Genomes and Genes
Experts and Doctors on phospholipids in New York, United States
Locale: New York, United States
- Briley Saebo K, Shaw P, Mulder W, Choi S, Vucic E, Aguinaldo J, et al. Targeted molecular probes for imaging atherosclerotic lesions with magnetic resonance using antibodies that recognize oxidation-specific epitopes. Circulation. 2008;117:3206-15 pubmed publisher..Magnetic resonance imaging with micelles containing gadolinium and oxidation-specific antibodies demonstrates specific targeting and excellent image quality of oxidation-rich atherosclerotic lesions. ..
- Valiyaveetil F, Zhou Y, MacKinnon R. Lipids in the structure, folding, and function of the KcsA K+ channel. Biochemistry. 2002;41:10771-7 pubmed..We confirm that the presence of negatively charged lipids is required for ion conduction through the KcsA potassium channel, suggesting that the lipid bound to KcsA is important for ion channel function. ..
- Schlame M. Formation of molecular species of mitochondrial cardiolipin 2. A mathematical model of pattern formation by phospholipid transacylation. Biochim Biophys Acta. 2009;1791:321-5 pubmed publisher..It is concluded that acyl-specific cardiolipin patterns could arise from phospholipid transacylations in the tafazzin domain, even if tafazzin itself does not have substrate specificity. ..
- Swanson E, Mohan V, Kheir J, Borden M. Phospholipid-stabilized microbubble foam for injectable oxygen delivery. Langmuir. 2010;26:15726-9 pubmed publisher..Injection into an undersaturated solution led to the immediate release of the oxygen gas core. Injectable gas delivery by OMBs may find use in a variety of medical and industrial fields. ..
- Tsuji M. Glycolipids and phospholipids as natural CD1d-binding NKT cell ligands. Cell Mol Life Sci. 2006;63:1889-98 pubmed..This review is intended to list natural NKT cell ligands identified to date, and discuss how their structures relate to their propensity to bind CD1d molecules and, as a consequence, stimulate NKT cells. ..
- Sublette M, Hibbeln J, Galfalvy H, Oquendo M, Mann J. Omega-3 polyunsaturated essential fatty acid status as a predictor of future suicide risk. Am J Psychiatry. 2006;163:1100-2 pubmed..If confirmed, this finding would have implications for the neurobiology of suicide and reduction of suicide risk. ..
- Jenco J, Rawlingson A, Daniels B, Morris A. Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins. Biochemistry. 1998;37:4901-9 pubmed..Our findings suggest that inhibition of PLD2 may be a function of synucleins. Modulation of PLD2 activity by synucleins may play a role in some aspects of the pathophysiologies that characterize these neurodegenerative diseases. ..
- Mailloux B, Dochenetz A, Bishop M, Dong H, Ziolkowski L, Wommack K, et al. A carbon free filter for collection of large volume samples of cellular biomass from oligotrophic waters. J Microbiol Methods. 2012;90:145-51 pubmed publisher..In summary, we have developed a filter that is easy to use and deploy for collection of biomass for CSRA including total and individual PLFAs. ..
- Qian C, Zhang Q, Wang X, Zeng L, Farooq A, Zhou M. Structure of the adaptor protein p14 reveals a profilin-like fold with distinct function. J Mol Biol. 2005;347:309-21 pubmed..We further mapped the MP1 binding sites on p14 by NMR, and discuss the implications of these important findings on the possible function of p14. ..
- Chrisman C, Albuquerque P, Guimaraes A, Nieves E, Casadevall A. Phospholipids trigger Cryptococcus neoformans capsular enlargement during interactions with amoebae and macrophages. PLoS Pathog. 2011;7:e1002047 pubmed publisher..neoformans to both amoebae and macrophages provide additional support for the notion that certain aspects of cryptococcal virulence emerged as a consequence of environmental interactions with other microorganisms such as protists. ..
