Genomes and Genes
Experts and Doctors on oxygen in California, United States
Locale: California, United States
- Brown C, Neidig M, Neibergall M, Lipscomb J, Solomon E. VTVH-MCD and DFT studies of thiolate bonding to [FeNO]7/[FeO2]8 complexes of isopenicillin N synthase: substrate determination of oxidase versus oxygenase activity in nonheme Fe enzymes. J Am Chem Soc. 2007;129:7427-38 pubmed..This single center reaction allows IPNS to avoid the O2 bridged binding generally invoked in other nonheme Fe enzymes that leads to oxygen insertion (i.e., oxygenase function) and determines the oxidase activity of IPNS. ..
- Pau M, Davis M, Orville A, Lipscomb J, Solomon E. Spectroscopic and electronic structure study of the enzyme-substrate complex of intradiol dioxygenases: substrate activation by a high-spin ferric non-heme iron site. J Am Chem Soc. 2007;129:1944-58 pubmed
- Grossman A, Bhaya D, Apt K, Kehoe D. Light-harvesting complexes in oxygenic photosynthesis: diversity, control, and evolution. Annu Rev Genet. 1995;29:231-88 pubmed..e. light quantity and quality, nutrients) modulate the synthesis of these complexes, and discuss the evolutionary relationships among the LHC structural polypeptides. ..
- Friedlander M. Combination angiostatic therapies: targeting multiple angiogenic pathways. Retina. 2009;29:S27-9 pubmed publisher..For the prevention of new blood vessel formation in neovascular eye diseases like age-related macular degeneration, the experimental evidence supports combination therapies that inhibit more than one molecular pathway. ..
- Hilgendorff A, Parai K, Ertsey R, Juliana Rey Parra G, Thebaud B, Tamosiuniene R, et al. Neonatal mice genetically modified to express the elastase inhibitor elafin are protected against the adverse effects of mechanical ventilation on lung growth. Am J Physiol Lung Cell Mol Physiol. 2012;303:L215-27 pubmed publisher..These results suggest that degradation and remodeling of lung elastin can contribute to defective lung growth in response to MV-O(2) and might be targeted therapeutically to prevent ventilator-induced neonatal lung injury. ..
- DeBeer George S, Basumallick L, Szilagyi R, Randall D, Hill M, Nersissian A, et al. Spectroscopic investigation of stellacyanin mutants: axial ligand interactions at the blue copper site. J Am Chem Soc. 2003;125:11314-28 pubmed..These spectroscopic studies are complemented by DFT calculations to obtain insight into the factors that allow stellacyanin to maintain a trigonally distorted tetrahedral structure with a relatively strong axial Cu(II)-oxygen bond. ..
- Op t Holt B, Vance M, Mirica L, Heppner D, Stack T, Solomon E. Reaction coordinate of a functional model of tyrosinase: spectroscopic and computational characterization. J Am Chem Soc. 2009;131:6421-38 pubmed publisher..Parallels and contrasts are drawn between the spectroscopically and computationally supported mechanism of the DBED system, presented here, and the experimentally derived mechanism of the coupled binuclear copper protein tyrosinase. ..
- Stapleton J, Swartz J. A cell-free microtiter plate screen for improved [FeFe] hydrogenases. PLoS ONE. 2010;5:e10554 pubmed publisher..The system is based on our ability to activate these complex enzymes in E. coli cell extracts, which allows unhindered access to the protein maturation and assay environment. ..
- Lee S, George S, Antholine W, Hedman B, Hodgson K, Solomon E. Nature of the intermediate formed in the reduction of O(2) to H(2)O at the trinuclear copper cluster active site in native laccase. J Am Chem Soc. 2002;124:6180-93 pubmed..Thus, the native intermediate appears to be the catalytically relevant fully oxidized form of the enzyme, and its role in catalysis is considered. ..
- Lin A, Reinhard M. Photodegradation of common environmental pharmaceuticals and estrogens in river water. Environ Toxicol Chem. 2005;24:1303-9 pubmed..The presence of oxygen doubled the direct photolysis rates of naproxen and propranolol. In nonautoclaved river water, 80% of E2 rapidly biotransformed to E1 within less than 20 min, whereas all other compounds remained stable over 22 h. ..
- Grossman A, Lohr M, Im C. Chlamydomonas reinhardtii in the landscape of pigments. Annu Rev Genet. 2004;38:119-73 pubmed..These areas of research have become especially attractive for intensive development with the application of potent molecular and genomic tools currently being applied to studies of C. reinhardtii. ..
