. Cell. 1992;68:659-71 pubmed
    ..Thus, extrinsic signals override the intrinsic commitment of myoblast nuclei to particular programs of gene expression. We conclude that in postnatal development, pattern is not dictated by myoblast lineage. ..
  51. Nicolls M, Aversa G, Pearce N, Spinelli A, Berger M, Gurley K, et al. Induction of long-term specific tolerance to allografts in rats by therapy with an anti-CD3-like monoclonal antibody. Transplantation. 1993;55:459-68 pubmed
    ..These hosts with long-surviving cardiac transplants, when grafted from PVG skin, accepted these grafts but rejected third-party skin in first-set. Thus G4.18 was shown to induce long-term specific tolerance to an organ allograft. ..
  52. Dascher C, Balch W. Mammalian Sly1 regulates syntaxin 5 function in endoplasmic reticulum to Golgi transport. J Biol Chem. 1996;271:15866-9 pubmed
    ..These results suggest that rSly1 functions to positively regulate syntaxin 5 function. ..
  53. Lin P, Yao Y, Hofmeister R, Tsien R, Farquhar M. Overexpression of CALNUC (nucleobindin) increases agonist and thapsigargin releasable Ca2+ storage in the Golgi. J Cell Biol. 1999;145:279-89 pubmed
    ..These results provide direct evidence that CALNUC binds Ca2+ in vivo and together with SERCA and IP3R is involved in establishment of the agonist-mobilizable Golgi Ca2+ store. ..
  54. Giffard R, Papadopoulos M, van Hooft J, Xu L, Giuffrida R, Monyer H. The electrogenic sodium bicarbonate cotransporter: developmental expression in rat brain and possible role in acid vulnerability. J Neurosci. 2000;20:1001-8 pubmed
  55. Frankel A, Clarke S. PRMT3 is a distinct member of the protein arginine N-methyltransferase family. Conferral of substrate specificity by a zinc-finger domain. J Biol Chem. 2000;275:32974-82 pubmed
    ..These results suggest that native forms of PRMTs can have different properties than their GST-catalytic chain fusion protein counterparts, which may lack associated noncatalytic subunits. ..
  56. Prieto A, Weber J, Lai C. Expression of the receptor protein-tyrosine kinases Tyro-3, Axl, and mer in the developing rat central nervous system. J Comp Neurol. 2000;425:295-314 pubmed
    ..These studies provide initial clues for elucidating the cellular functions of the Axl subfamily members and suggest potential complex Gas6/RPTK as well as RPTK/RPTK signaling interactions in the mature and developing CNS. ..
  57. Rader K, Orlando R, Lou X, Farquhar M. Characterization of ANKRA, a novel ankyrin repeat protein that interacts with the cytoplasmic domain of megalin. J Am Soc Nephrol. 2000;11:2167-78 pubmed
  58. Taupin P, Ray J, Fischer W, Suhr S, Hakansson K, Grubb A, et al. FGF-2-responsive neural stem cell proliferation requires CCg, a novel autocrine/paracrine cofactor. Neuron. 2000;28:385-97 pubmed
    ..We propose that the process of neurogenesis is controlled by the cooperation between trophic factors and autocrine/paracrine cofactors, of which CCg is a prototype. ..
  59. Yenari M, Dumas T, Sapolsky R, Steinberg G. Gene therapy for treatment of cerebral ischemia using defective herpes simplex viral vectors. Ann N Y Acad Sci. 2001;939:340-57 pubmed
    ..Although gene therapy is limited to the few hundred cells the vector is capable of transfecting, we consider the possibility of such gene therapy becoming relevant to clinical neurology in the future...
  60. Cui C, Booker T, Allen R, Grady S, Whiteaker P, Marks M, et al. The beta3 nicotinic receptor subunit: a component of alpha-conotoxin MII-binding nicotinic acetylcholine receptors that modulate dopamine release and related behaviors. J Neurosci. 2003;23:11045-53 pubmed
  61. Nishimura N, Schaffer C, Friedman B, Tsai P, Lyden P, Kleinfeld D. Targeted insult to subsurface cortical blood vessels using ultrashort laser pulses: three models of stroke. Nat Methods. 2006;3:99-108 pubmed
    ..This demonstrates that a single blockage to a microvessel can lead to local cortical ischemia. Lastly, we show that hemodilution leads to a restoration of flow in secondary downstream vessels. ..
  62. Wang Z, Hao Y, Lowe A. The adenocarcinoma-associated antigen, AGR2, promotes tumor growth, cell migration, and cellular transformation. Cancer Res. 2008;68:492-7 pubmed publisher
    ..AGR2 may be important for the growth and development of the intestine as well as esophageal adenocarcinomas. ..
  63. Roberto M, Gilpin N, O Dell L, Cruz M, Morse A, Siggins G, et al. Cellular and behavioral interactions of gabapentin with alcohol dependence. J Neurosci. 2008;28:5762-71 pubmed publisher
  64. Prescott S, De Koninck Y, Sejnowski T. Biophysical basis for three distinct dynamical mechanisms of action potential initiation. PLoS Comput Biol. 2008;4:e1000198 pubmed publisher
    ..Through detailed analysis of the spike-initiating process, we have explained a fundamental link between biophysical properties and qualitative differences in how neurons encode sensory input. ..
