Genomes and Genes
Experts and Doctors on neurons in New York, United States
Locale: New York, United States
Publications761 found, 100 shown here
- Thirumalai V, Cline H. Endogenous dopamine suppresses initiation of swimming in prefeeding zebrafish larvae. J Neurophysiol. 2008;100:1635-48 pubmed publisher..These results led us to propose that endogenous dopamine release transiently suppresses swim circuits in developing zebrafish. ..
- Shirvalkar P. Hippocampal neural assemblies and conscious remembering. J Neurophysiol. 2009;101:2197-200 pubmed publisher..This review examines recent advances in understanding recollection in the context of spatiotemporally organized relational memory coding and discusses predictions and challenges for future research on conscious remembering...
- Gallo E, Iadecola C. Neuronal nitric oxide contributes to neuroplasticity-associated protein expression through cGMP, protein kinase G, and extracellular signal-regulated kinase. J Neurosci. 2011;31:6947-55 pubmed publisher..Our data unveil a previously unrecognized link between neuronal NO and the molecular machinery responsible for the sustained synaptic changes underlying neuroplasticity. ..
- Gillespie P, Tajuba J, Lippmann M, Chen L, Veronesi B. Particulate matter neurotoxicity in culture is size-dependent. Neurotoxicology. 2013;36:112-7 pubmed publisher..Together, these data suggest that the inverse relationship between size and toxicity reported in cardiopulmonary systems occurs in cultures of isolated dopaminergic neurons and in primary cultures of the rat striatum. ..
- Markowitz D, Wong Y, Gray C, Pesaran B. Optimizing the decoding of movement goals from local field potentials in macaque cortex. J Neurosci. 2011;31:18412-22 pubmed publisher..The results indicate that the performance of LFP-based neuroprostheses strongly depends on recording configuration and that recording depth is a critical parameter limiting system performance. ..
- HOANG P, Grueber W. Dendritic self-avoidance: protocadherins have it covered. Cell Res. 2013;23:323-5 pubmed publisher..A recent paper by Lefebvre and colleagues reveals that clustered protocadherins provide a basis for neuronal recognition during dendrite self-avoidance in vertebrates. ..
- Lafaille F, Pessach I, Zhang S, Ciancanelli M, Herman M, Abhyankar A, et al. Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells. Nature. 2012;491:769-73 pubmed publisher..Thus, impaired TLR3- and UNC-93B-dependent IFN-?/? intrinsic immunity to HSV-1 in the CNS, in neurons and oligodendrocytes in particular, may underlie the pathogenesis of HSE in children with TLR3-pathway deficiencies. ..
- Chin L, Li L, Ferreira A, Kosik K, Greengard P. Impairment of axonal development and of synaptogenesis in hippocampal neurons of synapsin I-deficient mice. Proc Natl Acad Sci U S A. 1995;92:9230-4 pubmed..Furthermore, synapse formation was significantly delayed in these mutant neurons. These results indicate that synapsin I plays a role in regulation of axonogenesis and synaptogenesis. ..
- Abbadie C, Pasternak G. Differential in vivo internalization of MOR-1 and MOR-1C by morphine. Neuroreport. 2001;12:3069-72 pubmed..In contrast, only DAMGO, and not morphine, internalized MOR-1-LI. These results illustrate differences in internalization between two MOR-1 variants that have alternative splicing at the COOH terminus. ..
- Bair W, Cavanaugh J, Movshon J. Time course and time-distance relationships for surround suppression in macaque V1 neurons. J Neurosci. 2003;23:7690-701 pubmed..We offer refinements to circuits for surround suppression that account for these results and describe how feedback from cells with large CRFs can account for the rapid propagation of suppression within V1. ..
- Sgaier S, Millet S, Villanueva M, Berenshteyn F, Song C, Joyner A. Morphogenetic and cellular movements that shape the mouse cerebellum; insights from genetic fate mapping. Neuron. 2005;45:27-40 pubmed..Thus, we show that progressive changes in the axes of the cerebellum underlie its genesis. ..