- Parathath S, Connelly M, Rieger R, Klein S, Abumrad N, de la Llera Moya M, et al. Changes in plasma membrane properties and phosphatidylcholine subspecies of insect Sf9 cells due to expression of scavenger receptor class B, type I, and CD36. J Biol Chem. 2004;279:41310-8 pubmed..Scavenger receptor-mediated changes in membrane phosphatidylcholine may contribute to the increased flux of cholesterol and other lipids elicited by these receptors. ..
- Skowronek K, Guo F, Zheng Y, Nassar N. The C-terminal basic tail of RhoG assists the guanine nucleotide exchange factor trio in binding to phospholipids. J Biol Chem. 2004;279:37895-907 pubmed..Our data suggest a role for the phosphoinositide 3-kinase, PI 3-kinase, in modulating the Trio/RhoG signaling pathway. ..
- Moir R, Gross D, Silver D, Willis I. SCS3 and YFT2 link transcription of phospholipid biosynthetic genes to ER stress and the UPR. PLoS Genet. 2012;8:e1002890 pubmed publisher..g. due to low inositol) to Opi1-regulated transcription of phospholipid biosynthetic genes. We conclude that SCS3 and YFT2 are required for normal ER membrane biosynthesis in response to perturbations in lipid metabolism and ER stress. ..
- Hathcock J, Rusinova E, Gentry R, Andree H, Nemerson Y. Phospholipid regulates the activation of factor X by tissue factor/factor VIIa (TF/VIIa) via substrate and product interactions. Biochemistry. 2005;44:8187-97 pubmed..Xa leaves the vicinity of the enzyme, either by lateral diffusion or desorption from the surface, regulates the rate of F.X activation. We argue that these findings require reevaluation of existing models of coagulation. ..
- Jiang X, Bruce C, Mar J, Lin M, Ji Y, Francone O, et al. Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels. J Clin Invest. 1999;103:907-14 pubmed..Vesicular lipoproteins accumulating in PLTP-/- mice on a high-fat diet could influence the development of atherosclerosis. ..
- Sehayek E, Wang R, Ono J, Zinchuk V, Duncan E, Shefer S, et al. Localization of the PE methylation pathway and SR-BI to the canalicular membrane: evidence for apical PC biosynthesis that may promote biliary excretion of phospholipid and cholesterol. J Lipid Res. 2003;44:1605-13 pubmed..Based on these findings, a model is proposed in which local canalicular membrane PC biosynthesis in concert with the phospholipid transporter mdr2 and SR-BI, promotes the excretion of phospholipid and cholesterol into the bile...
- Weber U, Eroglu C, Mlodzik M. Phospholipid membrane composition affects EGF receptor and Notch signaling through effects on endocytosis during Drosophila development. Dev Cell. 2003;5:559-70 pubmed..A further link between PC/PI content, endocytosis, and signaling is supported by genetic interactions of dCCT1 with Egfr, Notch, and genes affecting endosomal traffic. ..
- Wang N, Silver D, Costet P, Tall A. Specific binding of ApoA-I, enhanced cholesterol efflux, and altered plasma membrane morphology in cells expressing ABC1. J Biol Chem. 2000;275:33053-8 pubmed..Plasma membrane ABC1 may act as a phospholipid/cholesterol flippase, providing lipid to bound apoA-I, or to the outer membrane hemileaflet...
- Butterwick J, MacKinnon R. Solution structure and phospholipid interactions of the isolated voltage-sensor domain from KvAP. J Mol Biol. 2010;403:591-606 pubmed publisher..Using paramagnetically labeled phospholipids, we show that bilayer-forming lipids interact with the S3 and S4 helices more strongly than with S1 and S2. ..
- Jiang X, Bruce C. Regulation of murine plasma phospholipid transfer protein activity and mRNA levels by lipopolysaccharide and high cholesterol diet. J Biol Chem. 1995;270:17133-8 pubmed
- Benach J, Chou Y, Fak J, Itkin A, Nicolae D, Smith P, et al. Phospholipid-induced monomerization and signal-peptide-induced oligomerization of SecA. J Biol Chem. 2003;278:3628-38 pubmed..Cycles of SecA subunit recruitment and dissociation could potentially be employed to achieve processivity in polypeptide transport. ..
