Genomes and Genes
Experts and Doctors on rats in California, United States
Locale: California, United States
Publications406 found, 100 shown here
- Kim Y, Remacle A, Chernov A, Liu H, Shubayev I, Lai C, et al. The MMP-9/TIMP-1 axis controls the status of differentiation and function of myelin-forming Schwann cells in nerve regeneration. PLoS ONE. 2012;7:e33664 pubmed publisher..Our findings of the MMP-dependent regulation of Na(v) channels, which we document here for the first time, provide a basis for therapeutic intervention in sensorimotor pathologies and pain. ..
- Zhao L, Donaldson C, Smith G, Vale W. The structures of the mouse and human urocortin genes (Ucn and UCN). Genomics. 1998;50:23-33 pubmed
- Leo C, Hsu S, McGee E, Salanova M, Hsueh A. DEFT, a novel death effector domain-containing molecule predominantly expressed in testicular germ cells. Endocrinology. 1998;139:4839-48 pubmed..In conclusion, we have identified a novel DED-containing protein with high expression in testis germ cells. This protein may be important in the regulation of death factor-induced apoptosis in the testis and other tissues. ..
- Leal A, Takabe K, Wang L, Donaldson C, Macconell L, Bilezikjian L, et al. Effect of adenovirus-mediated overexpression of follistatin and extracellular domain of activin receptor type II on gonadotropin secretion in vitro and in vivo. Endocrinology. 2002;143:964-9 pubmed
- Hayashi T, Saito A, Okuno S, Ferrand Drake M, Chan P. Induction of GRP78 by ischemic preconditioning reduces endoplasmic reticulum stress and prevents delayed neuronal cell death. J Cereb Blood Flow Metab. 2003;23:949-61 pubmed..Immunoprecipitation and double staining demonstrated involvement of GRP78 in prevention of PERK phosphorylation. These results suggest that GRP78 induced by preconditioning may reduce ER stress and eventual DND after ischemia. ..
- Austin J, Buckmaster P. Recurrent excitation of granule cells with basal dendrites and low interneuron density and inhibitory postsynaptic current frequency in the dentate gyrus of macaque monkeys. J Comp Neurol. 2004;476:205-18 pubmed..These primate characteristics may contribute to the susceptibility of the human dentate gyrus to epileptogenic injuries. ..
- Zhao H, Sapolsky R, Steinberg G. Interrupting reperfusion as a stroke therapy: ischemic postconditioning reduces infarct size after focal ischemia in rats. J Cereb Blood Flow Metab. 2006;26:1114-21 pubmed..In conclusion, postconditioning reduced infarct size, most plausibly by blocking apoptosis and free radical generation. With further study it may eventually be clinically applicable for stroke treatment. ..
- Schiltz J, Sawchenko P. Specificity and generality of the involvement of catecholaminergic afferents in hypothalamic responses to immune insults. J Comp Neurol. 2007;502:455-67 pubmed..Residual Fos induction seen in lesioned animals in response to higher doses of LPS provides a basis for probing additional circuits that may be recruited in a hierarchical manner in response to more strenuous or complex immune insults. ..
- Jessberger S, Aigner S, Clemenson G, Toni N, Lie D, Karalay O, et al. Cdk5 regulates accurate maturation of newborn granule cells in the adult hippocampus. PLoS Biol. 2008;6:e272 pubmed publisher..The data presented here also suggest a mechanistic dissociation between accurate dendritic targeting and subsequent synapse formation. ..
- Brar B, Helgeland E, Mahata S, Zhang K, O Connor D, Helle K, et al. Human catestatin peptides differentially regulate infarct size in the ischemic-reperfused rat heart. Regul Pept. 2010;165:63-70 pubmed publisher..3%) increased myocardial infarct size via a mechanism involving dephosphorylation of Akt and the two downstream targets during ischemic reperfusion in the isolated rat heart. ..
- Zhang W, Huguenard J, Buckmaster P. Increased excitatory synaptic input to granule cells from hilar and CA3 regions in a rat model of temporal lobe epilepsy. J Neurosci. 2012;32:1183-96 pubmed publisher..The aberrant development of these additional positive-feedback circuits might contribute to epileptogenesis in temporal lobe epilepsy. ..