- Skeberdis V, Chevaleyre V, Lau C, Goldberg J, Pettit D, Suadicani S, et al. Protein kinase A regulates calcium permeability of NMDA receptors. Nat Neurosci. 2006;9:501-10 pubmed..Our data link PKA-dependent synaptic plasticity to Ca2+ signaling in spines and thus provide a new mechanism whereby PKA regulates the induction of LTP. ..
- Weinberger J. Evolving therapeutic approaches to treating acute ischemic stroke. J Neurol Sci. 2006;249:101-9 pubmed..Several promising therapeutic areas include targeting of free radicals, modulation of glutamatergic transmission, and membrane stabilization via ion channels. ..
- Ieraci A, Herrera D. Single alcohol exposure in early life damages hippocampal stem/progenitor cells and reduces adult neurogenesis. Neurobiol Dis. 2007;26:597-605 pubmed..This may explain certain aspects of impaired hippocampal functions in FAS. ..
- Roy N, Chandler Militello D, Lu G, Wang S, Goldman S. Retrovirally mediated telomerase immortalization of neural progenitor cells. Nat Protoc. 2007;2:2815-25 pubmed
- Bao L, Avshalumov M, Patel J, Lee C, Miller E, Chang C, et al. Mitochondria are the source of hydrogen peroxide for dynamic brain-cell signaling. J Neurosci. 2009;29:9002-10 pubmed publisher..These data provide the first demonstration that respiring mitochondria are the primary source of H(2)O(2) generation for dynamic neuronal signaling. ..
- Choi D, Hwang O, Lee K, Lee J, Beal M, Kim Y. DJ-1 cleavage by matrix metalloproteinase 3 mediates oxidative stress-induced dopaminergic cell death. Antioxid Redox Signal. 2011;14:2137-50 pubmed publisher..Our data suggest that DJ-1 is fragmented by the intracellular MMP3 in response to cell stress, abolishing the protective role of DJ-1 against oxidative damage, and this contributes to the pathogenesis of PD. ..
- Bounoutas A, Kratz J, Emtage L, Ma C, Nguyen K, Chalfie M. Microtubule depolymerization in Caenorhabditis elegans touch receptor neurons reduces gene expression through a p38 MAPK pathway. Proc Natl Acad Sci U S A. 2011;108:3982-7 pubmed publisher..This reduction requires a p38 MAPK pathway (DLK-1, MKK-4, and PMK-3) and the transcription factor CEBP-1. Cells may use this feedback pathway that couples microtubule state and MAPK activation to regulate cellular functions. ..
- Capetillo Zarate E, Gracia L, Tampellini D, Gouras G. Intraneuronal A? accumulation, amyloid plaques, and synapse pathology in Alzheimer's disease. Neurodegener Dis. 2012;10:56-9 pubmed publisher..The data support that A?42 accumulation and aggregation begin within AD-vulnerable neurons in the brain. Progressive intraneuronal A?42 aggregation disrupts the normal cytoarchitecture of neurites. ..
- Puthanveettil S, Antonov I, Kalachikov S, Rajasethupathy P, Choi Y, Kohn A, et al. A strategy to capture and characterize the synaptic transcriptome. Proc Natl Acad Sci U S A. 2013;110:7464-9 pubmed publisher..One of these RNAs, myosin heavy chain, is critical in presynaptic sensory neurons for the establishment of long-term facilitation, but not for its persistence...
- Buran B, von Trapp G, Sanes D. Behaviorally gated reduction of spontaneous discharge can improve detection thresholds in auditory cortex. J Neurosci. 2014;34:4076-81 pubmed publisher..These findings suggest that auditory cortex spontaneous discharge rate can be modulated transiently during task performance, thereby increasing the signal-to-noise ratio and enhancing signal detection. ..
- Jaramillo S, Borges K, Zador A. Auditory thalamus and auditory cortex are equally modulated by context during flexible categorization of sounds. J Neurosci. 2014;34:5291-301 pubmed publisher..Our results suggest that the AC and thalamus play only a limited role in mediating changes in associations between acoustic stimuli and behavioral responses. ..
