Experts and Doctors on protein binding in New York, United States


Locale: New York, United States
Topic: protein binding

Top Publications

  1. Roy A, Carruthers C, Gutjahr T, Roeder R. Direct role for Myc in transcription initiation mediated by interactions with TFII-I. Nature. 1993;365:359-61 pubmed
    ..TBP probably interacts with Myc, but only slowly. These observations indicate that Myc has the potential to interact physically and functionally with components of the general transcription machinery. ..
  2. Kenny M, Mendez F, Sandigursky M, Kureekattil R, Goldman J, Franklin W, et al. Heat shock protein 70 binds to human apurinic/apyrimidinic endonuclease and stimulates endonuclease activity at abasic sites. J Biol Chem. 2001;276:9532-6 pubmed
    ..These findings provide a possible mechanism by which HSP70 protects cells against oxidative stress. ..
  3. Buschmann T, Lin Y, Aithmitti N, Fuchs S, Lu H, Resnick Silverman L, et al. Stabilization and activation of p53 by the coactivator protein TAFII31. J Biol Chem. 2001;276:13852-7 pubmed
    ..Our results suggest that direct interaction of TAF(II)31 and p53 not only mediates p53 transcriptional activation but also protects p53 from mdm2-mediated degradation, thereby resulting in activation of p53 functions. ..
  4. Urbatsch I, Wilke Mounts S, Gimi K, Senior A. Purification and characterization of N-glycosylation mutant mouse and human P-glycoproteins expressed in Pichia pastoris cells. Arch Biochem Biophys. 2001;388:171-7 pubmed
    ..Mass spectrometry indicated that mutant and wild-type proteins did not differ significantly in mass, demonstrating that the wild-type proteins contain no N-glycosylation. ..
  5. Liang X, Wisniewski D, Strife A, Shivakrupa -, Clarkson B, Resh M. Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling. J Biol Chem. 2002;277:13732-8 pubmed
    ..Taken together, these data indicate that activation of PI 3-kinase by KL promotes binding of the Dok pleckstrin homology domain and Dok-1 recruitment to the plasma membrane where Dok-1 is phosphorylated by Src and/or Tec family kinases. ..
  6. Bristow C, Mercatante D, Kole R. HIV-1 preferentially binds receptors copatched with cell-surface elastase. Blood. 2003;102:4479-86 pubmed
  7. Bussell R, Eliezer D. Effects of Parkinson's disease-linked mutations on the structure of lipid-associated alpha-synuclein. Biochemistry. 2004;43:4810-8 pubmed
    ..The potential implications of these results for the role of alphaS in PD are discussed. ..
  8. Liu X, Kirschenbaum A, Yu K, Yao S, Levine A. Cyclooxygenase-2 suppresses hypoxia-induced apoptosis via a combination of direct and indirect inhibition of p53 activity in a human prostate cancer cell line. J Biol Chem. 2005;280:3817-23 pubmed
    ..These data imply that COX-2-positive prostate cancer cells can have impaired p53 function even in the presence of wild-type p53 and that p53 activity can be restored in these cells via inhibition of COX-2 activity. ..
  9. Wang P, Wang J, Xiao Y, Murray J, Novikoff P, Angeletti R, et al. Interaction with PDZK1 is required for expression of organic anion transporting protein 1A1 on the hepatocyte surface. J Biol Chem. 2005;280:30143-9 pubmed
    ..Because its ability to transport substances into the cell requires surface expression, this must be considered in any assessment of physiologic function. ..

More Information

Publications665 found, 100 shown here

  1. Vetting M, Yu M, Rendle P, Blanchard J. The substrate-induced conformational change of Mycobacterium tuberculosis mycothiol synthase. J Biol Chem. 2006;281:2795-802 pubmed
    ..In addition, this structure provides further evidence that the N-terminal acetyltransferase domain no longer has enzymatic activity and is vestigial in nature. ..
  2. Yanagida Asanuma E, Asanuma K, Kim K, Donnelly M, Young Choi H, Hyung Chang J, et al. Synaptopodin protects against proteinuria by disrupting Cdc42:IRSp53:Mena signaling complexes in kidney podocytes. Am J Pathol. 2007;171:415-27 pubmed
    ..The identification of synaptopodin as an inhibitor of Cdc42:IRSp53:Mena signaling defines a novel antiproteinuric signaling pathway and offers new targets for the development of antiproteinuric therapeutic modalities. ..