- Marquez Lona E, Torres Machorro A, Gonzales F, Pillus L, Patrick G. Phosphorylation of the 19S regulatory particle ATPase subunit, Rpt6, modifies susceptibility to proteotoxic stress and protein aggregation. PLoS ONE. 2017;12:e0179893 pubmed publisher..Together, these data suggest that Rpt6 phosphorylation at S119 may play an important function in proteasome-dependent relief of proteotoxic stress that can be critical in protein aggregation pathologies. ..
- Jackson A, Parham P. Structure of human clathrin light chains. Conservation of light chain polymorphism in three mammalian species. J Biol Chem. 1988;263:16688-95 pubmed..The faithful preservation of clathrin light chain polymorphism in three mammalian species provides evidence supporting a functional diversification of the brain and non-brain forms of LCa and LCb. ..
- Shahbaz M, Hoch J, Trach K, Hural J, Webber S, Whiteley J. Structural studies and isolation of cDNA clones providing the complete sequence of rat liver dihydropteridine reductase. J Biol Chem. 1987;262:16412-6 pubmed..In contrast, the sequence shows little homology with that of mammalian dihydrofolate reductase: reduced pyridine nucleotide-requiring enzymes with superficial mechanistic similarities. ..
- Siegel J. Narcolepsy: a key role for hypocretins (orexins). Cell. 1999;98:409-12 pubmed
- Xu C, Lee S, Singh T, Sho E, Li X, Sho M, et al. Molecular mechanisms of aortic wall remodeling in response to hypertension. J Vasc Surg. 2001;33:570-8 pubmed..Cell proliferation precedes apoptosis by 2 weeks in this procedure. ..
- Liu X, Weiss F. Reversal of ethanol-seeking behavior by D1 and D2 antagonists in an animal model of relapse: differences in antagonist potency in previously ethanol-dependent versus nondependent rats. J Pharmacol Exp Ther. 2002;300:882-9 pubmed..The results also indicate that chronic ethanol exposure produces changes in D1 and D2 receptor function that lead to enhanced sensitivity to the behavioral effects of antagonists for these receptors. ..
- Zhang Y, Okada A, Lew C, McConnell S. Regulated nuclear trafficking of the homeodomain protein otx1 in cortical neurons. Mol Cell Neurosci. 2002;19:430-46 pubmed..These results suggest that ventricular cells actively sequester Otx1 in the cytoplasm, either by preventing nuclear import or by promoting a balance of export over import signals. ..
- Liao J, Schultz P. Three sweet receptor genes are clustered in human chromosome 1. Mamm Genome. 2003;14:291-301 pubmed..All three hT1Rs genes are expressed selectively in human taste receptor cells in the fungiform papillae, consistent with their role in taste perception. ..
- Dosanjh A, Ikonen T, Morris R. Respiratory epithelial expression of integrin alphaVbeta6 in chronic progressive allograft rejection. J Heart Lung Transplant. 2004;23:456-60 pubmed..Integrin alphaVbeta6 is readily detectable in healing isografts. Integrin alphaVbeta6 may be crucial in maintaining a viable epithelial cell layer, which is related to slowed progression of airway obliteration in OB. ..
- Markou A, Paterson N, Semenova S. Role of gamma-aminobutyric acid (GABA) and metabotropic glutamate receptors in nicotine reinforcement: potential pharmacotherapies for smoking cessation. Ann N Y Acad Sci. 2004;1025:491-503 pubmed..Thus, compounds that increase GABAergic neurotransmission and antagonists at mGluR5 have potential as anti-smoking medications for humans. ..
- Christopherson K, Ullian E, Stokes C, Mullowney C, Hell J, Agah A, et al. Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis. Cell. 2005;120:421-33 pubmed
- Kutschka I, Chen I, Kofidis T, von Degenfeld G, Sheikh A, Hendry S, et al. In vivo optical bioluminescence imaging of collagen-supported cardiac cell grafts. J Heart Lung Transplant. 2007;26:273-80 pubmed..Optical bioluminescence is a powerful method for assessment of cardiac cell graft survival in vivo. Collagen matrices support early survival of cardiomyoblasts after transplantation into injured musculature. ..