- Yang W, Stockwell B. Ferroptosis: Death by Lipid Peroxidation. Trends Cell Biol. 2016;26:165-176 pubmed publisher..Here we summarize the discovery of ferroptosis, the mechanism of ferroptosis regulation, and its increasingly appreciated relevance to both normal and pathological physiology. ..
- Yang X, Zhong R, Heintz N. Granule cell specification in the developing mouse brain as defined by expression of the zinc finger transcription factor RU49. Development. 1996;122:555-66 pubmed
- Hardy R, Loushin C, Friedrich V, Chen Q, Ebersole T, Lazzarini R, et al. Neural cell type-specific expression of QKI proteins is altered in quakingviable mutant mice. J Neurosci. 1996;16:7941-9 pubmed..These observations implicate QKI proteins as regulators of myelination and reveal key insights into the mechanisms of dysmyelination in the quakingviable mutant. ..
- Cai D, Qiu J, Cao Z, McAtee M, Bregman B, Filbin M. Neuronal cyclic AMP controls the developmental loss in ability of axons to regenerate. J Neurosci. 2001;21:4731-9 pubmed..Thus, the switch from promotion to inhibition by myelin-MAG, which marks the developmental loss of regenerative capacity, is mediated by a developmentally regulated decrease in endogenous neuronal cAMP levels. ..
- Chuang J, Zhou H, Zhu M, Li S, Li X, Sung C. Characterization of a brain-enriched chaperone, MRJ, that inhibits Huntingtin aggregation and toxicity independently. J Biol Chem. 2002;277:19831-8 pubmed..Collectively, these results suggest that MRJ has a relevant functional role in neurons. ..
- Chesler D, Dodard C, Lee G, Levy D, Reiss C. Interferon-gamma-induced inhibition of neuronal vesicular stomatitis virus infection is STAT1 dependent. J Neurovirol. 2004;10:57-63 pubmed..Using olfactory bulb-enriched primary neuronal cultures, the inhibition of VSV replication was found to be STAT1 dependent, but did not require IRF-1. ..
- Zhang G, Neubert T. Use of detergents to increase selectivity of immunoprecipitation of tyrosine phosphorylated peptides prior to identification by MALDI quadrupole-TOF MS. Proteomics. 2006;6:571-8 pubmed..In addition, the signal intensities from pY-containing peptides were enhanced significantly after enrichment, allowing characterization of tyrosine phosphorylation sites with greater sensitivity. ..
- Johnson E, Kinoshita Y, Weinreb D, Wortman M, Simon R, Khalili K, et al. Role of Pur alpha in targeting mRNA to sites of translation in hippocampal neuronal dendrites. J Neurosci Res. 2006;83:929-43 pubmed..These results help define a mechanism by which Pur alpha targets specific mRNA molecules to sites of dendritic translation. ..
- Jordan B, Fernholz B, Khatri L, Ziff E. Activity-dependent AIDA-1 nuclear signaling regulates nucleolar numbers and protein synthesis in neurons. Nat Neurosci. 2007;10:427-35 pubmed..We propose that AIDA-1d mediates a link between synaptic activity and control of protein biosynthetic capacity by regulating nucleolar assembly. ..
- Kruglikov I, Rudy B. Perisomatic GABA release and thalamocortical integration onto neocortical excitatory cells are regulated by neuromodulators. Neuron. 2008;58:911-24 pubmed publisher..This is supplemented by the muscarinic-mediated depolarization of thalamo-recipient excitatory neurons and the nicotinic enhancement of thalamic input onto these neurons to promote thalamocortical excitation. ..
- Miyawaki T, Ofengeim D, Noh K, Latuszek Barrantes A, Hemmings B, Follenzi A, et al. The endogenous inhibitor of Akt, CTMP, is critical to ischemia-induced neuronal death. Nat Neurosci. 2009;12:618-26 pubmed publisher..Our results indicate that CTMP is important in the neurodegeneration that is associated with stroke and identify CTMP as a therapeutic target for the amelioration of hippocampal injury and cognitive deficits. ..
