Experts and Doctors on protein transport in California, United States

Summary

Locale: California, United States
Topic: protein transport

Top Publications

  1. Guo B, Zhai D, Cabezas E, Welsh K, Nouraini S, Satterthwait A, et al. Humanin peptide suppresses apoptosis by interfering with Bax activation. Nature. 2003;423:456-61 pubmed
    ..We speculate therefore that HN arose from mitochondria and transferred to the nuclear genome, providing a mechanism for protecting these organelles from Bax. ..
  2. Trylska J, Tozzini V, McCammon J. Exploring global motions and correlations in the ribosome. Biophys J. 2005;89:1455-63 pubmed
    ..Our model provides an efficient and reliable way to study the dynamics of large biomolecular systems composed of both proteins and nucleic acids. ..
  3. Dammermann A, Pemble H, Mitchell B, McLeod I, Yates J, Kintner C, et al. The hydrolethalus syndrome protein HYLS-1 links core centriole structure to cilia formation. Genes Dev. 2009;23:2046-59 pubmed publisher
  4. Yang W, Patel K, Lee J, Ghebremariam Y, Wong H, Cooke J, et al. Cell-free production of transducible transcription factors for nuclear reprogramming. Biotechnol Bioeng. 2009;104:1047-58 pubmed publisher
  5. Iniesta A, Hillson N, Shapiro L. Polar remodeling and histidine kinase activation, which is essential for Caulobacter cell cycle progression, are dependent on DNA replication initiation. J Bacteriol. 2010;192:3893-902 pubmed publisher
    ..Thus, CckA activation is dependent on polar remodeling and a DNA replication initiation checkpoint that is tightly integrated with the polar phospho-signaling cascade governing cell cycle progression...
  6. Zhong F, Savage S, Shkreli M, Giri N, Jessop L, Myers T, et al. Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita. Genes Dev. 2011;25:11-6 pubmed publisher
    ..Our findings establish telomerase mislocalization as a novel cause of DC, and suggest that telomerase trafficking defects may contribute more broadly to the pathogenesis of telomere-related disease. ..
  7. King C, Sastri M, Chang P, Pennypacker J, Taylor S. The rate of NF-κB nuclear translocation is regulated by PKA and A kinase interacting protein 1. PLoS ONE. 2011;6:e18713 pubmed publisher
    ..Taken together, these results suggest that AKIP 1A acts to scaffold PKAc to NF-κB in the cytosol by protecting the phosphorylation site and thereby regulating the rate of nuclear translocation of p65. ..
  8. Tomar A, Lawson C, Ghassemian M, Schlaepfer D. Cortactin as a target for FAK in the regulation of focal adhesion dynamics. PLoS ONE. 2012;7:e44041 pubmed publisher
    ..Cortactin is an actin binding adaptor protein that can influence FA dynamics. FAK and cortactin interact, but the cellular role of this complex remains unclear...
  9. Garcia J, Huang M, Medeiros B, Mitchell B. Selective Toxicity of Investigational Ixazomib for Human Leukemia Cells Expressing Mutant Cytoplasmic NPM1: Role of Reactive Oxygen Species. Clin Cancer Res. 2016;22:1978-88 pubmed publisher
    ..These data suggest that intracellular determinants of antioxidant responses may be good predictors of therapeutic response to ixazomib. ..

More Information

Publications114 found, 100 shown here

  1. Perkins L, Yan Q, Schmidt B, Kolodieznyi D, Saurabh S, Larsen M, et al. Genetically Targeted Ratiometric and Activated pH Indicator Complexes (TRApHIC) for Receptor Trafficking. Biochemistry. 2018;57:861-871 pubmed publisher
    ..Quantitative profiling of the endocytosis and recycling of tagged ?2-adrenergic receptor (B2AR) at a single-vesicle level revealed differences among B2AR agonists, consistent with more detailed pharmacological profiling. ..