- Smart F, Aschrafi A, Atkins A, Owens G, Pilotte J, Cunningham B, et al. Two isoforms of the cold-inducible mRNA-binding protein RBM3 localize to dendrites and promote translation. J Neurochem. 2007;101:1367-79 pubmed..These data suggest that RBM3 plays a distinctive role in enhancing translation in neurons. ..
- Conboy M, Karasov A, Rando T. High incidence of non-random template strand segregation and asymmetric fate determination in dividing stem cells and their progeny. PLoS Biol. 2007;5:e102 pubmed
- Vaingankar S, Li Y, Biswas N, Gayen J, Choksi S, Rao F, et al. Effects of chromogranin A deficiency and excess in vivo: biphasic blood pressure and catecholamine responses. J Hypertens. 2010;28:817-25 pubmed publisher..Thus, across mammalian species, an optimal amount of CHGA may be required to establish appropriate catecholamine storage and release, and hence BP homeostasis. ..
- Klein E, Simmons D, Swanson L, Rosenfeld M. Tissue-specific RNA splicing generates an ankyrin-like domain that affects the dimerization and DNA-binding properties of a bHLH protein. Genes Dev. 1993;7:55-71 pubmed..Thus, REB alpha and REB beta represent a novel example of a regulated formation of an ankyrin-like domain within a bHLH protein, thereby mediating control of protein-protein interactions. ..
- Wender P, Jankowski O, Longcore K, Tabet E, Seto H, Tomikawa T. Correlation of F0F1-ATPase inhibition and antiproliferative activity of apoptolidin analogues. Org Lett. 2006;8:589-92 pubmed..Potent F(0)F(1)-ATPase inhibition was not a sufficient determinant of antiproliferative activity for several analogues, suggesting the existence of a secondary biological target or more complex mode of action for apoptolidin. ..
- Shimasaki S, Uchiyama F, Shimonaka M, Ling N. Molecular cloning of the cDNAs encoding a novel insulin-like growth factor-binding protein from rat and human. Mol Endocrinol. 1990;4:1451-8 pubmed..6-kilobase IGFBP-4 mRNA band was detectable in all tissues examined, including adrenal, testis, spleen, heart, lung, kidney, liver, stomach, hypothalamus, and brain cortex. ..
- Rivier C, Meunier H, Roberts V, Vale W. Possible involvement of inhibin in altered follicle-stimulating hormone (FSH) secretion during dissociated luteinizing hormone (LH) and FSH release: unilateral castration and experimental cryptorchidism. Biol Reprod. 1989;41:967-81 pubmed..abstract truncated at 400 words) ..
- Richieri G, Ogata R, Kleinfeld A. Equilibrium constants for the binding of fatty acids with fatty acid-binding proteins from adipocyte, intestine, heart, and liver measured with the fluorescent probe ADIFAB. J Biol Chem. 1994;269:23918-30 pubmed..These results provide a framework with which to understand better the biological function of FABPs and the FA-FABP interaction. ..
- Kim D, Zhang L, Dzau V, Pratt R. H19, a developmentally regulated gene, is reexpressed in rat vascular smooth muscle cells after injury. J Clin Invest. 1994;93:355-60 pubmed..The vascular injury model may be a useful system to use in examining the function of H19. ..
- Iyer R, Bando J, Jenkinson C, Vockley J, Kim P, Kern R, et al. Cloning and characterization of the mouse and rat type II arginase genes. Mol Genet Metab. 1998;63:168-75 pubmed..Sequence homology to the human type II arginase, arginase activity data, and immunoprecipitation with an anti-AII antibody confirm the identity of these cloned genes as rodent extrahepatic type II arginases. ..
- Le Niculescu H, Bonfoco E, Kasuya Y, Claret F, Green D, Karin M. Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death. Mol Cell Biol. 1999;19:751-63 pubmed..Hence, the JNK-to-c-Jun-to-FasL pathway is an important mediator of stress-induced neuronal apoptosis. ..
- Kim J, Noskov V, Lu X, Bergmann A, Ren X, Warth T, et al. Discovery of a novel, paternally expressed ubiquitin-specific processing protease gene through comparative analysis of an imprinted region of mouse chromosome 7 and human chromosome 19q13.4. Genome Res. 2000;10:1138-47 pubmed..This identification of a third imprinted gene, Usp29, from the Peg3/Zim1-region confirms the presence of a conserved imprinted domain spanning at least 500 kb in the proximal portion of mouse chromosome 7 (Mmu7). ..
