Experts and Doctors on phosphorylation in California, United States

Summary

Locale: California, United States
Topic: phosphorylation

Top Publications

  1. Vuori K, Hirai H, Aizawa S, Ruoslahti E. Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases. Mol Cell Biol. 1996;16:2606-13 pubmed
    ..These observations suggest that Cas serves as a docking protein and may transduce signals to downstream signaling pathways following integrin-mediated cell adhesion. ..
  2. Wang H, Rapp U, Reed J. Bcl-2 targets the protein kinase Raf-1 to mitochondria. Cell. 1996;87:629-38 pubmed
    ..Bcl-2 can therefore target Raf-1 to mitochondrial membranes, allowing this kinase to phosphorylate BAD or possibly other protein substrates involved in apoptosis regulation. ..
  3. Fisher A, Ferrario A, Rucker N, Zhang S, Gomer C. Photodynamic therapy sensitivity is not altered in human tumor cells after abrogation of p53 function. Cancer Res. 1999;59:331-5 pubmed
    ..These results indicate that p53 expression does not directly modulate tumor cell sensitivity to PDT in either apoptosis-responsive (LS513) or nonresponsive (MCF-7) cells. ..
  4. Tan S, Somia N, Maher P, Schubert D. Regulation of antioxidant metabolism by translation initiation factor 2alpha. J Cell Biol. 2001;152:997-1006 pubmed
  5. Chen E, Mazure N, Cooper J, Giaccia A. Hypoxia activates a platelet-derived growth factor receptor/phosphatidylinositol 3-kinase/Akt pathway that results in glycogen synthase kinase-3 inactivation. Cancer Res. 2001;61:2429-33 pubmed
    ..In conclusion, we propose that hypoxia activates a growth factor receptor/PI 3-K/Akt cascade that leads to GSK-3 inactivation, a pathway that can impact cell survival, proliferation, and metabolism. ..
  6. Foletti D, Blitzer J, Scheller R. Physiological modulation of rabphilin phosphorylation. J Neurosci. 2001;21:5473-83 pubmed
  7. Kasirer Friede A, Ware J, Leng L, Marchese P, Ruggeri Z, Shattil S. Lateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha IIbbeta 3. J Biol Chem. 2002;277:11949-56 pubmed
    ..By extrapolation, GP Ib-IX clustering in platelets may promote thrombus formation. ..
  8. Irie F, Yamaguchi Y. EphB receptors regulate dendritic spine development via intersectin, Cdc42 and N-WASP. Nat Neurosci. 2002;5:1117-8 pubmed
  9. Hayashi T, Saito A, Okuno S, Ferrand Drake M, Chan P. Induction of GRP78 by ischemic preconditioning reduces endoplasmic reticulum stress and prevents delayed neuronal cell death. J Cereb Blood Flow Metab. 2003;23:949-61 pubmed
    ..Immunoprecipitation and double staining demonstrated involvement of GRP78 in prevention of PERK phosphorylation. These results suggest that GRP78 induced by preconditioning may reduce ER stress and eventual DND after ischemia. ..

More Information

Publications246 found, 100 shown here

  1. Brar B, Chen A, Perrin M, Vale W. Specificity and regulation of extracellularly regulated kinase1/2 phosphorylation through corticotropin-releasing factor (CRF) receptors 1 and 2beta by the CRF/urocortin family of peptides. Endocrinology. 2004;145:1718-29 pubmed
    ..Based on the data in this study, we present putative signaling pathways by which the CRF/Ucn family of peptides activate ERK1/2-p42, 44 by CRFRs. ..
  2. Okram B, Nagle A, Adrian F, Lee C, Ren P, Wang X, et al. A general strategy for creating "inactive-conformation" abl inhibitors. Chem Biol. 2006;13:779-86 pubmed
    ..We demonstrate that the designed compounds function as type II inhibitors by using biochemical and cellular kinase assays and by cocrystallography with Abl. ..