- Sengupta P, Ruano M, Tebar F, Golebiewska U, Zaitseva I, Enrich C, et al. Membrane-permeable calmodulin inhibitors (e.g. W-7/W-13) bind to membranes, changing the electrostatic surface potential: dual effect of W-13 on epidermal growth factor receptor activation. J Biol Chem. 2007;282:8474-86 pubmed..Our interpretation is that the former effect is due to W-13 inhibition of Ca2+/CaM, but the latter results could be due to binding of W-13 to the plasma membrane. ..
- Seimon T, Nadolski M, Liao X, Magallon J, Nguyen M, Feric N, et al. Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress. Cell Metab. 2010;12:467-82 pubmed publisher..These findings provide insight into how atherogenic lipoproteins trigger macrophage apoptosis in the setting of ER stress and how TLR activation might promote macrophage apoptosis and plaque necrosis in advanced atherosclerosis. ..
- Sano H, Renault A, Lehmann R. Control of lateral migration and germ cell elimination by the Drosophila melanogaster lipid phosphate phosphatases Wunen and Wunen 2. J Cell Biol. 2005;171:675-83 pubmed..Our results suggest that expression of wun/wun-2 repellents along the migratory paths provides faithful control over the sorting of PGCs into two gonads and eliminates PGCs left in the middle of the embryo. ..
- Zhou W, Parent L, Wills J, Resh M. Identification of a membrane-binding domain within the amino-terminal region of human immunodeficiency virus type 1 Gag protein which interacts with acidic phospholipids. J Virol. 1994;68:2556-69 pubmed..We propose that the N-terminal Gag sequence functions as a targeting signal to direct interaction with acidic phospholipids on the cytoplasmic leaflet of the plasma membrane. ..
- Simons M, Gault W, Gotthardt D, Rohatgi R, Klein T, Shao Y, et al. Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization. Nat Cell Biol. 2009;11:286-94 pubmed publisher..This stabilization is particularly important for the PCP signalling branch and, thus, promotes specific pathway selection in Wnt signalling. ..
- Malvezzi M, Chalat M, Janjusevic R, Picollo A, Terashima H, Menon A, et al. Ca2+-dependent phospholipid scrambling by a reconstituted TMEM16 ion channel. Nat Commun. 2013;4:2367 pubmed publisher..We propose that the spatial separation of the ion and lipid pathways underlies the evolutionary divergence of the TMEM16 family, and that other homologues, such as TMEM16F, might also be dual-function channel/scramblases. ..
- Mesmin B, Maxfield F. Intracellular sterol dynamics. Biochim Biophys Acta. 2009;1791:636-45 pubmed publisher..Although still poorly characterized in many trafficking routes, several potential sterol transport proteins have been described in detail; as a result, molecular mechanisms for sterol transport among membranes start to be appreciated...
- Selimi F, Cristea I, Heller E, Chait B, Heintz N. Proteomic studies of a single CNS synapse type: the parallel fiber/purkinje cell synapse. PLoS Biol. 2009;7:e83 pubmed publisher..Our data identify a novel synapse-specific signaling pathway, and provide an approach for detailed investigations of the biochemical complexity of central nervous system synapse types. ..
- Zheng J, Chen R, Corblan Garcia S, Cahill S, Bar Sagi D, Cowburn D. The solution structure of the pleckstrin homology domain of human SOS1. A possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology domains. J Biol Chem. 1997;272:30340-4 pubmed
- Bisgaier C, Siebenkas M, Williams K. Effects of apolipoproteins A-IV and A-I on the uptake of phospholipid liposomes by hepatocytes. J Biol Chem. 1989;264:862-6 pubmed..However, these apolipoproteins may modulate receptor-mediated uptake of particles by reducing the amount of particle-bound apolipoprotein E. ..
- Tseng C, Tseng C. Identification of a novel secretory leukocyte protease inhibitor-binding protein involved in membrane phospholipid movement. FEBS Lett. 2000;475:232-6 pubmed..Co-expression of SLPI and SLPI-BP followed by an S-protein pulldown assay confirmed the specific interaction between these two proteins. Our data represent the first report for the identity of SLPI-BP. ..