- Lynch C, Uddin L, Supekar K, Khouzam A, Phillips J, Menon V. Default mode network in childhood autism: posteromedial cortex heterogeneity and relationship with social deficits. Biol Psychiatry. 2013;74:212-9 pubmed publisher..This work links hyperconnectivity of DMN-related circuits to the core social deficits in young children with ASD and highlights fundamental aspects of posteromedial cortex heterogeneity. ..
- Dam T, Ewing S, Ancoli Israel S, Ensrud K, Redline S, Stone K. Association between sleep and physical function in older men: the osteoporotic fractures in men sleep study. J Am Geriatr Soc. 2008;56:1665-73 pubmed publisher..Greater sleep fragmentation and hypoxia are associated with poorer physical function in older men. ..
- Zhou D, Xue J, Chen J, Morcillo P, Lambert J, White K, et al. Experimental selection for Drosophila survival in extremely low O(2) environment. PLoS ONE. 2007;2:e490 pubmed..Because of conservation of pathways, we believe that such genes are critical in hypoxia adaptation in physiological or pathological conditions not only in Drosophila but also in mammals. ..
- Fee J, Case D, Noodleman L. Toward a chemical mechanism of proton pumping by the B-type cytochrome c oxidases: application of density functional theory to cytochrome ba3 of Thermus thermophilus. J Am Chem Soc. 2008;130:15002-21 pubmed publisher..E. M.; Blomberg, M. A. R. Chem. Rev. 2000, 100, 421-437) and shows how the chemistry of O 2 reduction in the heme a 3 -Cu B dinuclear center can be harnessed to generate an electrochemical proton gradient across the lipid bilayer. ..
- Cumming R, Andon N, Haynes P, Park M, Fischer W, Schubert D. Protein disulfide bond formation in the cytoplasm during oxidative stress. J Biol Chem. 2004;279:21749-58 pubmed..Our findings indicate that disulfide bond formation within families of cytoplasmic proteins is dependent on the nature of the oxidative insult and may provide a common mechanism used to control multiple physiological processes. ..
- Christie J, Hitomi K, Arvai A, Hartfield K, Mettlen M, Pratt A, et al. Structural tuning of the fluorescent protein iLOV for improved photostability. J Biol Chem. 2012;287:22295-304 pubmed publisher..These findings provide a framework for structural fine-tuning of LOV scaffold proteins to maximize their potential as oxygen-independent fluorescent reporters. ..
- Vicente J, Tran V, Pinto L, Teixeira M, Singh U. A detoxifying oxygen reductase in the anaerobic protozoan Entamoeba histolytica. Eukaryot Cell. 2012;11:1112-8 pubmed publisher..This observation represents a new mechanism of oxygen resistance in the anaerobic protozoan pathogen E. histolytica...
- Ingraham C, Park G, Makarenkova H, Crossin K. Matrix metalloproteinase (MMP)-9 induced by Wnt signaling increases the proliferation and migration of embryonic neural stem cells at low O2 levels. J Biol Chem. 2011;286:17649-57 pubmed publisher..Thus, MMP-9 is a key molecular effector, downstream of HIF-1? and Wnt activation, responsible for increased rates of NSC proliferation and migration in 1% O(2). ..
- Payne J, Groves J, Jost A, Nguyen T, Moffitt S, Hill T, et al. Late paleozoic fusulinoidean gigantism driven by atmospheric hyperoxia. Evolution. 2012;66:2929-39 pubmed publisher..These findings provide the first quantitative confirmation of a direct connection between Paleozoic gigantism and atmospheric hyperoxia. ..
- Schuenemann D, Amin P, Hartmann E, Hoffman N. Chloroplast SecY is complexed to SecE and involved in the translocation of the 33-kDa but not the 23-kDa subunit of the oxygen-evolving complex. J Biol Chem. 1999;274:12177-82 pubmed..The antibodies inhibited translocation of OE33 but not OE23, indicating that cpSecY comprises the protein-conducting channel used in the SecA-dependent pathway, whereas a distinct protein conducting channel is used to translocate OE23. ..
- Richardson R, Grassi B, Gavin T, Haseler L, Tagore K, Roca J, et al. Evidence of O2 supply-dependent VO2 max in the exercise-trained human quadriceps. J Appl Physiol (1985). 1999;86:1048-53 pubmed
- Sinha P, Torres Bacete J, Nakamaru Ogiso E, Castro Guerrero N, Matsuno Yagi A, Yagi T. Critical roles of subunit NuoH (ND1) in the assembly of peripheral subunits with the membrane domain of Escherichia coli NDH-1. J Biol Chem. 2009;284:9814-23 pubmed publisher..Implications for the involvement of NuoH (ND1) in maintaining the structure and function of NDH-1 are discussed. ..
