Experts and Doctors on peptide receptors in California, United States

Summary

Locale: California, United States
Topic: peptide receptors

Top Publications

  1. Sharma S, Thomas D, Marlett J, Manchester M, Young J. Efficient neutralization of antibody-resistant forms of anthrax toxin by a soluble receptor decoy inhibitor. Antimicrob Agents Chemother. 2009;53:1210-2 pubmed publisher
  2. Pfeffer S. Unsolved mysteries in membrane traffic. Annu Rev Biochem. 2007;76:629-45 pubmed
    ..But much remains to be learned. This review highlights underlying themes in membrane traffic to help us refocus and solve many remaining and newly emerging issues that are fundamental to mammalian cell biology and human physiology. ..
  3. Prossnitz E. Desensitization of N-formylpeptide receptor-mediated activation is dependent upon receptor phosphorylation. J Biol Chem. 1997;272:15213-9 pubmed
  4. Simon M. Signal transduction during the development of the Drosophila R7 photoreceptor. Dev Biol. 1994;166:431-42 pubmed
  5. Scobie H, Thomas D, Marlett J, Destito G, Wigelsworth D, Collier R, et al. A soluble receptor decoy protects rats against anthrax lethal toxin challenge. J Infect Dis. 2005;192:1047-51 pubmed
    ..Stoichiometric concentrations of sCMG2 protect rats against lethal toxin challenge, making sCMG2 one of the most effective anthrax antitoxins described to date. ..
  6. Kumagai J, Hsu S, Matsumi H, Roh J, Fu P, Wade J, et al. INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent. J Biol Chem. 2002;277:31283-6 pubmed
    ..Demonstration of INSL3 as the ligand for LGR8 facilitates understanding of the mechanism of testis descent and allows studies on the role of INSL3 in gonadal and other physiological processes. ..
  7. Chen Z, Zandonatti M, Jakubowski D, Fox H. Brain capillary endothelial cells express MBEC1, a protein that is related to the Clostridium perfringens enterotoxin receptors. Lab Invest. 1998;78:353-63 pubmed
    ..Our research thus provides a new molecule for further study of the function of normal and abnormal blood-brain barrier as well as of other specialized endothelia and epithelia. ..
  8. Van Wye J, Ghori N, Webster P, Mitschler R, Elmendorf H, Haldar K. Identification and localization of rab6, separation of rab6 from ERD2 and implications for an 'unstacked' Golgi, in Plasmodium falciparum. Mol Biochem Parasitol. 1996;83:107-20 pubmed
    ..Hence the Golgi of ring stage parasites may comprise of multiple, 'unstacked' tubulovesicular clusters, suggesting a primitive organization of the organelle in Plasmodia. ..
  9. Prossnitz E, Kim C, Benovic J, Ye R. Phosphorylation of the N-formyl peptide receptor carboxyl terminus by the G protein-coupled receptor kinase, GRK2. J Biol Chem. 1995;270:1130-7 pubmed

More Information

Publications18

  1. Wu L, Russell P. Roles of Wee1 and Nim1 protein kinases in regulating the switch from mitotic division to sexual development in Schizosaccharomyces pombe. Mol Cell Biol. 1997;17:10-7 pubmed
    ..These findings indicate that Wee1 and Rum1 act jointly to inhibit Cdc2 and promote sexual development in nitrogen-starved cells. ..
  2. Sudo S, Kumagai J, Nishi S, Layfield S, Ferraro T, Bathgate R, et al. H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2. J Biol Chem. 2003;278:7855-62 pubmed
  3. Almenoff J, Jurka J, Schoolnik G. Induction of heat-stable enterotoxin receptor activity by a human Alu repeat. J Biol Chem. 1994;269:16610-7 pubmed
    ..An unrelated Alu-rich genomic clone did not confer ST binding, suggesting that there may be structural and functional specificity within individual Alu sequences. ..
  4. Scobie H, Wigelsworth D, Marlett J, Thomas D, Rainey G, Lacy D, et al. Anthrax toxin receptor 2-dependent lethal toxin killing in vivo. PLoS Pathog. 2006;2:e111 pubmed
    ..Moreover, a D683K mutant form of PA that bound specifically to human and rat ANTXR2 mediated killing of rats by anthrax lethal toxin, providing strong evidence for the physiological importance of ANTXR2 in anthrax disease pathogenesis. ..
  5. Ptasznik A, Traynor Kaplan A, Bokoch G. G protein-coupled chemoattractant receptors regulate Lyn tyrosine kinase.Shc adapter protein signaling complexes. J Biol Chem. 1995;270:19969-73 pubmed
    ..Regulation of Shc by G protein-coupled receptors may also allow these receptors to modulate the activity of the Ras/mitogen-activated protein kinase cascade. ..
  6. Lewis K, Gray P, Blount A, MacConell L, Wiater E, Bilezikjian L, et al. Betaglycan binds inhibin and can mediate functional antagonism of activin signalling. Nature. 2000;404:411-4 pubmed
    ..The ability of betaglycan to facilitate inhibin antagonism of activin provides a variation on the emerging roles of proteoglycans as co-receptors modulating ligand-receptor sensitivity, selectivity and function. ..
  7. Hsu S, Kudo M, Chen T, Nakabayashi K, Bhalla A, van der Spek P, et al. The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7. Mol Endocrinol. 2000;14:1257-71 pubmed
  8. Egea P, Shan S, Napetschnig J, Savage D, Walter P, Stroud R. Substrate twinning activates the signal recognition particle and its receptor. Nature. 2004;427:215-21 pubmed
    ..This unique circle of twinned interactions is severed twice on hydrolysis, leading to complex dissociation after cargo delivery...
  9. Santelli E, Bankston L, Leppla S, Liddington R. Crystal structure of a complex between anthrax toxin and its host cell receptor. Nature. 2004;430:905-8 pubmed publisher
    ..The structure provides new leads for the discovery of anthrax anti-toxins, and should aid the design of cancer therapeutics...