- Bogdanov V, Balasubramanian V, Hathcock J, Vele O, Lieb M, Nemerson Y. Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein. Nat Med. 2003;9:458-62 pubmed..We propose that binding of asHTF to the edge of thrombi contributes to thrombus growth by creating a surface that both initiates and propagates coagulation. ..
- Hailman E, Albers J, Wolfbauer G, Tu A, Wright S. Neutralization and transfer of lipopolysaccharide by phospholipid transfer protein. J Biol Chem. 1996;271:12172-8 pubmed..These results suggest that while PLTP and LBP both bind and transfer LPS, PLTP is unable to transfer LPS to CD14 and thus does not mediate responses of cells to LPS. ..
- Xu Y, Malhotra A, Ren M, Schlame M. The enzymatic function of tafazzin. J Biol Chem. 2006;281:39217-24 pubmed..The data show that Drosophila tafazzin is a CoA-independent, acyl-specific phospholipid transacylase with substrate preference for cardiolipin and phosphatidylcholine. ..
- Wang N, Chen W, Linsel Nitschke P, Martinez L, Agerholm Larsen B, Silver D, et al. A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I. J Clin Invest. 2003;111:99-107 pubmed..Inhibition of ABCA1 degradation by calpain could represent a novel therapeutic approach to increasing macrophage cholesterol efflux and decreasing atherosclerosis...
- Hathcock J, Rusinova E, Vaananen H, Nemerson Y. Lipid-bound factor Xa regulates tissue factor activity. Biochemistry. 2007;46:6134-40 pubmed..Moreover, the inhibitory properties of fXa can be described on the basis of the estimated surface density of fXa molecules on the TF-phospholipid surface. ..
- Buglino J, Resh M. Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog. J Biol Chem. 2008;283:22076-88 pubmed publisher..This study establishes Hhat as a bona fide Shh PAT and serves as a model for understanding how secreted morphogens are modified by distinct PATs. ..
- Hathcock J, Rusinova E, Andree H, Nemerson Y. Phospholipid surfaces regulate the delivery of substrate to tissue factor:VIIa and the removal of product. Blood Cells Mol Dis. 2006;36:194-8 pubmed..We have determined the binding parameters of Xa to vesicles and a continuous supported bilayer. Our data are in excellent agreement with the data derived using a lipid coated Biacore chip. ..
- Li J, Mao X, Dong L, Liu F, Tong L. Crystal structures of the BAR-PH and PTB domains of human APPL1. Structure. 2007;15:525-33 pubmed..Lipid binding assays show that the BAR, PH, and PTB domains can bind phospholipids. The ability of APPL1 to interact with multiple signaling molecules and phospholipids supports an important role for this adaptor in cell signaling. ..
- Renault A, Sigal Y, Morris A, Lehmann R. Soma-germ line competition for lipid phosphate uptake regulates germ cell migration and survival. Science. 2004;305:1963-6 pubmed..We propose that Drosophila germ cell migration and survival are controlled by competition for hydrolysis of a lipid phosphate between germ cells and soma. ..
- Wang N, Silver D, Thiele C, Tall A. ATP-binding cassette transporter A1 (ABCA1) functions as a cholesterol efflux regulatory protein. J Biol Chem. 2001;276:23742-7 pubmed..The data suggest that the binding of apoA-I to ABCA1 leads to the formation of phospholipid-apoA-I complexes, which subsequently promote cholesterol efflux in an autocrine or paracrine fashion...
- Nakanishi H, de los Santos P, Neiman A. Positive and negative regulation of a SNARE protein by control of intracellular localization. Mol Biol Cell. 2004;15:1802-15 pubmed..Thus, the SNARE Spo20p is both positively and negatively regulated by control of its intracellular localization. ..