  3. Dentin R, Liu Y, Koo S, Hedrick S, Vargas T, Heredia J, et al. Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. Nature. 2007;449:366-9 pubmed
    ..Because TORC2 protein levels and activity were increased in diabetes owing to a block in TORC2 phosphorylation, our results point to an important role for this pathway in the maintenance of glucose homeostasis. ..
  4. Haudenschild D, Chen J, Pang N, Lotz M, D Lima D. Rho kinase-dependent activation of SOX9 in chondrocytes. Arthritis Rheum. 2010;62:191-200 pubmed publisher
    ..These results demonstrate a new interaction that directly links ROCK to increased cartilage matrix production via activation of SOX9 in response to mechanical and growth factor stimulation. ..
  5. Yeh T, Ogawa W, Danielsen A, Roth R. Characterization and cloning of a 58/53-kDa substrate of the insulin receptor tyrosine kinase. J Biol Chem. 1996;271:2921-8 pubmed
    ..This sequence was utilized to isolate a cDNA clone that encodes a previously uncharacterized 53-kDa protein which, when expressed in mammalian cells, is tyrosine phosphorylated by the insulin receptor. ..
  6. Gao T, Newton A. The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C. J Biol Chem. 2002;277:31585-92 pubmed
    ..Disruption of this interaction prevents re-phosphorylation and targets the enzyme for down-regulation. ..
  7. Man A, Young L, Tynan J, Lesperance J, Egeblad M, Werb Z, et al. Ets2-dependent stromal regulation of mouse mammary tumors. Mol Cell Biol. 2003;23:8614-25 pubmed
  8. Barbero S, Barilà D, Mielgo A, Stagni V, Clair K, Stupack D. Identification of a critical tyrosine residue in caspase 8 that promotes cell migration. J Biol Chem. 2008;283:13031-4 pubmed publisher
    ..The results identify a novel mechanism by which caspase 8 is recruited to the lamella of a migrating cell, promoting cell migration independent of its protease activity. ..
  9. Steichen J, Kuchinskas M, Keshwani M, Yang J, Adams J, Taylor S. Structural basis for the regulation of protein kinase A by activation loop phosphorylation. J Biol Chem. 2012;287:14672-80 pubmed publisher
    ..These alterations are reflected in a 20-fold decrease in the apparent phosphoryl transfer rate as measured by pre-steady-state kinetic methods. ..
  10. Foisner R, Gerace L. Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation. Cell. 1993;73:1267-79 pubmed
    ..Together, these data suggest that LAP 2 may have a key role in initial events of nuclear envelope reassembly, and that both LAP 2 and LAP 1 may be involved in attaching lamins to the nuclear envelope. ..
  11. Greene N, Williams D, Newton A. Identification of protein kinase C phosphorylation sites on bovine rhodopsin. J Biol Chem. 1997;272:10341-4 pubmed
    ..Identification of Ser334 as a primary protein kinase C target in vitro is consistent with protein kinase C modulating the phosphorylation of this site in vivo. ..
  12. Liu E, Li X, Yan F, Zhao Q, Wu X. Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation. J Biol Chem. 2004;279:17283-8 pubmed
    ..These data suggest that cyclin/Cdk-mediated Cdt1 phosphorylation is required for the association of Cdt1 with the SCF(Skp2) ubiquitin ligase and thus is important for the cell cycle dependent degradation of Cdt1 in mammalian cells. ..
  13. Hayashi M, Fearns C, Eliceiri B, Yang Y, Lee J. Big mitogen-activated protein kinase 1/extracellular signal-regulated kinase 5 signaling pathway is essential for tumor-associated angiogenesis. Cancer Res. 2005;65:7699-706 pubmed
  14. Rieg T, Tang T, Uchida S, Hammond H, Fenton R, Vallon V. Adenylyl cyclase 6 enhances NKCC2 expression and mediates vasopressin-induced phosphorylation of NKCC2 and NCC. Am J Pathol. 2013;182:96-106 pubmed publisher
    ..Renal AC6 determines total NKCC2 expression and mediates vasopressin-induced NKCC2/NCC phosphorylation. These regulatory mechanisms, which are defective in AC knockout mice, are likely responsible for the observed mild Bartter syndrome. ..
