Experts and Doctors on phagocytosis in New York, United States


Locale: New York, United States
Topic: phagocytosis

Top Publications

  1. Finnemann S. Focal adhesion kinase signaling promotes phagocytosis of integrin-bound photoreceptors. EMBO J. 2003;22:4143-54 pubmed
    ..In contrast, inhibition of FAK signaling diminishes MerTK phosphorylation. These results demonstrate that FAK provides an essential link between binding and engulfment mechanisms of integrin-mediated phagocytosis. ..
  2. Steenbergen J, Nosanchuk J, Malliaris S, Casadevall A. Cryptococcus neoformans virulence is enhanced after growth in the genetically malleable host Dictyostelium discoideum. Infect Immun. 2003;71:4862-72 pubmed
    ..neoformans virulence in the environment and suggest that D. discoideum promises to be an extremely useful system for studying the interaction of C. neoformans with phagocytic cells. ..
  3. Spaide R. Autofluorescence from the outer retina and subretinal space: hypothesis and review. Retina. 2008;28:5-35 pubmed publisher
    ..Accumulation of the shed but not phagocytized outer segments plays a role in disease manifestations for a number of macular diseases. ..
  4. Boateng R, Nguyen K, Hall D, Golden A, Allen A. Novel functions for the RNA-binding protein ETR-1 in Caenorhabditis elegans reproduction and engulfment of germline apoptotic cell corpses. Dev Biol. 2017;429:306-320 pubmed publisher
    ..Combined, this data identifies a novel role for ETR-1 in hermaphrodite gametogenesis and in the process of engulfment of germline apoptotic cell corpses. ..
  5. Wright S, Tobias P, Ulevitch R, Ramos R. Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages. J Exp Med. 1989;170:1231-41 pubmed
    ..The results of our studies define LBP as an opsonin. During the acute phase, LBP can be expected to bind gram-negative bacteria and bacterial fragments and promote the interaction of coated bacteria with phagocytes. ..
  6. Chen W, Jarzyna P, van Tilborg G, Nguyen V, Cormode D, Klink A, et al. RGD peptide functionalized and reconstituted high-density lipoprotein nanoparticles as a versatile and multimodal tumor targeting molecular imaging probe. FASEB J. 2010;24:1689-99 pubmed publisher
    ..This study demonstrates the ability to reroute HDL from its natural targets to tumor blood vessels and its potential for multimodal imaging of tumor-associated processes. ..
  7. Subklewe M, Paludan C, Tsang M, Mahnke K, Steinman R, Munz C. Dendritic cells cross-present latency gene products from Epstein-Barr virus-transformed B cells and expand tumor-reactive CD8(+) killer T cells. J Exp Med. 2001;193:405-11 pubmed
    ..Therefore, the capacity of DCs to cross-present antigens from dead cells extends to the expansion of high affinity T cells specific for viral latency antigens involved in cell transformation. ..
  8. Li Y, Loike J, Ember J, Cleary P, Lu E, Budhu S, et al. The bacterial peptide N-formyl-Met-Leu-Phe inhibits killing of Staphylococcus epidermidis by human neutrophils in fibrin gels. J Immunol. 2002;168:816-24 pubmed
    ..The latter finding is surprising and suggests that in the presence of fibrin fMLP promotes bacterial virulence. ..
  9. Finnemann S, Leung L, Rodriguez Boulan E. The lipofuscin component A2E selectively inhibits phagolysosomal degradation of photoreceptor phospholipid by the retinal pigment epithelium. Proc Natl Acad Sci U S A. 2002;99:3842-7 pubmed
    ..Because of the circadian rhythm of RPE phagocytosis in the eye, a delay in lipid degradation would likely result in a build up of undigested material in RPE that could contribute to the development of age-related macular degeneration. ..

More Information

Publications133 found, 100 shown here

  1. Bickham K, Goodman K, Paludan C, Nikiforow S, Tsang M, Steinman R, et al. Dendritic cells initiate immune control of epstein-barr virus transformation of B lymphocytes in vitro. J Exp Med. 2003;198:1653-63 pubmed
    ..We suggest that the cross-presentation of EBV-latent antigens from infected B cells by DCs is required for the initiation of EBV-specific immune control in vivo and that future EBV vaccine strategies should target viral antigens to DCs. ..