  2. Dodd D, Giddings T, Kirkegaard K. Poliovirus 3A protein limits interleukin-6 (IL-6), IL-8, and beta interferon secretion during viral infection. J Virol. 2001;75:8158-65 pubmed
  3. Schechtman D, Craske M, Kheifets V, Meyer T, Schechtman J, Mochly Rosen D. A critical intramolecular interaction for protein kinase Cepsilon translocation. J Biol Chem. 2004;279:15831-40 pubmed
    ..Together our data suggest that intramolecular interaction between the psiepsilonRACK site and RACK-binding site within epsilonPKC is critical and rate limiting in the process of PKC translocation. ..
  4. Kim M, Soontornniyomkij V, Ji B, ZHOU X. System-wide immunohistochemical analysis of protein co-localization. PLoS ONE. 2012;7:e32043 pubmed publisher
    ..Repeated use of the same section could combine assessments of co-localization and differential expression of multiple proteins. ..
  5. Zhang Y, Luo W, Wang H, Lin P, Vetrivel K, Liao F, et al. Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components. J Biol Chem. 2005;280:17020-6 pubmed
  6. Rautengarten C, Ebert B, Herter T, Petzold C, Ishii T, Mukhopadhyay A, et al. The interconversion of UDP-arabinopyranose and UDP-arabinofuranose is indispensable for plant development in Arabidopsis. Plant Cell. 2011;23:1373-90 pubmed publisher
    ..Concomitant downregulation of RGP1 and RGP2 expression results in plants almost completely deficient in cell wall–derived L-Ara and exhibiting severe developmental defects. ..
  7. Firestone A, Weinger J, Maldonado M, Barlan K, Langston L, O DONNELL M, et al. Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein. Nature. 2012;484:125-9 pubmed publisher
    ..Ciliobrevins therefore will be useful reagents for studying cellular processes that require this microtubule motor and may guide the development of additional AAA+ ATPase superfamily inhibitors. ..
  8. Yoo J, Moyer B, Bannykh S, Yoo H, Riordan J, Balch W. Non-conventional trafficking of the cystic fibrosis transmembrane conductance regulator through the early secretory pathway. J Biol Chem. 2002;277:11401-9 pubmed
  9. Kawai T, Akira S, Reed J. ZIP kinase triggers apoptosis from nuclear PML oncogenic domains. Mol Cell Biol. 2003;23:6174-86 pubmed
    ..These results suggest that ZIPK, in collaboration with Daxx and Par-4, mediates a novel nuclear pathway for apoptosis. ..
  10. Takanaga H, Frommer W. Facilitative plasma membrane transporters function during ER transit. FASEB J. 2010;24:2849-58 pubmed publisher
    ..Expression levels and residence time of transporters in the ER, as well as their coupling mechanisms, could be key determinants of ER permeability. ..
  11. Rennie E, Hansen S, Baidoo E, Hadi M, Keasling J, Scheller H. Three members of the Arabidopsis glycosyltransferase family 8 are xylan glucuronosyltransferases. Plant Physiol. 2012;159:1408-17 pubmed publisher
    ..We also show that several related proteins, GUX2 to GUX5 and Plant Glycogenin-like Starch Initiation Protein6, are Golgi localized and that only two of these proteins, GUX2 and GUX4, have activity as xylan ?-glucuronosyltransferases. ..
  12. Bischoff K, Ballew A, Simon M, O Reilly A. Wing defects in Drosophila xenicid mutant clones are caused by C-terminal deletion of additional sex combs (Asx). PLoS ONE. 2009;4:e8106 pubmed publisher
    ..Our results suggest that upregulation of Ubx transforms cells from a wing blade fate to a haltere fate, and that the presence of haltere cells within the wing blade is the primary defect leading to the adult wing phenotypes observed. ..