- Mosharov E, Larsen K, Kanter E, Phillips K, Wilson K, Schmitz Y, et al. Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons. Neuron. 2009;62:218-29 pubmed publisher..Thus, an interaction between Ca2+, DA(cyt), and alpha-synuclein may underlie the susceptibility of SN neurons in PD, suggesting multiple therapeutic targets. ..
- Kessels H, Kopec C, Klein M, Malinow R. Roles of stargazin and phosphorylation in the control of AMPA receptor subcellular distribution. Nat Neurosci. 2009;12:888-96 pubmed publisher..Our results suggest that AMPAR surface expression, but not its intracellular production or accumulation, is critical for regulating synaptic transmission. ..
- Stern E, GarcÃa Crescioni K, Miller M, Peskin C, Brezina V. A method for decoding the neurophysiological spike-response transform. J Neurosci Methods. 2009;184:337-56 pubmed publisher..The functions are such that they may be interpreted mechanistically. We examine the performance of the method as applied to synthetic data. We then use the method to decode real synaptic and muscle contraction transforms. ..
- Agatsuma S, Dang M, Li Y, Hiroi N. N-methyl-D-aspartic acid receptors on striatal neurons are essential for cocaine cue reactivity in mice. Biol Psychiatry. 2010;67:778-80 pubmed publisher..Our finding identifies a brain region whose constitutive NMDAR level serves as a determinant for susceptibility to this aspect of cocaine addiction. ..
- Krause D, Suh H, Tarassishin L, Cui Q, Durafourt B, Choi N, et al. The tryptophan metabolite 3-hydroxyanthranilic acid plays anti-inflammatory and neuroprotective roles during inflammation: role of hemeoxygenase-1. Am J Pathol. 2011;179:1360-72 pubmed publisher..Together, our results demonstrate the novel neuroprotective activity of the tryptophan metabolite 3-HAA and have implications for future therapeutic approaches for neuroinflammatory disorders. ..
- Anthony T, Dee N, Bernard A, Lerchner W, Heintz N, Anderson D. Control of stress-induced persistent anxiety by an extra-amygdala septohypothalamic circuit. Cell. 2014;156:522-36 pubmed publisher..These data identify a subset of LS projection neurons that promote, rather than suppress, stress-induced behavioral and endocrinological dimensions of persistent anxiety states and provide a cellular point of entry to LS circuitry. ..
- Sun S, Zhang H, Liu J, Popugaeva E, Xu N, Feske S, et al. Reduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice. Neuron. 2014;82:79-93 pubmed publisher..Our results identify STIM2-nSOC-CaMKII synaptic maintenance pathway as a novel potential therapeutic target for treatment of AD and age-related memory decline. ..
- Cottrell J, Li B, Kyung J, Ashford C, Mann J, Horvath T, et al. Calcineurin AÎ³ is a Functional Phosphatase That Modulates Synaptic Vesicle Endocytosis. J Biol Chem. 2016;291:1948-56 pubmed publisher..These data indicate that CNAÎ³ regulates a critical aspect of synaptic vesicle cycling and suggest that variation in PPP3CC may contribute to psychiatric disease by altering presynaptic function. ..
- Packer A. Neocortical neurogenesis and the etiology of autism spectrum disorder. Neurosci Biobehav Rev. 2016;64:185-95 pubmed publisher..This view of ASD suggests the need for a better understanding of the relationship between variation in neuron number, laminar composition, and the neural circuitry most relevant to the disorder. ..
- Zhu Y, Vidaurre O, Adula K, Kezunovic N, Wentling M, Huntley G, et al. Subcellular Distribution of HDAC1 in Neurotoxic Conditions Is Dependent on Serine Phosphorylation. J Neurosci. 2017;37:7547-7559 pubmed publisher..Here, we use transgenic lines to define the in vivo relevance of HDAC1 and identify calcineurin-dependent serine dephosphorylation as the signal modulating the neurotoxic role of HDAC1 in response to neurotoxic stimuli. ..