  2. Blander J, Sander L. Beyond pattern recognition: five immune checkpoints for scaling the microbial threat. Nat Rev Immunol. 2012;12:215-25 pubmed publisher
    ..Here, we propose five immune checkpoints that, as defined here, collectively determine the gravity of microbial encounters. ..
  3. Lee S, Zheng N, Clavijo M, Nussenzweig M. Normal host defense during systemic candidiasis in mannose receptor-deficient mice. Infect Immun. 2003;71:437-45 pubmed
    ..We conclude that the MR is not required for the normal host defense during disseminated candidiasis or for the phagocytosis of C. albicans and that a beta-glucan receptor may be required for C. albicans phagocytosis. ..
  4. Steenbergen J, Nosanchuk J, Malliaris S, Casadevall A. Interaction of Blastomyces dermatitidis, Sporothrix schenckii, and Histoplasma capsulatum with Acanthamoeba castellanii. Infect Immun. 2004;72:3478-88 pubmed
    ..These results are consistent with the view that soil amoebae may contribute to the selection and maintenance of certain traits in pathogenic dimorphic fungi that confer on these microbes the capacity for virulence in mammals...
  5. Bristow C, Wolkowicz R, Trucy M, Franklin A, Di Meo F, Kozlowski M, et al. NF-kappaB signaling, elastase localization, and phagocytosis differ in HIV-1 permissive and nonpermissive U937 clones. J Immunol. 2008;180:492-9 pubmed
    ..Results presented suggest that HIV-1 uptake and production efficiency are influenced by signaling profiles, receptor distribution, and the phagocytic capacity specific to the stage of differentiation of the CD4+ target cell. ..
  6. Randolph G, Inaba K, Robbiani D, Steinman R, Muller W. Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo. Immunity. 1999;11:753-61 pubmed
    ..Thus, a substantial minority of inflammatory monocytes carry phagocytosed particles to lymph nodes and differentiate into DCs. ..
  7. Sauter B, Albert M, Francisco L, Larsson M, Somersan S, Bhardwaj N. Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells. J Exp Med. 2000;191:423-34 pubmed
    ..g., monocyte-conditioned medium. Thus, DCs are able to distinguish two types of tumor cell death, with necrosis providing a control that is critical for the initiation of immunity. ..
  8. Somersan S, Bhardwaj N. Tethering and tickling: a new role for the phosphatidylserine receptor. J Cell Biol. 2001;155:501-4 pubmed
    ..New studies shed light on the role of the phosphatidyl serine (PS) receptor (PSR). Ligation of PSR by PS on AC surfaces is considered essential for signaling uptake of ACs that are tethered to phagocytes via other receptors. ..
  9. Kazeros A, Harvey B, Carolan B, Vanni H, Krause A, Crystal R. Overexpression of apoptotic cell removal receptor MERTK in alveolar macrophages of cigarette smokers. Am J Respir Cell Mol Biol. 2008;39:747-57 pubmed publisher
  10. Borderia A, Hartmann B, Fernandez Sesma A, Moran T, Sealfon S. Antiviral-activated dendritic cells: a paracrine-induced response state. J Immunol. 2008;181:6872-6881 pubmed
    ..Although further in vivo study is needed, the characteristics of the AVDC suggest that it is well suited to play a role in the early innate-adaptive transition of the immune system. ..
  11. Noel B, Lilo S, Capurso D, Hill J, Bliska J. Yersinia pestis can bypass protective antibodies to LcrV and activation with gamma interferon to survive and induce apoptosis in murine macrophages. Clin Vaccine Immunol. 2009;16:1457-66 pubmed publisher
    ..We conclude that Y. pestis can bypass protective antibodies to LcrV and activation with IFN-gamma to survive and induce apoptosis in murine macrophages. ..