  13. Wilson C, Tsuchida M, Allen G, Barnhart E, Applegate K, Yam P, et al. Myosin II contributes to cell-scale actin network treadmilling through network disassembly. Nature. 2010;465:373-7 pubmed publisher
  14. Varsano T, Lau E, Feng Y, Garrido M, Milan L, Heynen Genel S, et al. Inhibition of melanoma growth by small molecules that promote the mitochondrial localization of ATF2. Clin Cancer Res. 2013;19:2710-22 pubmed publisher
  15. Tea J, Chihara T, Luo L. Histone deacetylase Rpd3 regulates olfactory projection neuron dendrite targeting via the transcription factor Prospero. J Neurosci. 2010;30:9939-46 pubmed publisher
    ..Our study suggests a specific function for the general chromatin remodeling factor Rpd3 in regulating dendrite targeting in neurons, largely through the postmitotic action of the Pros transcription factor. ..
  16. Taulet N, Delorme Walker V, DerMardirossian C. Reactive oxygen species regulate protrusion efficiency by controlling actin dynamics. PLoS ONE. 2012;7:e41342 pubmed publisher
    ..Thus, this study demonstrates that ROS modulate both the lamellipodium and the lamella networks to control protrusion efficiency. ..
  17. Chiu C, Patsch K, Cutrale F, Soundararajan A, Agus D, Fraser S, et al. Intracellular kinetics of the androgen receptor shown by multimodal Image Correlation Spectroscopy (mICS). Sci Rep. 2016;6:22435 pubmed publisher
    ..These findings may have implications for the future design of novel therapeutics targeting the AR pathway in PCa. ..
  18. Don A, Martinez Lamenca C, Webb W, Proia R, Roberts E, Rosen H. Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues. J Biol Chem. 2007;282:15833-42 pubmed
  19. Catz S. Characterization of Rab27a and JFC1 as constituents of the secretory machinery of prostate-specific antigen in prostate carcinoma cells. Methods Enzymol. 2008;438:25-40 pubmed publisher
    ..Here, we present methods for the characterization of Rab27a and its effector JFC1/Slp1 as key components of the secretory machinery that regulates exocytosis in prostate carcinoma cells. ..
  20. Humke E, Dorn K, Milenkovic L, Scott M, Rohatgi R. The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. Genes Dev. 2010;24:670-82 pubmed publisher
    ..We propose that the Sufu-Gli3 interaction is a major control point in the Hedgehog pathway, a pathway that plays important roles in both development and cancer. ..
  21. Sellmyer M, Chen L, Egeler E, Rakhit R, Wandless T. Intracellular context affects levels of a chemically dependent destabilizing domain. PLoS ONE. 2012;7:e43297 pubmed publisher
    ..These data reinforce that DD is an effective tool for protein perturbation, show that the local QC machinery affects levels of the DD, and suggest that the DD may be a useful probe for monitoring protein quality control machinery. ..
  22. Saito A, Hayashi T, Okuno S, Nishi T, Chan P. Modulation of p53 degradation via MDM2-mediated ubiquitylation and the ubiquitin-proteasome system during reperfusion after stroke: role of oxidative stress. J Cereb Blood Flow Metab. 2005;25:267-80 pubmed
    ..These results suggest that SOD1 promotes the MDM2 pathway and the ubiquitin-proteasome system after tFCI and that production of reactive oxygen species after tFCI prevents p53 degradation by inhibiting both systems. ..
  23. Darsow T, Booker T, Piña Crespo J, Heinemann S. Exocytic trafficking is required for nicotine-induced up-regulation of alpha 4 beta 2 nicotinic acetylcholine receptors. J Biol Chem. 2005;280:18311-20 pubmed
    ..Therefore, nicotine appears to regulate surface receptor levels at a step prior to initial insertion in the plasma membrane rather than by altering their endocytic trafficking or degradation rates as had been previously suggested. ..
  24. Venter P, Marshall D, Schneemann A. Dual roles for an arginine-rich motif in specific genome recognition and localization of viral coat protein to RNA replication sites in flock house virus-infected cells. J Virol. 2009;83:2872-82 pubmed publisher
    ..Our results are compatible with a model in which recognition of RNA1 and RNA2 for encapsidation occurs sequentially and in distinct cellular microenvironments. ..