- Leventhal A, Leslie C, Tabas I. Suppression of macrophage eicosanoid synthesis by atherogenic lipoproteins is profoundly affected by cholesterol-fatty acyl esterification and the Niemann-Pick C pathway of lipid trafficking. J Biol Chem. 2004;279:8084-92 pubmed
- Klig L, Homann M, Kohlwein S, Kelley M, Henry S, Carman G. Saccharomyces cerevisiae mutant with a partial defect in the synthesis of CDP-diacylglycerol and altered regulation of phospholipid biosynthesis. J Bacteriol. 1988;170:1878-86 pubmed..The cdg1 lesion also caused constitutive expression of inositol-1-phosphate synthase and elevated phosphatidylserine synthase. Phosphatidylinositol synthase was not affected in the cdg1 mutant. ..
- Menon A. A flip-flop switch in polarity signaling. Dev Cell. 2007;13:607-8 pubmed..In this issue of Developmental Cell, Saito et al. report that Cdc42 GAP activity is regulated by the phospholipid composition of the bud-tip membrane, under control of the phospholipid flippases Lem3-Dnf1 and Lem3-Dnf2...
- Swenson T, Brocia R, Tall A. Plasma cholesteryl ester transfer protein has binding sites for neutral lipids and phospholipids. J Biol Chem. 1988;263:5150-7 pubmed..The results indicate that the CETP has binding sites for CE, triglyceride, and PC which readily equilibrate with lipoprotein lipids and suggest that CETP can act as a carrier of lipid between lipoproteins. ..
- Wang B, Zhao A, Novick R, Muir T. Activation and inhibition of the receptor histidine kinase AgrC occurs through opposite helical transduction motions. Mol Cell. 2014;53:929-40 pubmed publisher..Binding of agonist or inverse-agonist peptides results in twisting of the linker in different directions. These two observations provide a view of the molecular motions triggered by ligand binding in an intact membrane-bound RHK. ..
- Jiang X, Tall A, Qin S, Lin M, Schneider M, Lalanne F, et al. Phospholipid transfer protein deficiency protects circulating lipoproteins from oxidation due to the enhanced accumulation of vitamin E. J Biol Chem. 2002;277:31850-6 pubmed
- Lemieux M, Song J, Kim M, Huang Y, Villa A, Auer M, et al. Three-dimensional crystallization of the Escherichia coli glycerol-3-phosphate transporter: a member of the major facilitator superfamily. Protein Sci. 2003;12:2748-56 pubmed..The resulting GlpT crystals diffracted isotropically to 3.3 A resolution and were suitable for structure determination by X-ray crystallography. ..
- Abbott G, Ramesh B, Srai S. Secondary structure of the MiRP1 (KCNE2) potassium channel ancillary subunit. Protein Pept Lett. 2008;15:63-75 pubmed..These data will provide a structural framework for ongoing mutagenesis-based in situ structure-function studies of MiRP1 and its relatives. ..
- Hyatt S, Liao L, Chapline C, Jaken S. Identification and characterization of alpha-protein kinase C binding proteins in normal and transformed REF52 cells. Biochemistry. 1994;33:1223-8 pubmed..The two major REF52 cell binding proteins (p71 and p > 200 kDa) were also down-regulated in the transformed cells, indicating transformation-sensitive regulation of PKC binding protein activity. ..
- Wang N, Lan D, Gerbod Giannone M, Linsel Nitschke P, Jehle A, Chen W, et al. ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux. J Biol Chem. 2003;278:42906-12 pubmed..These studies show that ABCA7 has the ability to bind apolipoproteins and promote efflux of cellular phospholipids without cholesterol, and they suggest a possible role of ABCA7 in cellular phospholipid metabolism in peripheral tissues...
- Sparrow J, Wu Y, Kim C, Zhou J. Phospholipid meets all-trans-retinal: the making of RPE bisretinoids. J Lipid Res. 2010;51:247-61 pubmed publisher..The propensity of these compounds to negatively impact on the cells has been linked to the pathogenesis of some retinal disorders including juvenile onset recessive Stargardt disease and age-related macular degeneration...
- Worgall T. Sphingolipid synthetic pathways are major regulators of lipid homeostasis. Adv Exp Med Biol. 2011;721:139-48 pubmed publisher..Together, manipulation of sphingolipid synthetic pathways is a potentially promising therapeutic target for treatment of low-HDL dyslipidemia and atherosclerosis...