- Lo H, Han H, D Souza L, Sinha S, Keinan E. Rhenium(VII) oxide catalyzed heteroacylative ring-opening dimerization of tetrahydrofuran. J Am Chem Soc. 2007;129:1246-53 pubmed..This synthetically useful reaction highlights the unique, frequently avoided Lewis acidity of transition-metal oxides...
- Schwartz J, Wei P, Mitchell K, Fox B, Solomon E. Geometric and electronic structure studies of the binuclear nonheme ferrous active site of toluene-4-monooxygenase: parallels with methane monooxygenase and insight into the role of the effector proteins in O2 activation. J Am Chem Soc. 2008;130:7098-109 pubmed publisher
- Le Q, Chen E, Salim A, Cao H, Kong C, Whyte R, et al. An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancers. Clin Cancer Res. 2006;12:1507-14 pubmed..Tumor hypoxia and elevated osteopontin levels and CD44 expression correlated with poor prognosis. A larger study is needed to confirm the prognostic significance of these factors. ..
- Dennery P, Spitz D, Yang G, Tatarov A, Lee C, Shegog M, et al. Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2. J Clin Invest. 1998;101:1001-11 pubmed..These results suggest that HO-2 functions to augment the turnover of lung iron during oxidative stress, and that this function does not appear to be compensated for by induction of HO-1 in the knockouts. ..
- Itahana K, Zou Y, Itahana Y, Martinez J, Beausejour C, Jacobs J, et al. Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1. Mol Cell Biol. 2003;23:389-401 pubmed..Our data suggest that Bmi-1 extends the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway. ..
- Kim C, Monack D, Falkow S. Modulation of virulence by two acidified nitrite-responsive loci of Salmonella enterica serovar Typhimurium. Infect Immun. 2003;71:3196-205 pubmed..We conclude that these genes are regulated by physiological nitrogen oxides and that the absence of these bacterial genes in some way diminishes the ability of mice to clear a low dose infection. ..
- Richardson R, Wagner H, Mudaliar S, Saucedo E, Henry R, Wagner P. Exercise adaptation attenuates VEGF gene expression in human skeletal muscle. Am J Physiol Heart Circ Physiol. 2000;279:H772-8 pubmed..4 +/- 1.3). These data support the concept that VEGF is involved in exercise-induced skeletal muscle angiogenesis and appears to be subject to a negative feedback mechanism as exercise adaptations occur...
- Decker A, Solomon E. Dioxygen activation by copper, heme and non-heme iron enzymes: comparison of electronic structures and reactivities. Curr Opin Chem Biol. 2005;9:152-63 pubmed..This review compares and contrasts the electronic structures and reactivities of these various oxygen intermediates. ..
- Yogalingam G, Hwang S, Ferreira J, Mochly Rosen D. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) phosphorylation by protein kinase C? (PKC?) inhibits mitochondria elimination by lysosomal-like structures following ischemia and reoxygenation-induced injury. J Biol Chem. 2013;288:18947-60 pubmed publisher..Taken together, we identified a GAPDH/PKC? signaling switch, which is activated during oxidative stress to regulate the balance between cell survival by mitophagy and cell death due to accumulation of damaged mitochondria. ..
- Zhao H, Zhou D, Nizet V, Haddad G. Experimental selection for Drosophila survival in extremely high O2 environments. PLoS ONE. 2010;5:e11701 pubmed publisher..Thus our study provides a molecular basis for understanding the mechanisms of hyperoxia tolerance. ..
- Montel V, Gaultier A, Lester R, Campana W, Gonias S. The low-density lipoprotein receptor-related protein regulates cancer cell survival and metastasis development. Cancer Res. 2007;67:9817-24 pubmed..0% O2. These results suggest mechanisms by which LRP-1 may facilitate the development and growth of cancer metastases in vivo. ..
- Jou T, Patterson S, Pauly J, Bowen C. Fat-suppressed alternating-SSFP for whole-brain fMRI using breath-hold and visual stimulus paradigms. Magn Reson Med. 2016;75:1978-88 pubmed publisher..Artifact-suppressed images are demonstrated, showing a practical pass-band-balanced steady-state free precession fMRI method that permits whole-brain imaging with excellent blood oxygen level-dependent sensitivity and fat suppression. ..