  12. Krajcovic M, Krishna S, Akkari L, Joyce J, Overholtzer M. mTOR regulates phagosome and entotic vacuole fission. Mol Biol Cell. 2013;24:3736-45 pubmed publisher
    ..These data identify a late stage of phagocytosis and entosis that involves processing of large vacuoles by mTOR-regulated membrane fission. ..
  13. Chung E, Liu J, Zhang Y, Ma X. Differential expression in lupus-associated IL-10 promoter single-nucleotide polymorphisms is mediated by poly(ADP-ribose) polymerase-1. Genes Immun. 2007;8:577-89 pubmed
    ..This study unveils a novel direct link between DNA damage repair/apoptosis pathways and IL-10-mediated immune regulation. ..
  14. Leiriao P, Mota M, Rodriguez A. Apoptotic Plasmodium-infected hepatocytes provide antigens to liver dendritic cells. J Infect Dis. 2005;191:1576-81 pubmed
    ..We propose that apoptotic Plasmodium-infected hepatocytes provide a source of parasite antigens for the initiation of the protective immune response. ..
  15. Kang Y, Kim J, Bruening S, Pack M, Charalambous A, Pritsker A, et al. The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide of Streptococcus pneumoniae in the marginal zone of mouse spleen. Proc Natl Acad Sci U S A. 2004;101:215-20 pubmed
    ..Therefore, marginal zone macrophages in mice have a receptor that interacts with capsular pneumococcal polysaccharides, setting the stage for further studies of the functional consequences of this interaction. ..
  16. Finnemann S, Silverstein R. Differential roles of CD36 and alphavbeta5 integrin in photoreceptor phagocytosis by the retinal pigment epithelium. J Exp Med. 2001;194:1289-98 pubmed
    ..They suggest that CD36 acts as a signaling molecule in postbinding steps of RPE phagocytosis independently of the OS binding receptor alphavbeta5 integrin. ..
  17. Pricop L, Redecha P, Teillaud J, Frey J, Fridman W, Sautes Fridman C, et al. Differential modulation of stimulatory and inhibitory Fc gamma receptors on human monocytes by Th1 and Th2 cytokines. J Immunol. 2001;166:531-7 pubmed
  18. Charpentier X, Gabay J, Reyes M, Zhu J, Weiss A, Shuman H. Chemical genetics reveals bacterial and host cell functions critical for type IV effector translocation by Legionella pneumophila. PLoS Pathog. 2009;5:e1000501 pubmed publisher
    ..pneumophila lifestyle. Chemical genetic screening provides a novel approach to probe the host cell functions and factors involved in host-pathogen interactions. ..
  19. Gershov D, Kim S, Brot N, Elkon K. C-Reactive protein binds to apoptotic cells, protects the cells from assembly of the terminal complement components, and sustains an antiinflammatory innate immune response: implications for systemic autoimmunity. J Exp Med. 2000;192:1353-64 pubmed
  20. Skoberne M, Somersan S, Almodovar W, Truong T, Petrova K, Henson P, et al. The apoptotic-cell receptor CR3, but not alphavbeta5, is a regulator of human dendritic-cell immunostimulatory function. Blood. 2006;108:947-55 pubmed
    ..Overall, our data suggest that under steady-state conditions, signaling via CRs predominates to render DCs tolerogenic. ..
  21. Zaba L, Fuentes Duculan J, Steinman R, Krueger J, Lowes M. Normal human dermis contains distinct populations of CD11c+BDCA-1+ dendritic cells and CD163+FXIIIA+ macrophages. J Clin Invest. 2007;117:2517-25 pubmed
    ..In summary, the normal dermis contains typical immunostimulatory myeloid DCs identified by CD11c and BDCA-1, as well as an additional population of poorly stimulatory macrophages marked by CD163 and FXIIIA. ..
  22. Nguyen L, Gacser A, Nosanchuk J. The stearoyl-coenzyme A desaturase 1 is essential for virulence and membrane stress in Candida parapsilosis through unsaturated fatty acid production. Infect Immun. 2011;79:136-45 pubmed publisher
    ..Taken together, these results demonstrate that Ole1 regulates the pathobiology of C. parapsilosis via UFA and that the OLE1 pathway is a promising antifungal target. ..