  25. Machacek M, Hodgson L, Welch C, Elliott H, Pertz O, Nalbant P, et al. Coordination of Rho GTPase activities during cell protrusion. Nature. 2009;461:99-103 pubmed publisher
  26. Bessler J, Andersen E, Villeneuve A. Differential localization and independent acquisition of the H3K9me2 and H3K9me3 chromatin modifications in the Caenorhabditis elegans adult germ line. PLoS Genet. 2010;6:e1000830 pubmed publisher
    ..Further, these and other data support a model in which these two modifications function independently in adult C. elegans germ cells...
  27. Kehlenbach R, Assheuer R, Kehlenbach A, Becker J, Gerace L. Stimulation of nuclear export and inhibition of nuclear import by a Ran mutant deficient in binding to Ran-binding protein 1. J Biol Chem. 2001;276:14524-31 pubmed
    ..These results provide physiological evidence that release of Ran-GTP from importin beta by RanBP1 and importin alpha is critical for the recycling of importin beta to a transport-competent state. ..
  28. Lunn M, Nassirpour R, Arrabit C, Tan J, McLeod I, Arias C, et al. A unique sorting nexin regulates trafficking of potassium channels via a PDZ domain interaction. Nat Neurosci. 2007;10:1249-59 pubmed
    ..The regulation of endosomal trafficking via sorting nexins reveals a previously unknown mechanism for controlling potassium channel surface expression. ..
  29. Fu G, Xu T, Shi Y, Wei N, Yang X. tRNA-controlled nuclear import of a human tRNA synthetase. J Biol Chem. 2012;287:9330-4 pubmed publisher
    ..The design in principle should coordinate nuclear import of a tRNA synthetase with the demands of protein synthesis in the cytoplasm. ..
  30. Moseley J, Chang C, Grossman A. Genome-based approaches to understanding phosphorus deprivation responses and PSR1 control in Chlamydomonas reinhardtii. Eukaryot Cell. 2006;5:26-44 pubmed
  31. Perroud T, Kaiser J, Sy J, Lane T, Branda C, Singh A, et al. Microfluidic-based cell sorting of Francisella tularensis infected macrophages using optical forces. Anal Chem. 2008;80:6365-72 pubmed publisher
    ..novicida. A total of 10,738 infected cells were sorted at a throughput of 11 cells/s with 93% purity and 39% recovery. ..
  32. Fleming T, Shin J, Lee S, Becker E, Huang K, Bustamante C, et al. Dynamic SpoIIIE assembly mediates septal membrane fission during Bacillus subtilis sporulation. Genes Dev. 2010;24:1160-72 pubmed publisher
    ..We propose a new model for the role of SpoIIIE assembly in septal membrane fission that has strong implications for how the chromosome terminus crosses the septum. ..
  33. Gao H, Toro T, Paschini M, Braunstein Ballew B, Cervantes R, Lundblad V. Telomerase recruitment in Saccharomyces cerevisiae is not dependent on Tel1-mediated phosphorylation of Cdc13. Genetics. 2010;186:1147-59 pubmed publisher
    ..We propose an alternative model for the role of Tel1 in telomere homeostasis, which is based on the assumption that Tel1 performs the same molecular task at double-strand breaks (DSBs) and chromosome termini. ..
  34. Nottingham R, Pusapati G, Ganley I, Barr F, Lambright D, Pfeffer S. RUTBC2 protein, a Rab9A effector and GTPase-activating protein for Rab36. J Biol Chem. 2012;287:22740-8 pubmed publisher
    ..These data show that RUTBC2 can act as a Rab36 GAP in cells and suggest that RUTBC2 links Rab9A function to Rab36 function in the endosomal system. ..