  15. Marquez Lona E, Torres Machorro A, Gonzales F, Pillus L, Patrick G. Phosphorylation of the 19S regulatory particle ATPase subunit, Rpt6, modifies susceptibility to proteotoxic stress and protein aggregation. PLoS ONE. 2017;12:e0179893 pubmed publisher
    ..Together, these data suggest that Rpt6 phosphorylation at S119 may play an important function in proteasome-dependent relief of proteotoxic stress that can be critical in protein aggregation pathologies. ..
  16. Lin K, Moroishi T, Meng Z, Jeong H, Plouffe S, Sekido Y, et al. Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation. Nat Cell Biol. 2017;19:996-1002 pubmed publisher
    ..Our data reveal a mechanism governing TEAD nucleocytoplasmic shuttling and show that TEAD localization is a critical determinant of Hippo signalling output. ..
  17. De Jong R, ten Hoeve J, Heisterkamp N, Groffen J. Crkl is complexed with tyrosine-phosphorylated Cbl in Ph-positive leukemia. J Biol Chem. 1995;270:21468-71 pubmed
    ..These findings suggest the existence of a trimolecular complex involving Bcr/Abl, Crkl, and Cbl and are consistent with a model in which Crkl mediates the oncogenic signal of Bcr/Abl to Cbl. ..
  18. ten Hoeve J, Kaartinen V, Fioretos T, Haataja L, Voncken J, Heisterkamp N, et al. Cellular interactions of CRKL, and SH2-SH3 adaptor protein. Cancer Res. 1994;54:2563-7 pubmed
    ..In addition, the nucleotide exchange factor mSOS1 was found to be coimmunoprecipitated with CRKL. These findings establish a putative signal transduction pathway way through which BCR/ABL mediates its oncogenic activity. ..
  19. Ojaniemi M, Vuori K. Epidermal growth factor modulates tyrosine phosphorylation of p130Cas. Involvement of phosphatidylinositol 3'-kinase and actin cytoskeleton. J Biol Chem. 1997;272:25993-8 pubmed
    ..These results demonstrate a novel signaling role for EGF in inducing changes in tyrosine phosphorylation of Cas and Cas-Crk complex formation and suggest that Cas could be a signaling component in EGF-mediated signal transduction. ..
  20. Stehlik C, Hayashi H, Pio F, Godzik A, Reed J. CARD6 is a modulator of NF-kappa B activation by Nod1- and Cardiak-mediated pathways. J Biol Chem. 2003;278:31941-9 pubmed
    ..Thus, CARD6 represents a selective modulator of NF-kappa B activation by Cardiak and Nod1, adding to the repertoire of CARD-family proteins implicated in inflammatory responses and innate immunity. ..
  21. Boddy M, Shanahan P, McDonald W, Lopez Girona A, Noguchi E, Yates III J, et al. Replication checkpoint kinase Cds1 regulates recombinational repair protein Rad60. Mol Cell Biol. 2003;23:5939-46 pubmed
    ..These studies indicate that regulation of Rad60 is an important part of the replication checkpoint response controlled by Cds1. We propose that control of Rad60 regulates recombination events at stalled forks. ..
  22. Zhang Y, Kim Y, Genoud N, Gao J, Kelly J, Pfaff S, et al. Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1. Mol Cell. 2006;24:759-770 pubmed publisher
    ..Ser5 of the CTD heptad repeat. Moreover, these results provide a template for the design of specific inhibitors of Scp1 for the study of neuronal stem cell development. ..