  23. Liu Q, Hengartner M. Candidate adaptor protein CED-6 promotes the engulfment of apoptotic cells in C. elegans. Cell. 1998;93:961-72 pubmed
    ..Our data suggest that CED-6 is an adaptor molecule acting in a signal transduction pathway that specifically mediates the recognition and engulfment of apoptotic cells. ..
  24. Gomes M, Paul S, Moreira A, Appelberg R, Rabinovitch M, Kaplan G. Survival of Mycobacterium avium and Mycobacterium tuberculosis in acidified vacuoles of murine macrophages. Infect Immun. 1999;67:3199-206 pubmed
    ..These results suggest that although both species of mycobacteria inhibit phagosome-lysosome fusion, they may be differentially susceptible to the toxic effects of the acidic environment in the mature phagolysosome. ..
  25. Rimal B, Greenberg A, Rom W. Basic pathogenetic mechanisms in silicosis: current understanding. Curr Opin Pulm Med. 2005;11:169-73 pubmed
    ..Potential therapeutic strategies include inhibition of cytokines such as IL-1, TNF alpha, the use of anti-oxidants, and the inhibition of apoptosis. ..
  26. Cox D, Greenberg S. Phagocytic signaling strategies: Fc(gamma)receptor-mediated phagocytosis as a model system. Semin Immunol. 2001;13:339-45 pubmed
    ..Here we focus on phagocytosis mediated by a well-studied class of phagocytic receptors that recognize the Fc portion of IgG (Fc(gamma)Rs ). ..
  27. Ochando J, Homma C, Yang Y, Hidalgo A, Garin A, Tacke F, et al. Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts. Nat Immunol. 2006;7:652-62 pubmed
    ..Thus, alloantigen-presenting pDCs home to the lymph nodes in tolerogenic conditions, where they mediate alloantigen-specific Treg cell development and allograft tolerance. ..
  28. Stone E, Fulton B, Ayres J, Pham L, Ziauddin J, Shirasu Hiza M. The circadian clock protein timeless regulates phagocytosis of bacteria in Drosophila. PLoS Pathog. 2012;8:e1002445 pubmed publisher
    ..pneumoniae. Taken together, these results suggest that loss of circadian oscillation of a specific immune function (phagocytosis) can have significant effects on long-term survival of infection. ..
  29. Whitin J, Cohen H. Disorders of respiratory burst termination. Hematol Oncol Clin North Am. 1988;2:289-99 pubmed
    ..Further investigations on the mechanisms of inactivation of the NADPH oxidase are warranted in order to gain a greater understanding of this important regulating mechanism. ..
  30. Pribic J, Garcia R, Kong M, Brazill D. Paxillin and phospholipase D interact to regulate actin-based processes in Dictyostelium discoideum. Eukaryot Cell. 2011;10:977-84 pubmed publisher
    ..Taken together, our data point to PldB being a required binding partner of PaxB during processes involving actin reorganization. ..
  31. Lee A, Kinney P, Chillrud S, Jack D. A Systematic Review of Innate Immunomodulatory Effects of Household Air Pollution Secondary to the Burning of Biomass Fuels. Ann Glob Health. 2015;81:368-74 pubmed publisher
    ..These studies have important public health implications and may lead to the design of interventions to improve the health of billions of people daily. ..
  32. Cox D, Chang P, Zhang Q, Reddy P, Bokoch G, Greenberg S. Requirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytes. J Exp Med. 1997;186:1487-94 pubmed
  33. Greenberg S, El Khoury J, Di Virgilio F, Kaplan E, Silverstein S. Ca(2+)-independent F-actin assembly and disassembly during Fc receptor-mediated phagocytosis in mouse macrophages. J Cell Biol. 1991;113:757-67 pubmed
    ..We conclude that Fc receptor-mediated phagocytosis in mouse macrophages is accompanied by an ordered sequence of assembly and disassembly of F-actin that is insensitive to [Ca2+]i. ..
  34. Sibille J, Kondo H, Aisen P. Interactions between isolated hepatocytes and Kupffer cells in iron metabolism: a possible role for ferritin as an iron carrier protein. Hepatology. 1988;8:296-301 pubmed
    ..Ferritin-mediated transfer of iron from Kupffer cells to hepatocytes may help explain the resistance of the liver to iron deficiency as well as the liver's susceptibility to iron overload. ..