- Salim A, Nacamuli R, Morgan E, Giaccia A, Longaker M. Transient changes in oxygen tension inhibit osteogenic differentiation and Runx2 expression in osteoblasts. J Biol Chem. 2004;279:40007-16 pubmed
- Kraut D, Sigala P, Pybus B, Liu C, Ringe D, Petsko G, et al. Testing electrostatic complementarity in enzyme catalysis: hydrogen bonding in the ketosteroid isomerase oxyanion hole. PLoS Biol. 2006;4:e99 pubmed
- Hammond E, Dorie M, Giaccia A. ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation. J Biol Chem. 2003;278:12207-13 pubmed..Taken together these data implicate both ATR and ATM as critical roles in the response of hypoxia and reperfusion in solid tumors. ..
- Dai X, Mashiguchi K, Chen Q, Kasahara H, Kamiya Y, Ojha S, et al. The biochemical mechanism of auxin biosynthesis by an arabidopsis YUCCA flavin-containing monooxygenase. J Biol Chem. 2013;288:1448-57 pubmed publisher..This work reveals the catalytic mechanism of the first known plant flavin monooxygenase and provides a foundation for further investigating how YUC activities are regulated in plants. ..
- Goldin P, McRae K, Ramel W, Gross J. The neural bases of emotion regulation: reappraisal and suppression of negative emotion. Biol Psychiatry. 2008;63:577-86 pubmed
- Catrina I, O Brien P, Purcell J, Nikolic Hughes I, Zalatan J, Hengge A, et al. Probing the origin of the compromised catalysis of E. coli alkaline phosphatase in its promiscuous sulfatase reaction. J Am Chem Soc. 2007;129:5760-5 pubmed..We suggest that the lower charge density of this oxygen atom on a transferred sulfuryl group accounts for a large fraction of the decreased stabilization of the transition state for its reaction relative to phosphoryl transfer. ..
- Banin E, Dorrell M, Aguilar E, Ritter M, Aderman C, Smith A, et al. T2-TrpRS inhibits preretinal neovascularization and enhances physiological vascular regrowth in OIR as assessed by a new method of quantification. Invest Ophthalmol Vis Sci. 2006;47:2125-34 pubmed..The results obtained using this method suggest enhanced clinical value for compounds such as T2-TrpRS that not only inhibit pathologic neovascularization, but also facilitate physiological revascularization of ischemic tissue. ..
- Wang Y, Zhang C, Yu R, Cho H, Nelson M, Bayuga Ocampo C, et al. Regulation of muscle fiber type and running endurance by PPARdelta. PLoS Biol. 2004;2:e294 pubmed..These results demonstrate that complex physiologic properties such as fatigue, endurance, and running capacity can be molecularly analyzed and manipulated. ..
- Chambers M, Song K, Schneider D. Listeria monocytogenes infection causes metabolic shifts in Drosophila melanogaster. PLoS ONE. 2012;7:e50679 pubmed publisher..Free amino acid levels also change during infection, including a drop in tyrosine levels which may be due to robust L. monocytogenes induced melanization. ..
- Larocque K, Smith M, Carr V, Witthoft N, Grill Spector K, Wagner A. Global similarity and pattern separation in the human medial temporal lobe predict subsequent memory. J Neurosci. 2013;33:5466-74 pubmed publisher..These data provide novel evidence that complementary MTL encoding computations subserve declarative memory. ..
- Avellaneda Matteo D, Grunseth A, Gonzalez E, Anselmo S, Kennedy M, Moman P, et al. Molecular mechanisms of isocitrate dehydrogenase 1 (IDH1) mutations identified in tumors: The role of size and hydrophobicity at residue 132 on catalytic efficiency. J Biol Chem. 2017;292:7971-7983 pubmed publisher..We report that one mutation can support both the normal and neomorphic reactions. These studies illuminate catalytic features of mutations found in the majority of patients with lower grade gliomas. ..
- Rowsell E, Smith J, Wolfe A, Taylor B. CheA, CheW, and CheY are required for chemotaxis to oxygen and sugars of the phosphotransferase system in Escherichia coli. J Bacteriol. 1995;177:6011-4 pubmed..Thus, we conclude that both the methylation-independent and methylation-dependent pathways converge at CheA, the histidine kinase product of cheA. ..