  23. North B, Verdin E. Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation. J Biol Chem. 2007;282:19546-55 pubmed
    ..Overexpression of SIRT2 mediates a delay in cellular proliferation that is dependent on serine 368 phosphorylation. Furthermore, mutation of serine 368 reduces hyperploidy in cells under mitotic stress due to microtubule poisons. ..
  24. Tseng P, Matsuzawa A, Zhang W, Mino T, Vignali D, Karin M. Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines. Nat Immunol. 2010;11:70-5 pubmed publisher
    ..Inhibition of degradative ubiquitination of TRAF3 prevented the expression of all proinflammatory cytokines without affecting the interferon response. ..
  25. Jarchow Choy S, Sjuvarsson E, Sintim H, Eriksson S, Kool E. Nonpolar nucleoside mimics as active substrates for human thymidine kinases. J Am Chem Soc. 2009;131:5488-94 pubmed publisher
    ..On the basis of these data, nonpolar nucleosides are likely to be active in the nucleotide salvage pathway in human cells, suggesting new designs for future bioactive molecules. ..
  26. Rodionova I, Yang C, Li X, Kurnasov O, Best A, Osterman A, et al. Diversity and versatility of the Thermotoga maritima sugar kinome. J Bacteriol. 2012;194:5552-63 pubmed
    ..Use of the integrated genomic and experimental approach greatly speeds up the identification of the biochemical function of unknown proteins and improves the quality of reconstructed pathways. ..
  27. Zang S, Li J, Yang H, Zeng H, Han W, Zhang J, et al. Mutations in 5-methylcytosine oxidase TET2 and RhoA cooperatively disrupt T cell homeostasis. J Clin Invest. 2017;127:2998-3012 pubmed publisher
    ..Our findings suggest a mutational cooperativity between epigenetic factors and GTPases in adult CD4+ T cells that may account for immunoinflammatory responses associated with AITL patients. ..
  28. Barker P, Lomen Hoerth C, Gensch E, Meakin S, Glass D, Shooter E. Tissue-specific alternative splicing generates two isoforms of the trkA receptor. J Biol Chem. 1993;268:15150-7 pubmed
    ..In rats and humans, trkAII is the only isoform expressed within neuronal tissues at appreciable levels whereas trkAI, the form of trkA originally cloned, appears to be expressed mainly in non-neuronal tissues. ..
  29. Charbit A, Reizer J, Saier M. Function of the duplicated IIB domain and oligomeric structure of the fructose permease of Escherichia coli. J Biol Chem. 1996;271:9997-10003 pubmed
  30. Sette C, Conti M. Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation. J Biol Chem. 1996;271:16526-34 pubmed
    ..These findings support the hypothesis that the PDE4D3 variant contains a regulatory domain target for phosphorylation at the amino terminus of the protein and that Ser54 in this domain plays a crucial role in activation. ..
  31. Schlaepfer D, Broome M, Hunter T. Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins. Mol Cell Biol. 1997;17:1702-13 pubmed
    ..These results show that there are additional FN-stimulated pathways to ERK2 that do not involve Grb2 binding to FAK. ..
  32. Livnah O, Johnson D, Stura E, Farrell F, Barbone F, You Y, et al. An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation. Nat Struct Biol. 1998;5:993-1004 pubmed
  33. Colanzi A, Deerinck T, Ellisman M, Malhotra V. A specific activation of the mitogen-activated protein kinase kinase 1 (MEK1) is required for Golgi fragmentation during mitosis. J Cell Biol. 2000;149:331-9 pubmed
    ..These fragments are similar in distribution, morphology, and size to the fragments observed in the prometaphase/metaphase stage of the cell cycle in vivo. ..
  34. Garber M, Mayall T, Suess E, Meisenhelder J, Thompson N, Jones K. CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA. Mol Cell Biol. 2000;20:6958-69 pubmed
    ..Taken together, these results demonstrate that CDK9 phosphorylation is required for high-affinity binding of Tat-P-TEFb to TAR RNA and that the state of P-TEFb phosphorylation may regulate Tat transactivation in vivo. ..
