Experts and Doctors on non histone chromosomal proteins in California, United States


Locale: California, United States
Topic: non histone chromosomal proteins

Top Publications

  1. Huang B, Mengersen A, Lee V. Molecular cloning of cDNA for caltractin, a basal body-associated Ca2+-binding protein: homology in its protein sequence with calmodulin and the yeast CDC31 gene product. J Cell Biol. 1988;107:133-40 pubmed
    ..The association of these sequence-related calcium-binding proteins to microtubule-organizing centers of divergent structure suggests a potential conserved function for the proteins. ..
  2. Yang J, Hildebrandt B, Luderschmidt C, Pollard K. Human scleroderma sera contain autoantibodies to protein components specific to the U3 small nucleolar RNP complex. Arthritis Rheum. 2003;48:210-7 pubmed
  3. Veeraraghavan S, Fagan P, Hu H, Lee V, Harper J, Huang B, et al. Structural independence of the two EF-hand domains of caltractin. J Biol Chem. 2002;277:28564-71 pubmed
    ..Thus, the C-terminal domain appears to also be capable of sensing Ca2+ signals but is activated by the binding of a single ion. ..
  4. Cairns B, Lorch Y, Li Y, Zhang M, Lacomis L, Erdjument Bromage H, et al. RSC, an essential, abundant chromatin-remodeling complex. Cell. 1996;87:1249-60 pubmed
    ..Contrary to a report for SWII/SNF complex, no association of RSC (nor of SWI/SNF complex) with RNA polymerase II holoenzyme was detected. ..
  5. Shelby R, Vafa O, Sullivan K. Assembly of CENP-A into centromeric chromatin requires a cooperative array of nucleosomal DNA contact sites. J Cell Biol. 1997;136:501-13 pubmed
  6. Kaeser M, Aslanian A, Dong M, Yates J, Emerson B. BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells. J Biol Chem. 2008;283:32254-63 pubmed publisher
    ..Taken together, our results provide insight into the function of compositionally diverse SWI/SNF enzymes that underlie their inherent gene-specific mode of action. ..
  7. Armstrong J, Bieker J, Emerson B. A SWI/SNF-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitro. Cell. 1998;95:93-104 pubmed
    ..Thus, a member of the SWI/SNF family acts directly in transcriptional activation and may regulate subsets of genes by selectively interacting with specific DNA-binding proteins. ..
  8. Zhao K, Wang W, Rando O, Xue Y, Swiderek K, Kuo A, et al. Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling. Cell. 1998;95:625-36 pubmed
    ..This work indicates that membrane signals control the activity of the mammalian SWI/SNF or BAF complex and demonstrates a direct interface between signaling and chromatin regulation. ..
  9. Kadam S, McAlpine G, Phelan M, Kingston R, Jones K, Emerson B. Functional selectivity of recombinant mammalian SWI/SNF subunits. Genes Dev. 2000;14:2441-51 pubmed