- Hori O, Brett J, Slattery T, Cao R, Zhang J, Chen J, et al. The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system. J Biol Chem. 1995;270:25752-61 pubmed
- Shi W, Wymore R, Wang H, Pan Z, Cohen I, McKinnon D, et al. Identification of two nervous system-specific members of the erg potassium channel gene family. J Neurosci. 1997;17:9423-32 pubmed..Expression of the erg1 gene in the sympathetic nervous system has potential implications for the etiology of the LQT2 form of the human genetic disease long QT syndrome. ..
- Dahmane N, Ruiz i Altaba A. Sonic hedgehog regulates the growth and patterning of the cerebellum. Development. 1999;126:3089-100 pubmed..In addition, they provide a cellular context for medulloblastomas, childhood cancers of the cerebellum. ..
- Windrem M, Roy N, Wang J, Nunes M, Benraiss A, Goodman R, et al. Progenitor cells derived from the adult human subcortical white matter disperse and differentiate as oligodendrocytes within demyelinated lesions of the rat brain. J Neurosci Res. 2002;69:966-75 pubmed..This being the case, they may constitute appropriate vectors for cell-based remyelination strategies. ..
- Chih B, Afridi S, Clark L, Scheiffele P. Disorder-associated mutations lead to functional inactivation of neuroligins. Hum Mol Genet. 2004;13:1471-7 pubmed
- Mazzoni E, Desplan C, Blau J. Circadian pacemaker neurons transmit and modulate visual information to control a rapid behavioral response. Neuron. 2005;45:293-300 pubmed..Furthermore, as clock gene mutations also affect photophobicity, the pacemaker neurons modulate the sensitivity of larvae to light, generating a circadian rhythm in visual sensitivity...
- Movshon J, Kiorpes L, Hawken M, Cavanaugh J. Functional maturation of the macaque's lateral geniculate nucleus. J Neurosci. 2005;25:2712-22 pubmed..In contrast to previous studies, we conclude that these limits are set by neural development in the visual cortex, not in or peripheral to the LGN. ..
- Zhang W, Benson D. Targeting and clustering citron to synapses. Mol Cell Neurosci. 2006;31:26-36 pubmed..Thus, citron's clustering at postsynaptic membranes is mediated by multiple domains, and its synaptic distribution is modified in response to Rho activation. ..
- Mason H, Rakowiecki S, Gridley T, Fishell G. Loss of notch activity in the developing central nervous system leads to increased cell death. Dev Neurosci. 2006;28:49-57 pubmed
- Moussaif M, Sze J. Intraflagellar transport/Hedgehog-related signaling components couple sensory cilium morphology and serotonin biosynthesis in Caenorhabditis elegans. J Neurosci. 2009;29:4065-75 pubmed publisher..elegans under stress and stress recovery...
- Gershon M. Developmental determinants of the independence and complexity of the enteric nervous system. Trends Neurosci. 2010;33:446-56 pubmed publisher..It is probable that highly prevalent disorders of gastrointestinal sensation and motility result from subtle defects in ENS development. ..
- Sutachan J, Chao M, Ninan I. Regulation of inhibitory neurotransmission by the scaffolding protein ankyrin repeat-rich membrane spanning/kinase D-interacting substrate of 220 kDa. J Neurosci Res. 2010;88:3447-56 pubmed publisher..Our results suggest that the ARMS/Kidins220 scaffold protein plays a critical role in the regulation of inhibitory transmission in hippocampal neurons. ..
- Brandt J, Aziz Zaman S, Juozaityte V, Martinez Velazquez L, Petersen J, Pocock R, et al. A single gene target of an ETS-family transcription factor determines neuronal CO2-chemosensitivity. PLoS ONE. 2012;7:e34014 pubmed publisher..Because ETS-5 and GCY-9 are members of gene families that are conserved between nematodes and vertebrates, a similar mechanism might act in the specification of CO(2)-sensing neurons in other phyla. ..