  3. Senoo Matsuda N, Johnston L. Soluble factors mediate competitive and cooperative interactions between cells expressing different levels of Drosophila Myc. Proc Natl Acad Sci U S A. 2007;104:18543-8 pubmed
  4. Kalakonda N, Fischle W, Boccuni P, Gurvich N, Hoya Arias R, Zhao X, et al. Histone H4 lysine 20 monomethylation promotes transcriptional repression by L3MBTL1. Oncogene. 2008;27:4293-304 pubmed publisher
    ..Our studies identify the importance of H4K20 monomethylation and of PR-SET7 for L3MBTL1 function. ..
  5. Zhang Y, Chen Y, Bangaru S, He L, Abele K, Tanabe S, et al. Origin of the voltage dependence of G-protein regulation of P/Q-type Ca2+ channels. J Neurosci. 2008;28:14176-88 pubmed publisher
  6. Brooks C, Gu W. How does SIRT1 affect metabolism, senescence and cancer?. Nat Rev Cancer. 2009;9:123-8 pubmed publisher
    ..Here we discuss the current understanding of how SIRT1 functions in light of recent discoveries and propose that the net outcome of the seemingly opposite oncogenic and tumour-suppressive effects of SIRT1 depends on the status of p53. ..
  7. Napetschnig J, Kassube S, Debler E, Wong R, Blobel G, Hoelz A. Structural and functional analysis of the interaction between the nucleoporin Nup214 and the DEAD-box helicase Ddx19. Proc Natl Acad Sci U S A. 2009;106:3089-94 pubmed publisher
    ..Repeat of these cycles would remove proteins from a mRNP, one at a time, akin to a ratchet mechanism for mRNA export. ..
  8. Zhao Q, Rank G, Tan Y, Li H, Moritz R, Simpson R, et al. PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing. Nat Struct Mol Biol. 2009;16:304-311 pubmed publisher
    ..Our findings define DNMT3A as both a reader and a writer of repressive epigenetic marks, thereby directly linking histone and DNA methylation in gene silencing. ..
  9. Collins M, Hendrickson W. Structural characterization of the Boca/Mesd maturation factors for LDL-receptor-type ? propeller domains. Structure. 2011;19:324-36 pubmed publisher
  10. Cyge B, Fischer V, Takemaru K, Li F. Generation and characterization of monoclonal antibodies against human Chibby protein. Hybridoma (Larchmt). 2011;30:163-8 pubmed publisher
    ..These Cby MAbs therefore hold promise as useful tools for the investigation of Wnt signaling and ciliogenesis. ..
  11. Chen C, Borden M. The role of poly(ethylene glycol) brush architecture in complement activation on targeted microbubble surfaces. Biomaterials. 2011;32:6579-87 pubmed publisher
    ..More generally, this study illustrates the use of flow cytometry and microbubbles to analyze the surface interactions between complex biological media and surface-engineered biomaterials. ..
  12. Ma W, Rai V, Hudson B, Song F, Schmidt A, Barile G. RAGE binds C1q and enhances C1q-mediated phagocytosis. Cell Immunol. 2012;274:72-82 pubmed publisher
    ..C1q induced U937 cell adhesion and phagocytosis was inhibited by antibodies to RAGE or Mac-1. These data link C1q and RAGE to the recruitment of leukocytes and phagocytosis of C1q-coated material. ..
  13. Colgan J, Ashali H, Manley J. A direct interaction between a glutamine-rich activator and the N terminus of TFIIB can mediate transcriptional activation in vivo. Mol Cell Biol. 1995;15:2311-20 pubmed
  14. Stone E, Yan L, Ahsan M, Lehmann M, Yeretsian J, Quartermain D. Role of CNS alpha1-adrenoceptor activity in central fos responses to novelty. Synapse. 2006;59:299-307 pubmed
  15. McGary K, Nudler E. RNA polymerase and the ribosome: the close relationship. Curr Opin Microbiol. 2013;16:112-7 pubmed publisher
    ..The direct link between the moving ribosome and RNAP provides a basis for maintaining genomic integrity while enabling efficient transcription and timely translation of various genes within the bacterial cell. ..
  16. Cortes P, Ye Z, Baltimore D. RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1. Proc Natl Acad Sci U S A. 1994;91:7633-7 pubmed
    ..Because this region of RAG-1 is not required for recombination and SRP1 appears to be bound to the nuclear envelope, we suggest that this interaction helps to localize RAG-1. ..