  35. Hu R, Diao J, Li J, Tang Z, Li X, Leitz J, et al. Intrinsic and membrane-facilitated α-synuclein oligomerization revealed by label-free detection through solid-state nanopores. Sci Rep. 2016;6:20776 pubmed publisher
  36. Yoshimoto K, Arora K, Brooks C. Hexameric helicase deconstructed: interplay of conformational changes and substrate coupling. Biophys J. 2010;98:1449-57 pubmed publisher
    ..Overall, these findings may provide clues toward understanding the mechanism of substrate translocation in other motor proteins. ..
  37. Sontag E, Vonk W, Frydman J. Sorting out the trash: the spatial nature of eukaryotic protein quality control. Curr Opin Cell Biol. 2014;26:139-146 pubmed publisher
  38. Dunn A, Spudich J. Dynamics of the unbound head during myosin V processive translocation. Nat Struct Mol Biol. 2007;14:246-8 pubmed
    ..We find that the unbound head rotates freely about the lever-arm junction, a trait that likely facilitates travel through crowded actin meshworks. ..
  39. MacLeod D, Nakatsuji T, Yamasaki K, Kobzik L, Gallo R. HSV-1 exploits the innate immune scavenger receptor MARCO to enhance epithelial adsorption and infection. Nat Commun. 2013;4:1963 pubmed publisher
    ..These findings demonstrate that herpes simplex virus type 1 binds to MARCO to enhance its capacity for disease, and suggests a new therapeutic target to alter pathogenicity of herpes simplex virus type 1 in skin infection. ..
  40. Wu S, Fagan R, Uttamapinant C, Lifshitz L, Fogarty K, Ting A, et al. The Dopamine Transporter Recycles via a Retromer-Dependent Postendocytic Mechanism: Tracking Studies Using a Novel Fluorophore-Coupling Approach. J Neurosci. 2017;37:9438-9452 pubmed publisher
    ..In addition to shedding light on this critical process, these findings resolve conflict among multiple, seemingly disparate, previous reports on DAT's postendocytic fate. ..
  41. Balana B, Bahima L, Bodhinathan K, Taura J, Taylor N, Nettleton M, et al. Ras-association domain of sorting Nexin 27 is critical for regulating expression of GIRK potassium channels. PLoS ONE. 2013;8:e59800 pubmed publisher
    ..Thus, the presence of a functional RA domain and the interaction with Ras-like G proteins comprise a novel mechanism for modulating SNX27b control of GIRK channel surface expression and cellular excitability. ..
  42. Xu B, Fu Y, Liu Y, Agvanian S, Wirka R, Baum R, et al. The ESCRT-III pathway facilitates cardiomyocyte release of cBIN1-containing microparticles. PLoS Biol. 2017;15:e2002354 pubmed publisher
    ..This study links the BAR protein superfamily to the ESCRT pathway for MP biogenesis in mammalian cardiac ventricular cells, identifying elements of a pathway by which cytoplasmic cBIN1 is released into blood. ..
  43. Gassmann R, Holland A, Varma D, Wan X, Civril F, Cleveland D, et al. Removal of Spindly from microtubule-attached kinetochores controls spindle checkpoint silencing in human cells. Genes Dev. 2010;24:957-71 pubmed publisher
    ..In the absence of Spindly, a second mechanism silences the checkpoint; this mechanism is likely evolutionarily ancient, as fungi and higher plants lack kinetochore dynein. ..
  44. Cuajungco M, Grimm C, Oshima K, D hoedt D, Nilius B, Mensenkamp A, et al. PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4. J Biol Chem. 2006;281:18753-62 pubmed
    ..Such a functional interaction could be important in cell types that show distribution of both proteins to the same subcellular regions such as renal tubule cells where the proteins are associated with the luminal plasma membrane. ..
  45. Shen W, Patel S, Miyoshi H, Greenberg A, Kraemer F. Functional interaction of hormone-sensitive lipase and perilipin in lipolysis. J Lipid Res. 2009;50:2306-13 pubmed publisher
    ..The results suggest the translocation of HSL to the lipid droplet occurs by virtue of Plin localization to the surface of lipid droplets and a physical interaction of HSL occurring with sequences within the N-terminal region of Plin. ..