  35. Phelps R, Shoji T. Update on panniculitis. Mt Sinai J Med. 2001;68:262-7 pubmed
    ..Recent developments in etiology, pathogenesis, molecular techniques, and therapy are discussed...
  36. James D, Nestor B, Sculco T, Ivashkiv L, Ross F, Goldring S, et al. The relative timing of exposure to phagocytosable particulates and to osteoclastogenic cytokines is critically important in the determination of myeloid cell fate. J Immunol. 2010;185:1265-73 pubmed publisher
    ..Thus, the relative timing of exposure to phagocytosable particulates and to osteoclastogenic cytokines is critically important in the determination of myeloid cell fate. ..
  37. Alonzo F, Benson M, Chen J, Novick R, Shopsin B, Torres V. Staphylococcus aureus leucocidin ED contributes to systemic infection by targeting neutrophils and promoting bacterial growth in vivo. Mol Microbiol. 2012;83:423-35 pubmed publisher
    ..Moreover, the tropism of LukED for murine phagocytes highlights the utility of murine models to study LukED pathobiology, including development and testing of strategies to inhibit toxin activity and control bacterial infection. ..
  38. Ma W, Rai V, Hudson B, Song F, Schmidt A, Barile G. RAGE binds C1q and enhances C1q-mediated phagocytosis. Cell Immunol. 2012;274:72-82 pubmed publisher
    ..C1q induced U937 cell adhesion and phagocytosis was inhibited by antibodies to RAGE or Mac-1. These data link C1q and RAGE to the recruitment of leukocytes and phagocytosis of C1q-coated material. ..
  39. Diehl G, Longman R, Zhang J, Breart B, Galan C, Cuesta A, et al. Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells. Nature. 2013;494:116-20 pubmed publisher
  40. Zhang S, Yeap X, Grigoryeva L, Dehn S, DeBerge M, Tye M, et al. Cardiomyocytes induce macrophage receptor shedding to suppress phagocytosis. J Mol Cell Cardiol. 2015;87:171-9 pubmed publisher
    ..These findings warrant future studies to identify other cofactors of macrophage-cardiomyocyte cross-talk that contribute to cardiac pathophysiology. ..
  41. Salmon J, Brogle N, Brownlie C, Edberg J, Kimberly R, Chen B, et al. Human mononuclear phagocytes express adenosine A1 receptors. A novel mechanism for differential regulation of Fc gamma receptor function. J Immunol. 1993;151:2775-85 pubmed
    ..This rapid and potent modulation of Fc gamma receptor-mediated function suggests that adenosine is an important local regulator of the inflammatory response. ..
  42. Frager S, Chrisman C, Shakked R, Casadevall A. Paramecium species ingest and kill the cells of the human pathogenic fungus Cryptococcus neoformans. Med Mycol. 2010;48:775-9 pubmed publisher
    ..rapidly ingested C. neoformans and killed the fungus. This study establishes yet another type of protist-fungal interaction supporting the notion that animal-pathogenic fungi in the environment are under constant selection by predation. ..
  43. Lopes L, Rollin Pinheiro R, Guimaraes A, Bittencourt V, Martinez L, Koba W, et al. Monoclonal antibodies against peptidorhamnomannans of Scedosporium apiospermum enhance the pathogenicity of the fungus. PLoS Negl Trop Dis. 2010;4:e853 pubmed publisher
    ..Further insights into the effects of these glycopeptides on the pathobiology of S. apiospermum may lead to new avenues for preventing and treating scedosporiosis. ..
  44. Entezari M, Weiss D, Sitapara R, Whittaker L, Wargo M, Li J, et al. Inhibition of high-mobility group box 1 protein (HMGB1) enhances bacterial clearance and protects against Pseudomonas Aeruginosa pneumonia in cystic fibrosis. Mol Med. 2012;18:477-85 pubmed publisher
    ..aeruginosa in the lung. Thus, HMGB1 may provide a therapeutic target for reducing bacterial infection and lung inflammation in CF. ..
