Experts and Doctors on neuropeptides in Massachusetts, United States
Locale: Massachusetts, United States
Li C, Nelson L, Kim K, Nathoo A, Hart A. Neuropeptide gene families in the nematode Caenorhabditis elegans. Ann N Y Acad Sci. 1999;897:239-52 pubmed
..Cellular expression patterns and genetic analysis of flp and nlp genes suggest that neuropeptides in nematodes also have widespread and varied roles in nervous system function. ..
Xie Z, Dong Y, Maeda U, Xia W, Tanzi R. RNA interference silencing of the adaptor molecules ShcC and Fe65 differentially affect amyloid precursor protein processing and Abeta generation. J Biol Chem. 2007;282:4318-25 pubmed
..These findings suggest that pharmacologically blocking interaction of APP with ShcC and Fe65 may provide novel therapeutic strategies against AD. ..
Benn S, Costigan M, Tate S, Fitzgerald M, Woolf C. Developmental expression of the TTX-resistant voltage-gated sodium channels Nav1.8 (SNS) and Nav1.9 (SNS2) in primary sensory neurons. J Neurosci. 2001;21:6077-85 pubmed
Augood S, Hollingsworth Z, Albers D, Yang L, Leung J, Breakefield X, et al
. Dopamine transmission in DYT1 dystonia. Adv Neurol. 2004;94:53-60 pubmed
Yokokura T, Dresnek D, Huseinovic N, Lisi S, Abdelwahid E, Bangs P, et al
. Dissection of DIAP1 functional domains via a mutant replacement strategy. J Biol Chem. 2004;279:52603-12 pubmed
..This ring domain function is required for Hid-induced apoptosis. We propose a model that synthesizes our data with those of other laboratories and provide a consistent model for DIAP1 function in living and dying cells. ..
Moon N, Frolov M, Kwon E, Di Stefano L, Dimova D, Morris E, et al
. Drosophila E2F1 has context-specific pro- and antiapoptotic properties during development. Dev Cell. 2005;9:463-75 pubmed
..These loss-of-function experiments demonstrate that E2F cannot be classified simply as a pro- or antiapoptotic factor. Instead, the overall role of E2F in the damage response varies greatly and depends on the cellular context. ..
Tzatsos A, Kandror K. Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation. Mol Cell Biol. 2006;26:63-76 pubmed
..Thus, diabetes-related hyperglycemia hyperactivates the mTOR pathway and may lead to insulin resistance due to suppression of IRS-1-dependent PI3-kinase/Akt signaling. ..
Zaidi N, Kuplast K, Washicosky K, Kajiwara Y, Buxbaum J, Wasco W. Calsenilin interacts with transcriptional co-repressor C-terminal binding protein(s). J Neurochem. 2006;98:1290-301 pubmed
..Finally, we demonstrated that calsenilin and CtBP are present in synaptic vesicles and can interact in vivo. ..
Amaya F, Wang H, Costigan M, Allchorne A, Hatcher J, Egerton J, et al
. The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity. J Neurosci. 2006;26:12852-60 pubmed
..9-/- mice. Na(v)1.9 is, we conclude, an effector of the hypersensitivity produced by multiple inflammatory mediators on nociceptor peripheral terminals and therefore plays a key role in mediating peripheral sensitization. ..