- Hawley S, Tamura T, Miles L. Purification, cloning, and characterization of a profibrinolytic plasminogen-binding protein, TIP49a. J Biol Chem. 2001;276:179-86 pubmed..These results suggest that TIP49a is a previously unrecognized plasminogen-binding protein on the U937 cell surface. ..
- Chin G, Lee S, Hsu M, Liu W, Kim W, Levinson H, et al. Discoidin domain receptors and their ligand, collagen, are temporally regulated in fetal rat fibroblasts in vitro. Plast Reconstr Surg. 2001;107:769-76 pubmed..Future studies will involve the characterization of the biomolecular functions of these receptor kinases during fetal wound repair. ..
- Kumagai J, Hsu S, Matsumi H, Roh J, Fu P, Wade J, et al. INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent. J Biol Chem. 2002;277:31283-6 pubmed..Demonstration of INSL3 as the ligand for LGR8 facilitates understanding of the mechanism of testis descent and allows studies on the role of INSL3 in gonadal and other physiological processes. ..
- Kaufer D, Ogle W, Pincus Z, Clark K, Nicholas A, Dinkel K, et al. Restructuring the neuronal stress response with anti-glucocorticoid gene delivery. Nat Neurosci. 2004;7:947-53 pubmed..Our findings elucidate three principal steps in the neuronal stress-response pathway, all of which are amenable to therapeutic intervention. ..
- Nacamuli R, Fong K, Lenton K, Song H, Fang T, Salim A, et al. Expression and possible mechanisms of regulation of BMP3 in rat cranial sutures. Plast Reconstr Surg. 2005;116:1353-62 pubmed..The authors investigated the expression pattern of the bone morphogenetic protein antagonist BMP3 in rat cranial sutures and the factors regulating its expression in vitro...
- Brignole E, Smith S, Asturias F. Conformational flexibility of metazoan fatty acid synthase enables catalysis. Nat Struct Mol Biol. 2009;16:190-7 pubmed publisher..Concomitant rearrangement of the beta-carbon-processing domains synchronizes acyl chain reduction in one chamber with acyl chain elongation in the other. ..
- Slater B, Kwan M, Gupta D, Lee J, Longaker M. The role of regional posterior frontal dura mater in the overlying suture morphology. Plast Reconstr Surg. 2009;123:463-9 pubmed publisher..The differential expression pattern of TGF-beta signaling from the dura mater further supports the regional paracrine effect of the dura mater. ..
- Gomez Ospina N, Panagiotakos G, Portmann T, Paşca S, Rabah D, Budzillo A, et al. A promoter in the coding region of the calcium channel gene CACNA1C generates the transcription factor CCAT. PLoS ONE. 2013;8:e60526 pubmed publisher..This study provides new insights into the regulation of CACNA1C, and provides an example of how exonic promoters contribute to the complexity of mammalian genomes. ..
- Hughes S, Blau H. Muscle fiber pattern is independent of cell lineage in postnatal rodent development. Cell. 1992;68:659-71 pubmed..Thus, extrinsic signals override the intrinsic commitment of myoblast nuclei to particular programs of gene expression. We conclude that in postnatal development, pattern is not dictated by myoblast lineage. ..
- Nicolls M, Aversa G, Pearce N, Spinelli A, Berger M, Gurley K, et al. Induction of long-term specific tolerance to allografts in rats by therapy with an anti-CD3-like monoclonal antibody. Transplantation. 1993;55:459-68 pubmed..These hosts with long-surviving cardiac transplants, when grafted from PVG skin, accepted these grafts but rejected third-party skin in first-set. Thus G4.18 was shown to induce long-term specific tolerance to an organ allograft. ..
- Dascher C, Balch W. Mammalian Sly1 regulates syntaxin 5 function in endoplasmic reticulum to Golgi transport. J Biol Chem. 1996;271:15866-9 pubmed..These results suggest that rSly1 functions to positively regulate syntaxin 5 function. ..