- Song R, Massenburg B, Wenderski W, Jayaraman V, Thompson L, Neves S. ERK regulation of phosphodiesterase 4 enhances dopamine-stimulated AMPA receptor membrane insertion. Proc Natl Acad Sci U S A. 2013;110:15437-42 pubmed publisher..The combination of dynamical models and experiments has helped us unravel the complex interactions between two protein kinase pathways in regulating a fundamental molecular process underlying synaptic plasticity. ..
- Wang J, Gong B, Zhao W, Tang C, Varghese M, Nguyen T, et al. Epigenetic mechanisms linking diabetes and synaptic impairments. Diabetes. 2014;63:645-54 pubmed publisher..Our study provides, for the first time, an epigenetic explanation for the increased risk of diabetic patients developing dementia. ..
- Fishell G, Hatten M. Astrotactin provides a receptor system for CNS neuronal migration. Development. 1991;113:755-65 pubmed..These results suggest astrotactin acts as a neuronal receptor for granule neuron migration along astroglial fibers. ..
- Chen J, Li Z, Pan H, Murphy D, Tamir H, Koepsell H, et al. Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters. J Neurosci. 2001;21:6348-61 pubmed..The watery diarrhea is probably attributable to the potentiation of serotonergic signaling in SERT -/- mice, whereas the transient constipation may be caused by episodes of enhanced 5-HT release leading to 5-HT receptor desensitization. ..
- Siao C, Tsirka S. Tissue plasminogen activator mediates microglial activation via its finger domain through annexin II. J Neurosci. 2002;22:3352-8 pubmed..Developing methods to inhibit the interaction of tPA with annexin II would offer a new and selective approach to interfere with microglial activation for therapeutic purposes. ..
- Sulzer D, Galli A. Dopamine transport currents are promoted from curiosity to physiology. Trends Neurosci. 2003;26:173-6 pubmed..This response extends the range of states regulated by neurotransmitter feedback, and could contribute importantly to understanding amphetamine action. ..
- Jia F, Pignataro L, Schofield C, Yue M, Harrison N, Goldstein P. An extrasynaptic GABAA receptor mediates tonic inhibition in thalamic VB neurons. J Neurophysiol. 2005;94:4491-501 pubmed..In view of the critical role of thalamic neurons in the generation of oscillatory activity associated with sleep, these receptors may represent a principal site of action for the novel hypnotic agent gaboxadol. ..
- Rothschild G, Zhao X, Iavarone A, Lasorella A. E Proteins and Id2 converge on p57Kip2 to regulate cell cycle in neural cells. Mol Cell Biol. 2006;26:4351-61 pubmed
- Galanopoulou A. Developmental patterns in the regulation of chloride homeostasis and GABA(A) receptor signaling by seizures. Epilepsia. 2007;48 Suppl 5:14-8 pubmed..The contrasting patterns of regulation of KCC2 by seizures in mature and immature neurons may be one of the age-related factors that protect the neonatal brain against the development of epilepsy. ..
- Ching G, Liem R. RE1 silencing transcription factor is involved in regulating neuron-specific expression of alpha-internexin and neurofilament genes. J Neurochem. 2009;109:1610-23 pubmed publisher..Thus, REST regulates expression of these neuronal genes, partly by a HDAC-dependent epigenetic mechanism. ..
- Myeku N, Figueiredo Pereira M. Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1/p62. J Biol Chem. 2011;286:22426-40 pubmed publisher..We also provide strong evidence that p62/SQSTM1 associates with proteasomes and that autophagy degrades p62/SQSTM1. Overall, the function of p62/SQSTM1 in the proteasomal pathway and autophagy requires further elucidation. ..
- ..This review describes emerging roles of H(2)O(2) as a signaling agent in the nigrostriatal pathway and basal ganglia neurons. ..
- Kaushik S, Arias E, Kwon H, Lopez N, ATHONVARANGKUL D, Sahu S, et al. Loss of autophagy in hypothalamic POMC neurons impairs lipolysis. EMBO Rep. 2012;13:258-65 pubmed publisher..Modulating hypothalamic autophagy might have implications for preventing obesity and metabolic syndrome of ageing. ..
