Experts and Doctors on polynucleotide adenylyltransferase in New York, United States


Locale: New York, United States
Topic: polynucleotide adenylyltransferase

Top Publications

  1. Briggs M, Butler J. RNA polymerase III defects suppress a conditional-lethal poly(A) polymerase mutation in Saccharomyces cerevisiae. Genetics. 1996;143:1149-61 pubmed
    ..Suppression of pap1-1 by mutations in an RNA polymerase III subunit suggests a number of potentially novel interactions between these enzymes. ..
  2. Murthy K, Manley J. The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation. Genes Dev. 1995;9:2672-83 pubmed
    ..We discuss the significance of these multiple functions and also a possible evolutionary link between yeast and mammalian polyadenylation suggested by the properties and sequence of 160K. ..
  3. Zhao W, Manley J. Complex alternative RNA processing generates an unexpected diversity of poly(A) polymerase isoforms. Mol Cell Biol. 1996;16:2378-86 pubmed
    ..Purified recombinant baculovirus-expressed PAPs were tested in several in vitro assays, and the short forms were found to be inactive. We discuss the possible significance of this complex expression pattern. ..
  4. Backes S, Shapiro J, Sabin L, Pham A, Reyes I, Moss B, et al. Degradation of host microRNAs by poxvirus poly(A) polymerase reveals terminal RNA methylation as a protective antiviral mechanism. Cell Host Microbe. 2012;12:200-10 pubmed publisher
    ..These findings suggest that poxviruses may degrade host miRNAs to promote replication and that virus-mediated small RNA degradation likely contributed to 2'OMe evolution. ..
  5. Di Giammartino D, Shi Y, Manley J. PARP1 represses PAP and inhibits polyadenylation during heat shock. Mol Cell. 2013;49:7-17 pubmed publisher
    ..Our results provide direct evidence that PARylation can control processing of mRNA precursors, and also identify PARP1 as a regulator of polyadenylation during thermal stress. ..