  35. Garcia Guzman M, Larsen E, Vuori K. The proto-oncogene c-Cbl is a positive regulator of Met-induced MAP kinase activation: a role for the adaptor protein Crk. Oncogene. 2000;19:4058-65 pubmed
    ..Oncogene (2000) 19, 4058 - 4065. ..
  36. Hayashi M, Tapping R, Chao T, Lo J, King C, Yang Y, et al. BMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase. J Biol Chem. 2001;276:8631-4 pubmed
    ..This BMK1-mediated phosphorylation event is necessary for the activation of SGK and, more importantly, for cell proliferation induced by growth factors. ..
  37. Bayer K, De Koninck P, Leonard A, Hell J, Schulman H. Interaction with the NMDA receptor locks CaMKII in an active conformation. Nature. 2001;411:801-5 pubmed
    ..Furthermore, the interaction leads to trapping of CaM that may reduce down-regulation of NMDA receptor activity. CaMKII-NR2B interaction may be prototypical for direct activation of a kinase by its targeting protein. ..
  38. Chang B, Harte R, Cartwright C. RACK1: a novel substrate for the Src protein-tyrosine kinase. Oncogene. 2002;21:7619-29 pubmed
    ..We think that RACK1 is an important Src substrate that signals downstream of growth factor receptor tyrosine kinases and is involved in the regulation of Src function and cell growth. ..
  39. Greene M, Sakaue H, Wang L, Alessi D, Roth R. Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation. J Biol Chem. 2003;278:8199-211 pubmed
    ..In summary, our results indicate that the insulin-stimulated degradation of IRS-1 via the phosphatidylinositol 3-kinase pathway is in part dependent upon the Ser(312) phosphorylation of IRS-1. ..
  40. Han J, Rose D, Woodside D, Goldfinger L, Ginsberg M. Integrin alpha 4 beta 1-dependent T cell migration requires both phosphorylation and dephosphorylation of the alpha 4 cytoplasmic domain to regulate the reversible binding of paxillin. J Biol Chem. 2003;278:34845-53 pubmed
    ..These data establish that optimal alpha 4-mediated cell migration requires both phosphorylation and dephosphorylation of the alpha 4 cytoplasmic domain to regulate the reversible binding of paxillin. ..
  41. Sanna M, Liao J, Jo E, Alfonso C, Ahn M, Peterson M, et al. Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. J Biol Chem. 2004;279:13839-48 pubmed
  42. Spangenburg E. SOCS-3 induces myoblast differentiation. J Biol Chem. 2005;280:10749-58 pubmed
    ..These data suggest that IGF-I induces myoblast differentiation, in part, by increasing SOCS-3 expression. ..
  43. Lawrence T, Bebien M, Liu G, Nizet V, Karin M. IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation. Nature. 2005;434:1138-43 pubmed
    ..Inactivation of IKKalpha in mice enhances inflammation and bacterial clearance. Hence, the two IKK catalytic subunits have evolved opposing but complimentary roles needed for the intricate control of inflammation and innate immunity. ..
  44. Copp J, Manning G, Hunter T. TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2. Cancer Res. 2009;69:1821-7 pubmed publisher
    ..Thus, phospho-S2481 on mTOR serves as a biomarker for intact mTORC2 and its sensitivity to rapamycin. ..
  45. Fonslow B, Kang S, Gestaut D, Graczyk B, Davis T, Sabatini D, et al. Native capillary isoelectric focusing for the separation of protein complex isoforms and subcomplexes. Anal Chem. 2010;82:6643-51 pubmed publisher
  46. Lee A, Chiba T, Truong L, Cheng A, Do J, Cho M, et al. Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint. J Biol Chem. 2012;287:2531-43 pubmed publisher
    ..These studies indicate that DDK is a direct substrate of ATM and ATR to mediate the intra-S-phase checkpoint in mammalian cells. ..