  45. Clark H, Jhingran A, Sun Y, Vareechon C, de Jesus Carrion S, Skaar E, et al. Zinc and Manganese Chelation by Neutrophil S100A8/A9 (Calprotectin) Limits Extracellular Aspergillus fumigatus Hyphal Growth and Corneal Infection. J Immunol. 2016;196:336-44 pubmed publisher
    ..Collectively, these studies demonstrate a novel stage-specific susceptibility of A. fumigatus to zinc and manganese chelation by neutrophil-derived calprotectin. ..
  46. Edberg J, Kimberly R, Taylor R. Functional characterization of non-human primate erythrocyte immune adherence receptors: implications for the uptake of immune complexes by the cells of the mononuclear phagocytic system. Eur J Immunol. 1992;22:1333-9 pubmed
    ..These findings, taken in context with previous clearance studies, suggest that serum-mediated release may not be required for the rapid transfer of the IC from the erythrocyte to the mononuclear phagocytic system. ..
  47. Aderem A. The MARCKS family of protein kinase-C substrates. Biochem Soc Trans. 1995;23:587-91 pubmed
  48. Anrather J, Racchumi G, Iadecola C. NF-kappaB regulates phagocytic NADPH oxidase by inducing the expression of gp91phox. J Biol Chem. 2006;281:5657-67 pubmed
    ..The findings raise the possibility of a positive feedback loop in which NF-kappaB activation by oxidative stress leads to further radical production via NADPH oxidase. ..
  49. Waters V, Gomez M, Soong G, Amin S, Ernst R, Prince A. Immunostimulatory properties of the emerging pathogen Stenotrophomonas maltophilia. Infect Immun. 2007;75:1698-703 pubmed
    ..Despite the lack of invasiveness of S. maltophilia, the immunostimulatory properties of this organism and its induction of TNF-alpha expression specifically indicate that it is likely to contribute significantly to airway inflammation. ..
  50. Vives Bauza C, Anand M, Shiraz A, Shirazi A, Magrane J, Gao J, et al. The age lipid A2E and mitochondrial dysfunction synergistically impair phagocytosis by retinal pigment epithelial cells. J Biol Chem. 2008;283:24770-80 pubmed publisher
    ..They suggest that synergy of sub-toxic lysosomal and mitochondrial changes in RPE cells with age may cause RPE dysfunction that is known to contribute to human retinal diseases like age-related macular degeneration. ..
  51. Magalhaes M, Glogauer M. Pivotal Advance: Phospholipids determine net membrane surface charge resulting in differential localization of active Rac1 and Rac2. J Leukoc Biol. 2010;87:545-55 pubmed publisher
  52. Guimaraes A, Frases S, Gomez F, Zancope Oliveira R, Nosanchuk J. Monoclonal antibodies to heat shock protein 60 alter the pathogenesis of Histoplasma capsulatum. Infect Immun. 2009;77:1357-67 pubmed publisher
    ..Hence, IgG1 and IgG2a MAbs to Hsp60 can modify H. capsulatum pathogenesis in part by altering the intracellular fate of the fungus and inducing the production of Th1-associated cytokines. ..
  53. Fernandez Arias C, Rivera Correa J, Gallego Delgado J, Rudlaff R, Fernandez C, Roussel C, et al. Anti-Self Phosphatidylserine Antibodies Recognize Uninfected Erythrocytes Promoting Malarial Anemia. Cell Host Microbe. 2016;19:194-203 pubmed publisher
    ..Inhibition of this pathway may be exploited for treating malarial anemia. ..
  54. Torchinsky M, Garaude J, Martin A, Blander J. Innate immune recognition of infected apoptotic cells directs T(H)17 cell differentiation. Nature. 2009;458:78-82 pubmed publisher
    ..Because T(H)17 cells have been correlated with autoimmune diseases, investigation of the pathways of innate recognition of infected apoptotic cells might lead to improved understanding of the causative defects in autoimmunity. ..