  65. Lewerenz J, Maher P. Basal levels of eIF2alpha phosphorylation determine cellular antioxidant status by regulating ATF4 and xCT expression. J Biol Chem. 2009;284:1106-15 pubmed publisher
  66. Francesconi W, Berton F, Koob G, Sanna P. Intrinsic neuronal plasticity in the juxtacapsular nucleus of the bed nuclei of the stria terminalis (jcBNST). Prog Neuropsychopharmacol Biol Psychiatry. 2009;33:1347-55 pubmed publisher
    ..These results provide a novel neurobiological target for vulnerability to alcohol and drug dependence. ..
  67. Tani H, Dulla C, Huguenard J, Reimer R. Glutamine is required for persistent epileptiform activity in the disinhibited neocortical brain slice. J Neurosci. 2010;30:1288-300 pubmed publisher
    ..These results indicate that availability of glutamine influences neuronal release of glutamate during periods of intense network activity. ..
  68. Gilpin N, Misra K, Herman M, Cruz M, Koob G, Roberto M. Neuropeptide Y opposes alcohol effects on gamma-aminobutyric acid release in amygdala and blocks the transition to alcohol dependence. Biol Psychiatry. 2011;69:1091-9 pubmed publisher
    ..Gamma-aminobutyric acid neurons in the CeA likely constitute a major point of convergence for neuromodulator systems recruited during the transition to alcohol dependence. ..
  69. Owen S, Tuncdemir S, Bader P, Tirko N, Fishell G, Tsien R. Oxytocin enhances hippocampal spike transmission by modulating fast-spiking interneurons. Nature. 2013;500:458-62 pubmed publisher
    ..This provides insight into how a diffusely delivered neuromodulator can improve the performance of neural circuitry that requires synapse specificity and millisecond precision. ..
  70. Jiang J, Chan A, ALI S, Saha A, Haushalter K, Lam W, et al. Hydrogen Sulfide--Mechanisms of Toxicity and Development of an Antidote. Sci Rep. 2016;6:20831 pubmed publisher
    ..We conclude that sulfide produces a high degree of oxidative stress in cells and tissues, and that cobinamide has promise as a first specific treatment for sulfide poisoning. ..
  71. Lin C, Shen W, Chen Z, Tu Y, Matsudaira P. Identification of I-plastin, a human fimbrin isoform expressed in intestine and kidney. Mol Cell Biol. 1994;14:2457-67 pubmed
    ..Immunofluorescence microscopy detected I-plastin in the brush border of the small intestine and colon. These results identify I-plastin as the human homolog of chicken intestine fimbrin and as a third plastin isoform in humans. ..
  72. Rowe T, Aridor M, McCaffery J, Plutner H, Nuoffer C, Balch W. COPII vesicles derived from mammalian endoplasmic reticulum microsomes recruit COPI. J Cell Biol. 1996;135:895-911 pubmed
    ..These results suggest that coat exchange is an early event preceding the targeting of ER-derived vesicles to pre-Golgi intermediates. ..
  73. Zisch A, Stallcup W, Chong L, Dahlin Huppe K, Voshol J, Schachner M, et al. Tyrosine phosphorylation of L1 family adhesion molecules: implication of the Eph kinase Cek5. J Neurosci Res. 1997;47:655-65 pubmed
    ..Furthermore, direct phosphorylation of the L1 cytoplasmic domain by Cek5 was demonstrated in an in vitro kinase assay. Tyrosine phosphorylation may represent a novel mechanism of signal cascade initiation through L1. ..
  74. Brown A, Lemke G. Multiple regulatory elements control transcription of the peripheral myelin protein zero gene. J Biol Chem. 1997;272:28939-47 pubmed
    ..These core elements are essential for the transcription observed from the transfected promoter in cultured Schwann cells. ..
  75. Hsu S, Hazuka C, Roth R, Foletti D, Heuser J, Scheller R. Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments. Neuron. 1998;20:1111-22 pubmed
    ..The sec6/8 and septin complexes likely play an important role in trafficking vesicles and organizing proteins at the plasma membrane of neurons. ..
  76. Yang B, Steegmaier M, Gonzalez L, Scheller R. nSec1 binds a closed conformation of syntaxin1A. J Cell Biol. 2000;148:247-52 pubmed
    ..These results support the hypothesis that Sec1 proteins function as syntaxin chaperons during vesicle docking, priming, and membrane fusion. ..
  77. Kanda H, Hori M, Golub M, Tuck M. Inhibitors of arachidonic acid metabolism have variable effects on calcium signaling pathways. Am J Hypertens. 2001;14:248-53 pubmed
    ..In other studies, the LO inhibitor ETI attenuated Ang II-induced Ca2+ influx, whereas inhibitors of CO and P450 pathways had no effect. These data show that 1) E ..
  78. Rosario H, Waldo S, Becker S, Schmid Schonbein G. Pancreatic trypsin increases matrix metalloproteinase-9 accumulation and activation during acute intestinal ischemia-reperfusion in the rat. Am J Pathol. 2004;164:1707-16 pubmed
    ..This process represents a powerful in vivo pathophysiological mechanism for trypsin-induced MMP-9 activation and is likely to play a central role in the development of acute intestinal inflammation and shock. ..
  79. Fukushi J, Makagiansar I, Stallcup W. NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin. Mol Biol Cell. 2004;15:3580-90 pubmed
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