  17. Lee T, Klampfer L, Shows T, Vilcek J. Transcriptional regulation of TSG6, a tumor necrosis factor- and interleukin-1-inducible primary response gene coding for a secreted hyaluronan-binding protein. J Biol Chem. 1993;268:6154-60 pubmed
    ..The results suggest that TSG6 gene expression is regulated by an interplay of positively and negatively acting transactivating factors. ..
  18. Laurent B, Treich I, Carlson M. The yeast SNF2/SWI2 protein has DNA-stimulated ATPase activity required for transcriptional activation. Genes Dev. 1993;7:583-91 pubmed
    ..Deletion analysis shows that the helicase-like region of SNF2 is necessary, but not sufficient, for transcriptional activation. ..
  19. Li C, Manley J. Even-skipped represses transcription by binding TATA binding protein and blocking the TFIID-TATA box interaction. Mol Cell Biol. 1998;18:3771-81 pubmed
    ..We conclude that Eve represses transcription via a direct interaction with TBP that blocks TFIID binding to the promoter. ..
  20. Carrano A, Eytan E, Hershko A, Pagano M. SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol. 1999;1:193-9 pubmed
    ..Thus, p27 degradation is subject to dual control by the accumulation of both SKP2 and cyclins following mitogenic stimulation. ..
  21. Yagyu H, Lutz E, Kako Y, Marks S, Hu Y, Choi S, et al. Very low density lipoprotein (VLDL) receptor-deficient mice have reduced lipoprotein lipase activity. Possible causes of hypertriglyceridemia and reduced body mass with VLDL receptor deficiency. J Biol Chem. 2002;277:10037-43 pubmed
    ..Therefore, the VLDLr is required for normal LpL regulation in vivo, and the disruption of VLDLr results in hypertriglyceridemia associated with decreased LpL activity. ..
  22. Niessen C, Gumbiner B. Cadherin-mediated cell sorting not determined by binding or adhesion specificity. J Cell Biol. 2002;156:389-399 pubmed
    ..These results show that cadherins are far more promiscuous in their adhesive-binding capacity than had been expected and that the ability to sort out must be determined by mechanisms other than simple adhesive-binding specificity. ..
  23. López de Saro F, Georgescu R, O Donnell M. A peptide switch regulates DNA polymerase processivity. Proc Natl Acad Sci U S A. 2003;100:14689-94 pubmed
    ..Therefore, DNA sensing by tau switches the polymerase peptide tail on and off the clamp and coordinates the dynamic turnover of polymerase during lagging strand synthesis. ..
  24. Park S, Liu G, Kubal A, Fury M, Cao L, Marx S. Direct interaction between BKCa potassium channel and microtubule-associated protein 1A. FEBS Lett. 2004;570:143-8 pubmed
    ..These studies identify a novel interaction between the C-terminal tail of the BKCa channel and the light chain of MAP1A, which enables channel association with and modulation by the cytoskeleton. ..
  25. Liang F, Lee S, Liang J, Lawrence D, Zhang Z. The role of protein-tyrosine phosphatase 1B in integrin signaling. J Biol Chem. 2005;280:24857-63 pubmed
  26. Pan D, Chen F, Neimark E, Li X, Shneider B. FTF and LRH-1, two related but different transcription factors in human Caco-2 cells: their different roles in the regulation of bile acid transport. Biochim Biophys Acta. 2005;1732:31-7 pubmed
    ..FTF is not involved directly in bile acid mediated negative feedback regulation of the ASBT. ..
  27. Liu C, Kong W, Ilalov K, Yu S, Xu K, Prazak L, et al. ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein. FASEB J. 2006;20:988-90 pubmed
    ..ADAMTS-7 is the first metalloproteinase found to bind directly to and degrade COMP. ..
  28. Chen J, Carcamo J, Golde D. The alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor interacts with c-Kit and inhibits c-Kit signaling. J Biol Chem. 2006;281:22421-6 pubmed
    ..Our results suggest that in addition to having the commonly appreciated roles in cytokine signal transduction, the receptors alphaGMR and c-Kit could interact to coordinate their signal initiation. ..
  29. Wei Y, Fu D. Binding and transport of metal ions at the dimer interface of the Escherichia coli metal transporter YiiP. J Biol Chem. 2006;281:23492-502 pubmed
    ..The functional significance of these findings is discussed based on the unique coordination chemistry of aspartyl residues and a model for the translocation pathway of metal ions at the YiiP dimer interface. ..