- Richardson R, Leigh J, Wagner P, Noyszewski E. Cellular PO2 as a determinant of maximal mitochondrial O(2) consumption in trained human skeletal muscle. J Appl Physiol (1985). 1999;87:325-31 pubmed
- Khurana A, Nakayama K, Williams S, Davis R, Mustelin T, RONAI Z. Regulation of the ring finger E3 ligase Siah2 by p38 MAPK. J Biol Chem. 2006;281:35316-26 pubmed..In all, our findings reveal the phosphorylation of Siah2 by p38 and the implications of such phosphorylation for Siah2 activity toward PHD3. ..
- Huang H, Haddad G. Drosophila dMRP4 regulates responsiveness to O2 deprivation and development under hypoxia. Physiol Genomics. 2007;29:260-6 pubmed..Thus, our data suggest novel roles for MRP in vivo: 1) dMRP4 regulates the sensitivity to acute or chronic O(2) deprivation, and 2) dMRP expression in neurons is sufficient to induce the sensitivity to O(2) in the whole organism. ..
- Wegner N, Sepulveda C, Bull K, Graham J. Gill morphometrics in relation to gas transfer and ram ventilation in high-energy demand teleosts: scombrids and billfishes. J Morphol. 2010;271:36-49 pubmed publisher..The branching of the gill filaments documented for the swordfish in this study appears to increase its gill surface area above that of other billfishes and may allow it to penetrate oxygen-poor waters at depth. ..
- Snyder R, Bell C, Diao Y, Krebs C, Bollinger J, Solomon E. Circular dichroism, magnetic circular dichroism, and variable temperature variable field magnetic circular dichroism studies of biferrous and mixed-valent myo-inositol oxygenase: insights into substrate activation of O2 reactivity. J Am Chem Soc. 2013;135:15851-63 pubmed publisher..This perturbation results in the release of a coordinated water from the Fe(II) that enables its O2 activation. ..
- Johnson M, Zhulin I, Gapuzan M, Taylor B. Oxygen-dependent growth of the obligate anaerobe Desulfovibrio vulgaris Hildenborough. J Bacteriol. 1997;179:5598-601 pubmed..Oxygen concentrations of 0.08% and higher arrested growth. We propose that in zones of transition from an oxic to an anoxic environment, D. vulgaris protects anoxic microenvironments from intrusion of oxygen...
- Edler A, Mariano E, Golianu B, Kuan C, Pentcheva K. An analysis of factors influencing postanesthesia recovery after pediatric ambulatory tonsillectomy and adenoidectomy. Anesth Analg. 2007;104:784-9 pubmed
- Thorpe I, Brooks C. The coupling of structural fluctuations to hydride transfer in dihydrofolate reductase. Proteins. 2004;57:444-57 pubmed..Such mutational changes are anticipated to adjust the hydride transfer efficacy of DHFR by modifying equilibrium distributions of hydride transfer barriers found in the enzyme. ..
- Zhulin I, Johnson M, Taylor B. How do bacteria avoid high oxygen concentrations?. Biosci Rep. 1997;17:335-42 pubmed..A novel protein, Aer, and the chemotaxis serine receptor, Tsr, have recently been identified as transducers for aerotaxis which monitor internal energy levels in the bacteria. ..
- Jarecki J, Johnson E, Krasnow M. Oxygen regulation of airway branching in Drosophila is mediated by branchless FGF. Cell. 1999;99:211-20 pubmed..Thus, a single growth factor is reiteratively used to pattern each level of airway branching, and the change in branch patterning results from a switch from developmental to physiological control of its expression. ..
- Liang Y, Wang H, Diao P, Chang W, Hong G, Li Y, et al. Oxygen reduction electrocatalyst based on strongly coupled cobalt oxide nanocrystals and carbon nanotubes. J Am Chem Soc. 2012;134:15849-57 pubmed
- Hepple R, Hogan M, Stary C, Bebout D, Mathieu Costello O, Wagner P. Structural basis of muscle O(2) diffusing capacity: evidence from muscle function in situ. J Appl Physiol (1985). 2000;88:560-6 pubmed..C muscle. The results show that a dramatically increased capillary density (and reduced diffusion distance) after short-term immobilization does not improve Dmus(O(2)) in heavily working skeletal muscle...
- Saito A, Hayashi T, Okuno S, Nishi T, Chan P. Modulation of proline-rich akt substrate survival signaling pathways by oxidative stress in mouse brains after transient focal cerebral ischemia. Stroke. 2006;37:513-7 pubmed..These results suggest that overexpression of SOD1 may affect the PRAS pathway after tFCI by reducing the direct oxidative reaction to pPRAS after reperfusion injury. ..