More Information


  1. Dingwall A, Beek S, McCallum C, Tamkun J, Kalpana G, Goff S, et al. The Drosophila snr1 and brm proteins are related to yeast SWI/SNF proteins and are components of a large protein complex. Mol Biol Cell. 1995;6:777-91 pubmed
  2. Bajpai R, Chen D, Rada Iglesias A, Zhang J, Xiong Y, Helms J, et al. CHD7 cooperates with PBAF to control multipotent neural crest formation. Nature. 2010;463:958-62 pubmed publisher
  3. Prudden J, Perry J, Arvai A, Tainer J, Boddy M. Molecular mimicry of SUMO promotes DNA repair. Nat Struct Mol Biol. 2009;16:509-16 pubmed publisher
    ..Our results provide a mechanistic basis for the near-synonymous roles of Rad60 and SUMO in survival of genotoxic stress and suggest unprecedented DNA-damage-response functions for SLDs in regulating sumoylation. ..
  4. Baskerville C, Segal M, Reed S. The protease activity of yeast separase (esp1) is required for anaphase spindle elongation independently of its role in cleavage of cohesin. Genetics. 2008;178:2361-72 pubmed publisher
    ..Such a function is consistent with the previous observation that Esp1 localizes to the mitotic spindle during anaphase. ..
  5. Raffa G, Wohlschlegel J, Yates J, Boddy M. SUMO-binding motifs mediate the Rad60-dependent response to replicative stress and self-association. J Biol Chem. 2006;281:27973-81 pubmed
    ..In addition, mutation of Rad60 Ser(32) and Ser(34) to alanine is lethal in cells deleted for the RecQ DNA helicase Rqh1. Finally, we find that Rad60 self-associates via its C-terminal SUMO-like domain and putative SUMO-binding motifs. ..
  6. Cheeseman I, Niessen S, Anderson S, Hyndman F, Yates J, Oegema K, et al. A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension. Genes Dev. 2004;18:2255-68 pubmed
    ..Thus, this protein network is a conserved constituent of the outer kinetochore, and the functions defined by our analysis in C. elegans are likely to be widely relevant. ..
  7. Boddy M, Shanahan P, McDonald W, Lopez Girona A, Noguchi E, Yates III J, et al. Replication checkpoint kinase Cds1 regulates recombinational repair protein Rad60. Mol Cell Biol. 2003;23:5939-46 pubmed
    ..These studies indicate that regulation of Rad60 is an important part of the replication checkpoint response controlled by Cds1. We propose that control of Rad60 regulates recombination events at stalled forks. ..
  8. Cairns B, Erdjument Bromage H, Tempst P, Winston F, Kornberg R. Two actin-related proteins are shared functional components of the chromatin-remodeling complexes RSC and SWI/SNF. Mol Cell. 1998;2:639-51 pubmed
    ..Our results suggest that actin-related proteins perform important roles in chromatin-remodeling complexes by virtue of structural rather than enzymatic similarities to actin. ..
  9. Cui X, De Vivo I, Slany R, Miyamoto A, Firestein R, Cleary M. Association of SET domain and myotubularin-related proteins modulates growth control. Nat Genet. 1998;18:331-7 pubmed
    ..We conclude that myotubularin-type phosphatases link SET-domain containing components of the epigenetic regulatory machinery with signalling pathways involved in growth and differentiation. ..
  10. Westendorf J, Konstantinov K, Wormsley S, Shu M, Matsumoto Taniura N, Pirollet F, et al. M phase phosphoprotein 10 is a human U3 small nucleolar ribonucleoprotein component. Mol Biol Cell. 1998;9:437-49 pubmed
    ..This association of MPP10 with U3 snoRNA was stable to 400 mM salt and suggested that MPP10 is a component of the human U3 small nucleolar ribonucleoprotein. ..
  11. Sullivan K, Hechenberger M, Masri K. Human CENP-A contains a histone H3 related histone fold domain that is required for targeting to the centromere. J Cell Biol. 1994;127:581-92 pubmed
    ..These data clearly indicate that the assembly of centromeres is driven, at least in part, by the incorporation of a novel core histone into centromeric chromatin...
  12. Yang J, Baserga S, Turley S, Pollard K. Fibrillarin and other snoRNP proteins are targets of autoantibodies in xenobiotic-induced autoimmunity. Clin Immunol. 2001;101:38-50 pubmed
    ..These studies suggest that the mercury-induced anti-nucleolar antibody response targets other protein components of the snoRNP particles in addition to fibrillarin...
  13. Dobie K, Hari K, Maggert K, Karpen G. Centromere proteins and chromosome inheritance: a complex affair. Curr Opin Genet Dev. 1999;9:206-17 pubmed
    ..A picture is beginning to emerge of the centromere-kinetechore as a complex and dynamic structure with conservation of function at the protein level across diverse species. ..
  14. Gao H, Cervantes R, Mandell E, Otero J, Lundblad V. RPA-like proteins mediate yeast telomere function. Nat Struct Mol Biol. 2007;14:208-14 pubmed
    ..Identification of an RPA-like complex that is targeted to a specific region of the genome suggests that multiple RPA-like complexes have evolved, each making individual contributions to genomic stability. ..
  15. Yoo A, Staahl B, Chen L, Crabtree G. MicroRNA-mediated switching of chromatin-remodelling complexes in neural development. Nature. 2009;460:642-6 pubmed publisher
    ..Indeed, expression of REST in post-mitotic neurons led to derepression of BAF53a, indicating that REST-mediated repression of microRNAs directs the essential switch of chromatin regulatory complexes. ..
  16. Olave I, Wang W, Xue Y, Kuo A, Crabtree G. Identification of a polymorphic, neuron-specific chromatin remodeling complex. Genes Dev. 2002;16:2509-17 pubmed
    ..We speculate that bBAF complexes create neuronal-specific patterns of chromatin accessibility, thereby imparting new regulatory characteristics to ubiquitous sequence-specific transcription factors in neurons. ..
  17. Blower M, Karpen G. The role of Drosophila CID in kinetochore formation, cell-cycle progression and heterochromatin interactions. Nat Cell Biol. 2001;3:730-9 pubmed
  18. Gorman M, Kuroda M, Baker B. Regulation of the sex-specific binding of the maleless dosage compensation protein to the male X chromosome in Drosophila. Cell. 1993;72:39-49 pubmed
    ..These data support a model whereby the activity of the mle protein is regulated through its association with one or more of the other msl proteins. ..