  46. Zhao B, Li L, Lu Q, Wang L, Liu C, Lei Q, et al. Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. Genes Dev. 2011;25:51-63 pubmed publisher
    ..These observations provide a potential link between the Hippo pathway and cell contact inhibition...
  47. Yeh E, Derisi J. Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum. PLoS Biol. 2011;9:e1001138 pubmed publisher
    ..Moreover, apicoplast-minus P. falciparum strains will be a powerful tool for further investigation of apicoplast biology as well as drug and vaccine development. ..
  48. Kong K, Yokosuka T, Canonigo Balancio A, Isakov N, Saito T, Altman A. A motif in the V3 domain of the kinase PKC-? determines its localization in the immunological synapse and functions in T cells via association with CD28. Nat Immunol. 2011;12:1105-12 pubmed publisher
  49. Jin L, Pahuja K, Wickliffe K, Gorur A, Baumgärtel C, Schekman R, et al. Ubiquitin-dependent regulation of COPII coat size and function. Nature. 2012;482:495-500 pubmed publisher
    ..As a result, ubiquitylation by CUL3-KLHL12 is essential for collagen export, yet less important for the transport of small cargo. We conclude that monoubiquitylation controls the size and function of a vesicle coat. ..
  50. Granger A, Shi Y, Lu W, Cerpas M, Nicoll R. LTP requires a reserve pool of glutamate receptors independent of subunit type. Nature. 2013;493:495-500 pubmed publisher
  51. Escusa Toret S, Vonk W, Frydman J. Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress. Nat Cell Biol. 2013;15:1231-43 pubmed publisher
    ..We conclude that spatial sequestration of misfolded proteins in Q-bodies is an early quality control strategy occurring synchronously with degradation to clear the cytoplasm of potentially toxic species. ..
  52. Tuo S, Nakashima K, Pringle J. Role of endocytosis in localization and maintenance of the spatial markers for bud-site selection in yeast. PLoS ONE. 2013;8:e72123 pubmed publisher
  53. Tsunoda S, Sun Y, Suzuki E, Zuker C. Independent anchoring and assembly mechanisms of INAD signaling complexes in Drosophila photoreceptors. J Neurosci. 2001;21:150-8 pubmed
    ..This may be a general mechanism used by cells to target different signaling machinery to the pertinent subcellular location. ..
  54. Sivars U, Aivazian D, Pfeffer S. Yip3 catalyses the dissociation of endosomal Rab-GDI complexes. Nature. 2003;425:856-9 pubmed
    ..We propose that the conserved Yip proteins serve as GDI-displacement factors for the targeting of Rab GTPases in eukaryotic cells. ..
  55. Chang M, Alsaigh T, Kistler E, Schmid Schonbein G. Breakdown of mucin as barrier to digestive enzymes in the ischemic rat small intestine. PLoS ONE. 2012;7:e40087 pubmed publisher
  56. Okamoto K, Bartocci C, Ouzounov I, Diedrich J, Yates J, Denchi E. A two-step mechanism for TRF2-mediated chromosome-end protection. Nature. 2013;494:502-5 pubmed publisher
    ..This two-step mechanism for TRF2-mediated end protection helps to explain the apparent paradox of frequent localization of DDR proteins at functional telomeres without concurrent induction of detrimental DNA-repair activities. ..
  57. Parrish W, Stefan C, Emr S. Essential role for the myotubularin-related phosphatase Ymr1p and the synaptojanin-like phosphatases Sjl2p and Sjl3p in regulation of phosphatidylinositol 3-phosphate in yeast. Mol Biol Cell. 2004;15:3567-79 pubmed
    ..In addition, this work defined an essential overlapping role for lipid phosphatases in the regulation of 3' phosphoinositides in yeast. ..
  58. Lloyd D, Hall F, Tarantino L, Gekakis N. Diabetes insipidus in mice with a mutation in aquaporin-2. PLoS Genet. 2005;1:e20 pubmed
    ..This novel mouse model allows for further mechanistic studies as well as testing of pharmacological and gene therapies for NDI...