- Zahr N, Mayer D, Rohlfing T, Hasak M, Hsu O, Vinco S, et al. Brain injury and recovery following binge ethanol: evidence from in vivo magnetic resonance spectroscopy. Biol Psychiatry. 2010;67:846-54 pubmed publisher..Rapid recovery of ventricular volume and metabolite levels with removal of the causative agent argues for transient rather than permanent effects of a single EtOH binge episode in rats. ..
- Taylor B, Zhulin I, Johnson M. Aerotaxis and other energy-sensing behavior in bacteria. Annu Rev Microbiol. 1999;53:103-28 pubmed..It plays a central role in the behavior of magnetotactic bacteria and also appears to be important in plant-microbe interactions. ..
- Crane B, Arvai A, Ghosh S, Getzoff E, Stuehr D, Tainer J. Structures of the N(omega)-hydroxy-L-arginine complex of inducible nitric oxide synthase oxygenase dimer with active and inactive pterins. Biochemistry. 2000;39:4608-21 pubmed..On the basis of these structures, we propose a testable mechanism where neutral H(4)B transfers both an electron and a 3,4-amide proton to the heme during the first step of NO synthesis. ..
- Howlett R, Hogan M. Intracellular PO(2) decreases with increasing stimulation frequency in contracting single Xenopus muscle fibers. J Appl Physiol (1985). 2001;91:632-6 pubmed..The linear decrease in intracellular PO(2) with stimulation frequency, and thus energy demand, suggests that a fall in intracellular PO(2) correlates with increased oxygen uptake in these single contracting cells...
- Boettiger C, Mitchell J, Tavares V, Robertson M, Joslyn G, D ESPOSITO M, et al. Immediate reward bias in humans: fronto-parietal networks and a role for the catechol-O-methyltransferase 158(Val/Val) genotype. J Neurosci. 2007;27:14383-91 pubmed..These results shed new light on the neurobiological underpinnings of temporal discounting behavior and identify novel behavioral and neural consequences of genetic variation in dopamine metabolism. ..
- Imamura T, Umezaki H, Kaushal K, Ducsay C. Long-term hypoxia alters endocrine and physiologic responses to umbilical cord occlusion in the ovine fetus. J Soc Gynecol Investig. 2004;11:131-40 pubmed..Despite similar ACTH responses to UCO, the cortisol response was greater in the LTH fetuses than in normoxic controls. LTH appears to result in enhanced adrenal sensitivity to a secondary stressor or altered cortisol metabolism. ..
- Jones B, Falkow S. Identification and characterization of a Salmonella typhimurium oxygen-regulated gene required for bacterial internalization. Infect Immun. 1994;62:3745-52 pubmed..The orgA mutant was as virulent as the wild-type strain was when inoculated intraperitoneally but is significantly reduced (> 60-fold) in its ability to cause disease by an oral route of infection. ..
- Hammond E, Dorie M, Giaccia A. Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation. Cancer Res. 2004;64:6556-62 pubmed..In conclusion, ATR and Chk1 play critical roles in the cellular response to hypoxia/reoxygenation, and inhibitors of ATR and Chk1 represent new hypoxic cell cytotoxins. ..
- Costa A, Trudell J. Toxicity of 1,2-dibromoethane in primary hepatocyte monolayer cultures: lack of dependence on oxygen concentration. Toxicol Appl Pharmacol. 1988;95:241-7 pubmed..This result is in direct contrast to a previous report where we showed that the toxicity of halothane is potentiated under hypoxic conditions. ..
- Suryanarayana S, Daunt D, von Zastrow M, Kobilka B. A point mutation in the seventh hydrophobic domain of the alpha 2 adrenergic receptor increases its affinity for a family of beta receptor antagonists. J Biol Chem. 1991;266:15488-92 pubmed..These data suggest that the Asn residue is involved in conferring specificity for binding to a specific class of beta receptor antagonists...
- Molotkov A, Duester G. Genetic evidence that retinaldehyde dehydrogenase Raldh1 (Aldh1a1) functions downstream of alcohol dehydrogenase Adh1 in metabolism of retinol to retinoic acid. J Biol Chem. 2003;278:36085-90 pubmed..These observations demonstrate that Raldh1 functions downstream of Adh1 in the oxidative metabolism of excess retinol and that toxicity correlates primarily with accumulating retinol rather than retinaldehyde. ..