- Lin P, Yao Y, Hofmeister R, Tsien R, Farquhar M. Overexpression of CALNUC (nucleobindin) increases agonist and thapsigargin releasable Ca2+ storage in the Golgi. J Cell Biol. 1999;145:279-89 pubmed..These results provide direct evidence that CALNUC binds Ca2+ in vivo and together with SERCA and IP3R is involved in establishment of the agonist-mobilizable Golgi Ca2+ store. ..
- Giffard R, Papadopoulos M, van Hooft J, Xu L, Giuffrida R, Monyer H. The electrogenic sodium bicarbonate cotransporter: developmental expression in rat brain and possible role in acid vulnerability. J Neurosci. 2000;20:1001-8 pubmed
- Frankel A, Clarke S. PRMT3 is a distinct member of the protein arginine N-methyltransferase family. Conferral of substrate specificity by a zinc-finger domain. J Biol Chem. 2000;275:32974-82 pubmed..These results suggest that native forms of PRMTs can have different properties than their GST-catalytic chain fusion protein counterparts, which may lack associated noncatalytic subunits. ..
- Prieto A, Weber J, Lai C. Expression of the receptor protein-tyrosine kinases Tyro-3, Axl, and mer in the developing rat central nervous system. J Comp Neurol. 2000;425:295-314 pubmed..These studies provide initial clues for elucidating the cellular functions of the Axl subfamily members and suggest potential complex Gas6/RPTK as well as RPTK/RPTK signaling interactions in the mature and developing CNS. ..
- Rader K, Orlando R, Lou X, Farquhar M. Characterization of ANKRA, a novel ankyrin repeat protein that interacts with the cytoplasmic domain of megalin. J Am Soc Nephrol. 2000;11:2167-78 pubmed
- Taupin P, Ray J, Fischer W, Suhr S, Hakansson K, Grubb A, et al. FGF-2-responsive neural stem cell proliferation requires CCg, a novel autocrine/paracrine cofactor. Neuron. 2000;28:385-97 pubmed..We propose that the process of neurogenesis is controlled by the cooperation between trophic factors and autocrine/paracrine cofactors, of which CCg is a prototype. ..
- Yenari M, Dumas T, Sapolsky R, Steinberg G. Gene therapy for treatment of cerebral ischemia using defective herpes simplex viral vectors. Ann N Y Acad Sci. 2001;939:340-57 pubmed..Although gene therapy is limited to the few hundred cells the vector is capable of transfecting, we consider the possibility of such gene therapy becoming relevant to clinical neurology in the future...
- Cui C, Booker T, Allen R, Grady S, Whiteaker P, Marks M, et al. The beta3 nicotinic receptor subunit: a component of alpha-conotoxin MII-binding nicotinic acetylcholine receptors that modulate dopamine release and related behaviors. J Neurosci. 2003;23:11045-53 pubmed
- Nishimura N, Schaffer C, Friedman B, Tsai P, Lyden P, Kleinfeld D. Targeted insult to subsurface cortical blood vessels using ultrashort laser pulses: three models of stroke. Nat Methods. 2006;3:99-108 pubmed..This demonstrates that a single blockage to a microvessel can lead to local cortical ischemia. Lastly, we show that hemodilution leads to a restoration of flow in secondary downstream vessels. ..
- Wang Z, Hao Y, Lowe A. The adenocarcinoma-associated antigen, AGR2, promotes tumor growth, cell migration, and cellular transformation. Cancer Res. 2008;68:492-7 pubmed publisher..AGR2 may be important for the growth and development of the intestine as well as esophageal adenocarcinomas. ..
- Prescott S, De Koninck Y, Sejnowski T. Biophysical basis for three distinct dynamical mechanisms of action potential initiation. PLoS Comput Biol. 2008;4:e1000198 pubmed publisher..Through detailed analysis of the spike-initiating process, we have explained a fundamental link between biophysical properties and qualitative differences in how neurons encode sensory input. ..
- Francesconi W, Berton F, Koob G, Sanna P. Intrinsic neuronal plasticity in the juxtacapsular nucleus of the bed nuclei of the stria terminalis (jcBNST). Prog Neuropsychopharmacol Biol Psychiatry. 2009;33:1347-55 pubmed publisher..These results provide a novel neurobiological target for vulnerability to alcohol and drug dependence. ..