  55. Oikonomou G, Shaham S. The glia of Caenorhabditis elegans. Glia. 2011;59:1253-63 pubmed publisher
    ..elegans. The recent studies we describe highlight the similarities and differences between C. elegans and vertebrate glia, and focus on novel insights that are likely to have general relevance to all nervous systems. ..
  56. Scharf B, Clement C, Wu X, Morozova K, Zanolini D, Follenzi A, et al. Annexin A2 binds to endosomes following organelle destabilization by particulate wear debris. Nat Commun. 2012;3:755 pubmed publisher
    ..Together, the results indicate a functional role of annexin A2 binding to endosomal membranes following organelle destabilization. ..
  57. PrabhuDas M, Baldwin C, Bollyky P, Bowdish D, Drickamer K, Febbraio M, et al. A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease. J Immunol. 2017;198:3775-3789 pubmed publisher
    ..The following manuscript is a consensus statement that combines the recommendations of the initial workshop and incorporates the input received from the participants at the three national meetings. ..
  58. Lee D, Cox D, Li J, Greenberg S. Rac1 and Cdc42 are required for phagocytosis, but not NF-kappaB-dependent gene expression, in macrophages challenged with Pseudomonas aeruginosa. J Biol Chem. 2000;275:141-6 pubmed
    ..Rac1 and Cdc42 serve as effectors of phagocytosis, but not NF-kappaB-dependent gene expression, in the macrophage response to P. aeruginosa. ..
  59. Davalos D, Grutzendler J, Yang G, Kim J, Zuo Y, Jung S, et al. ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci. 2005;8:752-8 pubmed
    ..Thus, extracellular ATP regulates microglial branch dynamics in the intact brain, and its release from the damaged tissue and surrounding astrocytes mediates a rapid microglial response towards injury. ..
  60. Du Z, Kelly E, Mecklenbrauker I, Agle L, Herrero C, Paik P, et al. Selective regulation of IL-10 signaling and function by zymosan. J Immunol. 2006;176:4785-92 pubmed
    ..The fate of individual cells in an inflammatory microenvironment is thus specified by dynamic interactions among host cells, microbes, and cytokines that determine the balance between protection and pathology. ..
  61. Sander L, Davis M, Boekschoten M, Amsen D, Dascher C, Ryffel B, et al. Detection of prokaryotic mRNA signifies microbial viability and promotes immunity. Nature. 2011;474:385-9 pubmed publisher
    ..Detection of vita-PAMPs triggers a state of alert not warranted for dead bacteria. Vaccine formulations that incorporate vita-PAMPs could thus combine the superior protection of live vaccines with the safety of dead vaccines. ..
  62. Ali W, Chen Q, DelGiorno K, Su W, Hall J, Hongu T, et al. Deficiencies of the lipid-signaling enzymes phospholipase D1 and D2 alter cytoskeletal organization, macrophage phagocytosis, and cytokine-stimulated neutrophil recruitment. PLoS ONE. 2013;8:e55325 pubmed publisher
    ..PLD1-driven processes in particular were observed to be critical in transmigration of macrophages exiting the vasculature during immune responses such as those seen in acute pancreatitis or irritant-induced skin vascularization. ..
  63. Finnemann S, Nandrot E. MerTK activation during RPE phagocytosis in vivo requires alphaVbeta5 integrin. Adv Exp Med Biol. 2006;572:499-503 pubmed
  64. Allina J, Stanca C, Garber J, Hu B, Sautes Fridman C, Bach N, et al. Anti-CD16 autoantibodies and delayed phagocytosis of apoptotic cells in primary biliary cirrhosis. J Autoimmun. 2008;30:238-45 pubmed
    ..050). In conclusion, PBC macrophage phagocytosis of opsonized apoptotic cells is impaired, irrespective of serum factors and may increase hepatic inflammation...
  65. Overholtzer M, Brugge J. The cell biology of cell-in-cell structures. Nat Rev Mol Cell Biol. 2008;9:796-809 pubmed publisher
    ..Some of these structures seem to form by the invasion of one cell into another, rather than by engulfment. The mechanisms of cell-in-cell formation and the possible physiological roles of these processes will be discussed. ..