  30. Zhou Z, Zhen J, Karpowich N, Goetz R, Law C, Reith M, et al. LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake. Science. 2007;317:1390-3 pubmed publisher
    ..Mutagenesis experiments on human SERT and DAT indicate that both the desipramine-binding site and its inhibition mechanism are probably conserved in the human neurotransmitter transporters...
  31. Lima C, Reverter D. Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7. J Biol Chem. 2008;283:32045-55 pubmed publisher
    ..Structure-guided mutational analysis reveals elements unique to the SENP6 and SENP7 subclass of SENP/ULP proteases that contribute to protease function during deconjugation of poly-SUMO chains. ..
  32. Hikasa H, Ezan J, Itoh K, Li X, Klymkowsky M, Sokol S. Regulation of TCF3 by Wnt-dependent phosphorylation during vertebrate axis specification. Dev Cell. 2010;19:521-32 pubmed publisher
    ..These findings reveal an alternative in vivo mechanism of Wnt signaling that involves TCF3 phosphorylation and subsequent derepression of target genes and link this molecular event to a specific developmental process...
  33. Graziano V, Luo G, Blainey P, Pérez Berná A, McGrath W, FLINT S, et al. Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: II. adenovirus proteinase is activated in an unusual one-dimensional biochemical reaction. J Biol Chem. 2013;288:2068-80 pubmed publisher
    ..This activation mechanism illustrates a new paradigm for virion maturation and a new way, by sliding on DNA, for bimolecular complexes to form among proteins not involved in DNA metabolism. ..
  34. Son J, Shen S, Margueron R, Reinberg D. Nucleosome-binding activities within JARID2 and EZH1 regulate the function of PRC2 on chromatin. Genes Dev. 2013;27:2663-77 pubmed publisher
    ..Our findings allow us to propose a model in which PRC2-Ezh2 is important for the de novo establishment of H3K27me3 in dividing cells, whereas PRC2-Ezh1 is required for its maintenance in resting cells. ..
  35. Sansó M, Levin R, Lipp J, Wang V, Greifenberg A, Quezada E, et al. P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates. Genes Dev. 2016;30:117-31 pubmed publisher
    ..Therefore, in addition to its role in elongation, P-TEFb regulates termination by promoting chromatin recruitment and activation of a cotranscriptional RNA processing enzyme, Xrn2. ..
  36. Dabrowska M, Sirotnak F. E2F site in the essential promoter region does not confer S phase-specific transcription of the ABCC10 gene in human prostate cancer cells. Acta Biochim Pol. 2017;64:371-374 pubmed publisher
    ..In G1 phase it decreased by 2.4- to 3-fold. It is thus inferred, that ABCC10 expression in CWR22Rv1 cells is not S phase-specific but is primarily associated with cell proliferation. ..
  37. Tougu K, Marians K. The interaction between helicase and primase sets the replication fork clock. J Biol Chem. 1996;271:21398-405 pubmed
    ..Thus, the interaction between DnaG and DnaB at the replication fork is the primary regulator of the cycle of Okazaki fragment synthesis. ..
  38. Crombie R, Silverstein R. Lysosomal integral membrane protein II binds thrombospondin-1. Structure-function homology with the cell adhesion molecule CD36 defines a conserved recognition motif. J Biol Chem. 1998;273:4855-63 pubmed
    ..Computer-assisted homology searches suggest that the TSP1 recognition motif identified from study of CD36 family members may be widely expressed in nature. ..
  39. Barton R, Worman H. Prenylated prelamin A interacts with Narf, a novel nuclear protein. J Biol Chem. 1999;274:30008-18 pubmed
    ..The prenyl-dependent binding of Narf to prelamin A is an important first step in understanding the functional significance of the lamin A precursor. ..
  40. Jankowsky E, Gross C, Shuman S, Pyle A. Active disruption of an RNA-protein interaction by a DExH/D RNA helicase. Science. 2001;291:121-5 pubmed
    ..This indicates that DExH/D proteins can effectively catalyze protein displacement from RNA and thereby participate in the structural reorganization of ribonucleoprotein assemblies. ..