- Tani H, Dulla C, Huguenard J, Reimer R. Glutamine is required for persistent epileptiform activity in the disinhibited neocortical brain slice. J Neurosci. 2010;30:1288-300 pubmed publisher..These results indicate that availability of glutamine influences neuronal release of glutamate during periods of intense network activity. ..
- Gilpin N, Misra K, Herman M, Cruz M, Koob G, Roberto M. Neuropeptide Y opposes alcohol effects on gamma-aminobutyric acid release in amygdala and blocks the transition to alcohol dependence. Biol Psychiatry. 2011;69:1091-9 pubmed publisher..Gamma-aminobutyric acid neurons in the CeA likely constitute a major point of convergence for neuromodulator systems recruited during the transition to alcohol dependence. ..
- Owen S, Tuncdemir S, Bader P, Tirko N, Fishell G, Tsien R. Oxytocin enhances hippocampal spike transmission by modulating fast-spiking interneurons. Nature. 2013;500:458-62 pubmed publisher..This provides insight into how a diffusely delivered neuromodulator can improve the performance of neural circuitry that requires synapse specificity and millisecond precision. ..
- Jiang J, Chan A, ALI S, Saha A, Haushalter K, Lam W, et al. Hydrogen Sulfide--Mechanisms of Toxicity and Development of an Antidote. Sci Rep. 2016;6:20831 pubmed publisher..We conclude that sulfide produces a high degree of oxidative stress in cells and tissues, and that cobinamide has promise as a first specific treatment for sulfide poisoning. ..
- Lin C, Shen W, Chen Z, Tu Y, Matsudaira P. Identification of I-plastin, a human fimbrin isoform expressed in intestine and kidney. Mol Cell Biol. 1994;14:2457-67 pubmed..Immunofluorescence microscopy detected I-plastin in the brush border of the small intestine and colon. These results identify I-plastin as the human homolog of chicken intestine fimbrin and as a third plastin isoform in humans. ..
- Rowe T, Aridor M, McCaffery J, Plutner H, Nuoffer C, Balch W. COPII vesicles derived from mammalian endoplasmic reticulum microsomes recruit COPI. J Cell Biol. 1996;135:895-911 pubmed..These results suggest that coat exchange is an early event preceding the targeting of ER-derived vesicles to pre-Golgi intermediates. ..
- Zisch A, Stallcup W, Chong L, Dahlin Huppe K, Voshol J, Schachner M, et al. Tyrosine phosphorylation of L1 family adhesion molecules: implication of the Eph kinase Cek5. J Neurosci Res. 1997;47:655-65 pubmed..Furthermore, direct phosphorylation of the L1 cytoplasmic domain by Cek5 was demonstrated in an in vitro kinase assay. Tyrosine phosphorylation may represent a novel mechanism of signal cascade initiation through L1. ..
- Brown A, Lemke G. Multiple regulatory elements control transcription of the peripheral myelin protein zero gene. J Biol Chem. 1997;272:28939-47 pubmed..These core elements are essential for the transcription observed from the transfected promoter in cultured Schwann cells. ..
- Hsu S, Hazuka C, Roth R, Foletti D, Heuser J, Scheller R. Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments. Neuron. 1998;20:1111-22 pubmed..The sec6/8 and septin complexes likely play an important role in trafficking vesicles and organizing proteins at the plasma membrane of neurons. ..
- Yang B, Steegmaier M, Gonzalez L, Scheller R. nSec1 binds a closed conformation of syntaxin1A. J Cell Biol. 2000;148:247-52 pubmed..These results support the hypothesis that Sec1 proteins function as syntaxin chaperons during vesicle docking, priming, and membrane fusion. ..
- Kanda H, Hori M, Golub M, Tuck M. Inhibitors of arachidonic acid metabolism have variable effects on calcium signaling pathways. Am J Hypertens. 2001;14:248-53 pubmed..In other studies, the LO inhibitor ETI attenuated Ang II-induced Ca2+ influx, whereas inhibitors of CO and P450 pathways had no effect. These data show that 1) E ..