  47. Ferreira J, Bôer B, Grinberg M, Brum P, Mochly Rosen D. Protein quality control disruption by PKC?II in heart failure; rescue by the selective PKC?II inhibitor, ?IIV5-3. PLoS ONE. 2012;7:e33175 pubmed publisher
    ..PQC disruption by increased PKC?II activity in vivo appears to contribute to the pathophysiology of heart failure, suggesting that PKC?II inhibition may benefit patients with heart failure. (218 words). ..
  48. Kuruganti S, Miersch S, Deshpande A, Speir J, Harris B, Schriewer J, et al. Cytokine Activation by Antibody Fragments Targeted to Cytokine-Receptor Signaling Complexes. J Biol Chem. 2016;291:447-61 pubmed publisher
    ..This suggests AcCS can be used to manipulate cytokine signaling for basic science and possibly for therapeutic applications. ..
  49. Tobias I, Newton A. Protein Scaffolds Control Localized Protein Kinase C? Activity. J Biol Chem. 2016;291:13809-22 pubmed publisher
  50. Kudo T, Jeknic S, Macklin D, Akhter S, Hughey J, Regot S, et al. Live-cell measurements of kinase activity in single cells using translocation reporters. Nat Protoc. 2018;13:155-169 pubmed publisher
    ..We provide detailed guidance for a computational analysis and parameterization pipeline. The entire procedure, from virus production to data analysis, can be completed in ∼10 d. ..
  51. Allard J, Herbst R, Carroll P, Simon M. Mutational analysis of the SRC homology 2 domain protein-tyrosine phosphatase Corkscrew. J Biol Chem. 1998;273:13129-35 pubmed
    ..In addition, we found that deletion of either the CSW protein- tyrosine phosphatase insert or the entire CSW carboxyl terminus, which includes a conserved DRK/GRB2 SH2 domain binding sequence, does not abolish CSW function. ..
  52. Potter L, Hunter T. Identification and characterization of the major phosphorylation sites of the B-type natriuretic peptide receptor. J Biol Chem. 1998;273:15533-9 pubmed
    ..These data indicate that phosphorylation of the kinase homology domain is a critical event in the regulation of NPR-B. ..
  53. Le N, Simon M. Disabled is a putative adaptor protein that functions during signaling by the sevenless receptor tyrosine kinase. Mol Cell Biol. 1998;18:4844-54 pubmed
    ..Taken together, these results indicate that DAB is a novel component of the SEV signaling pathway. ..
  54. Liu S, Thomas S, Woodside D, Rose D, Kiosses W, Pfaff M, et al. Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses. Nature. 1999;402:676-81 pubmed
    ..Thus, the tight association of paxillin with the alpha4 tail leads to distinct biochemical and biological responses to integrin-mediated cell adhesion. ..
  55. Chang B, Chiang M, Cartwright C. The interaction of Src and RACK1 is enhanced by activation of protein kinase C and tyrosine phosphorylation of RACK1. J Biol Chem. 2001;276:20346-56 pubmed
    ..We think that tyrosine phosphorylation of these proteins is an important mechanism of signal transduction in cells. ..
  56. Chiang G, Sefton B. Specific dephosphorylation of the Lck tyrosine protein kinase at Tyr-394 by the SHP-1 protein-tyrosine phosphatase. J Biol Chem. 2001;276:23173-8 pubmed
    ..The failure of SHP-1 to inactivate Lck may contribute to some of the lymphoid abnormalities observed in motheaten mice. ..
  57. Maslyar D, Aoki M, Vogt P. The growth-promoting activity of the Bad protein in chicken embryo fibroblasts requires binding to protein 14-3-3. Oncogene. 2001;20:5087-92 pubmed
    ..These results suggest that phosphorylated Bad promotes cell growth and in oncogenic transformation may contribute to the neoplastic phenotype of the cell. ..