- Jiang X, D ARMIENTO J, Mallampalli R, Mar J, Yan S, Lin M. Expression of plasma phospholipid transfer protein mRNA in normal and emphysematous lungs and regulation by hypoxia. J Biol Chem. 1998;273:15714-8 pubmed..These observations suggest that a hypoxic stimulus occurring in emphysema may be a novel mechanism that contributes to enhanced expression of PLTP. ..
- Zhao Z, Zhang X, Zhao C, Choi J, Shi J, Song K, et al. Protection of pancreatic beta-cells by group VIA phospholipase A(2)-mediated repair of mitochondrial membrane peroxidation. Endocrinology. 2010;151:3038-48 pubmed publisher..The low iPLA(2)beta expression level in db/db mouse beta-cells may render them vulnerable to injury by reactive oxygen species. ..
- Hulbert A, Faulks S, Buffenstein R. Oxidation-resistant membrane phospholipids can explain longevity differences among the longest-living rodents and similarly-sized mice. J Gerontol A Biol Sci Med Sci. 2006;61:1009-18 pubmed
- Schmidt D, Jiang Q, MacKinnon R. Phospholipids and the origin of cationic gating charges in voltage sensors. Nature. 2006;444:775-9 pubmed..We suggest that the usage of arginine residues in voltage sensors is an adaptation to the phospholipid composition of cell membranes. ..
- Li Y, Ge M, Ciani L, Kuriakose G, Westover E, Dura M, et al. Enrichment of endoplasmic reticulum with cholesterol inhibits sarcoplasmic-endoplasmic reticulum calcium ATPase-2b activity in parallel with increased order of membrane lipids: implications for depletion of endoplasmic reticulum calcium stores and ap. J Biol Chem. 2004;279:37030-9 pubmed..This biophysical model may underlie the critical connection between excess cholesterol, unfolded protein response induction, macrophage death, and plaque destabilization in advanced atherosclerosis. ..
- Sigal C, Zhou W, Buser C, McLaughlin S, Resh M. Amino-terminal basic residues of Src mediate membrane binding through electrostatic interaction with acidic phospholipids. Proc Natl Acad Sci U S A. 1994;91:12253-7 pubmed..In vivo experiments with Src mutants confirmed the role of positive charge in mediating membrane binding and cellular transformation. ..
- Bothe I, Deng S, Baylies M. PI(4,5)P2 regulates myoblast fusion through Arp2/3 regulator localization at the fusion site. Development. 2014;141:2289-301 pubmed publisher..Thus, PI(4,5)P2 enrichment at the fusion site encodes spatial and temporal information that regulates fusion progression through the localization of activators of actin polymerization. ..
- Park C, Wright S. Plasma lipopolysaccharide-binding protein is found associated with a particle containing apolipoprotein A-I, phospholipid, and factor H-related proteins. J Biol Chem. 1996;271:18054-60 pubmed..We suggest that FHRPs may be the defining constituent of this novel "lipoprotein" particle. ..
- Linsel Nitschke P, Jehle A, Shan J, Cao G, Bacic D, Lan D, et al. Potential role of ABCA7 in cellular lipid efflux to apoA-I. J Lipid Res. 2005;46:86-92 pubmed..Although ABCA7 does not contribute to apolipoprotein-mediated lipid efflux in resting macrophages, its cell surface location in the kidney suggests that it could serve such a role in tissue microenvironments...
- Sugar I, Mizuno N, Momsen M, Brockman H. Lipid lateral organization in fluid interfaces controls the rate of colipase association. Biophys J. 2001;81:3387-97 pubmed..Thus, our results suggest that lipid complexes may regulate the fluxes of other proteins to membranes during, for example, lipid-mediated signaling events in cells. ..
- Tambini M, Pera M, Kanter E, Yang H, Guardia Laguarta C, Holtzman D, et al. ApoE4 upregulates the activity of mitochondria-associated ER membranes. EMBO Rep. 2016;17:27-36 pubmed publisher..These data are consistent with a role of upregulated MAM function in the pathogenesis of AD and may help explain, in part, the contribution of ApoE4 as a risk factor in the disease. ..