  41. Nitabach M, Llamas D, Araneda R, Intile J, Thompson I, Zhou Y, et al. A mechanism for combinatorial regulation of electrical activity: Potassium channel subunits capable of functioning as Src homology 3-dependent adaptors. Proc Natl Acad Sci U S A. 2001;98:705-10 pubmed publisher
    ..This is a mechanism for information transfer between subunits in heteromultimeric ion channels that is likely to underlie the generation of combinatorial signaling diversity in the control of cellular electrical excitability...
  42. Gaiddon C, Lokshin M, Ahn J, Zhang T, Prives C. A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain. Mol Cell Biol. 2001;21:1874-87 pubmed
  43. Kaplan D, Davey M, O Donnell M. Mcm4,6,7 uses a "pump in ring" mechanism to unwind DNA by steric exclusion and actively translocate along a duplex. J Biol Chem. 2003;278:49171-82 pubmed
  44. Lu J, Schneider R. Tissue distribution of AU-rich mRNA-binding proteins involved in regulation of mRNA decay. J Biol Chem. 2004;279:12974-9 pubmed
  45. Carcamo J, Pedraza A, Borquez Ojeda O, Zhang B, Sanchez R, Golde D. Vitamin C is a kinase inhibitor: dehydroascorbic acid inhibits IkappaBalpha kinase beta. Mol Cell Biol. 2004;24:6645-52 pubmed
    ..These findings define a function for vitamin C in signal transduction other than as an antioxidant and mechanistically illuminate how vitamin C down-modulates NF-kappaB signaling. ..
  46. Kim J, Ghosh S, Liu H, Tateyama M, Kass R, Pitt G. Calmodulin mediates Ca2+ sensitivity of sodium channels. J Biol Chem. 2004;279:45004-12 pubmed
    ..Together, these data offer new biochemical evidence for Ca2+/CaM modulation of Na+ channel function. ..
  47. Wilhelm M, Xu Z, Kukekov N, Gire S, Greene L. Proapoptotic Nix activates the JNK pathway by interacting with POSH and mediates death in a Parkinson disease model. J Biol Chem. 2007;282:1288-95 pubmed
    ..These results indicate that Nix promotes cell death via interaction with POSH and activation of the JNK/c-Jun pathway and that Nix protein is induced and contributes to cell death in a cellular model of Parkinson disease. ..
  48. Nikolov D, Li C, Lackmann M, Jeffrey P, Himanen J. Crystal structure of the human ephrin-A5 ectodomain. Protein Sci. 2007;16:996-1000 pubmed
    ..The results of this study further emphasize the importance of the G-H loop for receptor recognition and selectivity, and could serve as a starting point for the development of structure-based Eph antagonists. ..
  49. Ray A, Bandyopadhyay A, Matsumoto T, Deng H, Maitra U. Fission yeast translation initiation factor 3 subunit eIF3h is not essential for global translation initiation, but deletion of eif3h+ affects spore formation. Yeast. 2008;25:809-23 pubmed publisher
    ..The implications of these results in relation to the functions of eIF3h in Sz. pombe are discussed. ..
  50. Redecha P, Van Rooijen N, Torry D, Girardi G. Pravastatin prevents miscarriages in mice: role of tissue factor in placental and fetal injury. Blood. 2009;113:4101-9 pubmed publisher
    ..These studies indicate that TF is an important mediator in fetal death and growth restriction and that statins may be a good treatment for women with recurrent miscarriages and IUGR. ..
  51. Welsch M, Snyder S, Stockwell B. Privileged scaffolds for library design and drug discovery. Curr Opin Chem Biol. 2010;14:347-61 pubmed publisher
  52. Henchey L, Porter J, Ghosh I, Arora P. High specificity in protein recognition by hydrogen-bond-surrogate ?-helices: selective inhibition of the p53/MDM2 complex. Chembiochem. 2010;11:2104-7 pubmed publisher
  53. Piserchio A, Warthaka M, Devkota A, Kaoud T, Lee S, Abramczyk O, et al. Solution NMR insights into docking interactions involving inactive ERK2. Biochemistry. 2011;50:3660-72 pubmed publisher
    ..These results demonstrate the feasibility of solution NMR techniques for a comprehensive analysis of docking interactions in a full-length ERK/MAP kinase. ..
  54. Zhang X, Upreti C, Stanton P. G?? and the C terminus of SNAP-25 are necessary for long-term depression of transmitter release. PLoS ONE. 2011;6:e20500 pubmed publisher
    ..The C-terminus of SNAP-25, which links synaptotagmin I to the SNARE complex, is a binding target for G?? necessary for both transient transmitter-mediated presynaptic inhibition, and the induction of presynaptic LTD. ..