- Sinnamon J, Waddell C, Nik S, Chen E, Czaplinski K. Hnrpab regulates neural development and neuron cell survival after glutamate stimulation. RNA. 2012;18:704-19 pubmed publisher..We also demonstrate that Hnrpab nucleocytoplasmic distribution in primary neurons is regulated by developmental stage. ..
- Jia X, Xing D, Kohn A. No consistent relationship between gamma power and peak frequency in macaque primary visual cortex. J Neurosci. 2013;33:17-25 pubmed publisher..We propose a simple model that can account for the complex stimulus dependence we observe, and suggest that separate mechanisms determine gamma power and peak frequency. ..
- Ren H, Lu T, McGraw T, Accili D. Anorexia and impaired glucose metabolism in mice with hypothalamic ablation of Glut4 neurons. Diabetes. 2015;64:405-17 pubmed publisher..We conclude that Glut4 neurons integrate hormonal and nutritional cues and mediate CNS actions of insulin on energy balance and peripheral metabolism. ..
- Neystat M, Rzhetskaya M, Oo T, Kholodilov N, Yarygina O, Wilson A, et al. Expression of cyclin-dependent kinase 5 and its activator p35 in models of induced apoptotic death in neurons of the substantia nigra in vivo. J Neurochem. 2001;77:1611-25 pubmed..We conclude that cdk5/p35 expression is a general feature of apoptotic neuron death in substantia nigra neurons in vivo. ..
- Rust N, Schultz S, Movshon J. A reciprocal relationship between reliability and responsiveness in developing visual cortical neurons. J Neurosci. 2002;22:10519-23 pubmed..We propose that these changes are a consequence of the increasing ability of cortical cells to encode rapid changes in the visual environment. ..
- Johnston R, Chang S, Etchberger J, Ortiz C, Hobert O. MicroRNAs acting in a double-negative feedback loop to control a neuronal cell fate decision. Proc Natl Acad Sci U S A. 2005;102:12449-54 pubmed..The interaction of miRNAs in double-negative feedback loops may not only be a means for miRNAs to regulate their own expression but may also represent a general paradigm for how terminal cell fates are selected and stabilized. ..
- Ogburn K, Bottiglieri T, Wang Z, Figueiredo Pereira M. Prostaglandin J2 reduces catechol-O-methyltransferase activity and enhances dopamine toxicity in neuronal cells. Neurobiol Dis. 2006;22:294-301 pubmed..Thus, COMT impairment following pro-inflammatory events may be a potential risk factor in neurodegeneration. ..
- Hof P, Van der Gucht E. Structure of the cerebral cortex of the humpback whale, Megaptera novaeangliae (Cetacea, Mysticeti, Balaenopteridae). Anat Rec (Hoboken). 2007;290:1-31 pubmed
- Nishiyama M, von Schimmelmann M, Togashi K, Findley W, Hong K. Membrane potential shifts caused by diffusible guidance signals direct growth-cone turning. Nat Neurosci. 2008;11:762-71 pubmed publisher..Thus, the polarity of growth-cone potential shifts imposes either attraction or repulsion, and Sema3A achieves this through cGMP signaling. ..
- de la Rocha J, Marchetti C, Schiff M, Reyes A. Linking the response properties of cells in auditory cortex with network architecture: cotuning versus lateral inhibition. J Neurosci. 2008;28:9151-63 pubmed publisher..We conclude that both types of circuits must be present to account for the wide variety of responses observed in vivo. ..
- Scobie K, Hall B, Wilke S, Klemenhagen K, Fujii Kuriyama Y, Ghosh A, et al. Krüppel-like factor 9 is necessary for late-phase neuronal maturation in the developing dentate gyrus and during adult hippocampal neurogenesis. J Neurosci. 2009;29:9875-87 pubmed publisher..Klf-9-dependent neuronal maturation may therefore represent a candidate regulatory mechanism underlying these temporally distinct processes. ..
- Drover J, Schiff N, Victor J. Dynamics of coupled thalamocortical modules. J Comput Neurosci. 2010;28:605-16 pubmed publisher..These considerations suggest a role for the reticular nucleus in modulating long distance cortical communication. ..