- Rosario H, Waldo S, Becker S, Schmid Schonbein G. Pancreatic trypsin increases matrix metalloproteinase-9 accumulation and activation during acute intestinal ischemia-reperfusion in the rat. Am J Pathol. 2004;164:1707-16 pubmed..This process represents a powerful in vivo pathophysiological mechanism for trypsin-induced MMP-9 activation and is likely to play a central role in the development of acute intestinal inflammation and shock. ..
- Fukushi J, Makagiansar I, Stallcup W. NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin. Mol Biol Cell. 2004;15:3580-90 pubmed
- Smith S, Vaughan J, Donaldson C, Fernandez R, Li C, Chen A, et al. Cocaine- and amphetamine-regulated transcript is localized in pituitary lactotropes and is regulated during lactation. Endocrinology. 2006;147:1213-23 pubmed..The current study describes the cellular localization and regulation of CART expression and protein release from the rat pituitary gland. These findings suggest a putative role for CART in lactation. ..
- Power A, Berlau D, McGaugh J, Steward O. Anisomycin infused into the hippocampus fails to block "reconsolidation" but impairs extinction: the role of re-exposure duration. Learn Mem. 2006;13:27-34 pubmed..The findings indicate that post-retrieval administration of anisomycin impairs subsequent retention performance only in the absence of extinction and that this impairment is temporary. ..
- Yu F, Sugawara T, Nishi T, Liu J, Chan P. Overexpression of SOD1 in transgenic rats attenuates nuclear translocation of endonuclease G and apoptosis after spinal cord injury. J Neurotrauma. 2006;23:595-603 pubmed..An increased level of SOD1 in mitochondria conceivably reduces oxidative stress, thereby attenuating EndoG translocation, and resulting in reduction of caspase-independent apoptosis. ..
- Lunn M, Nassirpour R, Arrabit C, Tan J, McLeod I, Arias C, et al. A unique sorting nexin regulates trafficking of potassium channels via a PDZ domain interaction. Nat Neurosci. 2007;10:1249-59 pubmed..The regulation of endosomal trafficking via sorting nexins reveals a previously unknown mechanism for controlling potassium channel surface expression. ..
- Lee C, Kim N, Choi H, Sun Y, Nam J, Rhee H, et al. Lysophosphatidic acid-induced c-fos up-regulation involves cyclic AMP response element-binding protein activated by mitogen- and stress-activated protein kinase-1. J Cell Biochem. 2008;104:785-94 pubmed publisher..Taken together, our results suggest that CREB plays an important role in up-regulation of c-fos mRNA level in LPA-stimulated Rat-2 fibroblast cells. ..
- Rivier C. Urocortin 1 inhibits rat leydig cell function. Endocrinology. 2008;149:6425-32 pubmed publisher..The functional role played by testicular Ucn 1 in stress models characterized by blunted androgen levels therefore needs to be further investigated. ..
- Cuellar J, Manering N, Klukinov M, Nemenov M, Yeomans D. Thermal nociceptive properties of trigeminal afferent neurons in rats. Mol Pain. 2010;6:39 pubmed publisher..A clear understanding of trigeminal nociceptors may be similarly useful in the investigation of trigeminal pain mechanisms and potential therapies. ..
- Kinney J, Spacek J, Bartol T, Bajaj C, Harris K, Sejnowski T. Extracellular sheets and tunnels modulate glutamate diffusion in hippocampal neuropil. J Comp Neurol. 2013;521:448-64 pubmed publisher..Thus, the non-uniformity found in the extracellular space may have specialized functions for signaling (sheets) and volume transmission (tunnels). ..
- Manley N, Caso J, Works M, Cutler A, Zemlyak I, Sun G, et al. Derivation of injury-responsive dendritic cells for acute brain targeting and therapeutic protein delivery in the stroke-injured rat. PLoS ONE. 2013;8:e61789 pubmed publisher..These results demonstrate a non-invasive method to target ischemic brain injury and may ultimately provide a way to selectively deliver therapeutic compounds to the injured brain. ..
- Do J, Bonni A, Tuszynski M. SnoN facilitates axonal regeneration after spinal cord injury. PLoS ONE. 2013;8:e71906 pubmed publisher..Thus, a developmental mechanism that specifies extension of the axonal compartment also promotes axonal regeneration after adult CNS injury. ..