  59. Heit J, Apelqvist A, Gu X, Winslow M, Neilson J, Crabtree G, et al. Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function. Nature. 2006;443:345-9 pubmed
    ..Thus, calcineurin/NFAT signalling regulates multiple factors that control growth and hallmark beta-cell functions, revealing unique models for the pathogenesis and therapy of diabetes. ..
  60. Yang X, Ongusaha P, Miles P, Havstad J, Zhang F, So W, et al. Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance. Nature. 2008;451:964-9 pubmed publisher
    ..These findings identify a molecular mechanism by which nutritional cues regulate insulin signalling through O-GlcNAc, and underscore the contribution of this modification to the aetiology of insulin resistance and type 2 diabetes. ..
  61. Mahapatra N, Taupenot L, Courel M, Mahata S, O Connor D. The trans-Golgi proteins SCLIP and SCG10 interact with chromogranin A to regulate neuroendocrine secretion. Biochemistry. 2008;47:7167-78 pubmed publisher
    ..We conclude that SCLIP and SCG10 interact with CHGA, share partial colocalization in the Golgi apparatus, and may be necessary for typical transmitter storage and release from chromaffin cells. ..
  62. Lim S, Mikolon D, Stupack D, Schlaepfer D. FERM control of FAK function: implications for cancer therapy. Cell Cycle. 2008;7:2306-14 pubmed
    ..We discuss how the pharmacological inhibition of FAK kinase activity may impact tumor progression through combined effects of blocking both tumor- and stromal-associated signaling regulating neo-vascularization. ..
  63. Wagner M, Smolka M, de Bruin R, Zhou H, Wittenberg C, Dowdy S. Whi5 regulation by site specific CDK-phosphorylation in Saccharomyces cerevisiae. PLoS ONE. 2009;4:e4300 pubmed publisher
    ..Although these four Whi5 CDK sites do not wholly determine Whi5 nuclear export, they do impact regulation of cell size. Taken together, these observations begin to dissect the regulatory role of specific phosphorylation sites on Whi5. ..
  64. Liu Y, Zhang Y, Wang X, Zhang H, You X, Liao F, et al. Intracellular trafficking of presenilin 1 is regulated by beta-amyloid precursor protein and phospholipase D1. J Biol Chem. 2009;284:12145-52 pubmed publisher
    ..Our results clearly elucidate a physiological function of APP in regulating protein trafficking and suggest that intracellular trafficking of PS1/gamma-secretase is regulated by multiple factors, including APP and PLD1. ..
  65. Sann S, Crane M, Lu H, Jin Y. Rabx-5 regulates RAB-5 early endosomal compartments and synaptic vesicles in C. elegans. PLoS ONE. 2012;7:e37930 pubmed publisher
    ..These results suggest that rabx-5 regulation of RAB-5 compartments is important for maintaining proper synaptic function throughout the lifetime...
  66. O Donnell A, Huang L, Thorner J, Cyert M. A calcineurin-dependent switch controls the trafficking function of ?-arrestin Aly1/Art6. J Biol Chem. 2013;288:24063-80 pubmed publisher
  67. Lin I, Sosso D, Chen L, Gase K, Kim S, Kessler D, et al. Nectar secretion requires sucrose phosphate synthases and the sugar transporter SWEET9. Nature. 2014;508:546-9 pubmed publisher
    ..The recruitment of SWEET9 for sucrose export may have been a key innovation, and could have coincided with the evolution of core eudicots and contributed to the evolution of nectar secretion to reward pollinators...
  68. Zhang J, Johnson J, He J, Napolitano G, Ramadass M, Rocca C, et al. Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A. J Biol Chem. 2017;292:10328-10346 pubmed publisher
    ..Altogether, we show that LAMP2A trafficking is regulated by cystinosin, Rab11, and RILP and that CMA up-regulation is a potential clinically relevant mechanism to increase cell survival in cystinosis. ..