  55. Mincer J, Simon S. Simulations of nuclear pore transport yield mechanistic insights and quantitative predictions. Proc Natl Acad Sci U S A. 2011;108:E351-8 pubmed publisher
  56. Oikonomou G, Perens E, Lu Y, Watanabe S, Jorgensen E, Shaham S. Opposing activities of LIT-1/NLK and DAF-6/patched-related direct sensory compartment morphogenesis in C. elegans. PLoS Biol. 2011;9:e1001121 pubmed publisher
    ..Our results suggest that the opposing daf-6 and lit-1 glial pathways act together to control sensory compartment size. ..
  57. Brasch J, Harrison O, Honig B, Shapiro L. Thinking outside the cell: how cadherins drive adhesion. Trends Cell Biol. 2012;22:299-310 pubmed publisher
    ..Cadherins outside the classical subfamily appear to have evolved distinct adhesive mechanisms that are only now beginning to be understood. ..
  58. Schweikert C, Brown S, Tang Z, Smith P, Hsu D. Combining multiple ChIP-seq peak detection systems using combinatorial fusion. BMC Genomics. 2012;13 Suppl 8:S12 pubmed publisher
    ..This analysis offers an alternate approach for increasing true positive rates, while decreasing false positive rates and hence improving the ChIP-seq peak identification process. ..
  59. Hafner M, Max K, Bandaru P, Morozov P, Gerstberger S, Brown M, et al. Identification of mRNAs bound and regulated by human LIN28 proteins and molecular requirements for RNA recognition. RNA. 2013;19:613-26 pubmed publisher
  60. Xu X, Jin D, Durgan J, Hall A. LKB1 controls human bronchial epithelial morphogenesis through p114RhoGEF-dependent RhoA activation. Mol Cell Biol. 2013;33:2671-82 pubmed publisher
    ..Together, LKB1 and p114RhoGEF control RhoA activity in these cells to promote apical junction assembly. ..
  61. Chodera J, Mobley D. Entropy-enthalpy compensation: role and ramifications in biomolecular ligand recognition and design. Annu Rev Biophys. 2013;42:121-42 pubmed publisher
  62. Li J, Wang C, Wu C, Cao T, Xu G, Meng Q, et al. PKA-mediated Gli2 and Gli3 phosphorylation is inhibited by Hedgehog signaling in cilia and reduced in Talpid3 mutant. Dev Biol. 2017;429:147-157 pubmed publisher
  63. Stitt T, Conn G, Gore M, Lai C, Bruno J, Radziejewski C, et al. The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases. Cell. 1995;80:661-70 pubmed
  64. Zhu C, Johansen F, Prywes R. Interaction of ATF6 and serum response factor. Mol Cell Biol. 1997;17:4957-66 pubmed
    ..ATF6 was previously partially cloned as a member of the ATF family. The complete cDNA of ATF6 was isolated, and its expression pattern was described. ..
  65. Chen C, Li Y, Chen J, Hou M, Papadaki P, Chang E. Moe1, a conserved protein in Schizosaccharomyces pombe, interacts with a Ras effector, Scd1, to affect proper spindle formation. Proc Natl Acad Sci U S A. 1999;96:517-22 pubmed
    ..Human and nematode Moe1 both can substitute for yeast Moe1, indicating that the function of Moe1 in spindle formation has been conserved substantially during evolution. ..
  66. Miller M, Cross F. Distinct subcellular localization patterns contribute to functional specificity of the Cln2 and Cln3 cyclins of Saccharomyces cerevisiae. Mol Cell Biol. 2000;20:542-55 pubmed
    ..The data presented here support the idea that cyclin function is regulated at the level of subcellular localization and that subcellular localization contributes to the functional specificity of Cln2p and Cln3p. ..
  67. Tseng C, Tseng C. Identification of a novel secretory leukocyte protease inhibitor-binding protein involved in membrane phospholipid movement. FEBS Lett. 2000;475:232-6 pubmed
    ..Co-expression of SLPI and SLPI-BP followed by an S-protein pulldown assay confirmed the specific interaction between these two proteins. Our data represent the first report for the identity of SLPI-BP. ..