  66. Aziz M, Jacob A, Matsuda A, Wu R, Zhou M, Dong W, et al. Pre-treatment of recombinant mouse MFG-E8 downregulates LPS-induced TNF-? production in macrophages via STAT3-mediated SOCS3 activation. PLoS ONE. 2011;6:e27685 pubmed publisher
    ..Our findings strongly suggest that MFG-E8 is a direct anti-inflammatory molecule, and that it could be developed as a therapy in attenuating inflammation and tissue injury. ..
  67. Elsbach P, Weiss J. The bactericidal/permeability-increasing protein (BPI), a potent element in host-defense against gram-negative bacteria and lipopolysaccharide. Immunobiology. 1993;187:417-29 pubmed
    ..Recombinant forms of both proteins protect animals against the lethal effects of administered LPS. ..
  68. Nandrot E, Kim Y, Brodie S, Huang X, Sheppard D, Finnemann S. Loss of synchronized retinal phagocytosis and age-related blindness in mice lacking alphavbeta5 integrin. J Exp Med. 2004;200:1539-45 pubmed
    ..Furthermore, they identify the beta5-/- integrin mouse strain as a new animal model of age-related retinal dysfunction. ..
  69. Allina J, Hu B, Sullivan D, Fiel M, Thung S, Bronk S, et al. T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis. J Autoimmun. 2006;27:232-41 pubmed
    ..BECs have the ability to present novel mitochondrial self-peptides derived from phagocytosed apoptotic BECs. Apoptotic cell phagocytosis by non-professional phagocytes may influence the tissue specificity of autoimmune diseases...
  70. Yvan Charvet L, Pagler T, Seimon T, Thorp E, Welch C, Witztum J, et al. ABCA1 and ABCG1 protect against oxidative stress-induced macrophage apoptosis during efferocytosis. Circ Res. 2010;106:1861-9 pubmed publisher
    ..The ATP-binding cassette transporters ABCA1 and ABCG1 have a major role in promoting cholesterol efflux from macrophages to apolipoprotein A-1 and HDL and are upregulated during the phagocytosis of apoptotic cells (efferocytosis)...
  71. Chrisman C, Alvarez M, Casadevall A. Phagocytosis of Cryptococcus neoformans by, and nonlytic exocytosis from, Acanthamoeba castellanii. Appl Environ Microbiol. 2010;76:6056-62 pubmed publisher
    ..These results provide additional support for the notion that some mechanisms of virulence observed during mammalian infection originated, and were selected for, by environmental interactions...
  72. Fernandez Arias C, Lopez J, Hernandez Perez J, Bautista Ojeda M, Branch O, Rodriguez A. Malaria inhibits surface expression of complement receptor 1 in monocytes/macrophages, causing decreased immune complex internalization. J Immunol. 2013;190:3363-72 pubmed publisher
    ..We propose that this decrease in CR1 plays an essential role in impaired IC clearance during malaria. ..
  73. Takai T, Li M, Sylvestre D, Clynes R, Ravetch J. FcR gamma chain deletion results in pleiotrophic effector cell defects. Cell. 1994;76:519-29 pubmed
    ..These mice thus represent an important tool for evaluating the role of these receptors in humoral and cellular immune responses. ..
  74. Parravicini E, van de Ven C, Anderson L, Cairo M. Myeloid hematopoietic growth factors and their role in prevention and/or treatment of neonatal sepsis. Transfus Med Rev. 2002;16:11-24 pubmed
  75. Cui D, Thorp E, Li Y, Wang N, Yvan Charvet L, Tall A, et al. Pivotal advance: macrophages become resistant to cholesterol-induced death after phagocytosis of apoptotic cells. J Leukoc Biol. 2007;82:1040-50 pubmed
    ..These findings have implications for macrophage physiology in both AC clearance and atherosclerotic plaque progression. ..
  76. Chang Y, Finnemann S. Tetraspanin CD81 is required for the alpha v beta5-integrin-dependent particle-binding step of RPE phagocytosis. J Cell Sci. 2007;120:3053-63 pubmed
    ..CD81 does not function as a binding receptor by itself but promotes outer segment particle binding through functional interaction specifically with alpha v beta5 integrin. ..
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