  69. Ben Efraim I, Gerace L. Gradient of increasing affinity of importin beta for nucleoporins along the pathway of nuclear import. J Cell Biol. 2001;152:411-7 pubmed
    ..These results indicate that nucleoporins themselves, as well as the nucleocytoplasmic compartmentalization of the Ran system, are likely to play an important role in conferring directionality to nuclear protein import. ..
  70. Lavoie C, Meerloo T, Lin P, Farquhar M. Calnuc, an EF-hand Ca(2+)-binding protein, is stored and processed in the Golgi and secreted by the constitutive-like pathway in AtT20 cells. Mol Endocrinol. 2002;16:2462-74 pubmed
    ..Together, these observations indicate that calnuc has a unique itinerary as it is retained in the Golgi and is then constitutively secreted extracellularly where it may influence cell behavior via its Ca(2+)-binding properties. ..
  71. Wu C, MacCoss M, Mardones G, Finnigan C, Mogelsvang S, Yates J, et al. Organellar proteomics reveals Golgi arginine dimethylation. Mol Biol Cell. 2004;15:2907-19 pubmed
  72. Rajan R, Kopito R. Suppression of wild-type rhodopsin maturation by mutants linked to autosomal dominant retinitis pigmentosa. J Biol Chem. 2005;280:1284-91 pubmed
    ..These data suggested a dominant negative effect on conformational maturation that may underlie the dominant inheritance of ARDP. ..
  73. Kim H, Puglisi J, Chu S. Fluctuations of transfer RNAs between classical and hybrid states. Biophys J. 2007;93:3575-82 pubmed
    ..The antibiotic viomycin, a translocation inhibitor, suppresses tRNA dynamics, suggesting that the enhanced fluctuations of tRNAs after peptide-bond formation drive spontaneous attempts at translocation by the ribosome. ..
  74. Makarenkova H, Gonzalez K, Kiosses W, Meech R. Barx2 controls myoblast fusion and promotes MyoD-mediated activation of the smooth muscle alpha-actin gene. J Biol Chem. 2009;284:14866-74 pubmed publisher
    ..Overall these data indicate that Barx2 cooperates with other muscle-expressed transcription factors to regulate the early cytoskeletal remodeling events that underlie efficient myoblast differentiation. ..
  75. Wang Y, Vera L, Fischer W, Montminy M. The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature. 2009;460:534-7 pubmed publisher
  76. Cavero S, Limbo O, Russell P. Critical functions of Rpa3/Ssb3 in S-phase DNA damage responses in fission yeast. PLoS Genet. 2010;6:e1001138 pubmed publisher
    ..From these studies we propose that Ssb3 plays a critical role in mediating RPA functions that are required for repair or tolerance of DNA lesions in S-phase. Rpa3 orthologs in humans and other species may have a similar function. ..
  77. Gallegos T, Martovetsky G, Kouznetsova V, Bush K, Nigam S. Organic anion and cation SLC22 "drug" transporter (Oat1, Oat3, and Oct1) regulation during development and maturation of the kidney proximal tubule. PLoS ONE. 2012;7:e40796 pubmed publisher
  78. Bouchecareilh M, Hutt D, Szajner P, Flotte T, Balch W. Histone deacetylase inhibitor (HDACi) suberoylanilide hydroxamic acid (SAHA)-mediated correction of ?1-antitrypsin deficiency. J Biol Chem. 2012;287:38265-78 pubmed publisher
    ..These data suggest that HDAC activity can influence Z-?1AT protein traffic and that SAHA may represent a potential therapeutic approach for ?1ATD and other protein misfolding diseases. ..
  79. De Ingeniis J, Ratnikov B, Richardson A, Scott D, Aza Blanc P, De S, et al. Functional specialization in proline biosynthesis of melanoma. PLoS ONE. 2012;7:e45190 pubmed publisher
    ..PYCRL, localized in the cytosol, is exclusively linked to the conversion of ornithine to proline. This analysis provides the first clarification of the role of PYCRs to proline biosynthesis...
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