  58. Brandt S, Mariani R, Holland A, Hope T, Landau N. Association of chemokine-mediated block to HIV entry with coreceptor internalization. J Biol Chem. 2002;277:17291-9 pubmed
    ..Last, M7-CCR5 is a useful tool for discriminating coreceptor internalization from binding site masking in the evaluation of small molecule inhibitors of HIV-1 entry. ..
  59. Fryer C, Lamar E, Turbachova I, Kintner C, Jones K. Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex. Genes Dev. 2002;16:1397-411 pubmed
    ..Thus MAM may function as a timer to couple transcription activation with disassembly of the Notch enhancer complex on chromatin. ..
  60. Nanjundan M, Sun J, Zhao J, Zhou Q, Sims P, Wiedmer T. Plasma membrane phospholipid scramblase 1 promotes EGF-dependent activation of c-Src through the epidermal growth factor receptor. J Biol Chem. 2003;278:37413-8 pubmed
    ..We propose that PLSCR1, through its interaction with Shc, promotes Src kinase activation through the EGF receptor. ..
  61. Ahamed J, Ruf W. Protease-activated receptor 2-dependent phosphorylation of the tissue factor cytoplasmic domain. J Biol Chem. 2004;279:23038-44 pubmed
    ..Thus, PAR2 signaling specifically phosphorylates TF in a receptor cross-talk that distinguishes upstream from downstream coagulation protease signaling. ..
  62. Wang S, Jones K. CK2 controls the recruitment of Wnt regulators to target genes in vivo. Curr Biol. 2006;16:2239-44 pubmed
    ..Taken together, these data indicate that CK2 is required for the assembly and cycling of Wnt-enhancer complexes in vivo. ..
  63. Wang J, Carnicella S, Phamluong K, Jeanblanc J, Ronesi J, Chaudhri N, et al. Ethanol induces long-term facilitation of NR2B-NMDA receptor activity in the dorsal striatum: implications for alcohol drinking behavior. J Neurosci. 2007;27:3593-602 pubmed
  64. Kai M, Furuya K, Paderi F, Carr A, Wang T. Rad3-dependent phosphorylation of the checkpoint clamp regulates repair-pathway choice. Nat Cell Biol. 2007;9:691-7 pubmed
    ..Our findings reveal a new mechanism by which phosphorylation of Rad9 at Thr 225 regulates the choice of repair pathways for maintaining genomic integrity during the cell cycle. ..
  65. Humke E, Dorn K, Milenkovic L, Scott M, Rohatgi R. The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. Genes Dev. 2010;24:670-82 pubmed publisher
    ..We propose that the Sufu-Gli3 interaction is a major control point in the Hedgehog pathway, a pathway that plays important roles in both development and cancer. ..
  66. Gutierrez G, Tsuji T, Chen M, Jiang W, Ronai Z. Interplay between Cdh1 and JNK activity during the cell cycle. Nat Cell Biol. 2010;12:686-95 pubmed publisher
    ..This regulatory mechanism between JNK and Cdh1 reveals an important function for JNK during the cell cycle. ..
  67. Paniagua R, Fiorentino D, Chung L, Robinson W. Tyrosine kinases in inflammatory dermatologic disease. J Am Acad Dermatol. 2011;65:389-403 pubmed publisher
    ..In this review, we highlight TK signaling implicated in inflammatory dermatologic diseases, evaluate strategies aimed at inhibiting these aberrant signaling pathways, and discuss prospects for future drug development. ..
  68. Sierecki E, Sinko W, McCammon J, Newton A. Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening. J Med Chem. 2010;53:6899-911 pubmed publisher
    ..Thus, chemical and virtual screening has resulted in the identification of small molecules that promote Akt signaling by inhibiting its negative regulator PHLPP. ..
  69. Wu Zhang A, Schramm C, Nabavi S, Malinow R, Newton A. Cellular pharmacology of protein kinase M? (PKM?) contrasts with its in vitro profile: implications for PKM? as a mediator of memory. J Biol Chem. 2012;287:12879-85 pubmed publisher
  70. Russell R, Tian Y, Yuan H, Park H, Chang Y, Kim J, et al. ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. Nat Cell Biol. 2013;15:741-50 pubmed publisher
    ..Our study reveals a molecular link from ULK1 to activation of the autophagy-specific VPS34 complex and autophagy induction. ..