  68. Mathur M, Tucker P, Samuels H. PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors. Mol Cell Biol. 2001;21:2298-311 pubmed
  69. Perlow R, Broyde S. Toward understanding the mutagenicity of an environmental carcinogen: structural insights into nucleotide incorporation preferences. J Mol Biol. 2002;322:291-309 pubmed
    ..Structural rationalization of the incorporation preference opposite (+)-trans-anti-[BP]-N(2)-dG by T7 DNA polymerase contributes to providing a molecular explanation for mutations caused by this carcinogen-DNA adduct in a model system. ..
  70. Campbell E, Tupy J, Gruber T, Wang S, Sharp M, Gross C, et al. Crystal structure of Escherichia coli sigmaE with the cytoplasmic domain of its anti-sigma RseA. Mol Cell. 2003;11:1067-78 pubmed
    ..In combination with a model of the sigma(E) holoenzyme and biochemical data, the structure reveals that RseA functions by sterically occluding the two primary binding determinants on sigma(E) for core RNA polymerase. ..
  71. Jiang G, Giannone G, Critchley D, Fukumoto E, Sheetz M. Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin. Nature. 2003;424:334-7 pubmed
  72. Shekar S, Wu H, Fu Z, Yip S, Nagajyothi -, Cahill S, et al. Mechanism of constitutive phosphoinositide 3-kinase activation by oncogenic mutants of the p85 regulatory subunit. J Biol Chem. 2005;280:27850-5 pubmed
    ..Based on these findings, we propose a general model for oncogenic mutants of p85 and p110 in which disruption of nSH2-p110 regulatory contacts leads to constitutive p110 activity. ..
  73. Li S, Depetris R, Barford D, Chernoff J, Hubbard S. Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase. Structure. 2005;13:1643-51 pubmed
    ..The crystal structure provides evidence for a noncatalytic mode of interaction between PTP1B and IRK, which could be important for the selective recruitment of PTP1B to the insulin receptor. ..
  74. Haynes C, Oldfield C, Ji F, Klitgord N, Cusick M, Radivojac P, et al. Intrinsic disorder is a common feature of hub proteins from four eukaryotic interactomes. PLoS Comput Biol. 2006;2:e100 pubmed
    ..The results of this study demonstrate that intrinsic structural disorder is a distinctive and common characteristic of eukaryotic hub proteins, and that disorder may serve as a determinant of protein interactivity. ..
  75. Sullivan G, Ogden R, Oquendo M, Kumar J, Simpson N, Huang Y, et al. Positron emission tomography quantification of serotonin-1A receptor binding in medication-free bipolar depression. Biol Psychiatry. 2009;66:223-30 pubmed publisher
    ..The raphe effect may be partly genetic. No difference in 5-HT1A BP(F) between BD and control females may reflect greater effect of prior antidepressant exposure in BD females. ..
  76. Hoos M, Ahmed M, Smith S, Van Nostrand W. Myelin basic protein binds to and inhibits the fibrillar assembly of Abeta42 in vitro. Biochemistry. 2009;48:4720-7 pubmed publisher
    ..These findings suggest that MBP may play a role in regulating the deposition of Abeta42 and thereby also may regulate the early formation of amyloid plaques in Alzheimer's disease. ..
  77. Gottschalk R, Corse E, Allison J. TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo. J Exp Med. 2010;207:1701-11 pubmed publisher
    ..However, in the persistence of induced Foxp3(+) T cells, TCR ligand potency and density are noninterchangeable factors that influence the route to peripheral tolerance. ..
  78. Kapoor N, Gupta R, Menon S, Folta Stogniew E, Raleigh D, Sakmar T. Nucleobindin 1 is a calcium-regulated guanine nucleotide dissociation inhibitor of G{alpha}i1. J Biol Chem. 2010;285:31647-60 pubmed publisher
    ..We propose that cytoplasmic NUCB1 might function to regulate heterotrimeric G protein trafficking and G protein-coupled receptor-mediated signal transduction pathways. ..
  79. FINAN G, Okada H, Kim T. BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin. J Biol Chem. 2011;286:12602-16 pubmed publisher
    ..g. SorCs1b and SorLA), plays a unique role in BACE1 trafficking. Our studies suggest a new function for sortilin as a modulator of BACE1 retrograde trafficking and subsequent generation of A?. ..
  80. Marks S, Kalderon D. Regulation of mammalian Gli proteins by Costal 2 and PKA in Drosophila reveals Hedgehog pathway conservation. Development. 2011;138:2533-42 pubmed publisher
    ..We also show that direct PKA phosphorylation regulates the activity, rather than the proteolysis of Gli in Drosophilia, and we provide evidence for an analogous action of PKA on Ci. ..
  81. Allen G, Wu C, Cardozo T, Stokes D. The architecture of CopA from Archeaoglobus fulgidus studied by cryo-electron microscopy and computational docking. Structure. 2011;19:1219-32 pubmed publisher
  82. Logue E, Taylor K, Goff P, Landau N. The cargo-binding domain of transportin 3 is required for lentivirus nuclear import. J Virol. 2011;85:12950-61 pubmed publisher
    ..The mutated TNPO3 proteins maintained their ability to localize to the nucleus, suggesting that their inability to restore lentivirus infection resulted from an inability to bind to a host or viral cargo protein. ..
  83. Keniry M, Pires M, Mense S, Lefebvre C, Gan B, Justiano K, et al. Survival factor NFIL3 restricts FOXO-induced gene expression in cancer. Genes Dev. 2013;27:916-27 pubmed publisher
    ..Therefore, NFIL3 alters cancer cell behavior and FOXO function by acting on chromatin to restrict the menu of FOXO target genes. Targeting of NFIL3 could be of therapeutic benefit for cancer patients. ..
  84. Chaari A, Eliezer D, Ladjimi M. The C-terminal α-helices of mammalian Hsc70 play a critical role in the stabilization of α-synuclein binding and inhibition of aggregation. Int J Biol Macromol. 2016;83:433-41 pubmed publisher
    ..Together these results suggest a mechanism in which inhibition of synuclein aggregation is the result of monomeric synuclein binding to the chaperone as any monomeric target unfolded protein or peptide binding to the chaperone. ..
  85. Whyte P, Williamson N, Harlow E. Cellular targets for transformation by the adenovirus E1A proteins. Cell. 1989;56:67-75 pubmed
    ..These results suggest that the interactions with these cellular proteins are fundamental to the transforming activity of E1A. ..
  86. Yussa M, Löhr U, Su K, Pick L. The nuclear receptor Ftz-F1 and homeodomain protein Ftz interact through evolutionarily conserved protein domains. Mech Dev. 2001;107:39-53 pubmed
    ..Ftz, on the other hand, influences Ftz-F1 activity by interacting with its AF-2 domain in a manner that mimics a nuclear receptor coactivator. ..
  87. Shi H, Xu R. Crystal structure of the Drosophila Mago nashi-Y14 complex. Genes Dev. 2003;17:971-6 pubmed
    ..This unexpected finding provides important insights for understanding the molecular mechanisms of EJC assembly and RRM-mediated protein-protein interactions. ..
  88. Pilloff D, Leyh T. Allosteric and catalytic functions of the PPi-binding motif in the ATP sulfurylase-GTPase system. J Biol Chem. 2003;278:50435-41 pubmed
  89. Kouchi Z, Barthet G, Serban G, Georgakopoulos A, Shioi J, Robakis N. p120 catenin recruits cadherins to gamma-secretase and inhibits production of Abeta peptide. J Biol Chem. 2009;284:1954-61 pubmed publisher
    ..Furthermore, our data suggest that specific members of the gamma-secretase complex may be used to recruit different substrates and that distinct PS1 sequences are required for processing of APP and cadherins. ..
  90. Zhou Z, Zhen J, Karpowich N, Law C, Reith M, Wang D. Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures. Nat Struct Mol Biol. 2009;16:652-7 pubmed publisher
    ..Thus, the specificity of SERT for SSRIs is dependent largely on interaction of the drug halogens with the protein's HBP...
  91. Aik W, Lin M, Tan D, Tripathy A, Marzluff W, Dominski Z, et al. The N-terminal domains of FLASH and Lsm11 form a 2:1 heterotrimer for histone pre-mRNA 3'-end processing. PLoS ONE. 2017;12:e0186034 pubmed publisher
    ..Using solution light scattering, we characterized the stoichiometry of the FLASH NTD-Lsm11 NTD complex and found that it is a 2:1 heterotrimer, which is supported by observations from analytical ultracentrifugation and crosslinking. ..
  92. Mandic Mulec I, Doukhan L, Smith I. The Bacillus subtilis SinR protein is a repressor of the key sporulation gene spo0A. J Bacteriol. 1995;177:4619-27 pubmed
    ..Finally, we present evidence that SinR controls sporulation through several independent genes, i.e., sp0A, spoIIA, and possibly spoIIG and spoIIE. ..