  71. Roberts D, Tan Sah V, Smith J, Miyamoto S. Akt phosphorylates HK-II at Thr-473 and increases mitochondrial HK-II association to protect cardiomyocytes. J Biol Chem. 2013;288:23798-806 pubmed publisher
    ..This increase is, at least in part, due to the decreased sensitivity to G-6P-induced dissociation. Thus, phosphorylation-mediated regulation of mitochondrial HK-II would be a critical component of the protective effect of Akt. ..
  72. Reddy P, Deguchi M, Cheng Y, Hsueh A. Actin cytoskeleton regulates Hippo signaling. PLoS ONE. 2013;8:e73763 pubmed publisher
    ..In summary, using an actin-stabilizing drug we show that actin cytoskeleton is one of the upstream regulators of Hippo signaling capable of activating YAP and increasing its downstream CCN growth factors. ..
  73. Koong A, Chen E, Giaccia A. Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues. Cancer Res. 1994;54:1425-30 pubmed
    ..These results suggest that tyrosine phosphorylation of I kappa B alpha during hypoxia is an important proximal step which precedes its dissociation and degradation from NF-kappa B. ..
  74. Yamada N, Kawakami Y, Kimura H, Fukamachi H, Baier G, Altman A, et al. Structure and expression of novel protein-tyrosine kinases, Emb and Emt, in hematopoietic cells. Biochem Biophys Res Commun. 1993;192:231-40 pubmed
    ..6-kb mRNA in mast cells, myeloid cells and T lymphocytes. The evidence for in vitro tyrosine kinase activity of Emb and Emt proteins is also provided. ..
  75. Couture C, Songyang Z, Jascur T, Williams S, Tailor P, Cantley L, et al. Regulation of the Lck SH2 domain by tyrosine phosphorylation. J Biol Chem. 1996;271:24880-4 pubmed
    ..This represents a novel mechanism for the regulation of the function of SH2 domains. ..
  76. Kanoh J, Russell P. The protein kinase Cdr2, related to Nim1/Cdr1 mitotic inducer, regulates the onset of mitosis in fission yeast. Mol Biol Cell. 1998;9:3321-34 pubmed
    ..Thus, Cdr2 is a novel mitotic control protein that appears to regulate Wee1...
  77. Reilly J, Mickey G, Maher P. Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner. J Biol Chem. 2000;275:7771-8 pubmed
    ..These data demonstrate an interaction between activated FGFR1 and Grb14 and suggest a role for Grb14 in FGF signaling. ..
  78. Chen P, Luo C, Deng Y, Ryan K, Register J, Margosiak S, et al. The 1.7 A crystal structure of human cell cycle checkpoint kinase Chk1: implications for Chk1 regulation. Cell. 2000;100:681-92 pubmed
    ..In addition, we found that the less conserved C-terminal region negatively impacts Chk1 kinase activity. ..
  79. Li E, Stupack D, Brown S, Klemke R, Schlaepfer D, Nemerow G. Association of p130CAS with phosphatidylinositol-3-OH kinase mediates adenovirus cell entry. J Biol Chem. 2000;275:14729-35 pubmed
    ..These studies reveal the molecular basis by which p130(CAS) coordinates the signaling pathways involved in integrin-mediated Ad endocytosis. ..
  80. Friedrichsen D, Joazeiro C, Li J, Hunter T, Chory J. Brassinosteroid-insensitive-1 is a ubiquitously expressed leucine-rich repeat receptor serine/threonine kinase. Plant Physiol. 2000;123:1247-56 pubmed
    ..Therefore, we conclude that BRI1 is a ubiquitously expressed leucine-rich repeat receptor that plays a role in BR signaling through Ser/Thr phosphorylation. ..
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